diclofenac has been researched along with Ectopic Ossification in 17 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sex, body height, hypertrophic osteoarthritis of higher degree, size of the femoral component of the prosthesis, previous ipsi- or contralateral HO, and short course of nonsteroidal anti-inflammatory drug (diclofenac) therapy significantly influenced the HO rate in univariate analysis." | 3.72 | Preoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement results of a prospective study in 462 hips. ( Flentje, M; Koelbl, O; Lehmann, H; Pohl, F; Seufert, J; Springorum, HW; Tauscher, A, 2003) |
| "Incidence of heterotopic ossification was 47." | 2.69 | Preoperative irradiation versus the use of nonsteroidal anti-inflammatory drugs for prevention of heterotopic ossification following total hip replacement: the results of a randomized trial. ( Barthel, T; Eulert, J; Flentje, M; Knelles, D; Kölbl, O; Raunecker, F, 1998) |
| "In the group treated with NSAID, 16 heterotopic ossifications stage Brooker I and 2 stage Brooker II could be detected." | 2.69 | The suppression of heterotopic ossifications: radiation versus NSAID therapy--a prospective study. ( Bamberg, M; Bruhn, G; Burkhardsmaier, F; Esenwein, S; Gaissmaier, C; Jany, R; Küsswetter, W; Martini, F; Sell, S; Willms, R, 1998) |
| "Significant degrees of heterotopic ossification did not occur with the drug." | 2.67 | The suppression of heterotopic ossification after total hip arthroplasty. ( Küsswetter, W; Reis, HJ; Schellinger, T, 1992) |
| "Heterotopic ossification is a common complication following total hip arthroplasty and surgery following acetabular trauma." | 2.44 | Pharmacological treatment of heterotopic ossification following hip and acetabular surgery. ( El Masry, MA; Gamie, Z; Macfarlane, RJ; Ng, BH; Schizas, C; Tsiridis, E; Velonis, S, 2008) |
| "The pharmacological prophylaxis of heterotopic ossification (HO) following total hip arthroplasty (THA) is debated." | 1.72 | A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion. ( Asparago, G; Cuozzo, F; Maffulli, N; Migliorini, F; Oliva, F, 2022) |
| "The formation of heterotopic ossifications after total hip endoprosthesis implantation is a well-known complication." | 1.30 | C-reactive protein as an early indicator of the formation of heterotopic ossifications after total hip replacement. ( Schleh, T; Sell, S, 1999) |
| "Diclofenac was released continuously for 2 weeks from micro-osmotic pumps for each demineralised bone implant in the rats." | 1.29 | The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats. ( Abdiu, A; Risto, O; Wahlström, O, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Migliorini, F | 1 |
| Asparago, G | 1 |
| Oliva, F | 1 |
| Cuozzo, F | 1 |
| Maffulli, N | 1 |
| Haffer, H | 1 |
| Müller, M | 1 |
| Ascherl, R | 1 |
| Perka, C | 1 |
| Winkler, T | 1 |
| Winkler, S | 1 |
| Springorum, HR | 1 |
| Vaitl, T | 1 |
| Handel, M | 3 |
| Barta, S | 1 |
| Kehl, V | 1 |
| Craiovan, B | 1 |
| Grifka, J | 1 |
| Elhassan, Y | 1 |
| Abdelhaq, A | 1 |
| Piggott, RP | 1 |
| Osman, M | 1 |
| McElwain, JP | 1 |
| Leonard, M | 1 |
| Koelbl, O | 1 |
| Seufert, J | 1 |
| Pohl, F | 1 |
| Tauscher, A | 1 |
| Lehmann, H | 1 |
| Springorum, HW | 1 |
| Flentje, M | 2 |
| Sell, S | 5 |
| Phillips, O | 2 |
| Anders, S | 1 |
| Köck, FX | 1 |
| Macfarlane, RJ | 1 |
| Ng, BH | 1 |
| Gamie, Z | 1 |
| El Masry, MA | 1 |
| Velonis, S | 1 |
| Schizas, C | 1 |
| Tsiridis, E | 1 |
| Jacobsson, SA | 1 |
| Djerf, K | 2 |
| Ivarsson, I | 1 |
| Wahlström, O | 3 |
| Risto, O | 2 |
| Abdiu, A | 1 |
| Eulert, J | 2 |
| Knelles, D | 2 |
| Barthel, T | 2 |
| Jockheck, M | 1 |
| Willms, R | 2 |
| Volkmann, R | 1 |
| Weller, S | 1 |
| Küsswetter, W | 3 |
| Kölbl, O | 1 |
| Raunecker, F | 1 |
| Jany, R | 1 |
| Esenwein, S | 1 |
| Gaissmaier, C | 1 |
| Martini, F | 1 |
| Bruhn, G | 1 |
| Burkhardsmaier, F | 1 |
| Bamberg, M | 1 |
| Schleh, T | 1 |
| Reis, HJ | 1 |
| Schellinger, T | 1 |
| Hammerby, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty[NCT05648916] | 200 participants (Anticipated) | Observational | 2022-08-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diclofenac and Ectopic Ossification
| Article | Year |
|---|---|
Diclofenac for prophylaxis of heterotopic ossification after hip arthroplasty: a systematic review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Diclofenac; Humans; Inciden | 2022 |
Pharmacological treatment of heterotopic ossification following hip and acetabular surgery.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Dicl | 2008 |
9 trials available for diclofenac and Ectopic Ossification
| Article | Year |
|---|---|
Comparative clinical study of the prophylaxis of heterotopic ossifications after total hip arthroplasty using etoricoxib or diclofenac.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, R | 2016 |
No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Diclofenac; Dose-Resp | 2004 |
Dose-dependent efficacy of diclofenac-cholestyramine on pain and periarticular ossifications after total hip arthroplasty: a double-blind, prospective, randomised trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2004 |
[Heterotopic ossifications].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthrography; Arthroplasty, Replacement, Hip; Aspirin | 1997 |
Prevention of periarticular heterotopic ossification after endoprosthetic hip joint replacement by means of diclofenac.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthr | 1998 |
Preoperative irradiation versus the use of nonsteroidal anti-inflammatory drugs for prevention of heterotopic ossification following total hip replacement: the results of a randomized trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Diclofenac; Female; H | 1998 |
The suppression of heterotopic ossifications: radiation versus NSAID therapy--a prospective study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Diclofenac; Female; Humans; | 1998 |
The suppression of heterotopic ossification after total hip arthroplasty.
Topics: Adult; Aged; Diclofenac; Double-Blind Method; Female; Hip Prosthesis; Humans; Male; Middle Aged; Oss | 1992 |
Heterotopic bone formation prevented by diclofenac. Prospective study of 100 hip arthroplasties.
Topics: Aged; Diclofenac; Double-Blind Method; Female; Hip Prosthesis; Humans; Male; Middle Aged; Ossificati | 1991 |
6 other studies available for diclofenac and Ectopic Ossification
| Article | Year |
|---|---|
A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Diclofenac; Expe | 2022 |
Heterotopic Ossification following acetabular fixation: Incidence and risk factors: 10-year experience of a tertiary centre.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chi | 2016 |
Preoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement results of a prospective study in 462 hips.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, | 2003 |
Effect of diclofenac on fixation of hydroxyapatite-coated implants. An experimental study.
Topics: Animals; Diclofenac; Drug Interactions; Durapatite; Female; Hip Prosthesis; Male; Osseointegration; | 1994 |
The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Male | 1995 |
C-reactive protein as an early indicator of the formation of heterotopic ossifications after total hip replacement.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; C-Reactive Protein; Diclofe | 1999 |