diclofenac has been researched along with Kidney Failure in 21 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl-β-cyclodextrin (HPβCD) following administration of the injectable NSAID HPβCD-diclofenac; and (2) the PK of HPβCD following administration of HPβCD-diclofenac and intravenous itraconazole formulated with HPβCD in healthy adults." | 9.27 | Pharmacokinetics of Diclofenac and Hydroxypropyl-β-Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD-Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment. ( Carr, DB; Ernst, CC; Hamilton, DA; Kramer, WG; Lacouture, PG; Lang, E; Liao, E; Madden, D; Ramaiya, A, 2018) |
| "A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1." | 7.69 | Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996) |
| " This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl-β-cyclodextrin (HPβCD) following administration of the injectable NSAID HPβCD-diclofenac; and (2) the PK of HPβCD following administration of HPβCD-diclofenac and intravenous itraconazole formulated with HPβCD in healthy adults." | 5.27 | Pharmacokinetics of Diclofenac and Hydroxypropyl-β-Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD-Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment. ( Carr, DB; Ernst, CC; Hamilton, DA; Kramer, WG; Lacouture, PG; Lang, E; Liao, E; Madden, D; Ramaiya, A, 2018) |
| " Both mothers had been administered diclofenac during pregnancy." | 3.78 | Maternal ingestion of diclofenac leading to renal failure in newborns. ( Bhardwaj, S; Kanhere, S; Phadke, V; Sahoo, B, 2012) |
| "Due to pain from infected 12 per cent TBSA flame injuries a 71-year-old female was treated with a non-steroidal antiinflammatory drug (diclofenac), thereby inhibiting the synthesis of prostaglandins, and developed transient impairment of renal function." | 3.69 | Impairment of renal function after treatment of a burn patient with diclofenac, a non-steroidal antiinflammatory drug. ( Ericsson, F; Jonsson, CE, 1995) |
| "A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1." | 3.69 | Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996) |
| "Decisions to use or avoid nonsteroidal anti-inflammatory drugs (NSAIDs) for postsurgical pain are often influenced by concerns about bleeding and renal adverse effects." | 2.78 | Safety of a novel parenteral formulation of diclofenac after major orthopedic or abdominal/pelvic surgery in a population including anticoagulated, elderly or renally insufficient patients: an open-label, multiday, repeated dose clinical trial. ( Carr, DB; Chelly, JE; Lacouture, PG; Melson, TI; Paadre, S; Singla, SK, 2013) |
| "No cases of post-operative renal failure requiring dialysis were described." | 2.41 | Effects of nonsteroidal anti-inflammatory drugs on post-operative renal function in adults. ( Cooper, MG; Craig, JC; Keneally, JP; Knight, JF; Lee, A, 2000) |
| "Pretreatment with aprepitant successfully ameliorated and improved all biochemical and molecular parameters induced by DIC." | 1.72 | Involvement of NOX-4/JAK/STAT pathway in the protective effect of aprepitant against diclofenac-induced renal toxicity. ( Hafez, HM; Mohamed, MZ; Rifaai, RA; Waz, S, 2022) |
| "The knowledge of pharmacokinetic and pharmacodynamic properties of antiepileptic drugs is helpful in optimizing drug therapy for epilepsy." | 1.46 | Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence. ( Kumar, B; Medhi, B; Modi, M; Saikia, B, 2017) |
| "In this model of renal failure induced by NSAID administration combined with water deprivation, NAC treatment successfully attenuated the deterioration of renal function by inducing renal vasodilatation, decreasing oxidative stress via inhibition of intrarenal ROS content and restoration of intrarenal PGE2 release back to the basal levels." | 1.34 | N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis. ( Averbukh, Z; Berman, S; Efrati, S; Golik, A; Lotan, R; Siman-Tov, Y; Weissgarten, J, 2007) |
| "To investigate the frequency of membranous nephropathy associated with nonsteroidal anti-inflammatory drug (NSAID) use and identify associated clinical characteristics." | 1.29 | Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs. ( Donadio, JV; Grande, JP; Holley, KE; Larson, TS; McCarthy, JT; Radford, MG; Wagoner, RD, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Stokstad, E | 1 |
| Hafez, HM | 1 |
| Waz, S | 1 |
| Rifaai, RA | 1 |
| Mohamed, MZ | 1 |
| Alorabi, M | 1 |
| Cavalu, S | 1 |
| Al-Kuraishy, HM | 1 |
| Al-Gareeb, AI | 1 |
| Mostafa-Hedeab, G | 1 |
| Negm, WA | 1 |
| Youssef, A | 1 |
| El-Kadem, AH | 1 |
| Saad, HM | 1 |
| Batiha, GE | 1 |
| Kumar, B | 1 |
| Modi, M | 1 |
| Saikia, B | 1 |
| Medhi, B | 1 |
| Hamilton, DA | 1 |
| Ernst, CC | 1 |
| Kramer, WG | 1 |
| Madden, D | 1 |
| Lang, E | 1 |
| Liao, E | 1 |
| Lacouture, PG | 2 |
| Ramaiya, A | 1 |
| Carr, DB | 2 |
| Chelly, JE | 1 |
| Singla, SK | 1 |
| Melson, TI | 1 |
| Paadre, S | 1 |
| Phadke, V | 1 |
| Bhardwaj, S | 1 |
| Sahoo, B | 1 |
| Kanhere, S | 1 |
| Kaiser, A | 1 |
| Oaks, JL | 2 |
| Gilbert, M | 2 |
| Virani, MZ | 1 |
| Watson, RT | 1 |
| Meteyer, CU | 2 |
| Rideout, BA | 2 |
| Shivaprasad, HL | 2 |
| Ahmed, S | 1 |
| Chaudhry, MJ | 1 |
| Arshad, M | 1 |
| Mahmood, S | 1 |
| Ali, A | 1 |
| Khan, AA | 1 |
| Risebrough, R | 1 |
| Ahrens, N | 1 |
| Schewior, L | 1 |
| Garbe, E | 1 |
| Kiesewetter, H | 1 |
| Salama, A | 1 |
| O'Rourke, K | 1 |
| Cohen, MP | 1 |
| Lautenslager, GT | 1 |
| Hud, E | 1 |
| Shea, E | 1 |
| Wang, A | 1 |
| Chen, S | 1 |
| Shearman, CW | 1 |
| Efrati, S | 1 |
| Berman, S | 1 |
| Siman-Tov, Y | 1 |
| Lotan, R | 1 |
| Averbukh, Z | 1 |
| Weissgarten, J | 1 |
| Golik, A | 1 |
| Green, RE | 1 |
| Taggart, MA | 1 |
| Senacha, KR | 1 |
| Raghavan, B | 1 |
| Pain, DJ | 1 |
| Jhala, Y | 1 |
| Cuthbert, R | 1 |
| Inoue, M | 1 |
| Akimoto, T | 1 |
| Saito, O | 1 |
| Ando, Y | 1 |
| Muto, S | 1 |
| Kusano, E | 1 |
| Jonsson, CE | 1 |
| Ericsson, F | 1 |
| Radford, MG | 1 |
| Holley, KE | 1 |
| Grande, JP | 1 |
| Larson, TS | 1 |
| Wagoner, RD | 1 |
| Donadio, JV | 1 |
| McCarthy, JT | 1 |
| Delrio, FG | 1 |
| Park, Y | 1 |
| Herzlich, B | 1 |
| Grob, D | 1 |
| Lee, A | 1 |
| Cooper, MG | 1 |
| Craig, JC | 1 |
| Knight, JF | 1 |
| Keneally, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label, Single-Dose Study to Evaluate the Safety and Pharmacokinetics of DIC075V in Subjects With Mild or Moderate Chronic Renal Insufficiency and in Subjects With Mild Chronic Hepatic Impairment Compared to Healthy Adult Volunteers and a Randomize[NCT00805090] | Phase 1 | 37 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diclofenac and Kidney Failure
| Article | Year |
|---|---|
Effects of nonsteroidal anti-inflammatory drugs on post-operative renal function in adults.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Diclofenac; Humans; Ketorolac; Kidney; P | 2000 |
2 trials available for diclofenac and Kidney Failure
| Article | Year |
|---|---|
Pharmacokinetics of Diclofenac and Hydroxypropyl-β-Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD-Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2018 |
Safety of a novel parenteral formulation of diclofenac after major orthopedic or abdominal/pelvic surgery in a population including anticoagulated, elderly or renally insufficient patients: an open-label, multiday, repeated dose clinical trial.
Topics: Abdomen; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulant | 2013 |
18 other studies available for diclofenac and Kidney Failure
| Article | Year |
|---|---|
Vultures face new toxic threat.
Topics: Animals; Cattle; Conservation of Natural Resources; Diclofenac; Extinction, Biological; Raptors; Ren | 2021 |
Involvement of NOX-4/JAK/STAT pathway in the protective effect of aprepitant against diclofenac-induced renal toxicity.
Topics: Animals; Aprepitant; Cyclooxygenase Inhibitors; Diclofenac; Gene Expression Regulation; Janus Kinase | 2022 |
Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Diclofenac; D | 2022 |
Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbon Tetrachl | 2017 |
Maternal ingestion of diclofenac leading to renal failure in newborns.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anuria; Diclofenac; Fatal Outcome; Female; Gestation | 2012 |
[Diclofenac caused renal insufficiency. A case illustrating the necessity of pharmaceutical intervention and care].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Therapy, Combination; Humans; Pressure Ulc | 2003 |
Diclofenac residues as the cause of vulture population decline in Pakistan.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autopsy; Bird Diseases; Cause of Death; Conservati | 2004 |
Conservation biology: fatal medicine for vultures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Cause of Death; Conservation of Nat | 2004 |
Massive haemolysis after intramuscular diclofenac in a patient who apparently tolerated oral medication.
Topics: Administration, Oral; Aged; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Antibodies; Diagnosis, | 2004 |
Veterinary drug kills vultures abroad.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Cattle; Cattle Diseases; Diclofenac | 2004 |
Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps bengalensis).
Topics: Animals; Animals, Wild; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Cause of Death; Dicl | 2005 |
Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.
Topics: Albumins; Animals; Collagen Type IV; Creatinine; Diabetes Mellitus, Experimental; Diclofenac; Glycos | 2007 |
N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytoprotection; Diclofenac; Dinopr | 2007 |
Rate of decline of the Oriental white-backed vulture population in India estimated from a survey of diclofenac residues in carcasses of ungulates.
Topics: Animals; Animals, Wild; Anti-Inflammatory Agents, Non-Steroidal; Cadaver; Cattle; Cattle Diseases; C | 2007 |
Successful relatively low-dose corticosteroid therapy for diclofenac-induced acute interstitial nephritis with severe renal failure.
Topics: Acetylglucosaminidase; Acute Disease; Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-S | 2008 |
Impairment of renal function after treatment of a burn patient with diclofenac, a non-steroidal antiinflammatory drug.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Burns; Diclofenac; Female; Humans; Pain; Renal Insuff | 1995 |
Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diclofenac; Female; Glomerulonephritis | 1996 |
Case report: diclofenac-induced rhabdomyolysis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Creatinine; Diclofenac; Erythema Mu | 1996 |