diclofenac has been researched along with Epilepsy in 8 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy." | 3.85 | Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. ( Ayyıldız, N; Taşdemir, A; Taşkıran, M, 2017) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "Diclofenac was used for the in vitro experiment, and its hydroxy metabolite (4'-hydroxydiclofenac) was measured by HPLC." | 1.31 | Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis. ( Hadama, A; Hayashibara, M; Higuchi, S; Ieiri, I; Kitada, M; Mamiya, K; Morita, T; Ninomiya, H; Ohmori, S; Otsubo, K; Tainaka, H; Tashiro, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Javed, L | 1 |
| Hanif, F | 1 |
| Malhi, SM | 1 |
| Zaman, U | 1 |
| Jahan, N | 1 |
| Amir, Q | 1 |
| Javed, A | 1 |
| Malik, AB | 1 |
| Abrar, H | 1 |
| Erdogan, A | 2 |
| Erdogan, MA | 2 |
| Gurgul, S | 2 |
| Erbas, O | 2 |
| Elgarhi, R | 1 |
| Shehata, MM | 1 |
| Abdelsameea, AA | 1 |
| Salem, AE | 1 |
| Vieira, V | 1 |
| Glassmann, D | 1 |
| Marafon, P | 1 |
| Pereira, P | 1 |
| Gomez, R | 1 |
| Coitinho, AS | 1 |
| Taşkıran, M | 1 |
| Taşdemir, A | 1 |
| Ayyıldız, N | 1 |
| Ieiri, I | 1 |
| Tainaka, H | 1 |
| Morita, T | 1 |
| Hadama, A | 1 |
| Mamiya, K | 1 |
| Hayashibara, M | 1 |
| Ninomiya, H | 1 |
| Ohmori, S | 1 |
| Kitada, M | 1 |
| Tashiro, N | 1 |
| Higuchi, S | 1 |
| Otsubo, K | 1 |
| Al-Waili, NS | 1 |
1 review available for diclofenac and Epilepsy
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
7 other studies available for diclofenac and Epilepsy
| Article | Year |
|---|---|
Diclofenac sodium enhances the antiepileptic effect of levetiracetam in pilocarpine induced epileptic mice model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Convulsants; Di | 2021 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Diclofenac; Epilepsy; Male; | 2017 |
Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis.
Topics: Adult; Alleles; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon H | 2000 |
Diclofenac sodium and intractable epilepsy.
Topics: Adult; Diclofenac; Epilepsy; Humans; Male | 1986 |