diclofenac has been researched along with Liver Neoplasms in 12 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of cyclooxygenase inhibitor diclofenac on the proliferation and cyclooxygenase-2 (COX-2) mRNA expression of cultured hepatocellular carcinoma cell lines HepG2, Hep3B and human hepatocellular cell line QSG-7701." | 3.73 | [Diclofenac suppresses hepatoma cell proliferation and promotes cyclooxygenase-2 mRNA expression]. ( Chen, NN; Wu, SG, 2006) |
| "IV-PCA was noninferior to TEA for the treatment of postoperative pain in patients undergoing open liver resection." | 2.90 | Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial. ( Andersen, MH; Bjørnelv, GMW; Dagenborg, VJ; Edwin, B; Fretland, ÅA; Hausken, J; Kristiansen, R; Kvarstein, G; Røysland, K; Tønnessen, TI, 2019) |
| " Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps." | 1.38 | Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012) |
| " The underlying mechanism for TL-118-treatment success was associated with hepatic perfusion attenuation resulting from reduced nitric-oxide (NO) serum levels as elucidated by using hemodynamic response imaging (HRI, a functional MRI combined with hypercapnia and hyperoxia)." | 1.38 | Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. ( Abramovitch, R; Corchia, N; Edrei, Y; Gross, E, 2012) |
| "Pirarubicin is a potent anti-VX2 agent." | 1.29 | Oral diclofenac combined with intra-portal pirarubicin: increased efficacy on liver VX2 tumour and hepatotoxicity in rabbits. ( Ardouin, P; Bognel, C; Donatini, B; Munck, JN; Ramirez, L; Rougier, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hausken, J | 1 |
| Fretland, ÅA | 1 |
| Edwin, B | 1 |
| Andersen, MH | 1 |
| Dagenborg, VJ | 1 |
| Bjørnelv, GMW | 1 |
| Kristiansen, R | 1 |
| Røysland, K | 1 |
| Kvarstein, G | 1 |
| Tønnessen, TI | 1 |
| Bass, SE | 1 |
| Sienkiewicz, P | 1 |
| Macdonald, CJ | 1 |
| Cheng, RY | 1 |
| Sparatore, A | 1 |
| Del Soldato, P | 1 |
| Roberts, DD | 1 |
| Moody, TW | 1 |
| Wink, DA | 1 |
| Yeh, GC | 1 |
| Niklas, J | 1 |
| Noor, F | 1 |
| Heinzle, E | 1 |
| Fredriksson, L | 1 |
| Herpers, B | 1 |
| Benedetti, G | 1 |
| Matadin, Q | 1 |
| Puigvert, JC | 1 |
| de Bont, H | 1 |
| Dragovic, S | 1 |
| Vermeulen, NP | 1 |
| Commandeur, JN | 1 |
| Danen, E | 1 |
| de Graauw, M | 1 |
| van de Water, B | 1 |
| Lin, J | 1 |
| Schyschka, L | 1 |
| Mühl-Benninghaus, R | 1 |
| Neumann, J | 1 |
| Hao, L | 1 |
| Nussler, N | 1 |
| Dooley, S | 1 |
| Liu, L | 1 |
| Stöckle, U | 1 |
| Nussler, AK | 1 |
| Ehnert, S | 1 |
| Edrei, Y | 1 |
| Gross, E | 1 |
| Corchia, N | 1 |
| Abramovitch, R | 1 |
| Cantoni, L | 1 |
| Valaperta, R | 1 |
| Ponsoda, X | 1 |
| Castell, JV | 1 |
| Barelli, D | 1 |
| Rizzardini, M | 1 |
| Mangolini, A | 1 |
| Hauri, L | 1 |
| Villa, P | 1 |
| Chen, NN | 1 |
| Wu, SG | 1 |
| Song, HJ | 1 |
| Kim, YS | 2 |
| Han, CH | 1 |
| Jang, JY | 1 |
| Kim, JH | 1 |
| Cheon, YK | 1 |
| Moon, JH | 1 |
| Cho, YD | 1 |
| Shim, CS | 1 |
| Kwon, KH | 1 |
| Kim, BS | 1 |
| Donatini, B | 1 |
| Bognel, C | 1 |
| Munck, JN | 1 |
| Ramirez, L | 1 |
| Ardouin, P | 1 |
| Rougier, P | 1 |
| Barlow, JW | 1 |
| Raggatt, LE | 1 |
| Scholz, GH | 1 |
| Loidl, NM | 1 |
| Blok, RB | 1 |
| Topliss, DJ | 1 |
| Stockigt, JR | 1 |
| Solinas, A | 1 |
| Biscarini, L | 1 |
| Morrelli, A | 1 |
| Del Favero, A | 1 |
1 trial available for diclofenac and Liver Neoplasms
| Article | Year |
|---|---|
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2019 |
11 other studies available for diclofenac and Liver Neoplasms
| Article | Year |
|---|---|
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Line, Tumor; Colorectal Neopl | 2009 |
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.
Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pr | 2009 |
Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 8; Cell Line, Tumor; Cyclooxygenase Inhibitor | 2011 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme | 2012 |
Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice.
Topics: Angiogenesis Inhibitors; Animals; Cimetidine; Colorectal Neoplasms; Cyclophosphamide; Diclofenac; Di | 2012 |
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytoch | 2003 |
[Diclofenac suppresses hepatoma cell proliferation and promotes cyclooxygenase-2 mRNA expression].
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase In | 2006 |
[A case of complete regression of hepatocellular carcinoma during administration of COX-2 inhibitor].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Celeco | 2006 |
Oral diclofenac combined with intra-portal pirarubicin: increased efficacy on liver VX2 tumour and hepatotoxicity in rabbits.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Pro | 1994 |
Preferential inhibition of cytoplasmic T3 binding is associated with reduced nuclear binding in cultured cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Cells, Cultured; Cytoplasm; Diclofenac; Hepat | 1996 |
Hepatocellular carcinoma and the watery diarrhea syndrome.
Topics: Carcinoma, Hepatocellular; Diarrhea; Diclofenac; Humans; Liver Neoplasms | 1988 |