diclofenac has been researched along with Intestinal Diseases in 39 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to explore the effect of geranylgeranylacetone on small-intestinal mucosal injuries induced by diclofenac sodium in patients with rheumatic diseases." | 9.20 | Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study. ( Chen, M; Huang, X; Li, L; Liang, L; Xiong, L; Yang, X; Ye, Y; Zhan, Z, 2015) |
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 5.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| "We aimed to explore the effect of geranylgeranylacetone on small-intestinal mucosal injuries induced by diclofenac sodium in patients with rheumatic diseases." | 5.20 | Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study. ( Chen, M; Huang, X; Li, L; Liang, L; Xiong, L; Yang, X; Ye, Y; Zhan, Z, 2015) |
| " Ulcerated lesions in intestinal mucosa were observed and breaking strength decreased in all diclofenac sodium treated rats." | 3.78 | Diclofenac sodium and Imipenem action on rat intestinal mucosa: a biomechanical and histological study. ( Gonçalves Junior, I; Kobayasi, S; Naresse, LE; Rodrigues, MA, 2012) |
| "Small intestinal ulceration is a frequent and potentially serious condition associated with nonselective cyclooxygenase 1/2 inhibitors (nonsteroidal anti-inflammatory drugs, NSAIDs) including diclofenac (DCF)." | 3.76 | Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice. ( Boelsterli, UA; Gavillet, B; LoGuidice, A; Proli, A; Ramirez-Alcantara, V, 2010) |
| "Small intestinal ulceration, bleeding, and inflammation are major adverse effects associated with the use of diclofenac (DCF) or other nonsteroidal anti-inflammatory drugs (NSAIDs)." | 3.75 | Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy. ( Boelsterli, UA; LoGuidice, A; Ramirez-Alcantara, V, 2009) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| "Rats were treated orally with diclofenac (10-100 mg/kg) and killed after 1-24 hours, and their gastrointestinal (GI) tracts were evaluated for ulcer number and area." | 3.70 | Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats. ( Aronson, JF; Atchison, CR; Balakumaran, A; Daiker, DH; Hargus, SJ; Hoffmann, WE; Pohl, LR; Shipp, BK; Treinen-Moslen, M; West, AB, 2000) |
| "Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy)." | 1.43 | Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity. ( Chen, Y; Li, Y; Ling, ZL; Liu, L; Liu, XD; Shu, N; Sun, BB; Tang, XG; Wang, F; Xia, LZ; Xie, QS; Xu, P; Zhang, M; Zhao, KJ; Zhong, ZY, 2016) |
| "Diclofenac (DCF) is a nonsteroidal anti-inflammatory drug commonly prescribed to reduce pain in acute and chronic inflammatory diseases." | 1.42 | Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac. ( Csanaky, IL; Goedken, MJ; Manautou, JE; Scialis, RJ, 2015) |
| " Pharmacokinetic analysis of Inh-1 revealed an absolute bioavailability (F) of 21% and a short t1/2 of <1 h." | 1.40 | Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. ( Boelsterli, UA; Fujimoto, K; Lee, KK; Redinbo, MR; Saitta, KS; Zhang, C, 2014) |
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 1.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 12 (30.77) | 29.6817 |
| 2010's | 16 (41.03) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| D'Antongiovanni, V | 1 |
| Antonioli, L | 2 |
| Benvenuti, L | 2 |
| Pellegrini, C | 2 |
| Di Salvo, C | 1 |
| Calvigioni, M | 1 |
| Panattoni, A | 1 |
| Ryskalin, L | 2 |
| Natale, G | 2 |
| Banni, S | 1 |
| Carta, G | 1 |
| Ghelardi, E | 2 |
| Fornai, M | 2 |
| Tirotta, E | 1 |
| Gentile, D | 1 |
| Colucci, R | 1 |
| Piccoli, E | 1 |
| Blandizzi, C | 1 |
| Xu, N | 1 |
| Zhang, C | 3 |
| Jing, L | 1 |
| Mou, S | 1 |
| Cao, X | 1 |
| Yu, Z | 1 |
| Feng, L | 1 |
| Yang, Y | 1 |
| Huo, X | 1 |
| Tian, X | 1 |
| Feng, Y | 1 |
| Yuan, H | 1 |
| Zhao, L | 1 |
| Wang, C | 1 |
| Chu, P | 1 |
| Long, F | 1 |
| Wang, W | 1 |
| Ma, X | 1 |
| Saitta, KS | 1 |
| Lee, KK | 1 |
| Fujimoto, K | 1 |
| Redinbo, MR | 2 |
| Boelsterli, UA | 4 |
| Satoh, H | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 2 |
| Ishihara, M | 1 |
| Ohmiya, N | 2 |
| Nakamura, M | 2 |
| Funasaka, K | 1 |
| Miyahara, R | 1 |
| Ohno, E | 1 |
| Kawashima, H | 1 |
| Itoh, A | 2 |
| Hirooka, Y | 2 |
| Watanabe, O | 1 |
| Ando, T | 2 |
| Goto, H | 2 |
| Xiong, L | 1 |
| Huang, X | 1 |
| Li, L | 1 |
| Yang, X | 1 |
| Liang, L | 1 |
| Zhan, Z | 1 |
| Ye, Y | 1 |
| Chen, M | 1 |
| Scialis, RJ | 1 |
| Csanaky, IL | 1 |
| Goedken, MJ | 1 |
| Manautou, JE | 1 |
| Zhong, ZY | 1 |
| Sun, BB | 1 |
| Shu, N | 1 |
| Xie, QS | 1 |
| Tang, XG | 1 |
| Ling, ZL | 1 |
| Wang, F | 1 |
| Zhao, KJ | 1 |
| Xu, P | 1 |
| Zhang, M | 1 |
| Li, Y | 1 |
| Chen, Y | 1 |
| Liu, L | 1 |
| Xia, LZ | 1 |
| Liu, XD | 1 |
| Mei, Y | 1 |
| Xiao, Z | 1 |
| Feng, J | 1 |
| Wang, T | 1 |
| Yuan, D | 1 |
| Liu, C | 1 |
| Björnsson, E | 1 |
| Westgaard, G | 1 |
| Bjarnason, I | 2 |
| Maiden, L | 2 |
| Fujimori, S | 2 |
| Seo, T | 2 |
| Gudis, K | 2 |
| Ehara, A | 2 |
| Kobayashi, T | 2 |
| Mitsui, K | 2 |
| Yonezawa, M | 2 |
| Tanaka, S | 2 |
| Tatsuguchi, A | 2 |
| Sakamoto, C | 2 |
| Pilgrim, S | 1 |
| Velchuru, V | 1 |
| Waters, G | 1 |
| Tsiamis, A | 1 |
| Lal, R | 1 |
| Takahashi, Y | 1 |
| Yamada, Y | 1 |
| Ramirez-Alcantara, V | 2 |
| LoGuidice, A | 3 |
| Proli, A | 1 |
| Gavillet, B | 1 |
| Zhang, S | 2 |
| Lü, B | 1 |
| Chao, GQ | 1 |
| Chen, FM | 1 |
| Chen, MY | 1 |
| Chen, HQ | 1 |
| Wallace, BD | 1 |
| Bendel, L | 1 |
| Gonçalves Junior, I | 1 |
| Naresse, LE | 1 |
| Rodrigues, MA | 1 |
| Kobayasi, S | 1 |
| Chao, G | 1 |
| Zhu, Y | 1 |
| Zhang, QY | 1 |
| Kim, JW | 1 |
| Jeon, WK | 1 |
| Yun, JW | 1 |
| Park, DI | 1 |
| Cho, YK | 1 |
| Sung, IK | 1 |
| Sohn, CI | 1 |
| Kim, BI | 1 |
| Yeom, JS | 1 |
| Park, HS | 1 |
| Kim, EJ | 1 |
| Shin, MS | 1 |
| Thjodleifsson, B | 1 |
| Theodors, A | 1 |
| Gonzalez, J | 1 |
| Yokota, A | 1 |
| Tanaka, A | 1 |
| Takahira, Y | 1 |
| Niwa, Y | 1 |
| Maeda, O | 1 |
| Bielecki, JW | 1 |
| Gebbers, JO | 1 |
| Filippini, L | 1 |
| Hudson, N | 1 |
| Wilkinson, MJ | 1 |
| Swannell, AJ | 1 |
| Steele, RJ | 1 |
| Hawkey, CJ | 1 |
| Schmassmann, A | 1 |
| Peskar, BM | 1 |
| Stettler, C | 1 |
| Netzer, P | 1 |
| Stroff, T | 1 |
| Flogerzi, B | 1 |
| Halter, F | 1 |
| Chaudhary, A | 3 |
| Gupta, RL | 4 |
| Reuter, BK | 1 |
| Wallace, JL | 1 |
| Golhar, KB | 1 |
| Atchison, CR | 2 |
| Balakumaran, A | 2 |
| West, AB | 2 |
| Hoffmann, WE | 2 |
| Treinen-Moslen, M | 2 |
| Hargus, SJ | 1 |
| Pohl, LR | 1 |
| Daiker, DH | 1 |
| Aronson, JF | 1 |
| Shipp, BK | 1 |
| Anthony, A | 1 |
| Somasundaram, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Preventive and Treatment Effects of Hp Eradication and Teprenone in Patients Taking NSAIDs[NCT01547559] | 369 participants (Actual) | Interventional | 2007-06-30 | Active, not recruiting | |||
| The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives[NCT03291743] | 38 participants (Actual) | Interventional | 2017-02-10 | Terminated (stopped due to Death of Principal Investigator) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diclofenac and Intestinal Diseases
| Article | Year |
|---|---|
Capsule endoscopic diagnosis of nonsteroidal antiinflammatory drug-induced enteropathy.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Controll | 2009 |
8 trials available for diclofenac and Intestinal Diseases
| Article | Year |
|---|---|
Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsule Endoscopy; Diclofenac; Di | 2015 |
Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Diclofenac; Humans; Intestinal Di | 2009 |
A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Delayed-Action Preparations; Dicl | 2005 |
Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective, randomized, double-blinded, placebo-controlled, cross-over study.
Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsule Endoscopy; Cross | 2008 |
Double-blind comparative prospective clinical evaluation of a combination antispasmodic--Manyana (R) (diclofenac pitafenone and fenpeverinium) and Baralgan (analgin + pitafenone and fenpeverinium) in intestinal, biliary and ureteric colic.
Topics: Adolescent; Adult; Benzophenones; Biliary Tract Diseases; Colic; Diclofenac; Dipyrone; Double-Blind | 1998 |
Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana) vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and int
Topics: Adolescent; Adult; Benzophenones; Biliary Tract Diseases; Colic; Diclofenac; Dipyrone; Double-Blind | 1999 |
Open labelled evaluation of injection Manyana (a combination of diclofenac + pitofenone + fenpiverinium) in ureteric, biliary and intestinal spasm--a preliminary report.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Biliary Tract Diseases; C | 1999 |
Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and inte
Topics: Adolescent; Adult; Benzophenones; Biliary Tract Diseases; Colic; Diclofenac; Dipyrone; Double-Blind | 1999 |
30 other studies available for diclofenac and Intestinal Diseases
| Article | Year |
|---|---|
Use of Saccharomyces boulardii CNCM I-745 as therapeutic strategy for prevention of nonsteroidal anti-inflammatory drug-induced intestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Diclofenac; Intestinal Diseases; Male; | 2023 |
Protective effects of the combination Bifidobacterium longum plus lactoferrin against NSAID-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium longum; Diclofenac; Feces; Hemoglo | 2020 |
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Claudin-1; Cytokines; Diclofenac; Disease | 2021 |
Highly Selective NIR Probe for Intestinal β-Glucuronidase and High-Throughput Screening Inhibitors to Therapy Intestinal Damage.
Topics: Acridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Catechin; Diclofenac; Enzyme | 2018 |
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Enzyme Inhibit | 2014 |
Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dose-Respo | 2014 |
Risk factors of symptomatic NSAID-induced small intestinal injury and diaphragm disease.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Capsul | 2014 |
Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B; Bil | 2015 |
Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Ciprofloxacin; Diclofenac; Dose-Response R | 2016 |
[The preventive effect of total saponins of Panax japonicus on nonsteroidal anti-inflammatory drug-induced enteropathy].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Endoplasmic Reticulum Chaperone BiP; E | 2016 |
Severe injury to the small bowel associated with a short course of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Intestinal Diseases; Intestine, | 2008 |
Diaphragm disease and small bowel enteropathy due to nonsteroidal anti-inflammatory drugs: a surgical perspective.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Constriction, Pathologic; Diaphragm; Diclofe | 2011 |
Distribution of small intestinal mucosal injuries as a result of NSAID administration.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Diclofenac; Humans; Intestinal Di | 2010 |
Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy.
Topics: Alkaline Phosphatase; Animals; Anthracenes; Apoptosis; Blood Proteins; Diclofenac; Intestinal Diseas | 2009 |
Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclophilins; Cyclospori | 2010 |
[The effects of milk and milk products on non-steroidal anti-inflammatory drug induced intestinal damage in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Colostrum; Diclofenac; Intestinal Diseases | 2011 |
Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Enterocytes; Escherichia coli; Escheri | 2012 |
Diclofenac sodium and Imipenem action on rat intestinal mucosa: a biomechanical and histological study.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Imipenem; Intes | 2012 |
Therapeutic effects of muscovite to non-steroidal anti-inflammatory drugs-induced small intestinal disease.
Topics: Aluminum Silicates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Intestinal Disease | 2012 |
Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Citrus paradisi; Cytochro | 2012 |
Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Colostrum; Diclofenac; Female; Ileum; Inte | 2005 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoproston | 2006 |
[Segmental small intestine lesions after taking non-steroidal antirheumatic drugs].
Topics: Abdominal Pain; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; H | 1995 |
Ileo-caecal ulceration associated with the use of diclofenac slow release.
Topics: Adult; Delayed-Action Preparations; Diclofenac; Humans; Intestinal Diseases; Joint Diseases; Male; U | 1993 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cyclooxygenase Inhibitors; Diclofenac; Intes | 1999 |
Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Diclofenac; Female; | 2000 |
Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Diclofenac; Dose-Response Relationship, Drug | 2000 |
Why the mesenteric margin?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Intestinal Diseases; Mesenteric Arterie | 2001 |
Pathogenesis of diclofenac enteropathy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Intestinal Diseases; Ulcer | 2001 |