diclofenac has been researched along with Dysmenorrhea in 22 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Dysmenorrhea: Painful menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results show that the recommended daily dose of diclofenac potassium, in three 50 mg doses across the day and evening, offers effective menstrual pain relief across 24 h, compared with placebo, in women with severe primary dysmenorrhea." | 9.19 | The 24-h progression of menstrual pain in women with primary dysmenorrhea when given diclofenac potassium: a randomized, double-blinded, placebo-controlled crossover study. ( Avidon, I; Baker, FC; Iacovides, S, 2014) |
| "The purpose of the present research work was to carry out clinical study on primary dysmenorrhea to comparatively examine the coded herbal drug formulation "Dysmo-off" with authentic allopathic medicine "Diclofenac sodium" (NSAIDs)." | 9.12 | Clinical evaluation to assess the safety and efficacy of coded herbal medicine "Dysmo-off" versus allopathic medicine "Diclofenac sodium" for the treatment of primary dysmenorrhea. ( Nazar, H; Usmanghani, K, 2006) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 9.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| "The efficacy of diclofenac sodium was investigated in the painful symptoms of primary dysmenorrhea and in reducing menstrual bleeding." | 9.05 | Treatment of primary dysmenorrhea with diclofenac sodium. ( Pulkkinen, MO; Riihiluoma, P; Wuolijoki, E, 1981) |
| "We included randomised, double-blind studies that compared a single dose of analgesic plus caffeine with the same dose of the analgesic alone in the treatment of acute pain." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "The aim of this study was to compare the efficiency of diclofenac sodium to paracetamol using a visual analog scale in the patients presenting to the emergency room with primary dysmenorrhea." | 7.79 | [Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale]. ( Arıcı, S; Ayan, M; Demirtürk, F; Esen, M; Karaman, S; Söğüt, E; Taş, U, 2013) |
| "They reduce menstrual pain by reducing uterine pressure and PGF2alpha levels in the menstrual fluid." | 6.90 | Comparison of the Effects of Piroxicam and Diclofenac Sodium as Treatments for Primary Dysmenorrhea. ( Camlibel, M; Erdur, B; Ozen, M; Uyanik, A; Yilmaz, A, 2019) |
| "When receiving placebo for menstrual pain, the women's performance in the tests was decreased significantly, compared with when they were receiving diclofenac potassium for menstrual pain (P < ." | 6.74 | Diclofenac potassium attenuates dysmenorrhea and restores exercise performance in women with primary dysmenorrhea. ( Chantler, I; Fuller, A; Mitchell, D, 2009) |
| "Primary dysmenorrhea is a common gynecological disorder that disrupts daytime functioning and nighttime sleep quality." | 6.74 | Diclofenac potassium restores objective and subjective measures of sleep quality in women with primary dysmenorrhea. ( Avidon, I; Baker, FC; Bentley, A; Iacovides, S, 2009) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 6.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "These results show that the recommended daily dose of diclofenac potassium, in three 50 mg doses across the day and evening, offers effective menstrual pain relief across 24 h, compared with placebo, in women with severe primary dysmenorrhea." | 5.19 | The 24-h progression of menstrual pain in women with primary dysmenorrhea when given diclofenac potassium: a randomized, double-blinded, placebo-controlled crossover study. ( Avidon, I; Baker, FC; Iacovides, S, 2014) |
| "Rofecoxib and diclofenac potassium, when taken in recommended doses, were equally effective in alleviating pain associated with primary dysmenorrhea." | 5.13 | The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrheic pain. ( Chantler, I; Fuller, A; Mitchell, D, 2008) |
| "Two randomized, multicenter, double-blind, placebo-controlled, crossover studies of similar design have assessed the efficacy and tolerability of two regimens of lumiracoxib compared with placebo (Study 1) or naproxen and placebo (Study 2) in women (aged 18-45 years) with moderate to severe primary dysmenorrhea." | 5.13 | Efficacy and tolerability of lumiracoxib 200 mg once daily for treatment of primary dysmenorrhea: results from two randomized controlled trials. ( Barton, S; Daniels, S; Gitton, X; Stricker, K; Zhou, W, 2008) |
| "The purpose of the present research work was to carry out clinical study on primary dysmenorrhea to comparatively examine the coded herbal drug formulation "Dysmo-off" with authentic allopathic medicine "Diclofenac sodium" (NSAIDs)." | 5.12 | Clinical evaluation to assess the safety and efficacy of coded herbal medicine "Dysmo-off" versus allopathic medicine "Diclofenac sodium" for the treatment of primary dysmenorrhea. ( Nazar, H; Usmanghani, K, 2006) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 5.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| " In clinical conditions marked by acute or chronic pain and inflammation, such as oral surgery, dysmenorrhea, low back pain, renal colic, and biliary colic, as well as in post-traumatic and postoperative conditions, diclofenac sodium, a nonsteroidal anti-inflammatory drug with potent prostaglandin synthetase inhibition, has been shown to be an effective analgesic agent." | 5.06 | Use of diclofenac in analgesia. ( Kantor, TG, 1986) |
| "A multicenter open crossover study compared piroxicam and mefenamic acid and piroxicam and diclofenac in the treatment of primary dysmenorrhea in 91 patients." | 5.06 | A comparative crossover study of piroxicam vs. mefenamic acid and diclofenac in France. ( Serfaty, D, 1986) |
| " As for efficacy outcomes, all the included analgesics except aspirin were more effective than placebo in treating dysmenorrhea [naproxen (OR 3." | 5.05 | Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis. ( Chen, Y; Hao, C; Nie, W; Wang, L; Xu, P; Yin, Y, 2020) |
| "The efficacy of diclofenac sodium was investigated in the painful symptoms of primary dysmenorrhea and in reducing menstrual bleeding." | 5.05 | Treatment of primary dysmenorrhea with diclofenac sodium. ( Pulkkinen, MO; Riihiluoma, P; Wuolijoki, E, 1981) |
| "We included randomised, double-blind studies that compared a single dose of analgesic plus caffeine with the same dose of the analgesic alone in the treatment of acute pain." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " In randomised, controlled clinical trials, lumiracoxib 100 - 200 mg/day has been shown to be superior to placebo in patients with symptomatic osteoarthritis, with clinical efficacy similar to diclofenac 150 mg/day, celecoxib 200 mg/day or rofecoxib 25 mg/day." | 4.82 | Clinical pharmacology of lumiracoxib, a second-generation cyclooxygenase 2 selective inhibitor. ( Bannwarth, B; Berenbaum, F, 2005) |
| "The aim of this study was to compare the efficiency of diclofenac sodium to paracetamol using a visual analog scale in the patients presenting to the emergency room with primary dysmenorrhea." | 3.79 | [Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale]. ( Arıcı, S; Ayan, M; Demirtürk, F; Esen, M; Karaman, S; Söğüt, E; Taş, U, 2013) |
| "They reduce menstrual pain by reducing uterine pressure and PGF2alpha levels in the menstrual fluid." | 2.90 | Comparison of the Effects of Piroxicam and Diclofenac Sodium as Treatments for Primary Dysmenorrhea. ( Camlibel, M; Erdur, B; Ozen, M; Uyanik, A; Yilmaz, A, 2019) |
| "When receiving placebo for menstrual pain, the women's performance in the tests was decreased significantly, compared with when they were receiving diclofenac potassium for menstrual pain (P < ." | 2.74 | Diclofenac potassium attenuates dysmenorrhea and restores exercise performance in women with primary dysmenorrhea. ( Chantler, I; Fuller, A; Mitchell, D, 2009) |
| "Primary dysmenorrhea is a common gynecological disorder that disrupts daytime functioning and nighttime sleep quality." | 2.74 | Diclofenac potassium restores objective and subjective measures of sleep quality in women with primary dysmenorrhea. ( Avidon, I; Baker, FC; Bentley, A; Iacovides, S, 2009) |
| "Both aceclofenac and naproxen were well tolerated." | 2.72 | The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea. ( Fortea, J; Lamarca, R; Letzel, H; Mégard, Y; Raber, A, 2006) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 2.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "Primary dysmenorrhea is a common inflammatory disease with an uncertain pathogenesis, although one consistent finding is increased neutrophil activity." | 1.39 | Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea. ( Aykur, M; Güney, M; Kaplan, Ö; Nazıroğlu, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Nie, W | 1 |
| Xu, P | 1 |
| Hao, C | 1 |
| Chen, Y | 1 |
| Yin, Y | 1 |
| Wang, L | 1 |
| Moore, RA | 2 |
| Derry, S | 2 |
| Camlibel, M | 1 |
| Erdur, B | 1 |
| Yilmaz, A | 1 |
| Ozen, M | 1 |
| Uyanik, A | 1 |
| Ayan, M | 1 |
| Taş, U | 1 |
| Söğüt, E | 1 |
| Arıcı, S | 1 |
| Karaman, S | 1 |
| Esen, M | 1 |
| Demirtürk, F | 1 |
| Iacovides, S | 2 |
| Baker, FC | 2 |
| Avidon, I | 2 |
| Kaplan, Ö | 1 |
| Nazıroğlu, M | 1 |
| Güney, M | 1 |
| Aykur, M | 1 |
| Derry, CJ | 1 |
| Chantler, I | 2 |
| Mitchell, D | 2 |
| Fuller, A | 2 |
| Bentley, A | 1 |
| Pareek, A | 1 |
| Chandurkar, NB | 1 |
| Patil, RT | 1 |
| Agrawal, SN | 1 |
| Uday, RB | 1 |
| Tambe, SG | 1 |
| Bitner, M | 1 |
| Kattenhorn, J | 1 |
| Hatfield, C | 1 |
| Gao, J | 1 |
| Kellstein, D | 1 |
| Bannwarth, B | 1 |
| Berenbaum, F | 1 |
| Letzel, H | 1 |
| Mégard, Y | 1 |
| Lamarca, R | 1 |
| Raber, A | 1 |
| Fortea, J | 1 |
| Nazar, H | 1 |
| Usmanghani, K | 1 |
| Daniels, S | 1 |
| Gitton, X | 1 |
| Zhou, W | 1 |
| Stricker, K | 1 |
| Barton, S | 1 |
| Riihiluoma, P | 1 |
| Wuolijoki, E | 1 |
| Pulkkinen, MO | 1 |
| Marchini, M | 1 |
| Tozzi, L | 1 |
| Bakshi, R | 1 |
| Pistai, R | 1 |
| Fedele, L | 1 |
| Facchinetti, F | 1 |
| Sgarbi, L | 1 |
| Piccinini, F | 1 |
| Volpe, A | 1 |
| Miller, LG | 1 |
| Bowman, RC | 1 |
| Kantor, TG | 1 |
| Serfaty, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea[NCT03697746] | 300 participants (Anticipated) | Interventional | 2018-10-01 | Not yet recruiting | |||
| The Effect of Post Colonoscopy Abdominal Massage on Abdominal Pain, Distension, Discomfort and Patient Satisfaction: A Randomized Controlled Study Protocol[NCT04979351] | 180 participants (Actual) | Interventional | 2020-11-09 | Active, not recruiting | |||
| Evaluation of the Effect of a Vaginal Ring With Meloxicam on Primary Dysmenorrhea in Women of Childbearing Age[NCT02255045] | Phase 2/Phase 3 | 68 participants (Actual) | Interventional | 2014-06-27 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for diclofenac and Dysmenorrhea
| Article | Year |
|---|---|
Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dysmeno | 2020 |
Diclofenac Potassium in Acute Postoperative Pain and Dysmenorrhoea: Results from Comprehensive Clinical Trial Reports.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Dysmenorrhea; Female; | 2018 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
Clinical pharmacology of lumiracoxib, a second-generation cyclooxygenase 2 selective inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors | 2005 |
15 trials available for diclofenac and Dysmenorrhea
| Article | Year |
|---|---|
Comparison of the Effects of Piroxicam and Diclofenac Sodium as Treatments for Primary Dysmenorrhea.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Dysmenorrhea; Emerg | 2019 |
The 24-h progression of menstrual pain in women with primary dysmenorrhea when given diclofenac potassium: a randomized, double-blinded, placebo-controlled crossover study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Dose-Response Relati | 2014 |
Diclofenac potassium attenuates dysmenorrhea and restores exercise performance in women with primary dysmenorrhea.
Topics: Administration, Oral; Adolescent; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Dic | 2009 |
Diclofenac potassium restores objective and subjective measures of sleep quality in women with primary dysmenorrhea.
Topics: Affect; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-Blind Method | 2009 |
Efficacy and safety of aceclofenac and drotaverine fixed-dose combination in the treatment of primary dysmenorrhoea: a double-blind, double-dummy, randomized comparative study with aceclofenac.
Topics: Adolescent; Adult; Analgesics; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Comb | 2010 |
Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhoea.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase | 2004 |
The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhib | 2006 |
Clinical evaluation to assess the safety and efficacy of coded herbal medicine "Dysmo-off" versus allopathic medicine "Diclofenac sodium" for the treatment of primary dysmenorrhea.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Dysmeno | 2006 |
The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrheic pain.
Topics: Adult; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationshi | 2008 |
Efficacy and tolerability of lumiracoxib 200 mg once daily for treatment of primary dysmenorrhea: results from two randomized controlled trials.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; D | 2008 |
Treatment of primary dysmenorrhea with diclofenac sodium.
Topics: Adult; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Dysmenorrhea; Female; Humans; Mens | 1981 |
Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 1995 |
A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclo | 2002 |
Use of diclofenac in analgesia.
Topics: Analgesia; Back Pain; Biliary Tract Diseases; Clinical Trials as Topic; Colic; Diclofenac; Double-Bl | 1986 |
A comparative crossover study of piroxicam vs. mefenamic acid and diclofenac in France.
Topics: Adult; Clinical Trials as Topic; Diclofenac; Dysmenorrhea; Female; Humans; Mefenamic Acid; Piroxicam | 1986 |
3 other studies available for diclofenac and Dysmenorrhea
| Article | Year |
|---|---|
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Calcium; Calcium Channels; Cells, C | 2013 |
Selective effect of diclofenac in the treatment of osteoarthritis versus dysmenorrhea.
Topics: Adult; Diclofenac; Dysmenorrhea; Female; Half-Life; Humans; Liver Function Tests; Osteoarthritis | 1990 |