diclofenac has been researched along with Hallux Valgus in 4 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Hallux Valgus: Lateral displacement of the great toe (HALLUX), producing deformity of the first METATARSOPHALANGEAL JOINT with callous, bursa, or BUNION formation over the bony prominence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lower-dose diclofenac submicron particle capsules provided effective analgesia in this phase 3 clinical study in patients with acute pain and are a potentially promising option for the treatment of patients with acute pain." | 5.17 | Lower-dose diclofenac submicron particle capsules provide early and sustained acute patient pain relief in a phase 3 study. ( Argoff, C; Daniels, S; Gibofsky, A; Jensen, S; Silberstein, S; Young, CL, 2013) |
| " Additional measures included NPRS scores at predefined times over 48 hours, the summed pain intensity difference over 48 hours (SPID48), the time-weighted sum of pain relief scores over the first 8 hours, the mean dosing interval (the time from dosing to the time rescue medication or the next dose of study medication was administered, whichever was less), the proportion of patients requiring rescue medication, and the onset of perceptible and meaningful pain relief (2-stopwatch method)." | 2.74 | Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days. ( Boesing, SE; Diamond, E; Duckor, S; Gottlieb, I; Raymond, G; Riff, DS; Soulier, S, 2009) |
| "Rofecoxib 50 mg was significantly more effective than placebo on all measures of treatment of post-bunionectomy pain." | 2.71 | A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain. ( Bird, SR; Black, PM; Chang, DJ; Daniels, S; Desjardins, PJ; Fitzgerald, BJ; Petruschke, RA; Tershakovec, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gibofsky, A | 1 |
| Silberstein, S | 1 |
| Argoff, C | 1 |
| Daniels, S | 2 |
| Jensen, S | 1 |
| Young, CL | 1 |
| Riff, DS | 1 |
| Duckor, S | 1 |
| Gottlieb, I | 1 |
| Diamond, E | 1 |
| Soulier, S | 1 |
| Raymond, G | 1 |
| Boesing, SE | 2 |
| Daniels, SE | 1 |
| Baum, DR | 1 |
| Clark, F | 1 |
| Golf, MH | 1 |
| McDonnell, ME | 1 |
| Desjardins, PJ | 1 |
| Black, PM | 1 |
| Bird, SR | 1 |
| Fitzgerald, BJ | 1 |
| Petruschke, RA | 1 |
| Tershakovec, A | 1 |
| Chang, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery[NCT00366444] | Phase 3 | 201 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery[NCT00375934] | Phase 3 | 200 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction[NCT03893175] | Phase 1 | 86 participants (Actual) | Interventional | 2019-05-10 | Completed | ||
| A Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled, Parallel-Group Study of Rofecoxib and Diclofenac Sodium in the Treatment of Post-Bunionectomy Surgery Pain[NCT00092378] | Phase 3 | 251 participants (Actual) | Interventional | 2003-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain intensity scores were measured using an 11-point numerical pain rating scale (NPRS) with 0=no pain to 10=worst possible pain (NCT00366444)
Timeframe: Over 48 hours after bunionectomy
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 2.5 |
| Placebo | 5.6 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 70.2 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 26.0 |
| Placebo | 22.2 |
(NCT00366444)
Timeframe: Day 1
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 40 |
| Placebo | 87 |
(NCT00366444)
Timeframe: Day 2
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 22 |
| Placebo | 64 |
Day 3 data reflect the use of rescue medication only up to the time of discharge (NCT00366444)
Timeframe: Day 3
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 5 |
| Placebo | 29 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 62 |
| Placebo | 40 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 58 |
| Placebo | 35 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 84 |
| Placebo | 69 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 60 |
Pain relief was rated using a 5-point categorial scale (0=none, 1=a little, 2=some, 3=a lot, and 4=complete) at time of dose (time=0) and over 15 time points afterwards (10, 15, 20, 30, 45, and 60 minutes and at 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after the initial dose on Day 1 or until time of re-medication). A score of 0 across all time points would be the lowest (worst) and a score of 60 (4 X 15 time points) would be the highest (best) possible score. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 8.2 |
| Placebo | 2.6 |
Pain intensity scores were measured using an 11-point numerical pain rating scale (NPRS) with 0=no pain to 10=worst possible pain (NCT00375934)
Timeframe: Over 48 hours after bunionectomy
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 3.3 |
| Placebo | 5.7 |
(NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 90.6 |
(NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 42.9 |
| Placebo | 36.0 |
(NCT00375934)
Timeframe: Day 1
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 53 |
| Placebo | 93 |
(NCT00375934)
Timeframe: Day 2
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 30 |
| Placebo | 68 |
Day 3 data reflect the use of rescue medication only up to the time of discharge. (NCT00375934)
Timeframe: Day 3
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 4 |
| Placebo | 19 |
(NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 51 |
| Placebo | 31 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 50 |
| Placebo | 30 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 72 |
| Placebo | 63 |
(NCT00375934)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 110 |
| Placebo | 300 |
Pain relief was rated using a 5-point categorial scale (0=none, 1=a little, 2=some, 3=a lot, and 4=complete) at time of dose (time=0) and over 15 time points afterwards (10, 15, 20, 30, 45, and 60 minutes and at 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after the initial dose on Day 1 or until time of re-medication). A score of 0 across all time points would be the lowest (worst) and a score of 60 (4 X 15 time points) would be the highest (best) possible score. (NCT00375934)
Timeframe: 8 hourse post single dose
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 5.9 |
| Placebo | 1.9 |
4 trials available for diclofenac and Hallux Valgus
| Article | Year |
|---|---|
Lower-dose diclofenac submicron particle capsules provide early and sustained acute patient pain relief in a phase 3 study.
Topics: Acute Pain; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Bli | 2013 |
Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; An | 2009 |
Diclofenac potassium liquid-filled soft gelatin capsules for the treatment of postbunionectomy pain.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Diclofenac; Dose-Respons | 2010 |
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Metho | 2004 |
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Metho | 2004 |
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Metho | 2004 |
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Metho | 2004 |