diclofenac has been researched along with Innate Inflammatory Response in 290 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Excerpt | Relevance | Reference |
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"To evaluate the comparative effects and safety of topical diclofenac sodium, fluorometholone, and dexamethasone for controlling inflammation after routine strabismus surgery." | 9.27 | A Randomized Clinical Trial of Topical Diclofenac, Fluorometholone, and Dexamethasone for Control of Inflammation After Strabismus Surgery. ( Bae, S; Choi, DC; Choi, DG; Kim, J; Lee, JY, 2018) |
"To compare the effects of topical diclofenac and betamethasone on postoperative inflammation after combined sutureless cataract and vitreoretinal surgery in patients with macular hole (MH), epiretinal membrane (ERM), diabetic macular edema (DME), and rhegmatogenous retinal detachment (RRD)." | 9.22 | Comparative Effects of Topical Diclofenac and Betamethasone on Inflammation After Vitrectomy and Cataract Surgery in Various Vitreoretinal Diseases. ( Kotake, O; Motohashi, R; Nakagawa, H; Noma, H; Shimura, M; Yasuda, K, 2016) |
"To determine whether topical application of 1% diclofenac sodium cream would decrease inflammation at sites of IV regional limb perfusion (IVRLP) in healthy horses." | 9.14 | Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate. ( Epstein, KL; Levine, DG; Neelis, DA; Ross, MW, 2009) |
"To address this limitation, we used an integrative omics approach to characterize modulation of inflammation in overweight men during an intervention with the non-steroidal anti-inflammatory drug diclofenac." | 9.14 | Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. ( Cnubben, NH; Hendriks, HF; Newman, JW; Pedersen, TL; Rubingh, C; Smilde, AK; van der Greef, J; van Erk, MJ; van Ommen, B; van Vliet, T; Verheij, E; Wopereis, S, 2010) |
"A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation." | 9.13 | Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy. ( Djalilian, A; Mirshahi, A; Namavari, A; Rafiee, F, 2008) |
"To compare the efficacy of methylprednisolone (corticoid) versus diclofenac (nonsteroidal anti-inflammatory--NSAID) in the treatment of inflammation and trismus after the surgical removal of lower third molars." | 9.12 | The use of methylprednisolone versus diclofenac in the treatment of inflammation and trismus after surgical removal of lower third molars. ( Donado Rodríguez, M; López Carriches, C; Martínez González, JM, 2006) |
"This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs." | 9.10 | Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. ( Burian, M; Geisslinger, G; Seegel, M; Tegeder, I, 2003) |
"1% diclofenac, in the management of post cataract surgery inflammation." | 9.08 | [Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery]. ( Arnaud, B; Trinquand, C, 1997) |
"Diclofenac appears to be as effective as betamethasone in controlling postoperative inflammation following strabismus surgery and may offer a safer alternative to the use of topical steroids." | 9.08 | Comparison of the efficacy of diclofenac and betamethasone following strabismus surgery. ( Butt, Z; Fleck, B; McIlwaine, G; Wright, M, 1997) |
"Diclofenac sodium was as effective as the control regimen in controlling postoperative inflammation after cataract surgery." | 9.08 | Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-term cystoid macular edema. Italian Diclofenac Study Group. ( , 1997) |
"The diclofenac- and prednisolone-treated eyes were compared on postoperative days 3 and 7 with respect to signs of inflammation (e." | 9.08 | A randomized clinical trial of the nonsteroidal eyedrop diclofenac after strabismus surgery. ( Apt, L; Isenberg, SJ; Voo, I, 1998) |
"One hundred forty-eight patients were enrolled in a randomized, prospective, placebo-controlled clinical trial evaluating the efficacy of diclofenac sodium (Voltaren Ophthalmic) in reducing ocular inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation." | 9.07 | Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. ( Kraff, MC; Martin, RG; Neumann, AC; Weinstein, AJ, 1994) |
"Topical diclofenac is widely used in the treatment of pain and inflammation." | 8.84 | Topical diclofenac and its role in pain and inflammation: an evidence-based review. ( Altman, R; Bellamy, N; Brühlmann, P; Da Silva, J; Huskisson, E; Taylor, RS; Zacher, J, 2008) |
" It has proved as effective as diclofenac, naproxen and piroxicam in patients with osteoarthritis, diclofenac, ketorolac, tenoxicam and indomethacin in patients with rheumatoid arthritis and tenoxicam, naproxen and indomethacin in patients with ankylosing spondylitis." | 8.82 | Aceclofenac in the management of inflammatory pain. ( Legrand, E, 2004) |
"The aim of this article is to critically review the potential role of aceclofenac in the treatment of inflammatory pain and chronic osteoarticular disorder, based on its activity on the mediators of inflammation, its effect on cartilage remodeling and on the results of clinical studies comparing aceclofenac with other NSAIDs in these disorders." | 8.81 | [What is the role of aceclofenac in the therapeutic arsenal against chronic osteoarthritis pathologies?]. ( Henrotin, Y; Paul, I; Reginster, JY, 2001) |
" Nonsteroidal anti-inflammatory drugs, including diclofenac sodium, are inflammation suppressive drugs that may modulate wound healing, including postoperative inflammation." | 8.31 | Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits. ( Bani, AP; La Distia Nora, R; Putera, I; Susanto, E, 2023) |
"The present study evaluated the anti-inflammatory and analgesic effects of conventional curcumin (cC) and curcumin nanoparticles (nC) associated with diclofenac sodium (D) in experimental acute inflammation (AI) induced by carrageenan administration." | 8.12 | Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation. ( Boarescu, I; Boarescu, PM; Bocșan, IC; Bolboacă, SD; Bulboacă, AE; Buzoianu, AD; Gheban, D; Pop, RM; Râjnoveanu, A; Râjnoveanu, RM, 2022) |
"Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition." | 8.02 | Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021) |
"Diclofenac (DCL), an anti-inflammatory drug used to reduce pain and inflammation, ranks in the top causes of drug-induced liver injury." | 7.96 | Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress. ( Al-Dossari, MH; Attia, HA; Fadda, LM; Hasan, IH; Mahmoud, AM, 2020) |
" The goal of this study was to determine the impact of administration of the non-selective NSAID diclofenac in the inflammatory phase of bone repair in mice with or without lipopolysaccharide-induced systemic inflammation." | 7.91 | Defective bone repair in diclofenac treated C57Bl6 mice with and without lipopolysaccharide induced systemic inflammation. ( Abou-Rjeili, M; Akoury, E; Al-Saran, Y; Awlia, A; Chan, D; Henderson, JE; Lemarié, CA; Martineau, PA; Ouellet, S; Ramirez-Garcia-Luna, JL; Wong, TH, 2019) |
" chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats." | 7.85 | Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats. ( Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Salinas-Caballero, M, 2017) |
" Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents." | 7.85 | Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats. ( Ortiz, MI, 2017) |
"The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA)." | 7.85 | Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. ( Garg, NK; Goni, VG; Kapil, N; Katare, OP; Pareek, A; Raza, K; Saini, MK; Sharma, G; Thakur, K, 2017) |
"Nonsteroidal anti-inflammatory drugs, such as diclofenac, are widely used to treat inflammation and pain in several conditions, including sports injuries." | 7.85 | Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway. ( Barcelos, RP; Bresciani, G; Cuevas, MJ; González-Gallego, J; Martínez-Flórez, S; Soares, FAA, 2017) |
"In this work a diclofenac acid nanosuspension formulation was produced as a novel approach for the treatment of skin inflammation." | 7.83 | Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. ( Caddeo, C; Ennas, G; Fadda, AM; Lai, F; Marongiu, F; Pireddu, R; Scano, A; Sinico, C; Valenti, D, 2016) |
"27-Hydroxycholesterol (27OHChol) is a cholesterol oxidation product that induces inflammation." | 7.83 | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. ( Eo, SK; Kim, BY; Kim, K; Park, YC; Son, Y, 2016) |
"Soft-tissue edema volumes in all diclofenac-treated groups were significantly lower than those observed in the rhBMP-2 alone." | 7.81 | Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model. ( Jang, KY; Kim, JR; Lee, KB; Wang, H; Wang, JC; Ye, S; Yim, JH, 2015) |
" Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 7.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
"The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model." | 7.80 | Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. ( Demidchenko, YO; Epstein, OI; Gorbunov, EA; Mani, K; Mathur, A; Sakat, SS; Tarasov, SA, 2014) |
" In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 7.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
"1% diclofenac eye drops for the management of postoperative inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy and in normal controls." | 7.78 | A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy. ( Miyazawa, A; Shimura, M; Yasuda, K, 2012) |
"This study demonstrates targeted delivery of diclofenac to an inflammatory environment using the granuloma air pouch model and diclofenac nanoemulsions with different compositions." | 7.78 | Albumin coupled lipid nanoemulsions of diclofenac for targeted delivery to inflammation. ( Goparaboina, S; Kandadi, P; Syed, MA; Veerabrahma, K, 2012) |
" Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 7.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
"To determine whether 1% diclofenac liposomal suspension (DLS) ointment would be absorbed transdermally and attenuate experimentally induced subcutaneous inflammation in horses." | 7.72 | Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses. ( Budsberg, SC; Caldwell, FJ; Lynn, RC; Mueller, PO, 2004) |
"A pan-European study involving 23407 patients with pain due to various inflammatory or degenerative rheumatic diseases was undertaken in Austria, Belgium, Germany and Greece, to evaluate overall pain relief and satisfaction with aceclofenac therapy." | 7.71 | Patient and physician satisfaction with aceclofenac: results of the European Observational Cohort Study (experience with aceclofenac for inflammatory pain in daily practice). Aceclofenac is the treatment of choice for patients and physicians in the manage ( Aslanidis, S; De Bast, J; Leeb, B; Lemmel, EM, 2002) |
"This study determines the effects of dexamethasone versus co-administered dexamethasone and diclofenac, on carrageenan-evoked spinal c-Fos expression and peripheral oedema in the freely moving rat." | 7.69 | Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat. ( Besson, JM; Buritova, J; Chapman, V; Honoré, P, 1996) |
"Diclofenac therapy was well tolerated, except in one patient, and may safely be used to reduce intraocular inflammation." | 6.66 | Treatment of ocular inflammation with diclofenac sodium: double-blind trial following cataract surgery. ( Berson, D; Ronen, S; Rozenman, Y; Zylbermann, R, 1985) |
" Stimulated inflammatory conditions seemed to reduce toxic effects." | 5.62 | Inflammation reduces osteoblast cytotoxicity induced by diclofenac: An in vitro study. ( Aguirre, J; Bonvini, JM; Borgeat, A; Camponovo, C; Rupnik, B; Saporito, A, 2021) |
" Specifically, we demonstrated that treatment with diclofenac (DCF), an NSAID commonly used to treat inflammation associated with acute infection and other conditions, globally suppressed cytokine secretion when dosed in isolation." | 5.62 | Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury ( Carrier, RL; Chen, WLK; Griffith, LG; Lauffenburger, DA; Miyazaki, H; Suter, E; Velazquez, J, 2021) |
" Spurred by topical advancement in polymer chemistry and drug delivery, hydrogels that release a drug in temporal, spatial and dosage controlled fashion have been trendy." | 5.56 | Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium. ( Butt, MTZ; Butt, OM; Gull, N; Islam, A; Jabeen, S; Khan, A; Khan, RU; Khan, SM; Khan, SU; Shah, A, 2020) |
"Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis." | 5.48 | Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation. ( Evan Prince, S; S, JP, 2018) |
"Diclofenac is a Non-Steroidal Anti-inflammatory drug which is used as an analgesic." | 5.48 | Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines. ( Evan Prince, S; Simon, JP, 2018) |
"Aceclofenac (ACE) is a systematically designed drug, developed to circumvent the concerns associated with diclofenac." | 5.43 | Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation. ( Goyal, H; Katare, OP; Raza, K; Sharma, G; Thakur, K, 2016) |
"The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 5.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
"Levels of inflammation were monitored by cell viability and cellular production of nitric oxide (NO) and prostaglandin E2 (PGE2)." | 5.42 | Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model. ( Abed, A; Britchford, ER; Buttery, LD; Heathman, TR; Rahman, CV; Sidney, LE, 2015) |
"Tendinitis is a painful condition that occurs in tendons in response to repetitive use or direct trauma." | 5.42 | Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats. ( de Souza, CT; Dohnert, LH; Dohnert, MB; Ferreira, GK; Paula, MM; Silveira, PC; Zanoni, ET, 2015) |
"An attempt has been made in the present study to formulate soluble ocular inserts of aceclofenac to facilitate the bioavailability of the drug into the eye, as no eye drop solution could be formulated." | 5.37 | Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation. ( Gilhotra, RM; Mathurm, M, 2011) |
"Inflammation is associated with enhanced vascular permeability, production of inflammatory markers and over production of reactive oxygen species (ROS) with depletion of endogenous antioxidants." | 5.37 | Drug targeting to inflammation: studies on antioxidant surface loaded diclofenac liposomes. ( Apte, S; Devaraj, G; Devaraj, R; Jukanti, R, 2011) |
" Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 5.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
"In this study, we investigated the bioavailability of iontophoretically delivered diclofenac with the methylnicotinate (MN) test." | 5.33 | Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay. ( Barel, AO; Clarys, P; Clijsen, R; Lambrecht, R, 2006) |
"Idiosyncratic adverse drug reactions (IADRs) represent an important human health problem, yet animal models for preclinical prediction of these reactions are lacking." | 5.33 | Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Luyendyk, JP; Maddox, JF; Roth, RA; Stachlewitz, RF; Waring, JF, 2006) |
"To evaluate the comparative effects and safety of topical diclofenac sodium, fluorometholone, and dexamethasone for controlling inflammation after routine strabismus surgery." | 5.27 | A Randomized Clinical Trial of Topical Diclofenac, Fluorometholone, and Dexamethasone for Control of Inflammation After Strabismus Surgery. ( Bae, S; Choi, DC; Choi, DG; Kim, J; Lee, JY, 2018) |
"To compare the effects of topical diclofenac and betamethasone on postoperative inflammation after combined sutureless cataract and vitreoretinal surgery in patients with macular hole (MH), epiretinal membrane (ERM), diabetic macular edema (DME), and rhegmatogenous retinal detachment (RRD)." | 5.22 | Comparative Effects of Topical Diclofenac and Betamethasone on Inflammation After Vitrectomy and Cataract Surgery in Various Vitreoretinal Diseases. ( Kotake, O; Motohashi, R; Nakagawa, H; Noma, H; Shimura, M; Yasuda, K, 2016) |
"DHEP mouthwash was at least as effective as diclofenac mouthwash at alleviating pain and inflammation symptoms and is well tolerated in patients with painful inflammatory conditions of the oral cavity." | 5.16 | Therapeutic efficacy and tolerability of the topical treatment of inflammatory conditions of the oral cavity with a mouthwash containing diclofenac epolamine: a randomized, investigator-blind, parallel-group, controlled, phase III study. ( Bandettini, B; Saponati, G; Serafini, G; Trevisan, S, 2012) |
"To determine whether topical application of 1% diclofenac sodium cream would decrease inflammation at sites of IV regional limb perfusion (IVRLP) in healthy horses." | 5.14 | Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate. ( Epstein, KL; Levine, DG; Neelis, DA; Ross, MW, 2009) |
"To address this limitation, we used an integrative omics approach to characterize modulation of inflammation in overweight men during an intervention with the non-steroidal anti-inflammatory drug diclofenac." | 5.14 | Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. ( Cnubben, NH; Hendriks, HF; Newman, JW; Pedersen, TL; Rubingh, C; Smilde, AK; van der Greef, J; van Erk, MJ; van Ommen, B; van Vliet, T; Verheij, E; Wopereis, S, 2010) |
"A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation." | 5.13 | Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy. ( Djalilian, A; Mirshahi, A; Namavari, A; Rafiee, F, 2008) |
"To compare the efficacy of methylprednisolone (corticoid) versus diclofenac (nonsteroidal anti-inflammatory--NSAID) in the treatment of inflammation and trismus after the surgical removal of lower third molars." | 5.12 | The use of methylprednisolone versus diclofenac in the treatment of inflammation and trismus after surgical removal of lower third molars. ( Donado Rodríguez, M; López Carriches, C; Martínez González, JM, 2006) |
"Dexamethasone and diclofenac were equally effective in reducing postoperative inflammation after phacoemulsification and IOL implantation in eyes with no other disease than cataract." | 5.10 | Effects of dexamethasone, diclofenac, or placebo on the inflammatory response after cataract surgery. ( Laurell, CG; Zetterström, C, 2002) |
"This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs." | 5.10 | Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. ( Burian, M; Geisslinger, G; Seegel, M; Tegeder, I, 2003) |
"1% diclofenac sodium (DS) eyedrops made in China on preventing surgically induced miosis and inflammation." | 5.09 | Clinical study of diclofenac sodium eyedrops used before and after cataract operation. ( Wei, H; Zhang, M, 1999) |
"To compare the effects of a topical nonsteroidal anti-inflammatory agent, diclofenac, and prednisolone acetate on wound healing, postoperative inflammation, and other clinical parameters in laser in situ keratomileusis (LASIK) patients." | 5.09 | Effects of topical diclofenac and prednisolone eyedrops in laser in situ keratomileusis patients. ( Juárez, CP; Luna, JD; Muiño, JC; Vantesone, DL, 1999) |
"1% diclofenac, in the management of post cataract surgery inflammation." | 5.08 | [Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery]. ( Arnaud, B; Trinquand, C, 1997) |
"Diclofenac appears to be as effective as betamethasone in controlling postoperative inflammation following strabismus surgery and may offer a safer alternative to the use of topical steroids." | 5.08 | Comparison of the efficacy of diclofenac and betamethasone following strabismus surgery. ( Butt, Z; Fleck, B; McIlwaine, G; Wright, M, 1997) |
"Diclofenac sodium was as effective as the control regimen in controlling postoperative inflammation after cataract surgery." | 5.08 | Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-term cystoid macular edema. Italian Diclofenac Study Group. ( , 1997) |
"The diclofenac- and prednisolone-treated eyes were compared on postoperative days 3 and 7 with respect to signs of inflammation (e." | 5.08 | A randomized clinical trial of the nonsteroidal eyedrop diclofenac after strabismus surgery. ( Apt, L; Isenberg, SJ; Voo, I, 1998) |
"One hundred forty-eight patients were enrolled in a randomized, prospective, placebo-controlled clinical trial evaluating the efficacy of diclofenac sodium (Voltaren Ophthalmic) in reducing ocular inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation." | 5.07 | Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. ( Kraff, MC; Martin, RG; Neumann, AC; Weinstein, AJ, 1994) |
"Various doses of a new topical nonsteroidal anti-inflammatory agent, diclofenac sodium, were tested against prednisolone sodium phosphate in a randomized double-masked study to determine comparative efficacy and safety regarding the reduction of postsurgical ocular inflammation." | 5.06 | Inhibition of blood-aqueous humor barrier breakdown with diclofenac. A fluorophotometric study. ( Kraff, MC; McGuigan, L; Raanan, MG; Sanders, DR, 1990) |
"The nonsteroidal anti-inflammatory drug (NSAID) diclofenac epolamine (DHEP) formulated as a topical patch has demonstrated efficacy and safety in the localized treatment of acute pain from minor strains, sprains and contusions, and for epicondylitis and knee osteoarthritis." | 5.01 | Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster. ( Jones, C; Nencioni, A; Rainsford, KD; Roberts, MS, 2019) |
"Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammation and pain." | 4.88 | Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels. ( Gwanyanya, A; Macianskiene, R; Mubagwa, K, 2012) |
" The pharmacological profiles of some hybrid lead compounds in the areas of inflammation, H(2)S-donating diclofenac (ACS 15); cardiovascular, H(2)S-donating aspirin (ACS 14); urology, H(2)S-donating sildenafil (ACS 6); and neurodegenerative, H(2)S-donating latanoprost (ACS 67) for glaucoma treatment and H(2)S-donating levodopa (ACS 84) for Parkinson's disease, are described." | 4.87 | Therapeutic potential of new hydrogen sulfide-releasing hybrids. ( Del Soldato, P; Giustarini, D; Rossi, R; Santus, G; Sparatore, A, 2011) |
"Topical formulations of non-steroidal anti-inflammatory drugs (NSAIDs), in particular diclofenac (DI), have become popular for treating various acute and chronic painful inflammatory conditions." | 4.84 | Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine. ( Ehrlich, GE; Kean, WF; Rainsford, KD, 2008) |
"Topical diclofenac is widely used in the treatment of pain and inflammation." | 4.84 | Topical diclofenac and its role in pain and inflammation: an evidence-based review. ( Altman, R; Bellamy, N; Brühlmann, P; Da Silva, J; Huskisson, E; Taylor, RS; Zacher, J, 2008) |
" It has proved as effective as diclofenac, naproxen and piroxicam in patients with osteoarthritis, diclofenac, ketorolac, tenoxicam and indomethacin in patients with rheumatoid arthritis and tenoxicam, naproxen and indomethacin in patients with ankylosing spondylitis." | 4.82 | Aceclofenac in the management of inflammatory pain. ( Legrand, E, 2004) |
"The aim of this article is to critically review the potential role of aceclofenac in the treatment of inflammatory pain and chronic osteoarticular disorder, based on its activity on the mediators of inflammation, its effect on cartilage remodeling and on the results of clinical studies comparing aceclofenac with other NSAIDs in these disorders." | 4.81 | [What is the role of aceclofenac in the therapeutic arsenal against chronic osteoarthritis pathologies?]. ( Henrotin, Y; Paul, I; Reginster, JY, 2001) |
" Nonsteroidal anti-inflammatory drugs, including diclofenac sodium, are inflammation suppressive drugs that may modulate wound healing, including postoperative inflammation." | 4.31 | Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits. ( Bani, AP; La Distia Nora, R; Putera, I; Susanto, E, 2023) |
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; 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Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; 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Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
" The present study investigated under in vivo conditions whether systemic administration of quercetin attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with mechanical hyperalgesia and compared its effect to the non-steroidal anti-inflammatory drug, diclofenac." | 4.12 | Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs. ( Itou, H; Takeda, M; Toyota, R, 2022) |
"The present study evaluated the anti-inflammatory and analgesic effects of conventional curcumin (cC) and curcumin nanoparticles (nC) associated with diclofenac sodium (D) in experimental acute inflammation (AI) induced by carrageenan administration." | 4.12 | Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation. ( Boarescu, I; Boarescu, PM; Bocșan, IC; Bolboacă, SD; Bulboacă, AE; Buzoianu, AD; Gheban, D; Pop, RM; Râjnoveanu, A; Râjnoveanu, RM, 2022) |
"Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition." | 4.02 | Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021) |
"Diclofenac (DCL), an anti-inflammatory drug used to reduce pain and inflammation, ranks in the top causes of drug-induced liver injury." | 3.96 | Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress. ( Al-Dossari, MH; Attia, HA; Fadda, LM; Hasan, IH; Mahmoud, AM, 2020) |
" Our aim was, for the first time, to analyze the morpho-functional effects of postoperative administration of two commonly used NSAIDs, Diclofenac and Ketorolac, on the healing process of colo-colic anastomoses constructed under condition of fecal peritonitis in a rat model." | 3.96 | Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration. ( Casciani, F; Ghiselli, R; Guerrieri, M; Lucarini, G; Orlando, F; Ortenzi, M; Provinciali, M; Saccomanno, S; Salvolini, E, 2020) |
" platensis on different types of pain and inflammation in comparison to diclofenac sodium." | 3.96 | Effects of Spirulina platensis on pain and inflammation in long Evans rats. ( Akhter, S; Ali, T; Nipa, NS; Rafiq, K, 2020) |
"This investigation evaluates the pro-apoptotic and anti-inflammatory effects of β-D-mannuronic acid [M2000] compared to diclofenac, based on gene expression involved in apoptosis and inflammation process [including Bcl2, NFκB, IL-8 and Cd49d] in Peripheral Blood Mononuclear Cells [PBMCs] of healthy donors under exvivo conditions." | 3.96 | Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC. ( Afraei, S; Aghazadeh, Z; Ghaderi, A; Jafarnezhad, F; Khalatbari, A; Mahdavi, M; Mirshafiey, A; Zavareh, FT, 2020) |
"In case of carrageenan mediated inflammation, the combination of 5 mg/kg diclofenac and 200 mg/kg ascorbic acid gave the highest inhibition of 74." | 3.96 | Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid. ( Ahmed, T; Ahsan, CR; Al Shoyaib, A; Archie, SR; Chowdhury, FA; Faruk, A, 2020) |
" The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug." | 3.91 | A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles ( Nagaraju, B; Prasanna, B; Seelam, N; Shanmukhakumar, JV; Subbaiah, T, 2019) |
" The goal of this study was to determine the impact of administration of the non-selective NSAID diclofenac in the inflammatory phase of bone repair in mice with or without lipopolysaccharide-induced systemic inflammation." | 3.91 | Defective bone repair in diclofenac treated C57Bl6 mice with and without lipopolysaccharide induced systemic inflammation. ( Abou-Rjeili, M; Akoury, E; Al-Saran, Y; Awlia, A; Chan, D; Henderson, JE; Lemarié, CA; Martineau, PA; Ouellet, S; Ramirez-Garcia-Luna, JL; Wong, TH, 2019) |
"The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation." | 3.91 | Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study. ( Cardoso, LCP; Lopes, MJP; Nobre, MEP; Pinto, NB; Pires, GM; Rodrigues, LMR; Silva, MR; Viana, GSB, 2019) |
"The NSAIDs ibuprofen and diclofenac were administered to C57BL/6 mice after induction of pancreatitis with serial injections of cerulein." | 3.88 | Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation. ( Bombardo, M; Chen, R; Graf, R; Malagola, E; Rudnicka, A; Sonda, S, 2018) |
" Finally, we tested the effect of the anti-inflammation drug diclofenac on leukemia mice." | 3.88 | Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation. ( Cui, M; Cui, P; Gao, J; Huang, S; Li, Z; Ma, G; Wang, N; Wang, R; Zhang, Y, 2018) |
" were studied in the models of acute aseptic inflammation induced by carrageenan, histamine, and serotonin and acetic acid-induced painful chemical stimulation." | 3.85 | Anti-Inflammatory and Analgesic Activities of the Complex of Flavonoids from Lychnis chalcedonica L. ( Afanas'eva, OG; Aksinenko, SG; Amosova, EN; Krylova, SG; Lopatina, KA; Nesterova, YV; Povet'eva, TN; Rybalkina, OY; Suslov, NI; Zibareva, LN; Zueva, EP, 2017) |
" chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats." | 3.85 | Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats. ( Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Salinas-Caballero, M, 2017) |
" Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents." | 3.85 | Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats. ( Ortiz, MI, 2017) |
"The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA)." | 3.85 | Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. ( Garg, NK; Goni, VG; Kapil, N; Katare, OP; Pareek, A; Raza, K; Saini, MK; Sharma, G; Thakur, K, 2017) |
"Nonsteroidal anti-inflammatory drugs, such as diclofenac, are widely used to treat inflammation and pain in several conditions, including sports injuries." | 3.85 | Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway. ( Barcelos, RP; Bresciani, G; Cuevas, MJ; González-Gallego, J; Martínez-Flórez, S; Soares, FAA, 2017) |
"In this work a diclofenac acid nanosuspension formulation was produced as a novel approach for the treatment of skin inflammation." | 3.83 | Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. ( Caddeo, C; Ennas, G; Fadda, AM; Lai, F; Marongiu, F; Pireddu, R; Scano, A; Sinico, C; Valenti, D, 2016) |
"27-Hydroxycholesterol (27OHChol) is a cholesterol oxidation product that induces inflammation." | 3.83 | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. ( Eo, SK; Kim, BY; Kim, K; Park, YC; Son, Y, 2016) |
" The aim was to investigate and compare the effect of docosahexaenoic acid (DHA) ester of PZ (PZ-DHA) and its parent compounds (phloridzin and DHA), phloretin (the aglycone of PZ) and cyclooxygenase inhibitory drugs (diclofenac and nimesulide) on production of pro-inflammatory biomarkers in inflammation-induced macrophages by lipopolysaccharide (LPS)-stimulation." | 3.81 | Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. ( Rupasinghe, HP; Sekhon-Loodu, S, 2015) |
"Soft-tissue edema volumes in all diclofenac-treated groups were significantly lower than those observed in the rhBMP-2 alone." | 3.81 | Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model. ( Jang, KY; Kim, JR; Lee, KB; Wang, H; Wang, JC; Ye, S; Yim, JH, 2015) |
" Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 3.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
"The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model." | 3.80 | Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. ( Demidchenko, YO; Epstein, OI; Gorbunov, EA; Mani, K; Mathur, A; Sakat, SS; Tarasov, SA, 2014) |
"Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats." | 3.80 | Anti-ulcer and wound healing activities of Sida corymbosa in rats. ( Isimi, CY; John-Africa, LB; Yahaya, TA, 2014) |
"We report a unique case of multiple ileal perforations due to regular diclofenac sodium injections and contend that ileal perforation can be considered as a source for pneumoperitoneum with concomitant peritonitis in patients with a history of NSAID use if other possibilities are excluded." | 3.79 | Multiple ileal perforations due to regular diclofenac sodium injections: a case report. ( Kim, SW; Lee, S; Lee, ST; Park, HS; Park, WS, 2013) |
" In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 3.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
"05) and dosedependent anti-inflammatory activity in carrageenan induced paw oedema models of inflammation and the result was comparable with the standard drug diclofenac." | 3.79 | Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L. ( Gupta, M; Haldar, PK; Mazumder, UK; Naskar, S; Pramanik, G; Saha, P, 2013) |
"The anti-edematous and anti-allodynic effects of JZL184 were compared to those of PF-3845, an inhibitor of fatty acid amide hydrolase (FAAH), and diclofenac, a non-selective cyclooxygenase inhibitor." | 3.79 | The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. ( Chen, Y; Cravatt, BF; Ghosh, S; Gujjar, R; Lichtman, AH; Mahadevan, A; Wise, LE, 2013) |
" The in vivo studies involving arachidonic acid-induced ocular inflammation in rabbits revealed significantly higher inhibition of polymorphonuclear leukocytes migration (p<0." | 3.79 | Eudragit RL 100-based nanoparticulate system of aceclofenac for ocular delivery. ( Katara, R; Majumdar, DK, 2013) |
"1% diclofenac eye drops for the management of postoperative inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy and in normal controls." | 3.78 | A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy. ( Miyazawa, A; Shimura, M; Yasuda, K, 2012) |
"This study demonstrates targeted delivery of diclofenac to an inflammatory environment using the granuloma air pouch model and diclofenac nanoemulsions with different compositions." | 3.78 | Albumin coupled lipid nanoemulsions of diclofenac for targeted delivery to inflammation. ( Goparaboina, S; Kandadi, P; Syed, MA; Veerabrahma, K, 2012) |
"To measure the inflammatory reaction in the anterior chamber after lens extraction in a rabbit model and to evaluate the effect of nonsteroidal antiinflammatory drugs (NSAIDs) or steroids on the amount of inflammation as measured by fibrinogen levels in the aqueous humor." | 3.78 | Fibrinoid reaction after lens extraction in rabbit eyes. ( Ben Simon, GJ; Kenet, G; Spierer, A, 2012) |
" Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity." | 3.78 | Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. ( Afzal, M; Afzal, O; Alam, J; Anwar, F; Gupta, G; Gupta, R; Hakeem, KR; Kazmi, I; Pravez, M; Rahman, M, 2012) |
"We compared the anti-hyperalgesic and anti-inflammatory effects of the α7 nACh receptor agonist compound B with the positive allosteric modulator (PAM) PNU-120596 and the standard non-steroidal anti-inflammatory drug (NSAID), diclofenac, in rats with hind paw inflammation induced by either formalin, carrageenan or complete Freund's adjuvant (CFA)." | 3.78 | The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. ( Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D, 2012) |
") have been studied on a model of acute exudative inflammation induced by carrageenan in outbred rats and concanavalin A (Con A) in CBA mice." | 3.78 | [An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines]. ( Alekseeva, SV; Durnev, AD; Gudasheva, TA; Kovalenko, LP; Tallerova, AV, 2012) |
" Anti-inflammatory activity screening of some synthesized compounds utilizing in vivo acute carrageenan-induced paw edema standard method in rats exhibited that the prepared heterocycles possess considerable pharmacological properties especially, 4a, 4b, 10a, and 10b which reveal remarkable activities relative to diclofenac sodium (reference standard)." | 3.77 | Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides. ( Barsoum, FF, 2011) |
" First, validate PEAP with Complete Freund's Adjuvant (CFA)-induced inflammation for the assessment of the affective component of pain using the reference analgesics celecoxib, diclofenac and duloxetine; fluoxetine and scopolamine were tested as negative controls." | 3.76 | Comparison of mechanical allodynia and the affective component of inflammatory pain in rats. ( Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C, 2010) |
"To compare the effectiveness of dexamethasone and diclofenac sodium eye drops in the resolution of inflammation following phacoemulsification surgery with posterior chamber intraocular lens implants." | 3.75 | Comparison of anti-inflammatory activity of dexamethasone and diclofenac sodium eye drops in phacoemulsification. ( Humayun, S; Waseem, M, 2009) |
" EtCD at the dose of 300 mg/kg produced significant decrease in paw volume and pain when compared with reference drug diclofenac and morphine, respectively." | 3.75 | Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. ( Arora, B; Arora, R; Bali, M; Bansal, S; Gill, NS; Muthuraman, A; Sharma, PD; Sood, S, 2009) |
"The aim was to assess and document the efficacy and tolerability of parflex (FDC of aceclofenac with paracetamol and serratiopeptidase) in management of pain and inflammation in adult patients undergoing surgical procedures (or operations)." | 3.74 | PARFLEX--a very useful drug for management of surgical pain. ( Dabholkar, P; Das, V; Grawal, SP; Khattri, S; Nath, R; Nischal, A; Pant, KK; Singh, A, 2008) |
" Administration of diclofenac, a nonselective cyclooxygenase (COX) inhibitor, at different doses (5, 50, 500, or 5,000 microg/kg) attenuated or abrogated LPS-induced fever and inhibited LPS-induced local PGE(2) formation (5 or 500 microg/kg diclofenac)." | 3.73 | Localized vs. systemic inflammation in guinea pigs: a role for prostaglandins at distinct points of the fever induction pathways? ( Barth, SW; Gerstberger, R; Hübschle, T; Korte, S; Roth, J; Rummel, C; Voss, T, 2005) |
" The antiinflammatory property of the aqueous leaf extract was investigated in rats, using fresh egg albumin-induced pedal (paw) edema, while the analgesic effect of the plant extract was evaluated by the "hot-plate" and "acetic acid" test models of pain in mice." | 3.73 | Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. ( Ojewole, JA, 2006) |
" Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 3.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
"To determine whether 1% diclofenac liposomal suspension (DLS) ointment would be absorbed transdermally and attenuate experimentally induced subcutaneous inflammation in horses." | 3.72 | Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses. ( Budsberg, SC; Caldwell, FJ; Lynn, RC; Mueller, PO, 2004) |
"The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats." | 3.71 | Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats. ( Cimşit, M; Eroglu, L; Sümen, G, 2001) |
"The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) and diclofenac (non-selective COX inhibitor)." | 3.71 | Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test. ( Alonso-López, R; Asomoza-Espinosa, R; Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Torres-López, JE, 2002) |
" The effect of the extracts against acute inflammation was studied by acetic acid increased vascular permeability and xylene-induced ear edema in mice." | 3.71 | Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. ( Fadishei, M; Hosseinzadeh, H; Mahmoudi, M; Ramezani, M, 2002) |
"A pan-European study involving 23407 patients with pain due to various inflammatory or degenerative rheumatic diseases was undertaken in Austria, Belgium, Germany and Greece, to evaluate overall pain relief and satisfaction with aceclofenac therapy." | 3.71 | Patient and physician satisfaction with aceclofenac: results of the European Observational Cohort Study (experience with aceclofenac for inflammatory pain in daily practice). Aceclofenac is the treatment of choice for patients and physicians in the manage ( Aslanidis, S; De Bast, J; Leeb, B; Lemmel, EM, 2002) |
"The present study shows that meloxicam dose-dependently exhibited systemic antinociceptive action when assessed against neurogenic and inflammatory pain caused by acetic acid, formalin and capsaicin models." | 3.70 | Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. ( De Freitas, GA; Santos, AR; Vedana, EM, 1998) |
"Indomethacin, a typical cyclo-oxygenase inhibitor, acts as an analgesic by preventing the hyperalgesia induced by prostaglandins during inflammation." | 3.69 | Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. ( Ferreira, SH; Tonussi, CR, 1994) |
"The antinociceptive activity of intramuscular 6-methoxy-2-naphthylacetic acid (6-MNA), the active metabolite of nabumetone, was examined in a rat model of unilateral hindpaw inflammation/hyperalgesia and compared with that of three other non-steroidal anti-inflammatory drugs (NSAIDs)--diclofenac, naproxen and piroxicam." | 3.69 | Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation. ( Clarke, GD; MacPherson, IS; Petrone, G; Spangler, RS, 1994) |
" The diclofenac derivative, 'nitrofenac', was examined in terms of its ability to induce acute gastric erosions and chronic-type gastric ulcers in rats and rabbits, respectively." | 3.69 | A diclofenac derivative without ulcerogenic properties. ( Cicala, C; Cirino, G; Grisham, M; McKnight, W; Reuter, B; Wallace, JL, 1994) |
"This study determines the effects of dexamethasone versus co-administered dexamethasone and diclofenac, on carrageenan-evoked spinal c-Fos expression and peripheral oedema in the freely moving rat." | 3.69 | Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat. ( Besson, JM; Buritova, J; Chapman, V; Honoré, P, 1996) |
"To quantify the advantage gained by direct administration to a target site for two non-steroidal anti-inflammatory drugs (NSAIDs) piroxicam and diclofenac in the rat air pouch model of inflammation." | 3.69 | Regional drug delivery II: relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation. ( Brennan, BS; Gifford, LA; Houston, JB; Martin, SW; McLachlan, A; Rowland, M; Stevens, AJ, 1995) |
"Anti-inflammatory activity of baicalein (5,6,7-trioxyflavone-7-O-beta-D-glucuronide) was greater in the chronic inflammation model (rat adjuvant arthritis, ED50 = 120." | 3.68 | Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. ( Butenko, IG; Galushko, SV; Gladtchenko, SV, 1993) |
"Sequential potentiation of antiinflammatory activity of dexamethasone was obtained by co-administration of diclofenac-Na (and indomethacin), but not of phenylbutazone and, apparently, of acetylsalicylic acid (ASA) in the carrageenin rat paw edema." | 3.67 | On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis. ( Bekemeier, H; Hirschelmann, R, 1986) |
" Dosing was 1 drop t." | 2.74 | Comparison of the efficacy and safety of a novel meloxicam ophthalmic formulation with a reference diclofenac solution in cataract surgery. ( Alanis-Villarreal, L; Avalos-Urzua, G; Baiza-Duran, LM; Bustos-Zermeño, R; Castañeda-Hernández, G; Domene-Hinojosa, JL; Gómez-Bastar, P; Ibañez-Hernandez, MA; Morales-Gómez, ME; Ortiz, MI; Quintana-Hau, J; Tornero-Montaño, R; Velasco-Gallegos, G; Villar-Kuri, J, 2009) |
"While inflammation is very significant in the abolition of pathogens and other causes of soreness, a protracted inflammatory procedure takes to outcomes in chronic disease that might finally affect in organ failure or damage." | 2.72 | Contemporary advances of cyclic molecules proposed for inflammation. ( Neha, K; Wakode, S, 2021) |
"Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively." | 2.67 | Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery. ( Becker, PJ; Grotepass, FW; Roelofse, JA; van der Westhuijzen, AJ, 1994) |
"Thus diclofenac sodium was as effective an anti-inflammatory agent for postoperative inflammation as prednisolone acetate." | 2.67 | A comparison of topical non-steroidal anti-inflammatory drugs to steroids for control of post cataract inflammation. ( Brennan, KM; Brown, RM; Roberts, CW, 1993) |
"The diclofenac treatment had no influence on hematological and coagulation profiles, nor on muscle and liver enzymes in comparison with placebo." | 2.67 | Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins. ( Camu, F; Claeys, MA; Maes, V, 1992) |
"Diclofenac therapy was well tolerated, except in one patient, and may safely be used to reduce intraocular inflammation." | 2.66 | Treatment of ocular inflammation with diclofenac sodium: double-blind trial following cataract surgery. ( Berson, D; Ronen, S; Rozenman, Y; Zylbermann, R, 1985) |
"Diclofenac is a widely prescribed anti-inflammatory drug having cardiovascular complications as one of the main liabilities that restrict its therapeutic use." | 1.91 | Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. ( Bag, S; Bhardwaj, M; Dhiman, SK; Dogra, A; Gour, A; Kour, D; Kumar, A; Nandi, U; Singh, G, 2023) |
"Oral aphthous ulcers are a common inflammatory efflorescence of oral mucosa, presenting as inflammation and oral mucosal damage and manifesting as pain." | 1.91 | Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection. ( Gao, S; Guo, J; Xu, H; Yan, F; Zhang, Q; Zhang, Z, 2023) |
"Despite the extensive therapeutic uses of diclofenac, it may cause several adverse effects, including hepatorenal injury." | 1.72 | Resveratrol mitigates diclofenac-induced hepatorenal toxicity in rats via modulation of miR-144/Nrf2/GSH axis. ( Abdelmonem, M; Ahmed, KA; Elbaz, EM, 2022) |
" Stimulated inflammatory conditions seemed to reduce toxic effects." | 1.62 | Inflammation reduces osteoblast cytotoxicity induced by diclofenac: An in vitro study. ( Aguirre, J; Bonvini, JM; Borgeat, A; Camponovo, C; Rupnik, B; Saporito, A, 2021) |
" Specifically, we demonstrated that treatment with diclofenac (DCF), an NSAID commonly used to treat inflammation associated with acute infection and other conditions, globally suppressed cytokine secretion when dosed in isolation." | 1.62 | Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury ( Carrier, RL; Chen, WLK; Griffith, LG; Lauffenburger, DA; Miyazaki, H; Suter, E; Velazquez, J, 2021) |
" Spurred by topical advancement in polymer chemistry and drug delivery, hydrogels that release a drug in temporal, spatial and dosage controlled fashion have been trendy." | 1.56 | Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium. ( Butt, MTZ; Butt, OM; Gull, N; Islam, A; Jabeen, S; Khan, A; Khan, RU; Khan, SM; Khan, SU; Shah, A, 2020) |
" But its long-term administration increases the risk of complications of pharmacotherapy." | 1.51 | Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels. ( Beskhmelnitsyna, EA; Kulikov, AL; Peresypkina, AA; Pokrovskii, MV; Varavin, EI, 2019) |
" The prostate tissue penetration and related pharmacokinetic parameters were evaluated by non-compartmental analysis." | 1.48 | Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue. ( Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK, 2018) |
"Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis." | 1.48 | Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation. ( Evan Prince, S; S, JP, 2018) |
"Diclofenac is a Non-Steroidal Anti-inflammatory drug which is used as an analgesic." | 1.48 | Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines. ( Evan Prince, S; Simon, JP, 2018) |
"Diclofenac was used for comparison." | 1.46 | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. ( Che Ahmad Tantowi, NA; Hussin, P; Lau, SF; Mohamed, S, 2017) |
"Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market." | 1.46 | Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. ( Honda, H; Ito, Y; Kawamoto, T; Morita, O, 2017) |
"Diclofenac sodium was chosen as the model drug." | 1.46 | Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac. ( Nguyen, CN; Nguyen, HT; Nguyen, TTT; Tran, TH, 2017) |
"Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent." | 1.43 | Antibacterial and Antiinflammatory Properties of Bovine Colostrum. ( Angolkar, T; Buttar, HS; Kaur, G; Yadav, R, 2016) |
"Aceclofenac (ACE) is a systematically designed drug, developed to circumvent the concerns associated with diclofenac." | 1.43 | Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation. ( Goyal, H; Katare, OP; Raza, K; Sharma, G; Thakur, K, 2016) |
"The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 1.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
"Levels of inflammation were monitored by cell viability and cellular production of nitric oxide (NO) and prostaglandin E2 (PGE2)." | 1.42 | Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model. ( Abed, A; Britchford, ER; Buttery, LD; Heathman, TR; Rahman, CV; Sidney, LE, 2015) |
"Curcumin has diverse biological activities including antioxidant and anti-inflammatory activity." | 1.42 | Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation. ( Agrawal, R; Kaur, IP; Sandhu, SK; Sharma, I, 2015) |
"Tendinitis is a painful condition that occurs in tendons in response to repetitive use or direct trauma." | 1.42 | Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats. ( de Souza, CT; Dohnert, LH; Dohnert, MB; Ferreira, GK; Paula, MM; Silveira, PC; Zanoni, ET, 2015) |
"Enhanced oral bioavailability of aceclofenac has been achieved using chitosan cocrystals of aceclofenac and its entrapment into alginate matrix a super saturated drug delivery system (SDDS)." | 1.42 | Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac. ( Ganesh, M; Hemalatha, P; Jang, HT; Jeon, UJ; Peng, MM; Saravanakumar, A; Ubaidulla, U, 2015) |
" The vesicles were characterized for physicochemical properties, ex vivo permeation using human skin and pharmacokinetic parameters and anti-inflammatory activity in rats." | 1.40 | Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation. ( Bhandari, A; Gaur, PK; Kumar, Y; Mishra, S; Purohit, S, 2014) |
"Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations." | 1.40 | Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres. ( Adedokun, MO; Attama, AA; Kenechukwu, FC; Momoh, MA; Odo, CE, 2014) |
"Inflammation was induced by carrageen and Freund's complete adjuvant in plantar surface of the rats." | 1.39 | Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model. ( Bhatia, M; Garg, LN; Gupta, S; Kumar, S, 2013) |
"An attempt has been made in the present study to formulate soluble ocular inserts of aceclofenac to facilitate the bioavailability of the drug into the eye, as no eye drop solution could be formulated." | 1.37 | Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation. ( Gilhotra, RM; Mathurm, M, 2011) |
"Inflammation is associated with enhanced vascular permeability, production of inflammatory markers and over production of reactive oxygen species (ROS) with depletion of endogenous antioxidants." | 1.37 | Drug targeting to inflammation: studies on antioxidant surface loaded diclofenac liposomes. ( Apte, S; Devaraj, G; Devaraj, R; Jukanti, R, 2011) |
" An ibuprofen dosage of 1,600 mg/day did not induce LUF syndrome either at continuous periovulatory or discontinuous exposure." | 1.37 | Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies. ( Micu, MC; Micu, R; Ostensen, M, 2011) |
"Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals." | 1.36 | Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models. ( Aslan, A; Aygun, H; Cakir, A; Halici, Z; Odabasoglu, F; Suleyman, H; Tanas, S, 2010) |
"Diclofenac treatment resulted in a significant reduction in COX-2 expression and its activity." | 1.36 | Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. ( Kaur, J; Sanyal, SN, 2010) |
" Oral bioavailability of P2026 was estimated from plasma concentration of diclofenac and nitrate/nitrite (NOx)." | 1.36 | Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat. ( Desai, DC; Deshattiwar, JJ; Deshmukh, NJ; Dhiman, M; Gaikwad, PP; Karwa, M; Mali, SV; Nemmani, KV; Pamidiboina, V; Pathan, AR; Satyam, A; Sharma, SD; Thanga Mariappan, T, 2010) |
"Diclofenac was directly linked to fiber microfibril hydroxylic groups using THF with thionyl chloride." | 1.36 | Synthesis, characterization, and anti-inflammatory activity of diclofenac-bound cotton fibers. ( Arena, V; Barone, E; Cassano, R; Ferrarelli, T; Mancuso, C; Picci, N; Trombino, S, 2010) |
"Inflammation was induced in one hind paw of rats by intraplantar injection of carrageenan (250 μg)." | 1.36 | Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity? ( Bakhle, YS; de Francischi, JN; dos Reis, WG; Ferreira-Alves, DL; Gassani, BC; Paiva-Lima, P; Rezende, RM, 2010) |
" Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 1.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
"Aceclofenac is a new generation non-steroidal anti-inflammatory drug showing effective anti-inflammatory and analgesic properties." | 1.36 | Aceclofenac topical dosage forms: in vitro and in vivo characterization. ( Dua, K; Pabreja, K; Ramana, MV, 2010) |
"Diclofenac is a nonsteroidal anti-inflammatory drug which is available as prescription (RX) and over-the-counter (OTC) medication for the systemic and topical treatment of painful and inflammatory conditions such as arthritis and back pain." | 1.35 | Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats. ( Hasler-Nguyen, N; Schweitzer, A; Zijlstra, J, 2009) |
"Peridural fibrosis is one of the more frequent complications of lumbar surgery." | 1.35 | Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs. ( Hernandez-Vaquero, D; Sandoval, MA, 2008) |
"Furthermore, she had suffered from an untreated psoriasis since the age of 20." | 1.35 | Lipomatous metaplasia after severe and chronic cutaneous inflammation. ( Albert, A; Darsow, U; Eberlein, B; Eyerich, K; Hein, R; Jakob, T; Kerzl, R; Ring, J; Rombold, S; Traidl-Hoffmann, C, 2008) |
"Carrageenan induced significant mechanical allodynia, thermal hyperalgesia and paw oedema at 6 h post-carrageenan, while paw incision surgery induced significant mechanical allodynia and thermal hyperalgesia at 6 and 24 h post-surgery." | 1.34 | Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain. ( Biddlestone, L; Corbett, AD; Dolan, S, 2007) |
"Treatment with aspirin (200 mg/kg, p." | 1.33 | Influence of protein malnutrition on induction and treatment of inflammation in mice. ( Bassiouny, K; Hamed, MR; Hassanein, NM; Talaat, RM, 2006) |
"In this study, we investigated the bioavailability of iontophoretically delivered diclofenac with the methylnicotinate (MN) test." | 1.33 | Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay. ( Barel, AO; Clarys, P; Clijsen, R; Lambrecht, R, 2006) |
"Idiosyncratic adverse drug reactions (IADRs) represent an important human health problem, yet animal models for preclinical prediction of these reactions are lacking." | 1.33 | Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Luyendyk, JP; Maddox, JF; Roth, RA; Stachlewitz, RF; Waring, JF, 2006) |
"Treatment with diclofenac sodium extending past the acute inflammatory phase was no more effective than short and timely treatment in this model of skeletal muscle damage." | 1.32 | Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats. ( Côté, CH; Frémont, P; Lapointe, BM, 2003) |
"Chronic pain resulting from metastatic bone cancer remains poorly understood and resistant to treatment." | 1.32 | Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. ( Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L, 2004) |
"Diclofenac was selected as the reference compound." | 1.31 | Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. ( Brady, MT; Gamache, DA; Graff, G; Spellman, JM; Yanni, JM, 2000) |
"Inflammation was evaluated by clinical observations, biochemical analysis of aqueous humour and by histology." | 1.31 | Beneficial effects of topical anti-inflammatory drugs against sulfur mustard-induced ocular lesions in rabbits. ( Amir, A; Chapman, S; Fishbeine, E; Frishman, G; Gilat, E; Kadar, T; Liani, H; Meshulam, J; Sahar, R; Turetz, J, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (5.86) | 18.7374 |
1990's | 36 (12.41) | 18.2507 |
2000's | 70 (24.14) | 29.6817 |
2010's | 126 (43.45) | 24.3611 |
2020's | 41 (14.14) | 2.80 |
Authors | Studies |
---|---|
Alagarsamy, V | 3 |
Raja Solomon, V | 1 |
Dhanabal, K | 2 |
Sujith, KV | 1 |
Rao, JN | 1 |
Shetty, P | 1 |
Kalluraya, B | 1 |
Maccari, R | 1 |
Ottanà, R | 1 |
Vivier, D | 1 |
Bennis, K | 1 |
Lesage, F | 1 |
Ducki, S | 1 |
Velcicky, J | 1 |
Miltz, W | 1 |
Oberhauser, B | 1 |
Orain, D | 1 |
Vaupel, A | 1 |
Weigand, K | 1 |
Dawson King, J | 1 |
Littlewood-Evans, A | 1 |
Nash, M | 1 |
Feifel, R | 1 |
Loetscher, P | 1 |
Gonzaga, DTG | 1 |
Ferreira, LBG | 1 |
Moreira Maramaldo Costa, TE | 1 |
von Ranke, NL | 1 |
Anastácio Furtado Pacheco, P | 1 |
Sposito Simões, AP | 1 |
Arruda, JC | 1 |
Dantas, LP | 1 |
de Freitas, HR | 1 |
de Melo Reis, RA | 1 |
Penido, C | 1 |
Bello, ML | 1 |
Castro, HC | 1 |
Rodrigues, CR | 1 |
Ferreira, VF | 1 |
Faria, RX | 1 |
da Silva, FC | 1 |
AlFadly, ED | 1 |
Elzahhar, PA | 1 |
Tramarin, A | 1 |
Elkazaz, S | 1 |
Shaltout, H | 1 |
Abu-Serie, MM | 1 |
Janockova, J | 1 |
Soukup, O | 1 |
Ghareeb, DA | 1 |
El-Yazbi, AF | 1 |
Rafeh, RW | 1 |
Bakkar, NZ | 1 |
Kobeissy, F | 1 |
Iriepa, I | 1 |
Moraleda, I | 1 |
Saudi, MNS | 1 |
Bartolini, M | 1 |
Belal, ASF | 1 |
Kumari, P | 1 |
Kaur, S | 1 |
Kaur, J | 2 |
Bhatti, R | 1 |
Singh, P | 2 |
Han, Y | 1 |
Huang, D | 2 |
Xu, S | 2 |
Li, L | 2 |
Tian, Y | 1 |
Li, S | 1 |
Chen, C | 2 |
Li, Y | 7 |
Sun, Y | 3 |
Hou, Y | 2 |
Qin, M | 1 |
Gong, P | 1 |
Gao, Z | 1 |
Zhao, Y | 3 |
Sagar, SR | 1 |
Singh, DP | 1 |
Das, RD | 1 |
Panchal, NB | 1 |
Sudarsanam, V | 1 |
Nivsarkar, M | 1 |
Vasu, KK | 1 |
Neha, K | 1 |
Wakode, S | 1 |
St Laurent, G | 1 |
Toma, I | 1 |
Seilheimer, B | 1 |
Cesnulevicius, K | 1 |
Schultz, M | 1 |
Tackett, M | 1 |
Zhou, J | 2 |
Ri, M | 1 |
Shtokalo, D | 1 |
Antonets, D | 1 |
Jepson, T | 1 |
McCaffrey, TA | 1 |
Mohan, T | 1 |
Ajdnik, U | 1 |
Nagaraj, C | 1 |
Lackner, F | 1 |
Dobaj Štiglic, A | 1 |
Palani, T | 1 |
Amornkitbamrung, L | 1 |
Gradišnik, L | 1 |
Maver, U | 1 |
Kargl, R | 1 |
Stana Kleinschek, K | 1 |
Albarakati, AJA | 1 |
Olival, A | 1 |
Vieira, SF | 1 |
Gonçalves, VMF | 1 |
Cunha, C | 1 |
Tiritan, ME | 1 |
Carvalho, A | 1 |
Reis, RL | 1 |
Ferreira, H | 1 |
Neves, NM | 1 |
Dogra, A | 1 |
Kour, D | 1 |
Gour, A | 1 |
Bhardwaj, M | 1 |
Bag, S | 1 |
Dhiman, SK | 1 |
Kumar, A | 1 |
Singh, G | 1 |
Nandi, U | 1 |
Wu, H | 1 |
Zhou, H | 1 |
Zhang, W | 1 |
Jin, P | 1 |
Shi, Q | 1 |
Miao, Z | 1 |
Wang, H | 5 |
Zha, Z | 1 |
Alorabi, M | 1 |
Cavalu, S | 1 |
Al-Kuraishy, HM | 1 |
Al-Gareeb, AI | 1 |
Mostafa-Hedeab, G | 1 |
Negm, WA | 1 |
Youssef, A | 1 |
El-Kadem, AH | 1 |
Saad, HM | 1 |
Batiha, GE | 1 |
Elbaz, EM | 1 |
Ahmed, KA | 1 |
Abdelmonem, M | 1 |
Itou, H | 1 |
Toyota, R | 1 |
Takeda, M | 1 |
El Azab, EF | 1 |
Saleh, AM | 1 |
Yousif, SO | 1 |
Mazhari, BBZ | 1 |
Abu Alrub, H | 1 |
Elfaki, EM | 1 |
Hamza, A | 1 |
Abdulmalek, S | 1 |
Nwaehujor, C | 1 |
Hodkovicova, N | 1 |
Hollerova, A | 1 |
Blahova, J | 1 |
Mikula, P | 1 |
Crhanova, M | 1 |
Karasova, D | 1 |
Franc, A | 1 |
Pavlokova, S | 1 |
Mares, J | 1 |
Postulkova, E | 1 |
Tichy, F | 1 |
Marsalek, P | 1 |
Lanikova, J | 1 |
Faldyna, M | 1 |
Svobodova, Z | 1 |
Boarescu, I | 1 |
Pop, RM | 1 |
Boarescu, PM | 1 |
Bocșan, IC | 1 |
Gheban, D | 1 |
Râjnoveanu, RM | 1 |
Râjnoveanu, A | 1 |
Bulboacă, AE | 1 |
Buzoianu, AD | 1 |
Bolboacă, SD | 1 |
Zhang, D | 1 |
Song, S | 1 |
Bian, Z | 1 |
Huang, Z | 1 |
Bani, AP | 2 |
Putera, I | 2 |
Susanto, E | 2 |
La Distia Nora, R | 2 |
Almehizia, AA | 1 |
Khattab, AEA | 1 |
Darwish, AM | 1 |
Al-Omar, MA | 1 |
Naglah, AM | 1 |
Bhat, MA | 1 |
Kalmouch, A | 1 |
Zhang, Z | 1 |
Zhang, Q | 2 |
Gao, S | 1 |
Xu, H | 1 |
Guo, J | 1 |
Yan, F | 1 |
Chaabani, R | 1 |
Bejaoui, M | 1 |
Zaouali, MA | 1 |
Ben Abdennebi, H | 1 |
Yao, Y | 2 |
Wei, G | 1 |
Ding, J | 1 |
Cui, W | 1 |
Hamdi, BA | 1 |
Amin, ZA | 1 |
Shareef, AMY | 1 |
Al-Bustany, HA | 1 |
Steckling, FM | 1 |
Lima, FD | 1 |
Farinha, JB | 1 |
Rosa, PC | 1 |
Royes, LFF | 1 |
Cuevas, MJ | 2 |
Bresciani, G | 2 |
Soares, FA | 1 |
González-Gallego, J | 2 |
Barcelos, RP | 2 |
Al-Dossari, MH | 1 |
Fadda, LM | 1 |
Attia, HA | 1 |
Hasan, IH | 1 |
Mahmoud, AM | 1 |
Ghiselli, R | 1 |
Lucarini, G | 1 |
Ortenzi, M | 1 |
Salvolini, E | 1 |
Saccomanno, S | 1 |
Orlando, F | 1 |
Provinciali, M | 1 |
Casciani, F | 1 |
Guerrieri, M | 1 |
Duman, E | 1 |
Ceylan, KC | 1 |
Akpınar, D | 1 |
Yücel, N | 1 |
Ünsal, Ş | 1 |
Duman, S | 1 |
Kaya, ŞÖ | 1 |
Nagaraju, B | 1 |
Shanmukhakumar, JV | 1 |
Seelam, N | 1 |
Subbaiah, T | 1 |
Prasanna, B | 1 |
Öztürk, AA | 1 |
Namlı, İ | 1 |
Güleç, K | 1 |
Kıyan, HT | 1 |
Gull, N | 1 |
Khan, SM | 1 |
Butt, OM | 1 |
Islam, A | 1 |
Shah, A | 1 |
Jabeen, S | 1 |
Khan, SU | 1 |
Khan, A | 1 |
Khan, RU | 1 |
Butt, MTZ | 1 |
Kudsi, SQ | 1 |
Antoniazzi, CTD | 1 |
Camponogara, C | 1 |
Brum, EDS | 1 |
Brusco, I | 1 |
Peres, DS | 1 |
Fischer, SPM | 1 |
Dalenogare, DP | 1 |
Stein, CDS | 1 |
Zaccaron, RP | 1 |
Silveira, PCL | 1 |
Moresco, RN | 1 |
Oliveira, SM | 1 |
Trevisan, G | 1 |
Nese, M | 1 |
Riboli, G | 1 |
Brighetti, G | 1 |
Sassi, V | 1 |
Camela, E | 1 |
Caselli, G | 1 |
Sassaroli, S | 1 |
Borlimi, R | 1 |
Aucoin, M | 1 |
Cooley, K | 1 |
Saunders, PR | 1 |
Carè, J | 1 |
Anheyer, D | 1 |
Medina, DN | 1 |
Cardozo, V | 1 |
Remy, D | 1 |
Hannan, N | 1 |
Garber, A | 1 |
Velayos, M | 1 |
Muñoz-Serrano, AJ | 1 |
Estefanía-Fernández, K | 1 |
Sarmiento Caldas, MC | 1 |
Moratilla Lapeña, L | 1 |
López-Santamaría, M | 1 |
López-Gutiérrez, JC | 1 |
Li, J | 1 |
Zhang, J | 1 |
Shen, S | 1 |
Zhang, B | 2 |
Yu, WW | 1 |
Toyoda, H | 1 |
Huang, DQ | 1 |
Le, MH | 1 |
Nguyen, MH | 1 |
Huang, R | 1 |
Zhu, L | 1 |
Wang, J | 6 |
Xue, L | 1 |
Liu, L | 2 |
Yan, X | 2 |
Huang, S | 2 |
Xu, T | 1 |
Li, C | 2 |
Ji, F | 1 |
Ming, F | 1 |
Cheng, J | 1 |
Wang, Y | 3 |
Zhao, H | 1 |
Hong, S | 1 |
Chen, K | 2 |
Zhao, XA | 1 |
Zou, L | 1 |
Sang, D | 1 |
Shao, H | 1 |
Guan, X | 1 |
Chen, X | 2 |
Chen, Y | 5 |
Wei, J | 1 |
Zhu, C | 1 |
Wu, C | 1 |
Moore, HB | 1 |
Barrett, CD | 1 |
Moore, EE | 1 |
Jhunjhunwala, R | 1 |
McIntyre, RC | 1 |
Moore, PK | 1 |
Hajizadeh, N | 1 |
Talmor, DS | 1 |
Sauaia, A | 1 |
Yaffe, MB | 1 |
Liu, C | 3 |
Lin, Y | 1 |
Dong, Y | 1 |
Wu, Y | 1 |
Bao, Y | 1 |
Yan, H | 2 |
Ma, J | 1 |
Fernández-Cuadros, ME | 1 |
Albaladejo-Florín, MJ | 1 |
Álava-Rabasa, S | 1 |
Usandizaga-Elio, I | 1 |
Martinez-Quintanilla Jimenez, D | 1 |
Peña-Lora, D | 1 |
Neira-Borrajo, I | 1 |
López-Muñoz, MJ | 1 |
Rodríguez-de-Cía, J | 1 |
Pérez-Moro, OS | 1 |
Abdallah, M | 1 |
Alsaleh, H | 1 |
Baradwan, A | 1 |
Alfawares, R | 1 |
Alobaid, A | 1 |
Rasheed, A | 1 |
Soliman, I | 1 |
Wendel Garcia, PD | 1 |
Fumeaux, T | 1 |
Guerci, P | 1 |
Heuberger, DM | 1 |
Montomoli, J | 2 |
Roche-Campo, F | 1 |
Schuepbach, RA | 1 |
Hilty, MP | 1 |
Poloni, TE | 1 |
Carlos, AF | 1 |
Cairati, M | 1 |
Cutaia, C | 1 |
Medici, V | 1 |
Marelli, E | 1 |
Ferrari, D | 1 |
Galli, A | 1 |
Bognetti, P | 1 |
Davin, A | 1 |
Cirrincione, A | 1 |
Ceretti, A | 1 |
Cereda, C | 1 |
Ceroni, M | 1 |
Tronconi, L | 1 |
Vitali, S | 1 |
Guaita, A | 1 |
Leeds, JS | 1 |
Raviprakash, V | 1 |
Jacques, T | 1 |
Scanlon, N | 1 |
Cundall, J | 1 |
Leeds, CM | 1 |
Riva, A | 1 |
Gray, EH | 1 |
Azarian, S | 1 |
Zamalloa, A | 1 |
McPhail, MJW | 1 |
Vincent, RP | 1 |
Williams, R | 1 |
Chokshi, S | 1 |
Patel, VC | 1 |
Edwards, LA | 1 |
Alqarawi, W | 1 |
Birnie, DH | 1 |
Golian, M | 1 |
Nair, GM | 1 |
Nery, PB | 1 |
Klein, A | 1 |
Davis, DR | 1 |
Sadek, MM | 1 |
Neilipovitz, D | 1 |
Johnson, CB | 1 |
Green, MS | 1 |
Redpath, C | 1 |
Miller, DC | 1 |
Beamer, P | 1 |
Billheimer, D | 1 |
Subbian, V | 1 |
Sorooshian, A | 1 |
Campbell, BS | 1 |
Mosier, JM | 1 |
Novaretti, JV | 1 |
Astur, DC | 1 |
Cavalcante, ELB | 1 |
Kaleka, CC | 1 |
Amaro, JT | 1 |
Cohen, M | 1 |
Huang, W | 1 |
Li, T | 1 |
Ling, Y | 1 |
Qian, ZP | 1 |
Zhang, YY | 1 |
Xu, SB | 1 |
Liu, XH | 1 |
Xia, L | 1 |
Yang, Y | 3 |
Lu, SH | 1 |
Lu, HZ | 1 |
Zhang, R | 2 |
Ma, JX | 1 |
Tang, S | 1 |
Li, CM | 1 |
Wan, J | 1 |
Wang, JF | 1 |
Ma, JQ | 1 |
Luo, JJ | 1 |
Chen, HY | 2 |
Mi, SL | 1 |
Chen, SY | 1 |
Su, YG | 1 |
Ge, JB | 1 |
Milheiro, SA | 1 |
Gonçalves, J | 1 |
Lopes, RMRM | 1 |
Madureira, M | 1 |
Lobo, L | 1 |
Lopes, A | 1 |
Nogueira, F | 1 |
Fontinha, D | 1 |
Prudêncio, M | 1 |
M Piedade, MF | 1 |
Pinto, SN | 1 |
Florindo, PR | 1 |
Moreira, R | 1 |
Castillo-Lora, J | 1 |
Delley, MF | 1 |
Laga, SM | 1 |
Mayer, JM | 1 |
Sutjarit, N | 1 |
Thongon, N | 1 |
Weerachayaphorn, J | 1 |
Piyachaturawat, P | 1 |
Suksamrarn, A | 1 |
Suksen, K | 1 |
Papachristou, DJ | 1 |
Blair, HC | 1 |
Hu, Y | 1 |
Shen, P | 1 |
Zeng, N | 1 |
Wang, L | 4 |
Yan, D | 1 |
Cui, L | 1 |
Yang, K | 2 |
Zhai, C | 1 |
Yang, M | 1 |
Lao, X | 1 |
Sun, J | 1 |
Ma, N | 1 |
Wang, S | 1 |
Ye, W | 1 |
Guo, P | 1 |
Rahimi, S | 1 |
Singh, MP | 1 |
Gupta, J | 1 |
Nakanishi, I | 1 |
Ohkubo, K | 1 |
Shoji, Y | 1 |
Fujitaka, Y | 1 |
Shimoda, K | 1 |
Matsumoto, KI | 1 |
Fukuhara, K | 1 |
Hamada, H | 1 |
van der Boom, T | 1 |
Gruppen, EG | 1 |
Lefrandt, JD | 1 |
Connelly, MA | 1 |
Links, TP | 1 |
Dullaart, RPF | 1 |
Berry, JD | 1 |
Bedlack, R | 1 |
Mathews, D | 1 |
Agnese, W | 1 |
Apple, S | 1 |
Meloncelli, S | 1 |
Divizia, M | 1 |
Germani, G | 1 |
Adefegha, SA | 1 |
Bottari, NB | 1 |
Leal, DB | 1 |
de Andrade, CM | 1 |
Schetinger, MR | 1 |
Martínez-Velasco, A | 1 |
Perez-Ortiz, AC | 1 |
Antonio-Aguirre, B | 1 |
Martínez-Villaseñor, L | 1 |
Lira-Romero, E | 1 |
Palacio-Pastrana, C | 1 |
Zenteno, JC | 1 |
Ramirez, I | 1 |
Zepeda-Palacio, C | 1 |
Mendoza-Velásquez, C | 1 |
Camacho-Ordóñez, A | 1 |
Ortiz Bibriesca, DM | 1 |
Estrada-Mena, FJ | 1 |
Martin, BL | 1 |
Thompson, LC | 1 |
Kim, YH | 2 |
Snow, SJ | 1 |
Schladweiler, MC | 1 |
Phillips, P | 1 |
Harmon, M | 1 |
King, C | 1 |
Richards, J | 1 |
George, I | 1 |
Haykal-Coates, N | 1 |
Gilmour, MI | 1 |
Kodavanti, UP | 1 |
Hazari, MS | 1 |
Farraj, AK | 1 |
Shen, Z | 1 |
Zou, Y | 1 |
Gao, K | 1 |
Lazar, S | 1 |
Wurtzel, JGT | 1 |
Ma, P | 1 |
Goldfinger, LE | 1 |
Vukelic, M | 1 |
Laloo, A | 1 |
Kyttaris, VC | 1 |
Chen, R | 2 |
Chen, J | 2 |
Xun, J | 1 |
Hu, Z | 1 |
Huang, Q | 2 |
Steinhart, C | 1 |
Shen, Y | 1 |
Lu, H | 1 |
Mansuri, A | 1 |
Lokhande, K | 1 |
Kore, S | 1 |
Gaikwad, S | 1 |
Nawani, N | 1 |
Swamy, KV | 1 |
Junnarkar, M | 1 |
Pawar, S | 1 |
Shaheen, MY | 1 |
Basudan, AM | 1 |
Niazy, AA | 1 |
van den Beucken, JJJP | 1 |
Jansen, JA | 1 |
Alghamdi, HS | 1 |
Gao, Q | 2 |
Guo, X | 1 |
Cao, Y | 1 |
Jia, X | 1 |
Lu, C | 2 |
Zhu, H | 2 |
Melku, M | 1 |
Abebe, G | 1 |
Teketel, A | 1 |
Asrie, F | 1 |
Yalew, A | 1 |
Biadgo, B | 1 |
Kassa, E | 1 |
Damtie, D | 1 |
Anlay, DZ | 1 |
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Scaricabarozzi, I | 2 |
el-Khatib, AS | 1 |
Díaz-González, F | 1 |
González-Alvaro, I | 1 |
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del Pozo, MA | 1 |
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Clavenna, G | 1 |
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Chapman, V | 2 |
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Suharwardy, J | 1 |
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Bell, JA | 1 |
Munton, CG | 1 |
van der Westhuijzen, AJ | 1 |
Roelofse, JA | 1 |
Grotepass, FW | 1 |
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Tonussi, CR | 1 |
Ferreira, SH | 2 |
Clarke, GD | 1 |
MacPherson, IS | 1 |
Petrone, G | 1 |
Spangler, RS | 1 |
Wallace, JL | 1 |
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McKnight, W | 1 |
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Martin, RG | 1 |
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Shoji, N | 2 |
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Masuda, K | 2 |
Arnaud, B | 1 |
Trinquand, C | 1 |
Khopade, AJ | 1 |
Jain, NK | 1 |
Wright, M | 1 |
Butt, Z | 1 |
McIlwaine, G | 1 |
Fleck, B | 1 |
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Gaino, S | 1 |
Benoni, G | 1 |
Bellavite, P | 1 |
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Vedana, EM | 1 |
De Freitas, GA | 1 |
Flach, AJ | 1 |
Dolan, BJ | 1 |
Donahue, ME | 1 |
Faktorovich, EG | 1 |
Gonzalez, GA | 1 |
Campana, V | 1 |
Moya, M | 1 |
Gavotto, A | 1 |
Juri, H | 1 |
Palma, JA | 1 |
Vantesone, DL | 1 |
Luna, JD | 1 |
Muiño, JC | 1 |
Juárez, CP | 1 |
Fioravanti, A | 1 |
Cicero, MR | 1 |
Nerucci, F | 1 |
Manopulo, R | 1 |
Marcolongo, R | 1 |
Cullen , DJ | 1 |
Seager, JM | 1 |
Holmes, S | 1 |
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Garrud, P | 1 |
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Maynard, A | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Relation Between Reduction of the Inflammatory Status and Glucose Metabolism in Healthy Overweight Men[NCT00221052] | 20 participants | Interventional | 2005-06-30 | Completed | |||
Randomized Trial of Mannitol Cream for Pain Relief After a Long Run[NCT01843088] | Phase 1 | 170 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
External Validation of a Clinical Scoring System to Predict Microscopic Colitis in Patients With Chronic Watery Diarrhoea[NCT06031064] | 200 participants (Anticipated) | Observational | 2022-05-15 | Recruiting | |||
Evaluation of Anti-inflammatory Steroids of Use in the Prevention of Tooth Sensitivity in Teeth Whitening Technique Office[NCT02956070] | 70 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
Analysis of Effect of Low Level Laser Therapy in Spinal Surgery[NCT02529657] | 48 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
Effect of Nepafenac Eye Drops on Intraocular Pressure - a Randomized Prospective Study[NCT01995890] | Phase 4 | 327 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The investigators evaluated the tooth sensibility 1 hour post-bleaching. Scale from 0-100 0 means no sensibility 100 means maximum sensibility (NCT02956070)
Timeframe: One hour
Intervention | units on a scale (Mean) |
---|---|
Experimental | 6.31 |
Placebo | 11.14 |
The investigators evaluated the tooth sensibility 24 hours post-bleaching. Scale from 0-100 0 means no sensibility 100 means maximum sensibility (NCT02956070)
Timeframe: Twenty four hours
Intervention | units on a scale (Mean) |
---|---|
Experimental | 5.06 |
Placebo | 8.26 |
The investigators evaluated the tooth sensibility 48 hours post-bleaching. Scale from 0-100 0 means no sensibility 100 means maximum sensibility (NCT02956070)
Timeframe: Forty eight hours
Intervention | units on a scale (Mean) |
---|---|
Experimental | 0.37 |
Placebo | 2.91 |
14 reviews available for diclofenac and Innate Inflammatory Response
Article | Year |
---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Contemporary advances of cyclic molecules proposed for inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular | 2021 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Heparin; Humans; Inflammation; Osteoarthritis, | 2019 |
Topical delivery of aceclofenac: challenges and promises of novel drug delivery systems.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Delivery Systems; | 2014 |
Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa.
Topics: Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspi | 2017 |
Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Delayed-Action Prep | 2008 |
Therapeutic potential of new hydrogen sulfide-releasing hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Humans; Hydrogen Sulfide; Inf | 2011 |
Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Design; Drug Interactions; Drug S | 2012 |
Aceclofenac in the management of inflammatory pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac | 2004 |
[Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine].
Topics: Administration, Topical; Animals; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Athletic | 2004 |
Topical diclofenac and its role in pain and inflammation: an evidence-based review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Double-Blind Metho | 2008 |
[What is the role of aceclofenac in the therapeutic arsenal against chronic osteoarthritis pathologies?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage; Chronic Disease; Diclofen | 2001 |
Clinical evidence for osteoarthritis as an inflammatory disease.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Combinations; Humans | 2001 |
40 trials available for diclofenac and Innate Inflammatory Response
Article | Year |
---|---|
Clinical Effect of Catgut Embedding plus Warm Needle Moxibustion on Improving Inflammation and Quality of Life of Knee Osteoarthritis Patients.
Topics: Acupuncture Points; Catgut; Delayed-Action Preparations; Diclofenac; Humans; Inflammation; Moxibusti | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
A Randomized Clinical Trial of Topical Diclofenac, Fluorometholone, and Dexamethasone for Control of Inflammation After Strabismus Surgery.
Topics: Administration, Topical; Adolescent; Adult; Child; Dexamethasone; Diclofenac; Female; Fluorometholon | 2018 |
Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie's disease (chronic inflammation of the tunica albuginea). Results of a controlled study.
Topics: Adult; Aged; Aged, 80 and over; Blueberry Plants; Case-Control Studies; Diclofenac; Humans; Inflamma | 2013 |
Comparative Effects of Topical Diclofenac and Betamethasone on Inflammation After Vitrectomy and Cataract Surgery in Various Vitreoretinal Diseases.
Topics: Administration, Topical; Aged; Betamethasone; Cataract; Diclofenac; Female; Humans; Inflammation; Ma | 2016 |
Comparison of the efficacy and safety of a novel meloxicam ophthalmic formulation with a reference diclofenac solution in cataract surgery.
Topics: Administration, Topical; Aged; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac | 2009 |
Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy.
Topics: Administration, Topical; Adult; Aged; Anterior Chamber; Diclofenac; Double-Blind Method; Female; Hum | 2008 |
Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate.
Topics: Administration, Topical; Amikacin; Animals; Diclofenac; Dosage Forms; Horse Diseases; Horses; Inflam | 2009 |
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study.
Topics: Adult; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Caspase 8; Diclofenac; | 2010 |
A randomized controlled trial of electrostimulation effects on effussion, swelling and pain recovery after anterior cruciate ligament reconstruction: a pilot study.
Topics: Adult; Anterior Cruciate Ligament Reconstruction; Anti-Inflammatory Agents, Non-Steroidal; Diclofena | 2012 |
Therapeutic efficacy and tolerability of the topical treatment of inflammatory conditions of the oral cavity with a mouthwash containing diclofenac epolamine: a randomized, investigator-blind, parallel-group, controlled, phase III study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Inflammation; Male; Middle Aged | 2012 |
Effects of dexamethasone, diclofenac, or placebo on the inflammatory response after cataract surgery.
Topics: Aged; Aged, 80 and over; Cataract Extraction; Dexamethasone; Diclofenac; Double-Blind Method; Eye Di | 2002 |
Clinical study of diclofenac sodium eyedrops used before and after cataract operation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Female; Humans; Inflammati | 1999 |
Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Central Nervous System; Cross-Over | 2003 |
Clinical trial of diclofenac sodium (Naclof) eye drops on Nigerians.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclof | 2004 |
Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery.
Topics: Adult; Anti-Inflammatory Agents; Dexamethasone; Diclofenac; Double-Blind Method; Drug Therapy, Combi | 2005 |
The use of methylprednisolone versus diclofenac in the treatment of inflammation and trismus after surgical removal of lower third molars.
Topics: Anti-Inflammatory Agents; Chi-Square Distribution; Diclofenac; Double-Blind Method; Humans; Inflamma | 2006 |
Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery.
Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Ch | 2007 |
Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1993 |
A comparative trial between diclofenac-gentamicin and betamethasone-neomycin drops in patients undergoing cataract extraction.
Topics: Aged; Aged, 80 and over; Betamethasone; Cataract Extraction; Diclofenac; Female; Gentamicins; Humans | 1994 |
Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-S | 1994 |
Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation.
Topics: Aged; Cataract Extraction; Diclofenac; Double-Blind Method; Endophthalmitis; Female; Follow-Up Studi | 1994 |
A comparison of topical non-steroidal anti-inflammatory drugs to steroids for control of post cataract inflammation.
Topics: Cataract Extraction; Diclofenac; Eye Diseases; Humans; Inflammation; Lenses, Intraocular; Postoperat | 1993 |
[Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Double-Blind Method; | 1997 |
Comparison of the efficacy of diclofenac and betamethasone following strabismus surgery.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Child; Child, Prescho | 1997 |
Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-term cystoid macular edema. Italian Diclofenac Study Group.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Double-Blind Method; | 1997 |
A randomized clinical trial of the nonsteroidal eyedrop diclofenac after strabismus surgery.
Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroid | 1998 |
Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; F | 1998 |
Effects of topical diclofenac and prednisolone eyedrops in laser in situ keratomileusis patients.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; C | 1999 |
Double-blind controlled clinical study of the efficacy and tolerability of diclofenac-N-(2-hydroxyethyl)-pyrrolidine lecithin gel compared with diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel in patients with peri and extraarticular inflammatory diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Phar | 1999 |
Thermographic imaging of postoperative inflammation modified by anti-inflammatory pretreatment.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; D | 2001 |
A comparison of two different formulations of diclofenac sodium 0.1% in the treatment of inflammation following cataract-intraocular lens surgery.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Benzalkonium Compounds; Cataract Extraction; Chemi | 2002 |
[Diclofenac in the treatment of inflammatory and degenerative diseases of the locomotor system].
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Humans; Indomethacin; Inflammati | 1977 |
[Comparative study of the efficacy of diclofenac sodium and indomethacin in post-operative inflammation following varicose vein surgery].
Topics: Adult; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Inflammation; Middle Aged; Phenyl | 1979 |
Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins.
Topics: Acute-Phase Proteins; Diclofenac; Double-Blind Method; Enzymes; Female; Hemodynamics; Humans; Inflam | 1992 |
[Anti-inflammatory effect of topical diclofenac sodium (Voltarène Ophta) after argon laser trabeculoplasty: preliminary results of a prospective double-blind method].
Topics: Aged; Anterior Chamber; Diclofenac; Double-Blind Method; Female; Glaucoma; Glaucoma, Open-Angle; Hum | 1992 |
[Diclofenac-dexamethasone combination in treatment of postoperative inflammation: prospective double-blind study].
Topics: Aged; Anterior Chamber; Dexamethasone; Diclofenac; Double-Blind Method; Drug Therapy, Combination; F | 1992 |
[Clinical efficacy of nimesulide compared to diclofenac sodium in the prevention and treatment of postoperative pain-inflammation symptomatology].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1990 |
Inhibition of blood-aqueous humor barrier breakdown with diclofenac. A fluorophotometric study.
Topics: Aged; Aged, 80 and over; Anterior Chamber; Aqueous Humor; Blood; Diclofenac; Dose-Response Relations | 1990 |
Treatment of ocular inflammation with diclofenac sodium: double-blind trial following cataract surgery.
Topics: Aged; Cataract Extraction; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Eye Diseases; | 1985 |
237 other studies available for diclofenac and Innate Inflammatory Response
Article | Year |
---|---|
Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Rela | 2007 |
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch | 2009 |
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Diabetes Complications; Diabetes Mellitus; Enzyme Inhibito | 2015 |
Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.
Topics: Administration, Oral; Animals; Drug Design; Female; HEK293 Cells; Humans; Inflammation; Neovasculari | 2017 |
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Inflammation; Lipopolysaccharides; Mice; Molec | 2017 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 In | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Carrageenan; Cell Survival; Dose-R | 2021 |
Investigations on substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones for the treatment of Alzheimer's disease.
Topics: Aluminum Chloride; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Respons | 2021 |
RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Diclofenac; Inflammation; Mice; Wound | 2021 |
One-Step Fabrication of Hollow Spherical Cellulose Beads: Application in pH-Responsive Therapeutic Delivery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Cellulose; Diclofenac; Drug Carrie | 2022 |
Protocatechuic acid counteracts oxidative stress and inflammation in carrageenan-induced paw edema in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Diclofenac; Edema; Hydroxybenzoates; I | 2022 |
Erythrocyte-derived liposomes for the treatment of inflammatory diseases.
Topics: Anti-Inflammatory Agents; Cytokines; Diclofenac; Erythrocytes; Humans; Inflammation; Interleukin-6; | 2022 |
Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Diclofenac; Fatty Acid Bi | 2023 |
Three birds with one stone: co-encapsulation of diclofenac and DL-menthol for realizing enhanced energy deposition, glycolysis inhibition and anti-inflammation in HIFU surgery.
Topics: Diclofenac; Glycolysis; High-Intensity Focused Ultrasound Ablation; Humans; Inflammation; Menthol | 2022 |
Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Diclofenac; D | 2022 |
Resveratrol mitigates diclofenac-induced hepatorenal toxicity in rats via modulation of miR-144/Nrf2/GSH axis.
Topics: Animals; Antioxidants; Biomarkers; Caspase 3; Diclofenac; Glutathione; Inflammation; MicroRNAs; NF-E | 2022 |
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Diclofenac; Hyperalgesia; Inflam | 2022 |
New insights into geraniol's antihemolytic, anti-inflammatory, antioxidant, and anticoagulant potentials using a combined biological and in silico screening strategy.
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Anticoagulants; Antioxidants; Chlorides; Di | 2022 |
Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Ficus; G | 2021 |
Non-steroidal anti-inflammatory drugs caused an outbreak of inflammation and oxidative stress with changes in the gut microbiota in rainbow trout (Oncorhynchus mykiss).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Diclofenac; Disease Outbreaks; Dysbios | 2022 |
Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Curcumin; Cytokines; Diclofenac; Inflamm | 2022 |
Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits.
Topics: Actins; Administration, Topical; Animals; Diclofenac; Inflammation; Muscle, Smooth; Rabbits; Strabis | 2023 |
Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits.
Topics: Actins; Administration, Topical; Animals; Diclofenac; Inflammation; Muscle, Smooth; Rabbits; Strabis | 2023 |
Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits.
Topics: Actins; Administration, Topical; Animals; Diclofenac; Inflammation; Muscle, Smooth; Rabbits; Strabis | 2023 |
Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits.
Topics: Actins; Administration, Topical; Animals; Diclofenac; Inflammation; Muscle, Smooth; Rabbits; Strabis | 2023 |
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease | 2023 |
Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection.
Topics: Adhesives; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Bacterial Infecti | 2023 |
Protective effects of diclofenac on liver graft preservation.
Topics: Animals; Diclofenac; Glutathione; Inflammation; Liver; NF-kappa B; Organ Preservation; Organ Preserv | 2023 |
[Injectable hydrogel microspheres experimental research for the treatment of osteoarthritis].
Topics: Aggrecans; Animals; Collagen Type II; Diclofenac; Hyaluronic Acid; Hydrogels; Inflammation; Matrix M | 2023 |
Diclofenac sodium and dexamethasone co-therapy restores brain neuron-specific enolase (NSE), S-100 Beta and glial fibrillary acid protein (GFAP) proteins in experimental rat's model: A possible inhibition of P-glycoprotein.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; D | 2023 |
Diclofenac attenuates inflammation through TLR4 pathway and improves exercise performance after exhaustive swimming.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytokines; Diclofenac; Inflammat | 2020 |
Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury, Chronic; Curcumin; Diclofenac; Inflamma | 2020 |
Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Di | 2020 |
The effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; Glucocorticoids; Inflam | 2020 |
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coordination Complexes; Cyclization; Diclofenac; Dis | 2019 |
Diclofenac sodium loaded PLGA nanoparticles for inflammatory diseases with high anti-inflammatory properties at low dose: Formulation, characterization and in vivo HET-CAM analysis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chick Embryo; Chorioallantoic Membrane; Diclofenac | 2020 |
Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium.
Topics: Animals; Artemia; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diclofenac; Drug Ca | 2020 |
Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Ani | 2020 |
Inflammation reduces osteoblast cytotoxicity induced by diclofenac: An in vitro study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Diclofenac; Humans; Inflammation; Osteo | 2021 |
Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Inflammation; Pharmaceutical P | 2021 |
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study.
Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; C | 2021 |
Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury
Topics: Diclofenac; Endotoxins; Epithelial Cells; Humans; Inflammation; Intestinal Mucosa | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldeh | 2020 |
Amelioration of autoimmunity and inflammation by zinc oxide nanoparticles in experimental rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Diclofenac; Freund's Adjuvant | 2021 |
Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclopropan | 2021 |
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.
Topics: Acute-Phase Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Coculture Techniqu | 2017 |
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
Topics: Acinar Cells; Animals; Cell Differentiation; Cell Proliferation; Ceruletide; Cytokines; Diclofenac; | 2018 |
Aceclofenac oil drops: characterization and evaluation against ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzyl Alcohol; Buffaloes; Chemistry, Pharmaceutic | 2018 |
Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Cartilage; Collagen Type II; Diclofenac; | 2017 |
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; D | 2017 |
Anti-Inflammatory and Analgesic Activities of the Complex of Flavonoids from Lychnis chalcedonica L.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Female; Flavono | 2017 |
Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, | 2017 |
Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats.
Topics: Animals; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; In | 2017 |
Novel drug delivery of dual acting prodrugs of hydroxychloroquine with aryl acetic acid NSAIDs: Design, kinetics and pharmacological study.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, R | 2017 |
Heterocyclic homoprostanoid derivative attenuates monoarthritis in rats: An in vitro and in vivo preclinical paradigm.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Diclofenac; | 2018 |
Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Celecoxib; | 2018 |
Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Cytokines; Diclofenac; F | 2018 |
Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coculture Techniques; Diclofenac; Hematopoiesis; H | 2018 |
Java Tea (Orthosiphon stamineus) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Diclofenac; Dose-Response Relationship, Drug | 2018 |
Three-dimensional plotted alginate fibers embedded with diclofenac and bone cells coated with chitosan for bone regeneration during inflammation.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Regeneration; Chitosan; Coated Mat | 2018 |
Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytokines; | 2018 |
Design, characterization, and evaluation of aceclofenac-loaded Eudragit RS 100 nanoparticulate system for ocular delivery.
Topics: Acrylic Resins; Administration, Ophthalmic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell M | 2019 |
Defective bone repair in diclofenac treated C57Bl6 mice with and without lipopolysaccharide induced systemic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Endothelial Cells; Humans; Inflammatio | 2019 |
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid.
Topics: Animals; Anti-Inflammatory Agents; Butyrates; Carrageenan; Diclofenac; Edema; Foot; Hindlimb; Inflam | 2018 |
Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; Gene Expression Profiling; Ge | 2020 |
Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 2019 |
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Diclofenac; D | 2019 |
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell | 2019 |
Anti-inflammatory effects of Phytodolor® (STW 1) and components (poplar, ash and goldenrod) on human monocytes/macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyclooxygenase 2; Diclofenac; Fraxinus; Humans; | 2019 |
Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Atorvastatin; Diclofenac; Disease Mo | 2020 |
Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d]pyrimidinones and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinones as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2019 |
Aceclofenac-loaded unsaturated esterified alginate/gellan gum microspheres: in vitro and in vivo assessment.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Mat | 2013 |
Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceramides; Chemistry, P | 2014 |
Multiple ileal perforations due to regular diclofenac sodium injections: a case report.
Topics: Abdominal Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ileum; In | 2013 |
Effect of ascophyllan from brown algae Padina tetrastromatica on inflammation and oxidative stress in carrageenan-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Diclofenac; Dinoprostone; Edema; Infla | 2013 |
What is the best treatment to decrease pro-inflammatory cytokine release in acute skeletal muscle injury induced by trauma in rats: low-level laser therapy, diclofenac, or cryotherapy?
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cryotherapy; Cytokines; D | 2014 |
Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac | 2014 |
Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres.
Topics: Acrylic Resins; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2014 |
The impact of nonsteroidal anti-inflammatory drugs on inflammatory response after aneurysmal subarachnoid hemorrhage.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; C-Rea | 2014 |
Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Diclofenac; Fibula; Fract | 2014 |
Effects of topical nasal steroids and diclofenac on the nasal mucosa during hyperbaric oxygen therapy: a double-blind experimental study.
Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroid | 2014 |
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carotenoids; Carrageenan; Cyclohexenes; Diclofenac; D | 2013 |
A novel nano-carrier transdermal gel against inflammation.
Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Ca | 2014 |
Anti-ulcer and wound healing activities of Sida corymbosa in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Diclofenac; Dose-Response Relationship, Drug; | 2014 |
The effect of diclofenac on proliferation and production of growth factors by endothelial cells (HMEC-1) under hypoxia and inflammatory conditions.
Topics: Cell Hypoxia; Cell Proliferation; Cell Survival; Cells, Cultured; Diclofenac; Dose-Response Relation | 2014 |
Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model.
Topics: Animals; Cell Survival; Cells, Cultured; Diclofenac; Dinoprostone; Drug Delivery Systems; Humans; In | 2015 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, An | 2014 |
Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Chemistry, Ph | 2015 |
Artesunate Ameliorates Functional Limitations in Freund's Complete Adjuvant-Induced Monoarthritis in Rat by Maintaining Oxidative Homeostasis and Inhibiting COX-2 Expression.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apoptosis; Artemisinins; Artesunate; Arthritis, Exper | 2015 |
Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Gold; Inflam | 2015 |
Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Capsaicin; Cell Proliferation; Diclofenac; Dise | 2014 |
Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chitosan; Crys | 2015 |
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cyclooxygenase Inhibitors; | 2015 |
Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Disea | 2015 |
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
Topics: Acetic Acid; Analgesics; Animals; Benzimidazoles; Diclofenac; Disease Models, Animal; Drug Evaluatio | 2015 |
Design, synthesis and QSAR studies on a series of 2, 5-disubstituted- 1,3,4-oxadiazole derivatives of diclofenac and naproxen for analgesic and anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Design; Female; Infla | 2015 |
Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Back; Bone Morphogenetic Protein 2; Cytokines; Dic | 2015 |
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, | 2015 |
Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cattle | 2016 |
Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2016 |
Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability | 2016 |
Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclohexane Monoterpe | 2016 |
Expression of Endoglin and Vascular Endothelial Growth Factor as Prognostic Markers in Experimental Colorectal Cancer.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 2 Inhibi | 2016 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, | 2016 |
Comparison of the Tolerability of Diclofenac and Nepafenac.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Diclofena | 2016 |
Diclofenac inhibits 27-hydroxycholesterol-induced inflammation.
Topics: Cell Line; Cell Movement; Chemokine CCL2; Diclofenac; Humans; Hydroxycholesterols; Inflammation; Lig | 2016 |
Bio thermodynamic studies of diclofenac interaction with lysozyme under various conditions using diclofenac-selective membrane electrode and molecular docking.
Topics: Diclofenac; Electrodes; Humans; Inflammation; Molecular Docking Simulation; Muramidase; Thermodynami | 2017 |
Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationshi | 2017 |
The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cluster Anal | 2017 |
Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study.
Topics: Animals; Arthritis, Rheumatoid; Delayed-Action Preparations; Diclofenac; Edema; Humans; Inflammation | 2017 |
Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway.
Topics: Animals; Cyclooxygenase 2; Diclofenac; Disease Models, Animal; Inflammation; Interleukin-1beta; Inte | 2017 |
Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Carrageenan; Diclofenac; Disease Mode | 2008 |
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, | 2008 |
Influence of protein malnutrition on induction and treatment of inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Diclofenac; Diet, Protein-Re | 2006 |
PARFLEX--a very useful drug for management of surgical pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fem | 2008 |
Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cotton Fiber; Diclofenac; D | 2008 |
Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; | 2008 |
M694V mutation may have a role in susceptibility to ankylosing spondylitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diclofenac; Drug Combinations; Female; F | 2009 |
Activation of macrophage peroxisome proliferator-activated receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytokines; Diclofenac; Dose-Resp | 2009 |
Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice.
Topics: Allergens; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Cyclooxygenase 1; Cyclooxygen | 2009 |
Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoradiography; Carrageenan; Diclofenac; Inflamma | 2009 |
Liposomal dexamethasone-diclofenac combinations for local osteoarthritis treatment.
Topics: Animals; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Drug Combinations; | 2009 |
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea | 2009 |
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.
Topics: Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzhydryl Compounds; Carra | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclo | 2010 |
Comparison of anti-inflammatory activity of dexamethasone and diclofenac sodium eye drops in phacoemulsification.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; Female; Glucocorticoids; Humans; | 2009 |
Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Citrus; Diclofenac; Dise | 2009 |
The effects of celecoxib, a COX-2 selective inhibitor, on acute inflammation induced in irradiated rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxyge | 2009 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclof | 2010 |
Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Diclofenac; Female; Freund | 2010 |
Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arthrit | 2010 |
Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Dose-Respons | 2010 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Fa | 2010 |
Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bio | 2010 |
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflamm | 2010 |
Synthesis, characterization, and anti-inflammatory activity of diclofenac-bound cotton fibers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bandages; Cotton Fiber; Cross-Linking Reagents; Di | 2010 |
The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carrageenan; Chromatography, High Pressure Liquid; Di | 2011 |
Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Topics: Acetazolamide; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationsh | 2010 |
Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrage | 2010 |
Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chemistry, Pharmaceutical | 2011 |
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase | 2011 |
In vitro and in vivo evaluation of anti-inflammatory agents using nanoengineered alginate carriers: towards localized implant inflammation suppression.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Biosensing Techniques; Blood | 2011 |
The influence of irradiation on the potential chondroprotective effect of aqueous extract of propolis in rats.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Exper | 2011 |
Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac; Drug Syn | 2010 |
Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis.
Topics: Adhesiveness; Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Del | 2010 |
Aceclofenac topical dosage forms: in vitro and in vivo characterization.
Topics: Acrylic Resins; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2010 |
Diclofenac-loaded Eudragit S100 nanosuspension for ophthalmic delivery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Chemical Precipitation; Diclofenac; | 2011 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; H | 2011 |
Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice.
Topics: Animals; Anti-Inflammatory Agents; Bivalvia; Carrageenan; Diclofenac; Edema; Ethanol; Formaldehyde; | 2011 |
Drug targeting to inflammation: studies on antioxidant surface loaded diclofenac liposomes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Drug Carriers; Drug Comp | 2011 |
Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chi-Square Distribution; Cyclo | 2011 |
Inhibition of 5-lipoxygenase and cyclooxygenase-2 pathways by pain-relieving plaster in macrophages.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cyclooxyg | 2011 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutic | 2011 |
A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Case-Control Studies; Cataract; Cataract Extracti | 2012 |
Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Cells, Cultured; Che | 2012 |
Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; E | 2012 |
Albumin coupled lipid nanoemulsions of diclofenac for targeted delivery to inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Diclofenac; Drug Delivery Systems; Emulsio | 2012 |
Topical mannitol reduces inflammatory edema in a rat model of arthritis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Diclofenac; E | 2012 |
Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Diclofenac; Female; Gold Sodium Thiomalate; Inflammation; Macroph | 2011 |
Preemptive analgesic effect of diclofenac: experimental study in rats.
Topics: Acute Pain; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Formalde | 2011 |
Fibrinoid reaction after lens extraction in rabbit eyes.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Cataract Extr | 2012 |
Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Diclofena | 2012 |
Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Cocos; Diclofenac; Disease Models, Anim | 2013 |
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicycl | 2012 |
Low-level laser therapy in collagenase-induced Achilles tendinitis in rats: analyses of biochemical and biomechanical aspects.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biochemistry; Biomechanical Pheno | 2012 |
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan; Diclo | 2013 |
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model.
Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory A | 2013 |
[An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Concanavalin A; Cytokines; Diclofenac | 2012 |
Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing.
Topics: Adhesiveness; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; | 2013 |
Eudragit RL 100-based nanoparticulate system of aceclofenac for ocular delivery.
Topics: Acrylic Resins; Administration, Ophthalmic; Animals; Arachidonic Acid; Calorimetry, Differential Sca | 2013 |
Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: a case report.
Topics: Abdominal Neoplasms; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Bio | 2012 |
[Studies of biological activity of mineral oil dialkyl disulfide (an experimental study)].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Central Nervous Sys | 2002 |
Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery.
Topics: Animals; Capsules; Cell Transplantation; Cells, Cultured; Dexamethasone; Diclofenac; Erythropoietin; | 2003 |
Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; | 2003 |
Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Drug Syner | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ster | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyc | 2004 |
Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatograp | 2004 |
Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema.
Topics: Adrenalectomy; Aluminum; Animals; Arsenates; Carrageenan; Diclofenac; Edema; Extremities; Gallium; I | 2004 |
[Inflammation, nonsteroidal anti-inflammatory drugs and Alzheimer disease].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxy | 2004 |
Localized vs. systemic inflammation in guinea pigs: a role for prostaglandins at distinct points of the fever induction pathways?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibito | 2005 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Inflammation; Iontophore | 2006 |
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Che | 2006 |
Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Diclofenac; Female; | 2006 |
Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dis | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Polyamines in inflammation and their modulation by conventional anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Prolif | 2007 |
Pro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varians.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotaxis, Leukocyte; Dexamethasone; D | 2008 |
Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Connective Tissue; Diclofenac; Disease M | 2008 |
Lipomatous metaplasia after severe and chronic cutaneous inflammation.
Topics: Adipose Tissue; Aged; Dermis; Diclofenac; Dipyrone; Drug Eruptions; Extremities; Female; Humans; Inf | 2008 |
Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparatio | 2008 |
[Effect of inhibitors of prostaglandin synthesis on the eye].
Topics: Animals; Burns, Chemical; Diclofenac; Eye; Eye Burns; Eye Diseases; Humans; Indomethacin; Inflammati | 1983 |
Involvement of prostaglandins in LPS-mediated regulation of plasminogen activator synthesis by inflammatory macrophages.
Topics: Animals; Bacterial Toxins; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endotoxins; Enteroto | 1984 |
[Effect of topical diclofenac sodium, a non-steroidal anti-inflammatory drug, on various ocular inflammatory models in animals].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Diclofenac; Eye Diseases; | 1983 |
Mechanisms involved in the antiinflammatory effect of propolis extract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Diclofenac; | 1993 |
Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Aspirin; Cell Adhesion; Cell Adhesion Molecul | 1995 |
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates; | 1995 |
Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat.
Topics: Animals; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Gene Expression; Inflammation; I | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activ | 1994 |
Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship | 1994 |
A diclofenac derivative without ulcerogenic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Diclofenac; Gastric Mucosa; Inflam | 1994 |
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Arthritis, | 1993 |
Effect of Cleome arabica leaves extract on inflammatory cells response in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Flavonoids; Inflammation; Leukocytes; | 1995 |
Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dexamethaso | 1996 |
Regional drug delivery II: relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Delivery Systems; Inflammation; M | 1995 |
Decrease of postoperative inflammation with diclofenac sodium.
Topics: Acetylcholine; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Drug Combin | 1996 |
[Anterior chamber inflammation after the injection of endothelin-1 into the vitreous and the effect of an anti-prostaglandin agent].
Topics: Animals; Anterior Chamber; Cyclooxygenase Inhibitors; Diclofenac; Endothelin-1; Female; Inflammation | 1997 |
Long-circulating lipospheres targeted to the inflammed tissue.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Drug Carriers; Drug Compo | 1997 |
Study on paradoxical effects of NSAIDs on platelet activation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase; Aristolochic Acids; Calcium; | 1997 |
Inflammatory reaction via arachidonic acid cascade after intravitreal injection of endothelin-1.
Topics: Administration, Topical; Animals; Anterior Chamber; Aqueous Humor; Cyclooxygenase Inhibitors; Diclof | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase I | 1998 |
Effects of diclofenac sodium and He:Ne laser irradiation on plasmatic fibrinogen levels in inflammatory processes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Cyclooxygenase Inhibito | 1998 |
Pharmacoepidemiology of non-steroidal anti-inflammatory drug use in Nottingham general practices.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Pres | 2000 |
Criteria for selecting and using non-steroidal anti-inflammatory drugs in primary health care.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Decision Making; Diclofenac; Drug Admini | 2000 |
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2000 |
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Biotransformation; Cornea; Dicl | 2000 |
Effect of dexamethasone plus vitamin B complex in the PIFIR model.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofena | 2000 |
Beneficial effects of topical anti-inflammatory drugs against sulfur mustard-induced ocular lesions in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Dermatologic Age | 2000 |
Anti-inflammatory effect of synthetic somatostatin analogues in the rat.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bradykinin; Capillary Permeability; Dext | 2001 |
Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Combined Modality Therapy; Diclofenac | 2001 |
Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Celecoxib; Cyclooxygenase In | 2001 |
Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Collagenases; Diclofenac; Dinoprostone | 2002 |
Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Cyclooxyge | 2002 |
Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Ag | 2002 |
Effects of dipyrone on inflammatory infiltration and oxidative metabolism in gastric mucosa: comparison with acetaminophen and diclofenac.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, | 2002 |
Patient and physician satisfaction with aceclofenac: results of the European Observational Cohort Study (experience with aceclofenac for inflammatory pain in daily practice). Aceclofenac is the treatment of choice for patients and physicians in the manage
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cohort Studies; Diclofenac; | 2002 |
[Study of the anti-inflammatory and analgesic actions of diclofenac in traumatology and orthopedic surgery].
Topics: Adult; Analgesics; Anti-Inflammatory Agents; Diclofenac; Female; Humans; Inflammation; Male; Middle | 1977 |
Analysis of the effects of cyclooxygenase and lipoxygenase inhibitors on leukocyte accumulation in the inflammatory site.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cimetidine; Cyclooxygenase Inhibito | 1989 |
Prostaglandin E2 prevents diclofenac-induced enhancement of histamine release and inflammation evoked by in vivo challenge with compound 48/80 in the hamster cheek pouch.
Topics: Animals; Cheek; Diclofenac; Dinoprostone; Guinea Pigs; Histamine Release; Indomethacin; Inflammation | 1989 |
Pharmacology of diclofenac sodium.
Topics: Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Diclofenac; Dos | 1986 |
Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.
Topics: Animals; Capillary Permeability; Diclofenac; Dinoprostone; Hypersensitivity; Indomethacin; Inflammat | 1986 |
On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Dexame | 1986 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |
A new metabolite of diclofenac sodium in human plasma.
Topics: Adult; Animals; Biotransformation; Cattle; Chemical Phenomena; Chemistry; Diclofenac; Gas Chromatogr | 1988 |
Inflammatory disease and the role of Voltaren (diclofenac sodium). Proceedings of a symposium, May 14-15, 1985, Tahiti.
Topics: Animals; Arthritis; Diclofenac; Humans; Inflammation | 1986 |
[Local treatment with diclofenac-Na eyedrops in diseases of the anterior eye segment].
Topics: Adult; Aged; Conjunctivitis, Allergic; Corneal Ulcer; Dexamethasone; Diclofenac; Drug Therapy, Combi | 1986 |
Effect of exposure to radiation on the inflammatory process and its influence by diclofenac.
Topics: Animals; Carrageenan; Diclofenac; Inflammation; Male; Phenylacetates; Radiation Injuries, Experiment | 1985 |