diclofenac has been researched along with Infections, Helicobacter in 12 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 9.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 5.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " Patients with a history of peptic ulcers were randomized to 1-week omeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg twice daily (eradication group; n = 51) or 1-week omeprazole 20 mg twice daily (omeprazole group; n = 49) before initiation of diclofenac 100 mg daily for 6 months." | 3.73 | Helicobacter pylori eradication prior to initiation of long-term non-steroidal anti-inflammatory drug therapy in Chinese patients-a cost-effectiveness analysis. ( Chan, FK; Ching, JY; Lau, W; Lee, IY; Lee, KK; You, JH; Yung, M, 2006) |
| "Diclofenac can cause gastric mucosal lesions, including ulcers, more easily than other NSAIDs." | 1.34 | Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis. ( Fukui, H; Takakura, Y; Yajima, H; Yamao, J, 2007) |
| "Diclofenac and aspirin were most common NSAIDs associated with peptic ulcers in 32." | 1.33 | Frequency of NSAID induced peptic ulcer disease. ( Abid, S; Hamid, S; Islam, M; Islam, S; Jafri, W; Yakoob, J, 2006) |
| "Some adaptation occurred in over 90% of subjects after 4 weeks dosing with an NSAID, but adaptation was less frequent in older subjects and in smokers." | 1.30 | The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs. ( Campbell, F; Lipscomb, GR; Rees, WD, 1997) |
| "Chronic gastritis was seen in 76% of the patients taking NSAID and in 58% of the control cases; active inflammation was detected in 10% of the NSAID treated patients and in 24% of the control cases, and it appeared closely related with Helicobacter pylori infection." | 1.29 | Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs. ( Aleotti, A; Alvisi, V; Caselli, M; DeCarlo, L; LaCorte, R; Ruina, M; Trevisani, L; Trotta, F, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Labenz, J | 1 |
| Blum, AL | 1 |
| Bolten, WW | 1 |
| Dragosics, B | 1 |
| Rösch, W | 1 |
| Stolte, M | 1 |
| Koelz, HR | 1 |
| Sikes, DH | 1 |
| Agrawal, NM | 1 |
| Zhao, WW | 1 |
| Kent, JD | 1 |
| Recker, DP | 1 |
| Verburg, KM | 1 |
| Graham, DY | 1 |
| McCarthy, DM | 1 |
| You, JH | 1 |
| Lau, W | 1 |
| Lee, IY | 1 |
| Yung, M | 1 |
| Ching, JY | 1 |
| Chan, FK | 2 |
| Lee, KK | 1 |
| Hamid, S | 1 |
| Yakoob, J | 1 |
| Jafri, W | 1 |
| Islam, S | 1 |
| Abid, S | 1 |
| Islam, M | 1 |
| Yajima, H | 1 |
| Yamao, J | 1 |
| Fukui, H | 1 |
| Takakura, Y | 1 |
| Caselli, M | 1 |
| LaCorte, R | 1 |
| DeCarlo, L | 1 |
| Aleotti, A | 1 |
| Trevisani, L | 1 |
| Ruina, M | 1 |
| Trotta, F | 1 |
| Alvisi, V | 1 |
| Lipscomb, GR | 1 |
| Campbell, F | 1 |
| Rees, WD | 1 |
| Sasahara, K | 1 |
| Uchida, Y | 1 |
| Matsuda, K | 1 |
| Kawabata, H | 1 |
| Nishioka, M | 1 |
| To, KF | 1 |
| Wu, JC | 1 |
| Yung, MY | 1 |
| Leung, WK | 1 |
| Kwok, T | 1 |
| Hui, Y | 1 |
| Chan, HL | 1 |
| Chan, CS | 1 |
| Hui, E | 1 |
| Woo, J | 1 |
| Sung, JJ | 1 |
| Wildgrube, HJ | 1 |
| Kierschke, G | 1 |
| Nowak, H | 1 |
| Weigmann, I | 1 |
| Terhaag, B | 1 |
1 review available for diclofenac and Infections, Helicobacter
| Article | Year |
|---|---|
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gas | 2002 |
4 trials available for diclofenac and Infections, Helicobacter
7 other studies available for diclofenac and Infections, Helicobacter
| Article | Year |
|---|---|
NSAIDs, Helicobacter pylori, and Pandora's Box.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2; | 2002 |
Helicobacter pylori eradication prior to initiation of long-term non-steroidal anti-inflammatory drug therapy in Chinese patients-a cost-effectiveness analysis.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents | 2006 |
Frequency of NSAID induced peptic ulcer disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclof | 2006 |
Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis.
Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Bone Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; End | 2007 |
Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Female; Gastric M | 1995 |
The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tole | 1997 |
Role of energy metabolism in drug-induced acute gastric mucosal injuries in humans.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anti-Inflammatory Agents; An | 2000 |