diclofenac has been researched along with Duodenal Ulcer in 27 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 9.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " The efficacy of misoprostol and ranitidine in the prevention of gastroduodenal damage in patients taking diclofenac for their cancer pain has been compared in this study." | 9.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| " Misoprostol is the only cytoprotective drug found to be effective in the prevention of both gastric and duodenal ulcers associated with NSAIDs." | 8.79 | Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis. ( McKenna, F, 1995) |
| "Patients with osteoarthritis (age, >or=50 y) were randomized to receive lumiracoxib 400 mg once daily, naproxen 500 mg twice daily, or ibuprofen 800 mg 3 times daily for 12 months." | 5.12 | Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study. ( Gitton, X; Hawkey, CJ; Krammer, G; Matchaba, P; Mellein, B; Richard, D; Sallstig, P; Smalley, W; Stricker, K; Weinstein, WM, 2007) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 5.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| " The efficacy of misoprostol and ranitidine in the prevention of gastroduodenal damage in patients taking diclofenac for their cancer pain has been compared in this study." | 5.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| "Three randomized, blinded, multicenter studies, including one in general practice, evaluated the efficacy of combination diclofenac/misoprostol versus diclofenac or ibuprofen in a total of 1824 patients with rheumatoid arthritis (RA) or osteoarthritis (OA)." | 5.08 | Diclofenac/misoprostol: the European clinical experience. ( McKenna, F, 1998) |
| " One hundred patients, free from endoscopically detectable lesions of the gastroduodenal mucosa, affected either by rheumatoid arthritis or osteoarthritis, and candidates for NSAID therapy, were randomly allocated either to 200 mg sulglycotide three times daily (n = 50) or to an indistinguishable placebo (n = 50) for 4 weeks, together with standard NSAID administration (50 mg diclofenac three times daily (n = 50); 50 mg indomethacin three times daily (n = 50))." | 5.07 | Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M, 1993) |
| " Misoprostol is the only cytoprotective drug found to be effective in the prevention of both gastric and duodenal ulcers associated with NSAIDs." | 4.79 | Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis. ( McKenna, F, 1995) |
| " In this case report, a 27-year patient, who received activated charcoal therapy after diclofenac intoxication developed duodenal ulcer perforation and charcoal peritonitis." | 4.12 | Duodenal Ulcer Perforatıon after Actıvated Charcoal Treatment. ( Ozer, N; Sahin, A, 2022) |
| " However, clinical examination revealed that the patient had put a diclofenac hydroxyethylpyrrolidine plaster, which had been prescribed for lower back pain, inadvertently on a large ulcus cruris." | 3.70 | [Ulcer + ulcer]. ( Christ, AD; Speich, R; Stocker, DN, 1998) |
| " However, compliance is limited by the different dosing regimens of misoprostol and NSAID and GI symptoms associated with misoprostol at its recommended q." | 2.69 | Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group. ( Ball, JA; Bocanegra, TS; Fort, JG; Geis, GS; Sikes, DH; Tindall, EA; Wallemark, CB; Weaver, AL, 1998) |
| "Diclofenac is a well established nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of a variety of painful inflammatory conditions." | 2.39 | Diclofenac/misoprostol. A review of its pharmacology and therapeutic efficacy in painful inflammatory conditions. ( Davis, R; Goa, KL; Yarker, YE, 1995) |
| ") occurring after the start of rabeprazole treatment were handled as adverse events." | 1.35 | Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan. ( Mizokami, Y, 2009) |
| "The costs of treating gastroduodenal ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs) are shown to increase the total cost of NSAID treatment to the Assurance-Maladie, the French national health insurance system." | 1.28 | The economic consequences of NSAID-induced gastropathy: the French context. ( de Pouvourville, G, 1992) |
| " Duodenal mucosal injury, with or without gastric lesions, related to long-term use of anti-inflammatory drugs such as aspirin, indomethacin, ibuprofen, diclofenac or others are reported in three patients, in which the diagnosis was confirmed by emergency endoscopy after hematemesis." | 1.26 | Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs. ( Ikeda, S; Tanaka, M; Uchiyama, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 14 (51.85) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Ozer, N | 1 |
| Sahin, A | 1 |
| Khayyal, MT | 1 |
| Wadie, W | 1 |
| Abd El-Haleim, EA | 1 |
| Ahmed, KA | 1 |
| Kelber, O | 1 |
| Ammar, RM | 1 |
| Abdel-Aziz, H | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Mizokami, Y | 1 |
| Caunedo-Alvarez, A | 1 |
| Gómez-Rodríguez, BJ | 1 |
| Romero-Vázquez, J | 1 |
| Argüelles-Arias, F | 1 |
| Romero-Castro, R | 1 |
| García-Montes, JM | 1 |
| Pellicer-Bautista, FJ | 1 |
| Herrerías-Gutiérrez, JM | 1 |
| Sikes, DH | 2 |
| Agrawal, NM | 1 |
| Zhao, WW | 1 |
| Kent, JD | 1 |
| Recker, DP | 1 |
| Verburg, KM | 1 |
| Chan, FK | 1 |
| Hung, LC | 1 |
| Suen, BY | 1 |
| Wu, JC | 1 |
| Lee, KC | 1 |
| Leung, VK | 1 |
| Hui, AJ | 1 |
| To, KF | 1 |
| Leung, WK | 1 |
| Wong, VW | 1 |
| Chung, SC | 1 |
| Sung, JJ | 1 |
| Shostak, NA | 1 |
| Riabkova, AA | 1 |
| Savel'ev, VS | 1 |
| Maliarova, LP | 1 |
| Ribeiro, AQ | 1 |
| Sevalho, G | 1 |
| César, CC | 1 |
| Hawkey, CJ | 1 |
| Weinstein, WM | 1 |
| Smalley, W | 1 |
| Gitton, X | 1 |
| Sallstig, P | 1 |
| Stricker, K | 1 |
| Krammer, G | 1 |
| Mellein, B | 1 |
| Richard, D | 1 |
| Matchaba, P | 1 |
| Zimmerman, J | 1 |
| Siguencia, J | 1 |
| Tsvang, E | 1 |
| Valentini, M | 1 |
| Cannizzaro, R | 1 |
| Poletti, M | 1 |
| Bortolussi, R | 1 |
| Fracasso, A | 1 |
| Testa, V | 1 |
| Sozzi, M | 1 |
| Fornasarig, M | 1 |
| Bortoluzzi, F | 1 |
| Grazioli, I | 1 |
| McKenna, F | 2 |
| Bianchi Porro, G | 2 |
| Montrone, F | 2 |
| Petrillo, M | 2 |
| Caruso, I | 1 |
| Ardizzone, S | 2 |
| Davis, R | 1 |
| Yarker, YE | 1 |
| Goa, KL | 1 |
| Miglioli, M | 1 |
| Vaira, D | 1 |
| Menegatti, M | 1 |
| Brunetti, G | 1 |
| Frizziero, L | 1 |
| Grandinetti, G | 1 |
| Newman, L | 1 |
| Bocanegra, TS | 1 |
| Weaver, AL | 1 |
| Tindall, EA | 1 |
| Ball, JA | 1 |
| Wallemark, CB | 1 |
| Geis, GS | 2 |
| Fort, JG | 1 |
| Stocker, DN | 1 |
| Christ, AD | 1 |
| Speich, R | 1 |
| Seitz, S | 1 |
| Boelsterli, UA | 1 |
| Medina Santillán, R | 1 |
| Reyes García, G | 1 |
| Mateos García, E | 1 |
| Dorta, G | 1 |
| Nicolet, M | 1 |
| Vouillamoz, D | 1 |
| Margalith, D | 1 |
| Saraga, E | 1 |
| Bouzourene, H | 1 |
| Häcki, WH | 1 |
| Stolte, M | 1 |
| Blum, AL | 1 |
| Armstrong, D | 1 |
| Novacek, G | 1 |
| Geppert, A | 1 |
| Kramer, L | 1 |
| Wrba, F | 1 |
| Herbst, F | 1 |
| Schima, W | 1 |
| Gangl, A | 1 |
| Pötzi, R | 1 |
| Tanaka, M | 1 |
| Uchiyama, M | 1 |
| Ikeda, S | 1 |
| de Pouvourville, G | 1 |
| Verdickt, W | 1 |
| Moran, C | 1 |
| Hantzschel, H | 1 |
| Fraga, AM | 1 |
| Stead, H | 1 |
3 reviews available for diclofenac and Duodenal Ulcer
| Article | Year |
|---|---|
Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diclofenac; Drug Combin | 1995 |
Diclofenac/misoprostol. A review of its pharmacology and therapeutic efficacy in painful inflammatory conditions.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; Cost-Ben | 1995 |
Liver penetration by a duodenal ulcer in a young woman.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; | 2001 |
11 trials available for diclofenac and Duodenal Ulcer
| Article | Year |
|---|---|
Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclo | 2002 |
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2; | 2002 |
Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study.
Topics: Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclof | 2007 |
Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antineop | 1995 |
Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheu | 1993 |
Prevention with sucralfate gel of NSAID-induced gastroduodenal damage in arthritic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Doubl | 1996 |
Diclofenac/misoprostol: the European clinical experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Doubl | 1998 |
Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Drug Therapy, | 1998 |
Prevention of gastroduodenal injury induced by NSAIDs with low-dose misoprostol.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Double-Blind Method; | 1999 |
The effects of omeprazole on healing and appearance of small gastric and duodenal lesions during dosing with diclofenac in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cross-Over Studies; Diclofenac; D | 2000 |
A double-blind comparison of the gastroduodenal safety and efficacy of diclofenac and a fixed dose combination of diclofenac and misoprostol in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Diclofenac; Digestive System; Double-Blind Me | 1992 |
13 other studies available for diclofenac and Duodenal Ulcer
| Article | Year |
|---|---|
Duodenal Ulcer Perforatıon after Actıvated Charcoal Treatment.
Topics: Charcoal; Diclofenac; Duodenal Ulcer; Humans; Peptic Ulcer Perforation; Peritonitis | 2022 |
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Duodenal Ulcer | 2019 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclo | 2009 |
Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Cyclooxygenase 2 Inhibitors | 2010 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno | 2003 |
The use of nonsteroidal anti-inflammatory drugs and the occurrence of gastric lesions among patients undergoing upper endoscopy in a university hospital in Brazil.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Confounding Factors, Epidemiologic; Diclof | 2006 |
Upper gastrointestinal hemorrhage associated with cutaneous application of diclofenac gel.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Upper gastrointestinal bleeding following major maxillofacial surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carcinoma, Squamous Cell; Chemopre | 1997 |
[Ulcer + ulcer].
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Back Pain | 1998 |
Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Duod | 1998 |
Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Diclofenac; Duodenal Ulcer; Endoscopy; Female; Fiber Optic | 1977 |
The economic consequences of NSAID-induced gastropathy: the French context.
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost of Illness; Diclofenac; Duodenal Ulce | 1992 |