diclofenac has been researched along with Keratosis in 40 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Keratosis: Any horny growth such as a wart or callus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical diclofenac and imiquimod have been reported to be effective in the treatment of actinic keratosis, but a study to compare these two drugs has not been reported yet." | 9.13 | Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis. ( Caliskan, E; Erbil, AH; Koc, E; Kose, O; Kurumlu, Z, 2008) |
| "This non-blinded, uncontrolled case series study evaluated the effects of diclofenac 3% gel in the treatment of actinic cheilitis." | 7.74 | Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. ( Forschner, T; Sterry, W; Stockfleth, E; Termeer, C; Ulrich, C; Ulrich, M, 2007) |
| "Topical diclofenac and imiquimod have been reported to be effective in the treatment of actinic keratosis, but a study to compare these two drugs has not been reported yet." | 5.13 | Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis. ( Caliskan, E; Erbil, AH; Koc, E; Kose, O; Kurumlu, Z, 2008) |
| " Diclofenac is the anti-neoplastic compound in diclofenac 3% gel (Solaraze) used for topical treatment of actinic keratosis (AK)." | 4.84 | The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs). ( Eberle, J; Fecker, LF; Forschner, T; Nindl, I; Stockfleth, E; Ulrich, C, 2007) |
| " The topical NSAID diclofenac works as a nonspecific COX inhibitor and is an effective and well tolerated treatment for actinic keratosis, which is a principal precursor of cutaneous squamous cell carcinoma." | 4.84 | The role of topical cyclo-oxygenase-2 inhibitors in skin cancer: treatment and prevention. ( Zhan, H; Zheng, H, 2007) |
| "Hyaluronan (HA) in combination with diclofenac is currently undergoing clinical trials as a topical preparation in the management of osteoarthritic pain, basal-cell carcinoma and actinic keratosis." | 4.79 | Hyaluronan as a drug delivery system for diclofenac: a hypothesis for mode of action. ( Moore, AR; Willoughby, DA, 1995) |
| "This non-blinded, uncontrolled case series study evaluated the effects of diclofenac 3% gel in the treatment of actinic cheilitis." | 3.74 | Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. ( Forschner, T; Sterry, W; Stockfleth, E; Termeer, C; Ulrich, C; Ulrich, M, 2007) |
| "Fluorouracil has been the traditional topical treatment for actinic keratoses, although imiquimod 5% cream and diclofenac 3% gel are effective alternative therapies." | 2.44 | Treatment options for actinic keratoses. ( Bedwell, SA; Downs, MR; McIntyre, WJ, 2007) |
| "Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma." | 2.42 | Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003) |
| "The ability to manage non-melanoma skin cancers and pre-malignant lesions with topical pharmacologic agents is highly compelling." | 2.42 | Topical treatment strategies for non-melanoma skin cancer and precursor lesions. ( Fein, H; McGillis, ST, 2004) |
| "Diclofenac 3% gel is an effective treatment for actinic keratoses (AKs) and is reported to be generally well tolerated with only mild local reactions." | 1.34 | Genetically determined susceptibility to COX-2 inhibitors: a report of exaggerated responders to diclofenac 3% gel in the treatment of actinic keratoses. ( Forschner, T; Patel, MJ; Ulrich, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 36 (90.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pickert, A | 1 |
| Kose, O | 1 |
| Koc, E | 1 |
| Erbil, AH | 1 |
| Caliskan, E | 1 |
| Kurumlu, Z | 1 |
| Berlin, JM | 1 |
| Rigel, DS | 1 |
| Kerr, OA | 1 |
| Kavanagh, G | 1 |
| Horn, H | 1 |
| Gebauer, K | 1 |
| Brown, P | 1 |
| Varigos, G | 1 |
| Jarvis, B | 1 |
| Figgitt, DP | 1 |
| Tutrone, WD | 1 |
| Saini, R | 1 |
| Caglar, S | 1 |
| Weinberg, JM | 2 |
| Crespo, J | 1 |
| del Rosso, JQ | 2 |
| Peterson, SR | 1 |
| Goldberg, LH | 2 |
| Young, J | 1 |
| Silapunt, S | 1 |
| Alam, M | 1 |
| Rivers, JK | 3 |
| Kleyn, CE | 1 |
| Bharati, A | 1 |
| King, CM | 1 |
| McGillis, ST | 1 |
| Fein, H | 1 |
| Jorizzo, JL | 1 |
| Pirard, D | 1 |
| Vereecken, P | 1 |
| Mélot, C | 1 |
| Heenen, M | 1 |
| Smith, SR | 1 |
| Morhenn, VB | 1 |
| Piacquadio, DJ | 1 |
| Berman, B | 2 |
| Villa, AM | 1 |
| Ramirez, CC | 1 |
| Bienstock, L | 1 |
| Kuritzky, L | 1 |
| Mayeaux, EJ | 1 |
| Tyring, SK | 1 |
| Kowalzick, L | 1 |
| Ziegler, H | 1 |
| Cox, NH | 1 |
| Merk, HF | 1 |
| Rivers, JJ | 1 |
| Wolf, J | 1 |
| Fecker, LF | 1 |
| Stockfleth, E | 4 |
| Nindl, I | 1 |
| Ulrich, C | 4 |
| Forschner, T | 4 |
| Eberle, J | 1 |
| Hackethal, M | 1 |
| Ulrich, M | 2 |
| Howorka, A | 1 |
| Sterry, W | 2 |
| Termeer, C | 1 |
| Patel, MJ | 2 |
| Zhan, H | 1 |
| Zheng, H | 1 |
| Nelson, CG | 2 |
| Spencer, J | 1 |
| McIntyre, WJ | 1 |
| Downs, MR | 1 |
| Bedwell, SA | 1 |
| Gold, MH | 1 |
| Iraji, F | 1 |
| Siadat, AH | 1 |
| Asilian, A | 1 |
| Enshaieh, S | 1 |
| Shahmoradi, Z | 1 |
| Moore, AR | 1 |
| Willoughby, DA | 1 |
| McLean, DI | 1 |
| McEwan, LE | 1 |
| Smith, JG | 1 |
| Burkhart, CN | 1 |
| Burkhart, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy and Tolerability of Solaraze for 3 vs. 6 Months in Patients With Mild to Moderate Actinic Keratosis Located at the Face and Head[NCT00204542] | Phase 4 | 418 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for diclofenac and Keratosis
| Article | Year |
|---|---|
Topical 3% diclofenac in 2.5% hyaluronic acid gel: a review of its use in patients with actinic keratoses.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2003 |
Topical therapy for actinic keratoses, II: Diclofenac, colchicine, and retinoids.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Colchicin | 2003 |
An update on newer topical therapies for actinic keratoses: advances and applications.
Topics: Administration, Topical; Aminoquinolines; Clinical Trials as Topic; Diclofenac; Humans; Imiquimod; K | 2003 |
New and emerging topical approaches for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Ster | 2003 |
Topical and light-based treatments for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Antineoplasti | 2003 |
Topical treatment strategies for non-melanoma skin cancer and precursor lesions.
Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2004 |
Current and novel treatment options for actinic keratosis.
Topics: Aminolevulinic Acid; Aminoquinolines; Cryotherapy; Diclofenac; Fluorouracil; Gels; Humans; Imiquimod | 2004 |
Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Clinical Trials as Topic; Diclofenac; Dou | 2005 |
Mechanisms of action of new treatment modalities for actinic keratosis.
Topics: Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antineoplastic Agents; Di | 2006 |
Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel.
Topics: Administration, Cutaneous; Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Consens | 2006 |
Topical diclofenac in the treatment of actinic keratoses.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Diclofen | 2007 |
The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Adjuvants, Immunologic; Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antin | 2007 |
The role of topical cyclo-oxygenase-2 inhibitors in skin cancer: treatment and prevention.
Topics: Administration, Topical; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhi | 2007 |
Treatment options for actinic keratoses.
Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2007 |
The safety of diclofenac for the management and treatment of actinic keratoses.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma in Situ; Diclofenac; G | 2008 |
Topical therapy for actinic keratoses: current and evolving therapies.
Topics: Administration, Cutaneous; Administration, Topical; Aminoquinolines; Antineoplastic Agents; Carcinom | 2006 |
Hyaluronan as a drug delivery system for diclofenac: a hypothesis for mode of action.
Topics: Animals; Carcinoma, Basal Cell; Carotid Stenosis; Diclofenac; Drug Delivery Systems; Humans; Hyaluro | 1995 |
8 trials available for diclofenac and Keratosis
| Article | Year |
|---|---|
Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminoquinolines; | 2008 |
Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2008 |
Topical diclofenac in hyaluronan gel for the treatment of solar keratoses.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2003 |
Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Diclofenac; Facial Dermato | 2006 |
Assessing clinically meaningful end points for the management of actinic keratosis with diclofenac 3% gel.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; H | 2007 |
A single-arm, open-label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; De | 2007 |
An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratoses.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Irritant; Der | 1997 |
Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofena | 1997 |
15 other studies available for diclofenac and Keratosis
| Article | Year |
|---|---|
Treatment of actinic keratoses.
Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2012 |
New treatments for actinic keratoses.
Topics: Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Dermatologic Agents; Diclofenac; Fluo | 2002 |
Allergic contact dermatitis from topical diclofenac in Solaraze gel.
Topics: Administration, Topical; Allergens; Dermatitis, Allergic Contact; Diclofenac; Dose-Response Relation | 2002 |
New and emerging treatments for nonmelanomas and actinic keratoses.
Topics: Adjuvants, Immunologic; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Basal C | 2003 |
Erythema multiforme-like eruption as a result of 'Solaraze' treatment.
Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dic | 2003 |
Topical 3% diclofenac in 2.5% hyaluronan gel for the treatment of actinic keratoses.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gels; Humans; Hyaluronic Acid; Keratosis | 2004 |
Contact dermatitis from 3 different allergens in Solaraze gel.
Topics: Aged; Aged, 80 and over; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Allergic Co | 2004 |
Photoallergic contact dermatitis from topical diclofenac in Solaraze gel.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Photoallergic; D | 2006 |
Diclofenac for actinic keratoses: a formulation issue.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Humans; Keratosis; M | 2006 |
Treatment of multiple actinic keratoses with topical diclofenac 3% gel in organ transplant recipients: a series of six cases.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gels; Humans; Immunoco | 2007 |
Management of actinic cheilitis using diclofenac 3% gel: a report of six cases.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cheilitis | 2007 |
Does progression from actinic keratosis and Bowen's disease end with treatment: diclofenac 3% gel, an old drug in a new environment?
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Bowen's Disease; Diclofenac; Disea | 2007 |
Genetically determined susceptibility to COX-2 inhibitors: a report of exaggerated responders to diclofenac 3% gel in the treatment of actinic keratoses.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhi | 2007 |
Pharmacoeconomic analysis of the treatment of multiple actinic keratoses.
Topics: Aminolevulinic Acid; Aminoquinolines; Clinical Trials, Phase III as Topic; Combined Modality Therapy | 2008 |
Reassessment of topical diclofenac/hyaluronan gel for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac | 2002 |