diclofenac has been researched along with Headache in 25 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preoperative diclofenac administration reduces postcraniotomy headache and postoperative analgesic requirements - a benefit that persisted throughout five postoperative days." | 9.20 | A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial. ( Bereczki, D; Fülesdi, B; Gál, J; Kazup, Á; Molnár, C; Molnár, L; Novák, L; Sessler, DI; Simon, É, 2015) |
| "The relatively low incidence of severe PCH on day five in the diclofenac group may indicate that preoperatively administered diclofenac effectively reduces postcraniotomy headache." | 9.16 | Administration of preemptive analgesia by diclofenac to prevent acute postcraniotomy headache. ( Bánk, J; Fülesdi, B; Gál, J; Molnár, C; Novák, L; Simon, E; Siró, P, 2012) |
| "Time to onset of pain relief with lornoxicam was compared with the quick-release formulation of diclofenac potassium in acute low back pain in a randomised, double-blind, multicentre study." | 9.12 | Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain. ( Guekht, A; Moller, PL; Olsen, KJ; Skoromets, A; Spirin, N; Strachunskaya, E; Ternavsky, A; Yakhno, N, 2006) |
| "Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile." | 9.12 | Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 6.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "Preoperative diclofenac administration reduces postcraniotomy headache and postoperative analgesic requirements - a benefit that persisted throughout five postoperative days." | 5.20 | A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial. ( Bereczki, D; Fülesdi, B; Gál, J; Kazup, Á; Molnár, C; Molnár, L; Novák, L; Sessler, DI; Simon, É, 2015) |
| "The relatively low incidence of severe PCH on day five in the diclofenac group may indicate that preoperatively administered diclofenac effectively reduces postcraniotomy headache." | 5.16 | Administration of preemptive analgesia by diclofenac to prevent acute postcraniotomy headache. ( Bánk, J; Fülesdi, B; Gál, J; Molnár, C; Novák, L; Simon, E; Siró, P, 2012) |
| "Time to onset of pain relief with lornoxicam was compared with the quick-release formulation of diclofenac potassium in acute low back pain in a randomised, double-blind, multicentre study." | 5.12 | Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain. ( Guekht, A; Moller, PL; Olsen, KJ; Skoromets, A; Spirin, N; Strachunskaya, E; Ternavsky, A; Yakhno, N, 2006) |
| "Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile." | 5.12 | Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "In our case report we report the case of a 45-year-old Turkish woman who developed Nicolau syndrome after an intramuscular injection in her right gluteal region of single-dose diclofenac sodium to treat a headache." | 3.80 | Nicolau syndrome due to diclofenac sodium (Voltaren®) injection: a case report. ( Çelik, İ; Demirel, T; Kaya, F; Kılıç, İ; Özdemir, AT, 2014) |
| " Two transcervical intra-uterine insertions of 216 mg of quinacrine, carried out at an interval of one month and associated with 50 mg of intra-uterine diclofenac and 150 mg of intra-muscular diclofenac resulted in a pregnancy rate after 12 months of 2." | 3.68 | [Non-surgical female sterilization using quinacrine: efficacy of two insertions of quinacrine pellets]. ( Rivera, M; Trujillo, V; Viel, B; Zipper, J, 1993) |
| " Also, dosage and frequency of the received Diclofenac and adverse effects of the intervention were recorded." | 3.11 | Effects of Aromatherapy with Lavender (Lavandula angustifolia MILL) on Post-Dural Puncture Headache: A Randomized Placebo-Controlled Trial. ( Asayesh, H; Bahadori, H; Hosseini Amiri, M; Nasiri, M; Rajaee, M; Yousefi Khosroabadi, Z, 2022) |
| "Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adverse events (AEs)." | 2.78 | Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs. ( Kinoshita, Y; Miwa, H; Sugano, K; Takeuchi, T, 2013) |
| "The alleviation of influenza-like symptoms, such as fever, headache, and muscle/joint aches and pains, is important so that sufferers can return to their normal daily activities." | 2.71 | A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms. ( Frank, WO; Gold, MS; Grebe, W; Ionescu, E; Liu, JM, 2003) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 2.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "Ankylosing spondylitis is a systemic rheumatic disorder characterized by inflammation of the spine, sacroiliac, and large peripheral joints." | 2.66 | Efficacy of diclofenac in ankylosing spondylitis. ( Calabro, JJ, 1986) |
| "These drugs can be categorized into migraine-specific and migraine-non-specific." | 1.72 | 2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022) |
| "Among migraine patients, 80% had used NSAIDs in the past year." | 1.46 | Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache. ( Affaitati, G; Cipollone, F; Costantini, R; Giamberardino, MA; Lapenna, D; Lopopolo, M; Martelletti, P; Massimini, F; Tana, C, 2017) |
| " The reference dose of Diclofenac used in all randomized controlled trials is 150 mg/die; this controlled release dosage allows to decrease the number of daily administrations, ensuring a better patient compliance, especially if elderly and/or in polytherapy." | 1.40 | [Diclofenac: update on tolerableness and spinal anti-inflammatory action]. ( Sandri, A, 2014) |
| "To report a case of hypertrophic cranial pachymeningitis (HCP) associated with the long-term administration of nonsteroidal antiinflammatory drugs (NSAIDs)." | 1.36 | Hypertrophic cranial pachymeningitis induced by long-term administration of nonsteroidal antiinflammatory drugs. ( Li, Q; Zheng, J; Zhou, Z, 2010) |
| "In 1996, 1254 patients were treated for headache and 64 of them required hospitalization." | 1.30 | [Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil]. ( Bigal, ME; Bordini, CA; Speciali, JG, 1999) |
| " We suggest that the immune complex mechanism could have induced these adverse reactions." | 1.29 | Serious adverse effects induced by simultaneous administration of two nonsteroidal anti-inflammatory drugs. ( Awaya, N; Handa, M; Matsuyama, M; Ogino, M; Okada, H; Saruta, T; Suzuki, H; Toya, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lau, CI | 1 |
| Wang, YF | 1 |
| Ghosh, R | 1 |
| Dubey, S | 1 |
| Chatterjee, S | 1 |
| Finsterer, J | 1 |
| Biswas, R | 1 |
| Lahiri, D | 1 |
| Ray, BK | 1 |
| Jia, J | 1 |
| Kumar, A | 1 |
| Soni, SL | 1 |
| Singh, A | 1 |
| Jain, C | 1 |
| Nasiri, M | 1 |
| Asayesh, H | 1 |
| Yousefi Khosroabadi, Z | 1 |
| Hosseini Amiri, M | 1 |
| Bahadori, H | 1 |
| Rajaee, M | 1 |
| Sugano, K | 1 |
| Kinoshita, Y | 1 |
| Miwa, H | 1 |
| Takeuchi, T | 1 |
| Sandri, A | 1 |
| Kılıç, İ | 1 |
| Kaya, F | 1 |
| Özdemir, AT | 1 |
| Demirel, T | 1 |
| Çelik, İ | 1 |
| Derry, CJ | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| Molnár, C | 2 |
| Simon, É | 2 |
| Kazup, Á | 1 |
| Gál, J | 2 |
| Molnár, L | 1 |
| Novák, L | 2 |
| Bereczki, D | 1 |
| Sessler, DI | 1 |
| Fülesdi, B | 2 |
| Affaitati, G | 1 |
| Martelletti, P | 1 |
| Lopopolo, M | 1 |
| Tana, C | 1 |
| Massimini, F | 1 |
| Cipollone, F | 1 |
| Lapenna, D | 1 |
| Giamberardino, MA | 1 |
| Costantini, R | 1 |
| Zhou, Z | 1 |
| Li, Q | 1 |
| Zheng, J | 1 |
| Bánk, J | 1 |
| Siró, P | 1 |
| Grebe, W | 1 |
| Ionescu, E | 1 |
| Gold, MS | 1 |
| Liu, JM | 1 |
| Frank, WO | 1 |
| Yakhno, N | 1 |
| Guekht, A | 1 |
| Skoromets, A | 1 |
| Spirin, N | 1 |
| Strachunskaya, E | 1 |
| Ternavsky, A | 1 |
| Olsen, KJ | 1 |
| Moller, PL | 1 |
| Willburger, RE | 1 |
| Mysler, E | 1 |
| Derbot, J | 1 |
| Jung, T | 1 |
| Thurston, H | 1 |
| Kreiss, A | 1 |
| Litschig, S | 1 |
| Krammer, G | 1 |
| Tate, GA | 1 |
| Guobis, G | 1 |
| Iushenaite, Ia | 1 |
| Okada, H | 1 |
| Suzuki, H | 1 |
| Awaya, N | 1 |
| Handa, M | 1 |
| Ogino, M | 1 |
| Matsuyama, M | 1 |
| Toya, S | 1 |
| Saruta, T | 1 |
| Trujillo, V | 1 |
| Zipper, J | 1 |
| Viel, B | 1 |
| Rivera, M | 1 |
| Bigal, ME | 1 |
| Bordini, CA | 1 |
| Speciali, JG | 1 |
| Warner, J | 1 |
| Facchinetti, F | 1 |
| Sgarbi, L | 1 |
| Piccinini, F | 1 |
| Volpe, A | 1 |
| Calabro, JJ | 1 |
| O'brien, WM | 1 |
| Sternfeld, M | 1 |
| Finkelstein, Y | 1 |
| Hai, E | 1 |
| Hod, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Long Term Study to Investigate the Efficacy and Safety Study of D961H (Esomeprazole) (20 mg Once Daily) for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use[NCT00595517] | Phase 3 | 395 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Double-blind, Prospective Comparison of Medications Used in Trigger Point Injections - Ketorolac, Lidocaine, or Dexamethasone[NCT03028012] | Phase 4 | 10 participants (Actual) | Interventional | 2017-05-02 | Terminated (stopped due to Poor enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00595517)
Timeframe: up to 52 weeks
| Intervention | Participants (Number) |
|---|---|
| Esomeprazole 20mg | 125 |
(NCT00595517)
Timeframe: up to 12 weeks after treatment
| Intervention | participants (Number) |
|---|---|
| Esomeprazole 20mg | 127 |
(NCT00595517)
Timeframe: up to 24 weeks after treatment
| Intervention | participants (Number) |
|---|---|
| Esomeprazole 20mg | 126 |
(NCT00595517)
Timeframe: up to 4 weeks after treatment
| Intervention | Participants (Number) |
|---|---|
| Esomeprazole 20mg | 130 |
Participants in this study underwent TPIs by the following method. The needle was inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. This was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain, one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Post Injections Up to Three Months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac | 1 |
| Lidocaine | 0 |
| Dexamethasone | 0 |
The BPI was evaluated on a scale from 0-10. Zero would mean no interference and 10 would be calculated at complete interferences. We used a 7-point questionnaire about pain. All scores were calculated at baseline and three months. (NCT03028012)
Timeframe: Baseline and Three Months
| Intervention | score on a scale (Number) | |||
|---|---|---|---|---|
| Participant Number #3 at Baseline | Participant Number #3 at 3 Months | Participant Number #8 at Baseline | Participant #8 at 3 Months | |
| Ketorolac | 8 | 3 | 5 | 3 |
TPI were treated with a needle inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. Such was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain,one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Injection and Three Month Post Injection(s)
| Intervention | score on a scale (Number) | |||
|---|---|---|---|---|
| Participant Number 3 at Baseline | Participant Number 3 at 3 Months | Participant Number 8 at Baseline | Participant Number 8 at 3 Months | |
| Ketorolac | 8 | 3 | 5 | 3 |
2 reviews available for diclofenac and Headache
| Article | Year |
|---|---|
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofena | 1981 |
10 trials available for diclofenac and Headache
| Article | Year |
|---|---|
Effects of Aromatherapy with Lavender (Lavandula angustifolia MILL) on Post-Dural Puncture Headache: A Randomized Placebo-Controlled Trial.
Topics: Aromatherapy; Diclofenac; Headache; Humans; Lavandula; Post-Dural Puncture Headache | 2022 |
Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Esomeprazole; Fema | 2013 |
A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Craniotomy; Diclofenac; Double-Blind Method; Female; | 2015 |
Administration of preemptive analgesia by diclofenac to prevent acute postcraniotomy headache.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Craniotomy; Diclofenac; Drug | 2012 |
A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Drug Administration | 2003 |
Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain.
Topics: Abdominal Pain; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness | 2006 |
Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
Topics: Abdominal Pain; Acute Disease; Administration, Oral; Adult; Aged; Analysis of Variance; Argentina; D | 2007 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofena | 1981 |
A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclo | 2002 |
Efficacy of diclofenac in ankylosing spondylitis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Gastrointestinal Dis | 1986 |
14 other studies available for diclofenac and Headache
| Article | Year |
|---|---|
2022 Taiwan Guidelines for Acute Treatment of Migraine.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G | 2022 |
Pathogenicity of the m.15043G>A variant.
Topics: Adult; Analgesics; Computational Biology; Diclofenac; Headache; Humans; Virulence | 2020 |
Response to letter to the editor.
Topics: Analgesics; Diclofenac; Headache; Humans; Postoperative Period; Research Design | 2020 |
Should proper estimation of sample size be required in RCT?
Topics: Adult; Analgesics; Diclofenac; Headache; Humans; Research Design; Sample Size | 2020 |
[Diclofenac: update on tolerableness and spinal anti-inflammatory action].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood-Brain Barrier; Car | 2014 |
Nicolau syndrome due to diclofenac sodium (Voltaren®) injection: a case report.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Buttocks; Debridement; Diclofenac; F | 2014 |
Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Follow-Up Studies; H | 2017 |
Hypertrophic cranial pachymeningitis induced by long-term administration of nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain; Diclofenac; Dura Mater; Headache; Humans; Indomethac | 2010 |
Serious adverse effects induced by simultaneous administration of two nonsteroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Agranulocytosis; Anemia, Hemolytic; Diclofenac; Drug Therapy, Combination; Fema | 1993 |
[Non-surgical female sterilization using quinacrine: efficacy of two insertions of quinacrine pellets].
Topics: Adult; Diclofenac; Drug Implants; Female; Fever; Headache; Humans; Injections, Intramuscular; Metror | 1993 |
[Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil].
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroida | 1999 |
Diclofenac as a cause of rebound headache?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Headache; Humans; Lupus Vulgaris; Recur | 2001 |
Adverse reactions to nonsteroidal anti-inflammatory drugs. Diclofenac compared with other nonsteroidal anti-inflammatory drugs.
Topics: Aged; Anaphylaxis; Anemia, Aplastic; Anti-Inflammatory Agents; Asthma; Blood Platelets; Chemical and | 1986 |
Tension headache treated by anti-inflammatory drug injected into GB 20 acupuncture point.
Topics: Acupuncture Therapy; Adult; Aged; Chronic Disease; Diclofenac; Female; Headache; Humans; Male; Middl | 1986 |