diclofenac has been researched along with Helicobacter Infections in 12 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 9.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 5.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " Patients with a history of peptic ulcers were randomized to 1-week omeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg twice daily (eradication group; n = 51) or 1-week omeprazole 20 mg twice daily (omeprazole group; n = 49) before initiation of diclofenac 100 mg daily for 6 months." | 3.73 | Helicobacter pylori eradication prior to initiation of long-term non-steroidal anti-inflammatory drug therapy in Chinese patients-a cost-effectiveness analysis. ( Chan, FK; Ching, JY; Lau, W; Lee, IY; Lee, KK; You, JH; Yung, M, 2006) |
| "Diclofenac can cause gastric mucosal lesions, including ulcers, more easily than other NSAIDs." | 1.34 | Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis. ( Fukui, H; Takakura, Y; Yajima, H; Yamao, J, 2007) |
| "Diclofenac and aspirin were most common NSAIDs associated with peptic ulcers in 32." | 1.33 | Frequency of NSAID induced peptic ulcer disease. ( Abid, S; Hamid, S; Islam, M; Islam, S; Jafri, W; Yakoob, J, 2006) |
| "Some adaptation occurred in over 90% of subjects after 4 weeks dosing with an NSAID, but adaptation was less frequent in older subjects and in smokers." | 1.30 | The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs. ( Campbell, F; Lipscomb, GR; Rees, WD, 1997) |
| "Chronic gastritis was seen in 76% of the patients taking NSAID and in 58% of the control cases; active inflammation was detected in 10% of the NSAID treated patients and in 24% of the control cases, and it appeared closely related with Helicobacter pylori infection." | 1.29 | Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs. ( Aleotti, A; Alvisi, V; Caselli, M; DeCarlo, L; LaCorte, R; Ruina, M; Trevisani, L; Trotta, F, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Labenz, J | 1 |
| Blum, AL | 1 |
| Bolten, WW | 1 |
| Dragosics, B | 1 |
| Rösch, W | 1 |
| Stolte, M | 1 |
| Koelz, HR | 1 |
| Sikes, DH | 1 |
| Agrawal, NM | 1 |
| Zhao, WW | 1 |
| Kent, JD | 1 |
| Recker, DP | 1 |
| Verburg, KM | 1 |
| Graham, DY | 1 |
| McCarthy, DM | 1 |
| You, JH | 1 |
| Lau, W | 1 |
| Lee, IY | 1 |
| Yung, M | 1 |
| Ching, JY | 1 |
| Chan, FK | 2 |
| Lee, KK | 1 |
| Hamid, S | 1 |
| Yakoob, J | 1 |
| Jafri, W | 1 |
| Islam, S | 1 |
| Abid, S | 1 |
| Islam, M | 1 |
| Yajima, H | 1 |
| Yamao, J | 1 |
| Fukui, H | 1 |
| Takakura, Y | 1 |
| Caselli, M | 1 |
| LaCorte, R | 1 |
| DeCarlo, L | 1 |
| Aleotti, A | 1 |
| Trevisani, L | 1 |
| Ruina, M | 1 |
| Trotta, F | 1 |
| Alvisi, V | 1 |
| Lipscomb, GR | 1 |
| Campbell, F | 1 |
| Rees, WD | 1 |
| Sasahara, K | 1 |
| Uchida, Y | 1 |
| Matsuda, K | 1 |
| Kawabata, H | 1 |
| Nishioka, M | 1 |
| To, KF | 1 |
| Wu, JC | 1 |
| Yung, MY | 1 |
| Leung, WK | 1 |
| Kwok, T | 1 |
| Hui, Y | 1 |
| Chan, HL | 1 |
| Chan, CS | 1 |
| Hui, E | 1 |
| Woo, J | 1 |
| Sung, JJ | 1 |
| Wildgrube, HJ | 1 |
| Kierschke, G | 1 |
| Nowak, H | 1 |
| Weigmann, I | 1 |
| Terhaag, B | 1 |
1 review available for diclofenac and Helicobacter Infections
| Article | Year |
|---|---|
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gas | 2002 |
4 trials available for diclofenac and Helicobacter Infections
7 other studies available for diclofenac and Helicobacter Infections
| Article | Year |
|---|---|
NSAIDs, Helicobacter pylori, and Pandora's Box.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2; | 2002 |
Helicobacter pylori eradication prior to initiation of long-term non-steroidal anti-inflammatory drug therapy in Chinese patients-a cost-effectiveness analysis.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents | 2006 |
Frequency of NSAID induced peptic ulcer disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclof | 2006 |
Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis.
Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Bone Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; End | 2007 |
Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Female; Gastric M | 1995 |
The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tole | 1997 |
Role of energy metabolism in drug-induced acute gastric mucosal injuries in humans.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anti-Inflammatory Agents; An | 2000 |