diclofenac and Inflammation, Endodontic studies

diclofenac and Inflammation, Endodontic

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Research Excerpts

Excerpt	Relevance	Reference
"The aim of this prospective, randomized, double-blind clinical trial was to evaluate the effect of a preoperative, single, oral dose of diclofenac potassium (DFK) on postoperative pain and rescue analgesic intake in patients with symptomatic irreversible pulpitis in mandibular molars treated in 1 visit."	9.34	Effect of Diclofenac Potassium Premedication on Postendodontic Pain in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Randomized Placebo-Controlled Double-Blind Trial. ( Al-Rawhani, AH; Gawdat, SI; Wanees Amin, SA, 2020)
"To determine the effect of administration of pre-operative lornoxicam (LNX) or diclofenac potassium (DP) on the success of inferior alveolar nerve blocks (IANB) in patients with irreversible pulpitis in a double-blind randomised controlled trial."	9.15	The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. ( Gutmann, JL; Prasanna, N; Subbarao, CV, 2011)
"The aim of this prospective, randomized, double-blind clinical trial was to evaluate the effect of a preoperative, single, oral dose of diclofenac potassium (DFK) on postoperative pain and rescue analgesic intake in patients with symptomatic irreversible pulpitis in mandibular molars treated in 1 visit."	5.34	Effect of Diclofenac Potassium Premedication on Postendodontic Pain in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Randomized Placebo-Controlled Double-Blind Trial. ( Al-Rawhani, AH; Gawdat, SI; Wanees Amin, SA, 2020)
"The combination of ibuprofen/paracetamol, taken immediately after initial endodontic therapy and root canal preparation in teeth with irreversible pulpitis, reduced post-endodontic pain (ClinicalTrials."	5.22	Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. ( Abubakr, NH; Elzaki, WM; Ibrahim, YE; Ziada, HM, 2016)
"To determine the effect of administration of pre-operative lornoxicam (LNX) or diclofenac potassium (DP) on the success of inferior alveolar nerve blocks (IANB) in patients with irreversible pulpitis in a double-blind randomised controlled trial."	5.15	The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. ( Gutmann, JL; Prasanna, N; Subbarao, CV, 2011)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	2 (50.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

2 (50.00)

24.3611

2020's

2 (50.00)

2.80

Authors

Authors	Studies
Vatankhah, M	1
Zargar, N	1
Naseri, M	1
Salem, S	1
Baghban, AA	1
Etemadi, A	1
Dianat, O	1
Al-Rawhani, AH	1
Gawdat, SI	1
Wanees Amin, SA	1
Elzaki, WM	1
Abubakr, NH	1
Ziada, HM	1
Ibrahim, YE	1
Prasanna, N	1
Subbarao, CV	1
Gutmann, JL	1

Studies

Vatankhah, M

Zargar, N

Naseri, M

Salem, S

Baghban, AA

Etemadi, A

Dianat, O

Al-Rawhani, AH

Gawdat, SI

Wanees Amin, SA

Elzaki, WM

Abubakr, NH

Ziada, HM

Ibrahim, YE

Prasanna, N

Subbarao, CV

Gutmann, JL

Clinical Trials (7)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial[NCT04593160]		72 participants (Anticipated)	Interventional	2021-01-31	Not yet recruiting
Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics[NCT02417337]	Phase 2	170 participants (Actual)	Interventional	2012-08-31	Completed
Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial[NCT03341260]	Phase 2/Phase 3	70 participants (Actual)	Interventional	2016-12-31	Completed
Effect of Pre-operative Diclofenac Potassium on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Cases With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial[NCT03163420]	Phase 2/Phase 3	68 participants (Anticipated)	Interventional	2016-07-31	Active, not recruiting
Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial[NCT03174860]	Phase 2/Phase 3	70 participants (Actual)	Interventional	2016-10-31	Completed
Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block on Patients With Symptomatic Irreversible Pulpitis: a Double Blinded, Randomized Controlled Trial.[NCT05488925]	Phase 4	120 participants (Actual)	Interventional	2021-06-21	Completed
Evaluation the Effect of Using Preoperative Ibuprofen Versus Low Level Laser Therapy on Inferior Alveolar Nerve Block[NCT05479175]		76 participants (Anticipated)	Interventional	2022-05-01	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial[NCT04593160]

72 participants (Anticipated)

Interventional

2021-01-31

Not yet recruiting

Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics[NCT02417337]

Phase 2

170 participants (Actual)

Interventional

2012-08-31

Completed

Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial[NCT03341260]

Phase 2/Phase 3

70 participants (Actual)

Interventional

2016-12-31

Completed

Effect of Pre-operative Diclofenac Potassium on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Cases With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial[NCT03163420]

Phase 2/Phase 3

68 participants (Anticipated)

Interventional

2016-07-31

Active, not recruiting

Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial[NCT03174860]

Phase 2/Phase 3

70 participants (Actual)

Interventional

2016-10-31

Completed

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block on Patients With Symptomatic Irreversible Pulpitis: a Double Blinded, Randomized Controlled Trial.[NCT05488925]

Phase 4

120 participants (Actual)

Interventional

2021-06-21

Completed

Evaluation the Effect of Using Preoperative Ibuprofen Versus Low Level Laser Therapy on Inferior Alveolar Nerve Block[NCT05479175]

76 participants (Anticipated)

Interventional

2022-05-01

Active, not recruiting

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for diclofenac and Inflammation, Endodontic

Article	Year
Analgesic Efficacy of Ibuprofen and Diclofenac Potassium on Postoperative Endodontic Pain in Maxillary and Mandibular First Molars with Irreversible Pulpitis: A Randomised Controlled Trial. European endodontic journal, 2023, Volume: 8, Issue:2 Topics: Analgesics; Diclofenac; Humans; Ibuprofen; Molar; Pain, Postoperative; Prospective Studies; Pulpitis	2023
Effect of Diclofenac Potassium Premedication on Postendodontic Pain in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Randomized Placebo-Controlled Double-Blind Trial. Journal of endodontics, 2020, Volume: 46, Issue:8 Topics: Diclofenac; Double-Blind Method; Humans; Mandibular Nerve; Molar; Premedication; Prospective Studies	2020
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. Journal of endodontics, 2016, Volume: 42, Issue:6 Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-	2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. Journal of endodontics, 2016, Volume: 42, Issue:6 Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-	2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. Journal of endodontics, 2016, Volume: 42, Issue:6 Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-	2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. Journal of endodontics, 2016, Volume: 42, Issue:6 Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-	2016
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011
The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. International endodontic journal, 2011, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distribution; Cyclooxygenase Inhibitors; D	2011

Article

Year

Analgesic Efficacy of Ibuprofen and Diclofenac Potassium on Postoperative Endodontic Pain in Maxillary and Mandibular First Molars with Irreversible Pulpitis: A Randomised Controlled Trial.

European endodontic journal, 2023, Volume: 8, Issue:2

Topics: Analgesics; Diclofenac; Humans; Ibuprofen; Molar; Pain, Postoperative; Prospective Studies; Pulpitis

2023

Effect of Diclofenac Potassium Premedication on Postendodontic Pain in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Randomized Placebo-Controlled Double-Blind Trial.

Journal of endodontics, 2020, Volume: 46, Issue:8

Topics: Diclofenac; Double-Blind Method; Humans; Mandibular Nerve; Molar; Premedication; Prospective Studies

2020

Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.

Journal of endodontics, 2016, Volume: 42, Issue:6

Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016

Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.

Journal of endodontics, 2016, Volume: 42, Issue:6

Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016

Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.

Journal of endodontics, 2016, Volume: 42, Issue:6

Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016

Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.

Journal of endodontics, 2016, Volume: 42, Issue:6

Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016

The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial.