diclofenac has been researched along with Disease Models, Animal in 245 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.63) | 18.7374 |
| 1990's | 12 (4.90) | 18.2507 |
| 2000's | 78 (31.84) | 29.6817 |
| 2010's | 126 (51.43) | 24.3611 |
| 2020's | 25 (10.20) | 2.80 |
| Authors | Studies |
|---|---|
| Bain, G; Beher, D; Chen, W; Jiang, X; Munoz, B; Peachey, J; Prasit, P; Shearman, MS; St-Jacques, R; Stock, N; Williamson, TL; Wrigley, JD | 1 |
| Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG | 1 |
| Avdeef, A; Tam, KY | 1 |
| Abdel-Aziz, AA; Asiri, YA; ElTahir, KE | 1 |
| Blanco, MJ; Chambers, M; Chandrasekhar, S; Fisher, MJ; Harvey, A; Lin, C; Mudra, D; Oskins, J; Vetman, T; Wang, XS; Warshawsky, AM; Yu, XP | 1 |
| Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF | 1 |
| Behera, D; Deshmukh, S; Gajera, JM; Gharat, LA; Gudi, GS; Honnegowda, S; Jadhav, SB; Karande, V; Kattige, VG; Khairatkar-Joshi, N; Kulkarni, A; Muthukaman, N; Narayana, L; Pisal, D; Sarode, N; Shaikh, M; Tambe, M; Tondlekar, S | 1 |
| Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN | 1 |
| Katselou, MG; Kourounakis, AP; Matralis, AN | 1 |
| Augustyns, K; Baán, A; Caljon, G; Kiekens, F; Maes, L; Matheeussen, A; Salado, IG; Van der Veken, P; Verdeyen, T | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL | 1 |
| Chávez-Riveros, A; Hernández-Vázquez, E; Miranda, LD; Nieto-Camacho, A; Ramírez-Trinidad, Á | 1 |
| Alqahtani, SS; Alshahrani, S; Banji, D; Banji, OJF; Rashida, S | 1 |
| Arai, T; Eguchi, Y; Furuya, T; Hagiwara, S; Hishiya, T; Hozumi, T; Inage, K; Kawarai, Y; Kim, G; Maki, S; Matsuura, Y; Mukaihata, T; Nakamura, J; Ohtori, S; Okuyama, K; Orita, S; Otagiri, T; Shiga, Y; Suzuki, T; Suzuki-Narita, M; Tajiri, I; Takeuchi, J; Tokeshi, S; Toshi, N; Tsuchiya, R | 1 |
| Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S | 1 |
| Al-Omar, MA; Almehizia, AA; Bhat, MA; Darwish, AM; Kalmouch, A; Khattab, AEA; Naglah, AM | 1 |
| Lau, SF; Madzuki, IN; Mohamad Shalan, NAA; Mohamed, S; Mohd Ishak, NI | 1 |
| Abd El-Haleim, EA; Abdel-Aziz, H; Ahmed, KA; Ammar, RM; Kelber, O; Khayyal, MT; Wadie, W | 1 |
| Arakawa, K; Ikeyama, Y; Ito, K; Sato, T; Segawa, M; Sekine, S | 1 |
| Nagaraju, B; Prasanna, B; Seelam, N; Shanmukhakumar, JV; Subbaiah, T | 1 |
| Heard, CM; Hewitt, M; Kelly, SL; Lewis, PN; Morgan, SR; Morrison, PWJ; Moseley, R; Moses, RL; Parker, JE; Pilia, N; Quantock, AJ; Whitaker, D | 1 |
| Corrêa, MEAB; de Bem Silveira, G; de Roch Casagrande, L; Dos Santos Haupenthal, DP; Duarte, MB; Feuser, PE; Machado-de-Ávila, RA; Mendes, C; Pinho, RA; Silveira, PCL; Zaccaron, RP; Zortea, D | 1 |
| Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA | 1 |
| Ailincai, D; Marin, L; Mititelu-Tartau, L | 1 |
| Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S | 1 |
| Antoniazzi, CTD; Brum, EDS; Brusco, I; Camponogara, C; Dalenogare, DP; Fischer, SPM; Kudsi, SQ; Moresco, RN; Oliveira, SM; Peres, DS; Silveira, PCL; Stein, CDS; Trevisan, G; Zaccaron, RP | 1 |
| Ishii, S; Morita, D; Yoshioka, K | 1 |
| Ha, W; Shi, YP; Wang, ZH; Zhao, XB | 1 |
| Chao, G; Qian, Y; Wang, Z; Yang, C; Zhang, S | 1 |
| Cao, X; Jing, L; Mou, S; Xu, N; Yu, Z; Zhang, C | 1 |
| Huang, X; Wen, X; Wu, H | 1 |
| Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M | 1 |
| Akhter, S; Ali, T; Nipa, NS; Rafiq, K | 1 |
| Abdel-Bary, A; El-Tahan, RA; Gowayed, MA | 1 |
| Binienda, A; Fichna, J; Kordek, R; Majchrzak, K; Małecka-Panas, E; Salaga, M; Zatorski, H; Zielińska, M | 1 |
| Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R | 1 |
| Abrar, H; Arsalan, A; Bano, R; Fatima, K; Hussain, RA; Islam, M; Jahan, N; Mahmud, S; Yasin, H | 1 |
| Kumar, B; Medhi, B; Modi, M; Saikia, B | 1 |
| Derbalah, AE; Oda, SS | 1 |
| Che Ahmad Tantowi, NA; Hussin, P; Lau, SF; Mohamed, S | 1 |
| Nguyen, CN; Nguyen, HT; Nguyen, TTT; Tran, TH | 1 |
| Katara, R; Majumdar, DK; Sachdeva, S | 2 |
| Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N | 1 |
| Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK | 1 |
| Alp, E; Demiraslan, H; Doganay, M; Kontas, O; Ture, Z | 1 |
| Deepika, G; Govardhan, P; Prasad, GS; Sashidhar, RB; Vakdevi, V | 1 |
| Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR | 1 |
| Murai, N; Naito, M; Nakano, T; Ohmichi, M; Ohmichi, Y; Oshibuchi, H; Sato, J; Takeshita, N; Yasui, M | 1 |
| Fernández-Torres, J; López-Reyes, A; Martínez-Flores, K; Martínez-Nava, GA; Zamudio-Cuevas, Y | 1 |
| Boatto, G; Burrai, L; Chegaev, K; Cristiano, C; De Caro, C; Gazzano, E; Lazzarato, L; Magliocca, S; Marabello, D; Marini, E; Nieddu, M; Riganti, C; Rimoli, MG; Rolando, B; Russo, R; Sodano, F | 1 |
| Chaudhari, PS; Chitlange, SS; Nanda, RK | 1 |
| Costa, FV; Kalueff, AV; Quadros, VA; Rosa, LV; Rosemberg, DB; Santos, ARS | 1 |
| Craciun, AM; Marin, L; Mititelu Tartau, L; Pinteala, M | 1 |
| Andreev, YA; Dyachenko, IA; Koshelev, SG; Kozlov, SA; Logashina, YA; Maleeva, EE; Osmakov, DI; Palikov, VA; Palikova, YA | 1 |
| Chenu, C; Chessell, IP; Luiz, AP; Santana-Varela, S; Ter Heegde, F; Welsh, F; Wood, JN | 1 |
| Cardoso, LCP; Lopes, MJP; Nobre, MEP; Pinto, NB; Pires, GM; Rodrigues, LMR; Silva, MR; Viana, GSB | 1 |
| Beskhmelnitsyna, EA; Kulikov, AL; Peresypkina, AA; Pokrovskii, MV; Varavin, EI | 1 |
| Fujiwara, Y; Higashimori, A; Hosomi, S; Itani, S; Kamata, N; Nadatani, Y; Nagami, Y; Nakata, A; Otani, K; Shiba, M; Shimada, S; Sugimura, N; Taira, K; Tanaka, F; Tanigawa, T; Watanabe, T; Yamagami, H | 1 |
| Ahmed, T; Ahsan, CR; Al Shoyaib, A; Archie, SR; Chowdhury, FA; Faruk, A | 1 |
| Apostolova, EG; Draganova-Filipova, MN; Kokova, VY; Lukanov, JB; Pilicheva, BA; Zagorchev, PI | 1 |
| Basu, SK; Das, A; Jana, S; Nayak, AK; Sen, KK | 1 |
| Bhandari, A; Gaur, PK; Kumar, Y; Mishra, S; Purohit, S | 1 |
| Becker, KG; D'Souza, T; Morin, PJ; Valle, BL; Wersto, RP; Wood, WH; Zhang, Y | 1 |
| Carmona-Díaz, E; Cortés-Peñaloza, JL; Guzmán-Priego, CG; Rocha-González, HI; Torres-López, JE | 1 |
| Agis, ER; Demirel-Yilmaz, E; Ercan, N; Uludag, MO | 1 |
| Adedokun, MO; Attama, AA; Kenechukwu, FC; Momoh, MA; Odo, CE | 1 |
| Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E | 1 |
| Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM | 1 |
| Chaudhary, H; Kohli, K; Kumar, V | 1 |
| Hayashi, E; Higuchi, A; Hoshino, T; Ishihara, T; Mizushima, T; Nakamura, S; Sawazaki, R; Tahara, K; Tsubota, K; Usui, S | 1 |
| Helen, A; Krishnan, K; Mathew, LE; Vijayalakshmi, NR | 1 |
| Arnold, G; Bjordal, JM; Frigo, L; Leal-Junior, EC; Lopes-Martins, RA; Magdalou, J; Marcos, RL; Pallotta, R; Rahouadj, R; Torres-Silva, R | 1 |
| Bhandari, AB; Dhokchawle, BV | 1 |
| de Souza, CT; Dohnert, LH; Dohnert, MB; Ferreira, GK; Paula, MM; Silveira, PC; Zanoni, ET | 1 |
| Boakye, CH; Godugu, C; Mendonca Faria, HA; Patel, AR; Singh, M; Somagoni, J; Zucolotto, V | 1 |
| Ganesh, M; Hemalatha, P; Jang, HT; Jeon, UJ; Peng, MM; Saravanakumar, A; Ubaidulla, U | 1 |
| Bannon, AW; Joshi, SK; Zhu, CZ | 1 |
| Bindu, DT; Chowdary, VH; Haritha, K; Raju, YP; Satyanarayana, RP; Vandana, KR; Vinesha, V | 1 |
| Datar, PA; Limaye, SA | 1 |
| Hernandez, B; Mally, A; Morissey, B; Pennington, SR; Ramm, S; Rooney, C | 1 |
| King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY | 1 |
| Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A | 1 |
| Aydogmus, Y; Buyukserbetci, M; Dadali, M; Eroglu, M; Hascicek, AM; Huri, E; Kilinc, AS; Ogus, E; Ozer, E | 1 |
| Barbosa, MA; Benz, K; Boldt, A; Gonçalves, RM; Ignatius, A; Nagl, I; Neidlinger-Wilke, C; Pereira, CL; Teixeira, GQ; Wilke, HJ | 1 |
| Popov, OS; Shalamay, AS; Shebeko, SK; Zupanets, IA | 1 |
| Angolkar, T; Buttar, HS; Kaur, G; Yadav, R | 1 |
| Kilic, S; Kulualp, K | 1 |
| Boonen, B; Bosmans, JW; Derikx, JP; Grootjans, J; Hulsewé, KW; Poeze, M; Reisinger, KW; Sastrowijoto, P; Schellekens, DH | 1 |
| Amdekar, S; Singh, V | 1 |
| Chen, WS; Chung, HY; Liao, AH; Yeh, MK | 1 |
| Choi, MR; Fernandez, BE; Gorzalczany, S; Mikusic, NLR; Penna, SLD; Roson, MI; Toblli, JE; Zotta, E | 1 |
| Greeshma, P; Janardhanan, KK; Neethu, MN; Pandey, M; Ravikumar, KS; Zuhara, KF | 1 |
| Doan, V; Huang, J; Huang, R; Lai, Z; Lin, X; Nguyen, V; Tang, X; Wei, J; Xie, Q | 1 |
| Kumar, VL; Pandey, A | 1 |
| Aksoy, A; Altunkaynak, B; Çokluk, C; Elibol, E; Kaplan, S; Onger, M; Türkmen, AP; Yurt, K | 1 |
| Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V | 1 |
| Dyuizen, IV; Kasyanov, SP; Kipryushina, YO; Latyshev, NA; Manzhulo, IV; Ogurtsova, OS; Tyrtyshnaia, AA | 1 |
| Banerjee, A; Jana, S; Maiti, S; Sen, KK | 1 |
| Kale, MA; Kuberkar, SV; Nawale, RB; Peharkar, MR | 1 |
| El-Shafei, RA; Saleh, RM | 1 |
| Abrishami, M; Hoseini, H; Jadidi, K; Naderi, M; Panahi, Y | 1 |
| Beckmann, H; Krügel, U; Schaefer, M; Straub, I | 1 |
| Barcelos, RP; Bresciani, G; Cuevas, MJ; González-Gallego, J; Martínez-Flórez, S; Soares, FAA | 1 |
| Abdulla, MM; Hosni, HM | 1 |
| Bassiouny, K; Hamed, MR; Hassanein, NM; Talaat, RM | 1 |
| Mythilypriya, R; Sachdanandam, P; Shanthi, P | 1 |
| Balal, M; Besen, A; Dogan, A; Gonlusen, G; Inal, T; Kibar, M; Kose, F; Paydas, S | 1 |
| Favre, J; Henry, JP; Lallemand, F; Marie, I; Richard, V; Solans, V; Thuillez, C | 1 |
| Biton, IE; Elron-Gross, I; Glucksam, Y; Margalit, R | 1 |
| Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J | 1 |
| Capuano, A; De Corato, A; Dello Russo, C; Navarra, P; Treglia, M; Tringali, G | 1 |
| Eter, EG; Haddad, A; Karam-Sarkis, D; Khazzaka, A; Mneimneh, W; Sarkis, R | 1 |
| Walker, TD | 1 |
| Alagarsamy, V; Parthiban, P; Shankar, D; Sheorey, RV; Solomon, VR | 1 |
| Dastidar, SG; Dutta, NK; Mazumdar, K; Park, JH | 2 |
| Cohen, MP; Shearman, CW | 1 |
| Bansal, Y; Goel, RK; Niazi, J; Singh, P | 1 |
| Barañano, DE; Durairaj, C; Edelhauser, HF; Handa, JT; Kim, SJ; Kompella, UB | 1 |
| Biddlestone, L; Dolan, S; Gunn, MD; Nolan, AM | 1 |
| Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C | 1 |
| McDougall, JJ; Schuelert, N | 1 |
| Arora, B; Arora, R; Bali, M; Bansal, S; Gill, NS; Muthuraman, A; Sharma, PD; Sood, S | 1 |
| Gruber, S; Jensen-Jarolim, E; Kinaciyan, T; Pali-Schöll, I; Riemer, AB; Untersmayr, E | 1 |
| Aslan, A; Aygun, H; Cakir, A; Halici, Z; Odabasoglu, F; Suleyman, H; Tanas, S | 1 |
| de Oliveira Costa, H; Franco, M; Miszputen, SJ; Oshima, CT; Paiotti, AP; Ribeiro, DA | 1 |
| Castañeda-Hernández, G; Ortiz, MI; Salazar-Morales, UE; Trocóniz, IF; Vásquez-Bahena, DA | 1 |
| Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR | 1 |
| Kaur, J; Sanyal, SN | 3 |
| Boelsterli, UA; Gavillet, B; LoGuidice, A; Proli, A; Ramirez-Alcantara, V | 1 |
| Dua, K; Pabreja, K; Padi, SS | 1 |
| Bleumink, R; Bol-Schoenmakers, M; Hassing, I; Ludwig, I; Marcondes Rezende, M; Mouser, E; Pieters, RH; Smit, JJ | 1 |
| Colbatzky, F; Göggel, R; Nickolaus, P; Peter, D | 1 |
| Grunewald, M; Mayorek, N; Naftali-Shani, N | 1 |
| Beasley, R; Eyers, S; Perrin, K; Shirtcliffe, P; Weatherall, M | 1 |
| El-Ghazaly, MA; El-Naby, DH; Khayyal, MT | 1 |
| Chakraborty, S; Dinda, SC; Khanam, N; Khandai, M; Patra, ChN; Sen, KK; Sharma, A | 1 |
| Chambers, MG; Jassal, K; Johnson, MP; McDougall, JJ; Oskins, JL; Schuelert, N | 1 |
| Barsoum, FF | 1 |
| Blagaic, AB; Brcic, L; Coric, M; Djakovic, Z; Djuzel, V; Drmic, D; Dzidic, S; Filipovic, M; Franjic, S; Gjurasin, M; Ilic, S; Klicek, R; Kolenc, D; Radic, B; Romic, Z; Seiwerth, S; Sever, M; Sikiric, P; Stambolija, V; Stupnisek, M; Zarkovic, K; Zoricic, I | 1 |
| Chevalier, J; Derkinderen, P; Mahé, MM; Neunlist, M; Savidge, T; Urvil, P; Van Landeghem, L; Wedel, T | 1 |
| Kikuchi, S; Konno, S; Sasaki, N; Sekiguchi, M | 1 |
| Abichaker, G; Htet, K; Jaskoll, T; Melnick, M; Sedghizadeh, P | 1 |
| Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S | 1 |
| Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN | 1 |
| Bafna, PA; Deshpande, AD; Kshirsagar, AD; Lende, AB; Muley, MM; Naik, SR; Patil, RR | 1 |
| Chouhan, CS; Singh, NK; Singh, SK; Sridevi, K | 1 |
| Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ | 1 |
| Eid, NM; Hassan, GS; Nissan, YM; Ragab, FA | 1 |
| Fukami, T; Higuchi, S; Nakajima, M; Tsuneyama, K; Yano, A; Yokoi, T | 1 |
| Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ | 1 |
| Cho, HR; Kim, JW; Ku, SK | 1 |
| Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M | 1 |
| Ichibangase, T; Imai, K; Ito, K; Kishikawa, N; Kuroda, N; Masuyama, R; Ohyama, K; Shiokawa, A | 1 |
| Franco, M; Marchi, P; Miszputen, SJ; Neto, RA; Oshima, CT; Paiotti, AP; Ribeiro, DA; Silva, RM | 1 |
| Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y | 1 |
| Afzal, M; Afzal, O; Alam, J; Anwar, F; Gupta, G; Gupta, R; Hakeem, KR; Kazmi, I; Pravez, M; Rahman, M | 1 |
| Imamachi, N; Narai, Y; Saito, Y | 1 |
| Abd El Latif, HA; Asaad, GF; El-Hussiny, M; Mahmoud, SS | 1 |
| Gupta, M; Haldar, PK; Mazumder, UK; Naskar, S; Pramanik, G; Saha, P | 1 |
| De Souza, CT; Dohnert, LH; Dohnert, MB; Luciano, TF; Paula, MM; Possato, JC; Venâncio, M; Zeferino, RC; Zugno, AI | 1 |
| Bogdahn, U; Chirasani, SR; Gottfried, E; Grauer, OM; Gronwald, W; Hau, P; Hochrein, J; Kreutz, M; Leukel, P; Neumann, B; Oefner, PJ; Stadler, K | 1 |
| Guo, HF; Li, P; Liu, L; Liu, XD; Zhang, J | 1 |
| Agalave, NM; Baharpoor, A; Bas, DB; Codeluppi, S; Holmdahl, R; Lundberg, J; Nandakumar, KS; Sandor, K; Su, J; Svensson, CI | 1 |
| Castañeda-Hernández, G; Jiménez-Andrade, JM; Ortiz, MI; Trocóniz, IF; Vásquez-Bahena, D; Vélez de Mendizábal, N | 1 |
| Bhatia, M; Garg, LN; Gupta, S; Kumar, S | 1 |
| Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C | 1 |
| Kanazawa, T; Kishida, T; Kuroda, J; Onozato, T; Tanaka, S | 1 |
| Basu, SK; Jana, S; Nayak, AK; Saha, A; Sen, KK | 1 |
| Büyükokuroğlu, ME | 1 |
| Côté, CH; Frémont, P; Lapointe, BM | 1 |
| Abacioglu, N; Altug, S; Demirkay, B; Tunçtan, B; Uludag, O | 1 |
| Asnis, GM; De La Garza, R | 1 |
| Cowan, A; Raffa, RB; Tallarida, RJ | 1 |
| Alagarsamy, V; Murugananthan, G; Venkateshperumal, R | 1 |
| Anagawa, A; Kida, H; Kimura, T; Matsuda, K; Ochiai, K; Park, CH; Sunden, Y; Umemura, T | 1 |
| Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L | 1 |
| Hashimoto, T; Hoshina, F; Igarashi, A; Kohno, S; Notsu, Y; Toyoda, Y; Yamada, M | 1 |
| Amir, M; Shikha, K | 1 |
| Alberti, LR; Chaves, DN; Pereira, WA; Petroianu, A | 1 |
| Hota, D; Pandhi, P | 1 |
| Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A | 1 |
| Jarrar, BM; Mubarak, MM; Taib, NT | 1 |
| Berry, C; Dawson, J; Du, Z; Esser, R; Fox, A; Fujimoto, RA; Haston, W; Kimble, EF; Koehler, J; Marshall, PJ; Peppard, J; Quadros, E; Quintavalla, J; Toscano, K; Urban, L; van Duzer, J; Zhang, X; Zhou, S | 1 |
| Jeon, WK; Kim, EJ; Kim, JW | 1 |
| Dal Cin, E; Dell'Antonio, G; Ferrero, ME; Foglieni, C; Franzone, JS; Fulgenzi, A; Ticozzi, P | 1 |
| Atalay, H; Aytekin, FO; Bir, F; Onem, G; Ors Kaya, S; Saçar, M | 1 |
| Ciulla, TA; Cornell, TL; Criswell, MH; Danis, RP; Hu, W; Lambrou, GN; Ottlecz, A | 1 |
| Acencio, MM; Antonangelo, L; Marchi, E; Paz, PF; Teixeira, LR; Vargas, FS; Vaz, MA | 1 |
| Hsieh, YL | 1 |
| Flach, AJ; Waterbury, LD | 1 |
| Ketonen, J; Leinonen, M; Paakkari, I; Saikku, P; Törmäkangas, L | 1 |
| Castañeda-Hernández, G; Ortiz, MI; Picazo, A | 1 |
| Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A | 1 |
| Cutler, JL; Labadie, RF; Wall, M | 1 |
| Aslan, H; Baş, O; Gokcimen, A; Kaplan, S; Rağbetli, MC; Tunc, AT; Yazici, AC | 1 |
| Apt, AS; Evstifeev, VV; Kondrat'eva, AV; Kondrat'eva, TK; Petrovskaia, SN; Rubakova, EI; Sosunov, VV | 1 |
| Furlong, EB; Muccillo-Baisch, AL; Parker, AG; Peraza, GG; Sena, J; Silva, ES; Soares, MC; Vaz, MR | 1 |
| Alagarsamy, V; Murugan, M; Rajesh, R; Shankar, D; Siddiqui, AA | 1 |
| Aydos, RD; Figueiredo, AS; Inouye, CM; Sassioto, MC | 1 |
| Arborelius, L; Berge, OG; Brodin, E; Heilborn, U | 1 |
| Biddlestone, L; Corbett, AD; Dolan, S | 1 |
| Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC | 1 |
| Fu, YF; Ni, J; Ren, J; Shu, YY; Tang, W; Wang, H; Wang, MW; Yang, YF; Zhong, XG; Zhu, YN; Zuo, JP | 1 |
| Alagarsamy, V; Anjana, G; Beevi, AJ; Deepa, G; Dhanabal, K; Murugesan, B; Parthiban, P; Rajkumar, S | 1 |
| Bhatia, M; Li, L; Moore, PK; Sidhapuriwala, J; Sparatore, A | 1 |
| Bhatia, M; Moore, PK; Sidhapuriwala, JN; Sparatore, A | 1 |
| Birkenmeier, K; Felix, SB; Janke, I; Krieg, T; Labitzke, C; Landsberger, M; Prange, T; Schunck, WH; Stangl, V; Staudt, A; Trimpert, C | 1 |
| Cunha, DC; de-Sales, MP; Lyra, IL; Moura, RM; Queiroz, AF; Ribeiro, JK; Santos, EA | 1 |
| Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T | 1 |
| Chaves, MH; Cunha, GM; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA | 1 |
| Hernandez-Vaquero, D; Sandoval, MA | 1 |
| Ahuja, A; Ali, J; Aqil, M; Baboota, S; Shafiq, S; Shakeel, F | 1 |
| Boĭkova, SP; Borisova, EN; Chumakov, AA; Dmitrieva, LA; Ershova, NI | 2 |
| McKnight, GW; Wallace, JL | 1 |
| Albrecht, DM; Krieter, H; Segiet, W; Stieber, C; van Ackern, K | 1 |
| Bitensky, L; Chambers, MG; Chayen, J | 1 |
| Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T | 1 |
| Alió, JL; Laria, C; Ruiz-Moreno, JM | 1 |
| Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T | 1 |
| Heller, A; Koch, T; Neuhof, H; Patt, B; Schmeck, J; van Ackern, K | 1 |
| Janzen, R; Koch, T; Münter, K; Neuhof, H; Schmeck, J | 1 |
| Amano, S; Kaji, Y; Obata, H; Ohashi, T; Oshika, T; Sakai, H; Shirasawa, E; Tsuru, T; Yamashita, H | 1 |
| Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I | 1 |
| Jabbar, A; Paul, RK; Rashid, MA | 1 |
| Gluth, H; Koch, T; Konrad, C; Krafft, P; Schmeck, J; Schöffel, S; Wendel-Wellner, M | 1 |
| Kobayashi, F; Kondo, Y; Matsui, H; Momo, K; Murata, Y; Muto, H; Nakahara, A; Shiba, R | 1 |
| Dervisoglu, S; Eryavuz, M; Gencosmanoglu, BE | 1 |
| Abe, M; Hori, T; Oka, T; Takahashi, S | 1 |
| Cornefjord, M; Olmarker, K; Otani, K; Rydevik, B | 2 |
| Chan, LY; Chiu, PY; Lau, TK; Siu, SS | 1 |
| Cimşit, M; Eroglu, L; Sümen, G | 1 |
| Miranda, HF; Pinardi, G; Sierralta, F | 1 |
| Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM | 1 |
| Björkman, RL; Hallman, KM; Hedner, J; Hedner, T; Henning, M | 1 |
| Attal, N; Guilbaud, G | 1 |
| Martel-Pelletier, J; Pelletier, JP | 1 |
| Dowling, EJ; Parke, DV; Symons, AM | 1 |
| Cash, WD; Della Puca, RA; Ford, CJ; Rowland, JM | 1 |
4 review(s) available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
Emergent nanotherapies in microcrystal-induced arthritis.
Topics: Animals; Calcium Phosphates; Chitosan; Chondrocalcinosis; Crystal Arthropathies; Diclofenac; Disease Models, Animal; Gold; Humans; Inflammation Mediators; Nanoparticles; Peptide Hydrolases; Urate Oxidase; Uric Acid | 2018 |
Pharmacological attempts to reduce posterior capsule opacification after cataract surgery--a review.
Topics: Animals; Cataract Extraction; Corneal Opacity; Dexamethasone; Diclofenac; Disease Models, Animal; Humans; Lens Capsule, Crystalline; Lens Implantation, Intraocular; Postoperative Complications; Tretinoin | 2008 |
The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Diclofenac; Disease Models, Animal; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice | 2009 |
The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Diclofenac; Disease Models, Animal; Humans; Influenza, Human; Orthomyxoviridae Infections | 2010 |
3 trial(s) available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
Oral misoprostol does not protect the kidneys from diclofenac induced toxicity: data from an unilateral ureteral obstructive rat model.
Topics: Administration, Oral; Animals; Diclofenac; Disease Models, Animal; Female; Kidney; Misoprostol; Rats; Rats, Wistar; Ureteral Obstruction | 2015 |
Efficacy of systemic diclofenac sodium on intravitreal concentration.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Chromatography, High Pressure Liquid; Corneal Injuries; Diclofenac; Disease Models, Animal; Eye Burns; Rabbits; Vitreous Body | 2018 |
Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Adhesion; Bacterial Translocation; Cattle; Colostrum; Diclofenac; Disease Models, Animal; Enterobacteriaceae; Glutamine; Intestinal Mucosa; Male; Milk; Organ Specificity; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2005 |
238 other study(ies) available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Mice; Peptide Fragments | 2006 |
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Topics: Amines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Histamine Antagonists; Ligands; Mice; Molecular Structure; Pain; Pyrimidines; Rats; Receptors, Histamine | 2008 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Hydrogen Bonding; Imides; Male; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Sheep; Stereoisomerism; Structure-Activity Relationship | 2011 |
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Topics: Animals; Benzoic Acid; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Half-Life; Humans; Inhibitory Concentration 50; Pain; Picolines; Protein Binding; Rats; Receptors, Prostaglandin E, EP4 Subtype; Structure-Activity Relationship | 2016 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Imidazolidines; Indazoles; Iodoacetic Acid; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Osteoarthritis; Pain; Pain Measurement; Pyrroles; Rats; Sodium Channel Blockers; Structure-Activity Relationship | 2016 |
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
Topics: A549 Cells; Administration, Oral; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Guinea Pigs; Half-Life; Humans; Hyperalgesia; Imidazoles; Inhibitory Concentration 50; Microsomes, Liver; Prostaglandin-E Synthases; Rats; Structure-Activity Relationship | 2017 |
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Indolizines; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Ulcer | 2017 |
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hypolipidemic Agents; Male; Mice; Mice, Hairless; Molecular Structure; Morpholines; Oxidative Stress; Rats; Structure-Activity Relationship; Thiazines | 2017 |
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.
Topics: Animals; Disease Models, Animal; Humans; Mice; Structure-Activity Relationship; Triazines; Tropolone; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2018 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship | 2021 |
Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Artemia; Cell Survival; Diphenylamine; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hydrophobic and Hydrophilic Interactions; Macrophages; Mice; Molecular Structure; RAW 264.7 Cells; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2021 |
Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bilirubin; Biological Availability; Boswellia; Diclofenac; Disease Models, Animal; Malondialdehyde; Methotrexate; Plant Extracts; Triterpenes | 2022 |
Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Diclofenac; Disease Models, Animal; Hyaluronic Acid; Injections, Intra-Articular; Iodoacetic Acid; Male; Osteoarthritis, Knee; Pain; Rats; Rats, Sprague-Dawley | 2022 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2023 |
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease Models, Animal; Immunoglobulin G; Immunoglobulin M; Inflammation; Intestinal Mucosa; Mice; Necrosis; Peroxidase; Tumor Necrosis Factor-alpha | 2023 |
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from
Topics: Aging; Animals; Bone Development; Cartilage; Chondrocytes; Diclofenac; Disease Models, Animal; Estrogen Receptor alpha; Flavonoids; Gallic Acid; Gene Expression Regulation; Humans; Iodoacetates; Matrix Metalloproteinase 13; Metabolism; Osteoarthritis; Ovariectomy; Plant Extracts; Primulaceae; Rats | 2019 |
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Stomach Ulcer; Treatment Outcome | 2019 |
Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Drug Synergism; Endotoxins; Heme Oxygenase (Decyclizing); Ischemia; Liver; Liver Function Tests; Male; Mitochondria, Liver; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species | 2019 |
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coordination Complexes; Cyclization; Diclofenac; Disease Models, Animal; Drug Design; Inflammation; Isoxazoles; Ketones; Molecular Structure; Oxidation-Reduction; Rats; Structure-Activity Relationship; Tin Compounds | 2019 |
Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Ophthalmic; Animals; Contact Lenses, Hydrophilic; Cornea; Diclofenac; Disease Models, Animal; Drug Combinations; Drug Liberation; Humans; Hydrogels; Parasitic Sensitivity Tests; Swine; Voriconazole | 2020 |
Effects of phonophoresis with diclofenac linked gold nanoparticles in model of traumatic muscle injury.
Topics: Animals; Catalase; Diclofenac; Disease Models, Animal; Glutathione; Gold; Hyperalgesia; Metal Nanoparticles; Muscle, Skeletal; Phonophoresis; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase; Wounds and Injuries | 2020 |
Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model.
Topics: Administration, Oral; Animals; Apigenin; Cytokines; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Glycosides; Iodoacetic Acid; Lamiaceae; Matrix Metalloproteinase 13; Osteoarthritis; Osteoporosis; Ovariectomy; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley | 2020 |
Citryl-imine-PEG-ylated chitosan hydrogels - Promising materials for drug delivery applications.
Topics: Animals; Chitosan; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Hydrogels; Pain; Polyethylene Glycols; Rats | 2020 |
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Glucuronides; Humans; Immunity; Injections, Intraperitoneal; Interleukin-17; Liver; Mice, Transgenic; Protein Interaction Maps; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cytokines; Diclofenac; Disease Models, Animal; Inflammation; Inflammation Mediators; Locomotion; Male; Muscle, Skeletal; Musculoskeletal Pain; Nociception; Nociceptive Pain; Oxidative Stress; Rats, Wistar; Wounds, Nonpenetrating | 2020 |
[Residual Property of SI-613, a Novel Drug for Osteoarthritis, in Knee Joint].
Topics: Animals; Cartilage; Diclofenac; Disease Models, Animal; Hyaluronic Acid; Injections, Intra-Articular; Knee Joint; Male; Osteoarthritis; Rabbits; Synovial Membrane; Time Factors | 2020 |
Reinforced Supramolecular Hydrogels from Attapulgite and Cyclodextrin Pseudopolyrotaxane for Sustained Intra-Articular Drug Delivery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Regeneration; Cyclodextrins; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Humans; Hydrogels; Injections, Intra-Articular; Magnesium Compounds; Osteoarthritis; Poloxamer; Polyethylene Glycols; Rats; Rotaxanes; Silicon Compounds | 2021 |
Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity.
Topics: Abdominal Injuries; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Diterpenes; Gene Expression Regulation; Humans; Intestinal Mucosa; Intestine, Small; Microscopy, Electron, Transmission; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, PAR-2 | 2021 |
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Claudin-1; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Humans; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Male; NF-kappa B; Quinolones; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Ulcer; Zonula Occludens-1 Protein | 2021 |
Development of a novel intraarticular injection of diclofenac for the treatment of arthritis: a preclinical study in the rabbit model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Precipitation; Diclofenac; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Drug Liberation; Female; Injections, Intra-Articular; Male; Nanoparticles; Particle Size; Polymethacrylic Acids; Polyvinyl Alcohol; Rabbits; Serum Albumin, Bovine; Treatment Outcome | 2021 |
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study.
Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytokines; Diclofenac; Disease Models, Animal; Inflammation; Male; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Seeds; Sirtuin 1; STAT3 Transcription Factor; Zingiberaceae | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldehyde; Gastric Mucosa; Inflammation; Male; Pain; Pain Threshold; Plant Extracts; Rats, Long-Evans; Spirulina; Stomach Ulcer | 2020 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Diclofenac; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Edema; Female; Formaldehyde; Neostigmine; Pain; Rats, Sprague-Dawley | 2021 |
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice.
Topics: Administration, Oral; Animals; Catalase; Diclofenac; Disease Models, Animal; Ethanol; Male; Mice; Omeprazole; Oxidative Stress; Peroxidase; Piperidines; Receptors, Adiponectin; Stomach Ulcer; Superoxide Dismutase; Treatment Outcome | 2021 |
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Gout; Herb-Drug Interactions; Joints; Magnoliopsida; Male; Nociception; Pain Management; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Quercetin; Rats, Wistar; Uric Acid | 2021 |
Anti-inflammatory and histopathological studies of leaves extracts of Croton bonplandianus in Albino rats.
Topics: Animals; Anti-Inflammatory Agents; Croton; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Male; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Reactive Oxygen Species | 2021 |
Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbon Tetrachloride; Caspase 3; Caspase 9; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Interleukins; Lacosamide; Liver Diseases; Male; Oxidative Stress; Rats, Wistar; Renal Insufficiency; Seizures; Tumor Necrosis Factor-alpha | 2017 |
Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity).
Topics: Animals; Apoptosis; Biomarkers; Cardiotoxicity; Caspase 3; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Heart Diseases; Kidney Diseases; Lipid Peroxidation; Male; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pulmonary Edema; Rats; Tylosin | 2018 |
Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Cartilage; Collagen Type II; Diclofenac; Dinoprostone; Disease Models, Animal; Down-Regulation; Female; Ficus; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 1; Osteoarthritis; Ovariectomy; Peptide Fragments; Phytotherapy; Plant Extracts; Plant Leaves; Postmenopause; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E | 2017 |
Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Inflammation; Lipids; Nanostructures; Particle Size; Permeability; Rats; Skin | 2017 |
Enhancement of ocular efficacy of aceclofenac using biodegradable PLGA nanoparticles: formulation and characterization.
Topics: Administration, Ophthalmic; Animals; Arachidonic Acid; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Drug Liberation; Eye Diseases; Lactic Acid; Nanoparticles; Particle Size; Permeability; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; X-Ray Diffraction | 2017 |
Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Disease Models, Animal; Hyperalgesia; Ketorolac; Male; Piroxicam; Rats; Rats, Wistar; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Celecoxib; Chromatography, Liquid; Comparative Effectiveness Research; Diclofenac; Disease Models, Animal; Ibuprofen; Inflammation; Male; Naproxen; Pelvic Pain; Prostate; Prostatitis; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2018 |
The role of nonsteroidal anti-inflammatory drugs intramuscular injection in the development and severity of deep soft tissue infection in mice.
Topics: Abscess; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Bacterial Load; Diclofenac; Disease Models, Animal; Female; Inflammation Mediators; Injections, Intramuscular; Interleukin-6; Mice, Inbred BALB C; Sepsis; Soft Tissue Infections; Streptococcal Infections; Streptococcus pyogenes; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Edema; Fenofibrate; Humans; Hypolipidemic Agents; Inhibitory Concentration 50; Male; Rats; Rats, Wistar | 2018 |
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Neuralgia; Oxidative Stress; Pain Measurement; Pain Threshold; Rats, Wistar; Treatment Outcome | 2018 |
Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
Topics: Animals; Chronic Pain; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Muscle, Skeletal; Muscular Disorders, Atrophic; Musculoskeletal Pain; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley | 2018 |
Design, characterization, and evaluation of aceclofenac-loaded Eudragit RS 100 nanoparticulate system for ocular delivery.
Topics: Acrylic Resins; Administration, Ophthalmic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Chemistry, Pharmaceutical; Crystallization; Diclofenac; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Stability; Eye Diseases; Inflammation; Nanoparticles; Neutrophils; Particle Size; Rabbits | 2019 |
Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations.
Topics: Acute Pain; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Caco-2 Cells; Carrageenan; Diclofenac; Disease Models, Animal; Drug Carriers; Drug Compounding; Edema; Galactose; Gastric Mucosa; Humans; Hydrolysis; Intestinal Mucosa; Male; Mice; Permeability; Platelet Aggregation; Prodrugs; Solubility; Stomach Ulcer | 2018 |
Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Male; Mice; Molecular Structure; Nitric Oxide; Picrates; Quinazolines; Rats, Wistar; Structure-Activity Relationship; Thiophenes | 2018 |
Understanding nociception-related phenotypes in adult zebrafish: Behavioral and pharmacological characterization using a new acetic acid model.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Disease Models, Animal; Drug Discovery; Drug Interactions; Female; Male; Morphine; Naloxone; Narcotic Antagonists; Nociception; Posture; Random Allocation; Visceral Pain; Zebrafish | 2019 |
Nitrosalicyl-imine-chitosan hydrogels based drug delivery systems for long term sustained release in local therapy.
Topics: Animals; Chitosan; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Hydrogels; Imines; Male; Nitro Compounds; Nociceptive Pain; Particle Size; Rats; Rats, Wistar; Salicylic Acid; Surface Properties | 2019 |
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Biological Products; Diclofenac; Disease Models, Animal; Humans; Hyperalgesia; Male; Mice; Nociception; Pain; Patch-Clamp Techniques; Peptides; Sea Anemones; Xenopus laevis | 2018 |
Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Behavior, Animal; Cartilage, Articular; Diclofenac; Disease Models, Animal; Gabapentin; Hyperesthesia; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Osteoarthritis, Knee; Weight-Bearing | 2019 |
Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Inflammation; Male; Phonophoresis; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ultrasonic Therapy | 2019 |
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Drug Discovery; Edema; Formaldehyde; Humans; Inflammation; Male; Mice; TRPA1 Cation Channel | 2019 |
Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Diclofenac; Diet, Gluten-Free; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gliadin; Glutens; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Permeability; Phosphorylation; Protein Kinase Inhibitors; Triticum | 2019 |
Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Atorvastatin; Diclofenac; Disease Models, Animal; Drug Combinations; Drug Dosage Calculations; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Prednisolone; Rats; Treatment Outcome | 2020 |
In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations.
Topics: Acrylic Resins; Analgesics; Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Gels; Hyperalgesia; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Soil; Time Factors | 2018 |
Aceclofenac-loaded unsaturated esterified alginate/gellan gum microspheres: in vitro and in vivo assessment.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Carrageenan; Delayed-Action Preparations; Diclofenac; Disease Models, Animal; Glucuronic Acid; Hexuronic Acids; Inflammation; Male; Microspheres; Polysaccharides, Bacterial; Rabbits; Rats; Rats, Sprague-Dawley | 2013 |
Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceramides; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Excipients; Humans; Inflammation; Male; Nanoparticles; Oleic Acid; Palmitic Acid; Particle Size; Rats; Rats, Wistar; Skin Absorption | 2014 |
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; E2F1 Transcription Factor; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Mice; Mice, Nude; Ovarian Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Antinociceptive synergy between diclofenac and morphine after local injection into the inflamed site.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Injections; Male; Morphine; Rats; Rats, Wistar | 2013 |
The anti-inflammatory effect of diclofenac is considerably augmented by topical capsaicinoids-containing patch in carrageenan-induced paw oedema of rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Capsicum; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Fruit; Herb-Drug Interactions; Injections, Intramuscular; Injections, Subcutaneous; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Sensory System Agents; Transdermal Patch | 2013 |
Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres.
Topics: Acrylic Resins; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Drug Carriers; Female; Hydrogen-Ion Concentration; Inflammation; Male; Microspheres; Particle Size; Rats, Wistar; Solubility; Technology, Pharmaceutical | 2014 |
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carotenoids; Carrageenan; Cyclohexenes; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Inflammation; Male; Neutrophil Infiltration; Pain; Pain Threshold; Rats; Rats, Wistar; Terpenes; Time Factors | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Pain; Pregabalin; Reserpine; Serotonin; Spider Venoms; Spiders | 2014 |
A novel nano-carrier transdermal gel against inflammation.
Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Carrageenan; Chemistry, Pharmaceutical; Chromatography, Liquid; Curcumin; Diclofenac; Disease Models, Animal; Drug Administration Schedule; Drug Carriers; Drug Combinations; Drug Stability; Gels; Inflammation; Male; Nanoparticles; Nanotechnology; Rats, Wistar; Skin; Skin Irritancy Tests; Tandem Mass Spectrometry; Technology, Pharmaceutical | 2014 |
Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Diclofenac; Disease Models, Animal; Dry Eye Syndromes; Epithelium, Corneal; Male; Osmotic Pressure; Rats; Rats, Sprague-Dawley; Transcription Factors; Treatment Outcome | 2014 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; India; Inflammation; Interleukin-6; Leukocytes, Mononuclear; Male; Medicine, Traditional; NF-kappa B; Oleanolic Acid; Plant Leaves; Rats; Rats, Sprague-Dawley | 2014 |
The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagenases; Cyclooxygenase 2; Diclofenac; Disease Models, Animal; Gene Expression; Interleukin-10; Interleukin-6; Low-Level Light Therapy; Male; Rats; Rats, Wistar; Tendinopathy; Tumor Necrosis Factor-alpha | 2015 |
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Drug Design; Drug Stability; Edema; Female; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Male; Mice; Pain; Prodrugs; Rats, Wistar; Risk Assessment; Solubility; Stomach Ulcer | 2015 |
Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Gold; Inflammation; Interleukin-1beta; Male; Metal Nanoparticles; Phonophoresis; Random Allocation; Rats; Rats, Wistar; Tendinopathy; Tumor Necrosis Factor-alpha | 2015 |
Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Capsaicin; Cell Proliferation; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Drug Stability; Emulsions; Gels; Humans; Imiquimod; Immunohistochemistry; In Vitro Techniques; Inflammation; Keratinocytes; Micelles; Microdialysis; Microscopy, Atomic Force; Nanoparticles; Organ Size; Permeability; Psoriasis; Rats; Rheology; Skin Absorption; Spleen | 2014 |
Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chitosan; Crystallization; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Glucuronic Acid; Hexuronic Acids; Inflammation; Male; Particle Size; Rats; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2015 |
Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Drug Stability; Edema; Gels; Hydrogen-Ion Concentration; Inflammation; Male; Rats; Rats, Wistar; Skin Absorption; Viscosity | 2015 |
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
Topics: Acetic Acid; Analgesics; Animals; Benzimidazoles; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Hyperkinesis; Inflammation; Male; Mannich Bases; Mice; Pain; Structure-Activity Relationship | 2015 |
Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration.
Topics: Animals; Biomarkers; Blood Proteins; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diclofenac; Disease Models, Animal; Lipopolysaccharides; Liver; Male; Proteomics; Rats, Sprague-Dawley; Risk Assessment; Tandem Mass Spectrometry | 2015 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Diclofenac; Disease Models, Animal; Female; Gyrus Cinguli; Lidocaine; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Rats; Rats, Inbred F344 | 2015 |
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Extremities; Female; Gelsolin; Inflammation; Mice, Inbred BALB C; Tail | 2015 |
A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Diclofenac; Disease Models, Animal; Equipment Design; Equipment Failure Analysis; Humans; In Vitro Techniques; Intervertebral Disc; Intervertebral Disc Degeneration; Lipopolysaccharides; Mesenchymal Stem Cell Transplantation; Organ Culture Techniques; Swine; Tissue Engineering; Treatment Outcome | 2016 |
Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Diclofenac; Disease Models, Animal; Drug Combinations; Female; Male; Osteoarthritis; Quercetin; Rats | 2016 |
Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cattle; Colostrum; Diclofenac; Disease Models, Animal; Disk Diffusion Antimicrobial Tests; Edema; Inflammation; Rats, Wistar | 2016 |
Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome.
Topics: Animals; Anti-Inflammatory Agents; Blinking; Cyclosporine; Diclofenac; Disease Models, Animal; Dry Eye Syndromes; Female; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Tears | 2016 |
Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing.
Topics: Anastomosis, Surgical; Anastomotic Leak; Angiogenesis Inducing Agents; Animals; Chi-Square Distribution; Colorectal Surgery; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Knockout; Random Allocation; Real-Time Polymerase Chain Reaction; Risk Assessment; Sensitivity and Specificity; Wound Healing | 2017 |
Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Diclofenac; Disease Models, Animal; Down-Regulation; Edema; Extremities; Female; Inflammation Mediators; Joint Diseases; Lacticaseibacillus rhamnosus; Probiotics; Rats; Rats, Wistar | 2016 |
Efficacy of Combined Ultrasound-and-Microbubbles-Mediated Diclofenac Gel Delivery to Enhance Transdermal Permeation in Adjuvant-Induced Rheumatoid Arthritis in the Rat.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Gels; Male; Microbubbles; Permeability; Rats; Rats, Sprague-Dawley; Treatment Outcome; Ultrasonic Waves | 2016 |
Synthesis and Biological Evaluation of New N-(4-Substituted phenyl)glycine Derivatives as Potential Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Drug Design; Drug Discovery; Edema; Glycine; Male; Molecular Structure; Rats, Wistar; Structure-Activity Relationship | 2016 |
Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes).
Topics: Agaricales; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Complex Mixtures; Diclofenac; Disease Models, Animal; Edema; Fruiting Bodies, Fungal; Male; Mice; Mycelium; Picrates; Sulfonic Acids | 2016 |
Protection from diclofenac-induced liver injury by Yulangsan polysaccharide in a mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; Disease Models, Animal; Liver; Liver Function Tests; Mice; Polysaccharides | 2016 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, Animal; Edema; Female; Glutathione; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Male; Metformin; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2016 |
Effects of diclofenac sodium on the hippocampus of rats with acute subdural hematoma: histological, stereological, and molecular approach.
Topics: Animals; Diclofenac; Disease Models, Animal; Hematoma, Subdural, Acute; Hippocampus; Immunohistochemistry; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley | 2016 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; Interleukin-1beta; Interleukin-6; Kindling, Neurologic; Male; Motor Activity; Rats, Wistar; Seizures; Tumor Necrosis Factor-alpha | 2016 |
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Diclofenac; Disease Models, Animal; Docosahexaenoic Acids; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Sciatica; Spinal Cord Dorsal Horn; Substance P; Time Factors; Weight-Bearing | 2016 |
Gelatin-carboxymethyl tamarind gum biocomposites: In vitro characterization & anti-inflammatory pharmacodynamics.
Topics: Animals; Anti-Inflammatory Agents; Calorimetry, Differential Scanning; Diclofenac; Disease Models, Animal; Drug Carriers; Drug Liberation; Edema; Female; Gelatin; Hydrogels; Male; Microscopy, Electron, Scanning; Polysaccharides; Rats; Spectroscopy, Fourier Transform Infrared; Tamarindus | 2016 |
Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Edema; Mass Spectrometry; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Rats, Wistar; Spectrophotometry, Infrared; Stomach Ulcer; Structure-Activity Relationship; Tetrazoles | 2016 |
Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cytoprotection; Diclofenac; Disease Models, Animal; Kidney; Male; Oxidative Stress; Rats, Wistar; Uremia; Vitamin E | 2016 |
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Maprotiline; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Pain; Pain Threshold; Patch-Clamp Techniques; Pregnenolone; Primidone; Rats; TRPM Cation Channels | 2017 |
Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway.
Topics: Animals; Cyclooxygenase 2; Diclofenac; Disease Models, Animal; Inflammation; Interleukin-1beta; Interleukin-6; Male; Muscle, Skeletal; NF-kappa B; Nitric Oxide Synthase Type II; Physical Conditioning, Animal; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2017 |
Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Carrageenan; Diclofenac; Disease Models, Animal; Female; Hot Temperature; Inflammation; Lethal Dose 50; Male; Mice; Molecular Structure; Nitriles; Pain; Pain Measurement; Pain Threshold; Pyridines; Rats; Spectrum Analysis; Structure-Activity Relationship | 2008 |
Influence of protein malnutrition on induction and treatment of inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Diclofenac; Diet, Protein-Restricted; Disease Models, Animal; Inflammation; Interleukin-12; Interleukin-1beta; Lymphocyte Count; Lymphocytes; Male; Malnutrition; Mice; Mice, Inbred Strains | 2006 |
Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cotton Fiber; Diclofenac; Disease Models, Animal; Edema; Freund's Adjuvant; Inflammation; Male; Medicine, Ayurvedic; Nuts; Plant Extracts; Rats; Rats, Wistar; Semecarpus; Time Factors | 2008 |
The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Creatinine; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Furosemide; Immunohistochemistry; Kidney; Kidney Function Tests; Male; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Urinalysis | 2009 |
Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1.
Topics: Acetylcholine; Animals; Bosentan; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Vasodilation; Vasodilator Agents | 2008 |
A novel Diclofenac-carrier for local treatment of osteoarthritis applying live-animal MRI.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen Type I; Delayed-Action Preparations; Diclofenac; Disease Models, Animal; Drug Carriers; Drug Compounding; Magnetic Resonance Imaging; Male; Mice; Microscopy, Electron, Scanning; Osteoarthritis; Phosphatidylethanolamines; Rats; Rats, Wistar; Surface Properties | 2009 |
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Morphine; Pain; Pain Threshold; Rats; Rats, Wistar; Time Factors | 2009 |
Antinociceptive activity of buprenorphine and lumiracoxib in the rat orofacial formalin test: a combination analysis study.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Facial Pain; Injections, Intraperitoneal; Male; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu | 2009 |
Does diclofenac increase the risk of cervical necrotizing fasciitis in a rat model?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fasciitis, Necrotizing; Gram-Positive Bacterial Infections; Neck; Opportunistic Infections; Peptostreptococcus; Rats; Rats, Wistar; Risk Factors | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; Female; Male; Mice; Pain Measurement; Quinazolinones; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2009 |
Reduction of Abeta42 in brains of transgenic APPswe mice by 2-3-chlorophenylaminophenylacetate.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Mice; Mice, Transgenic; Peptide Fragments | 2009 |
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitaceae; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fever; Inflammation; Male; Medicine, Traditional; Mice; Morphine; Pain; Plant Extracts; Plant Leaves; Rats; Rats, Wistar | 2009 |
Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Injections; Ketorolac; Lipopolysaccharides; Male; Rabbits; Treatment Outcome; Uveitis; Vitreous Body | 2009 |
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.
Topics: Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzhydryl Compounds; Carrageenan; Diclofenac; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intradermal; Injections, Spinal; Male; Pain; Pain, Postoperative; Phosphoserine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Escape Reaction; Fluoxetine; Inflammation; Male; Motor Activity; Neuropsychological Tests; Pain; Pain Measurement; Physical Stimulation; Pyrazoles; Rats; Rats, Sprague-Dawley; Scopolamine; Sulfonamides; Thiophenes; Treatment Outcome | 2010 |
Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociceptors in the knee joint of the rat.
Topics: Action Potentials; Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Iodoacetates; Knee Joint; Male; Movement; Neurons, Afferent; Nociceptors; Osteoarthritis, Knee; Pain; Physical Stimulation; Rats; Rats, Wistar; Rotation | 2009 |
Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Citrus; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Male; Mice; Morphine; Pain; Plant Extracts; Rats; Rats, Wistar; Solvents | 2009 |
Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model.
Topics: Animals; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antigen-Antibody Reactions; Diclofenac; Disease Models, Animal; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Female; Gastric Acid; Humans; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Middle Aged; Risk Factors; Skin Tests | 2010 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Indomethacin; Inflammation; Lichens; Lipid Peroxidation; Male; Neutrophil Infiltration; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
Effect of COX-2 inhibitor after TNBS-induced colitis in Wistar rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Inflammatory Bowel Diseases; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2009 |
Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.
Topics: Administration, Oral; Analgesics; Animals; Biological Availability; Carrageenan; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation Mediators; Models, Biological; Nonlinear Dynamics; Rats; Rats, Wistar; Time Factors | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal; Formaldehyde; Fruit; Hot Temperature; Male; Mice; Morphine; Muscle Contraction; Pain; Pain Threshold; Phytotherapy; Plant Extracts | 2010 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Inflammation; Intestinal Mucosa; Male; Neoplasm Proteins; Neoplasm Staging; NF-kappa B; PPAR gamma; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2010 |
Induction of apoptosis as a potential chemopreventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Chemoprevention; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2010 |
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Caspase 3; Caspase 9; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Wnt Proteins | 2010 |
Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclophilins; Cyclosporine; Diclofenac; Disease Models, Animal; Enterocytes; Intestinal Diseases; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Peptidyl-Prolyl Isomerase F; Ulcer | 2010 |
Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Diclofenac; Disease Models, Animal; Edema; Female; Gels; Hyperalgesia; Inflammation; Male; Polyethylene Glycols; Rats; Rats, Wistar | 2010 |
Diclofenac enhances allergic responses in a mouse peanut allergy model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Female; Immune Tolerance; Mice; Peanut Hypersensitivity | 2011 |
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopropanes; Diclofenac; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Male; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Wistar | 2011 |
Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Arginase; Cell Proliferation; Diclofenac; Disease Models, Animal; Down-Regulation; Female; Humans; Male; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2010 |
The influence of irradiation on the potential chondroprotective effect of aqueous extract of propolis in rats.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Cartilage, Articular; Combined Modality Therapy; Diclofenac; Disease Models, Animal; Gamma Rays; Inflammation; Male; Oxidative Stress; Propolis; Rats; Rats, Wistar; Water | 2011 |
Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis.
Topics: Adhesiveness; Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diclofenac; Disease Models, Animal; Drug Carriers; Edema; Glucuronic Acid; Hexuronic Acids; Inflammation; Male; Microspheres; Pectins; Rats; Rats, Wistar; Stomach | 2010 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Indoles; Iodoacetic Acid; Male; Nociceptors; Osteoarthritis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Time Factors; Weight-Bearing | 2011 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; Heterocyclic Compounds; Inflammation; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2011 |
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, Animal; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Diseases; Hepatic Encephalopathy; Injections, Intraperitoneal; Intestinal Mucosa; Liver Function Tests; Male; Peptide Fragments; Proteins; Rats; Rats, Wistar | 2011 |
Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.
Topics: Analysis of Variance; Animals; Caco-2 Cells; Cell Shape; Coculture Techniques; Culture Media, Conditioned; Dextran Sulfate; Diclofenac; Disease Models, Animal; Enteritis; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Focal Adhesion Kinase 1; Glial Fibrillary Acidic Protein; Humans; Intestinal Mucosa; Intestine, Small; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroglia; Paracrine Communication; Peptic Ulcer; Phosphorylation; Protein Precursors; Rats; RNA Interference; Signal Transduction; Simplexvirus; Thymidine Kinase; Time Factors; Transfection; Wound Healing | 2011 |
Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model.
Topics: Analgesics; Animals; Cattle; Diclofenac; Disease Models, Animal; Intervertebral Disc Displacement; Lactoferrin; Low Back Pain; Male; Milk; Pain Threshold; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots | 2010 |
Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis.
Topics: Amphiregulin; Animals; Animals, Newborn; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Female; Glycoproteins; Herpesviridae Infections; Host-Pathogen Interactions; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Muromegalovirus; Nitriles; Organ Culture Techniques; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Submandibular Gland | 2011 |
Preemptive analgesic effects of midazolam and diclofenac in rat model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Male; Midazolam; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis | 2011 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Carrageenan; Catalase; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Female; Freund's Adjuvant; Glutathione; Granuloma; Hydroxybenzoates; Inflammation; Lipid Peroxidation; Male; Mice; Nitric Oxide; Pain; Rats; Rats, Inbred WF; Superoxide Dismutase | 2011 |
Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Ethanol; Granuloma; Humans; Inflammation; Male; Medicine, Traditional; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Vitex | 2012 |
Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model.
Topics: 4-Aminopyridine; Activating Transcription Factor 3; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biophysics; Bone and Bones; Bone Neoplasms; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Extremities; Female; Functional Laterality; Ganglia, Spinal; Glycoproteins; Hyperalgesia; Lectins; Membrane Potentials; Nerve Tissue Proteins; Pain; Pain Threshold; Patch-Clamp Techniques; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Radiography; Rats; Rats, Wistar; RNA, Small Interfering; Scorpion Venoms; Sensory Receptor Cells; Time Factors; Versicans | 2012 |
Synthesis and anti-inflammatory activity of some benzofuran and benzopyran-4-one derivatives.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzopyrans; Binding Sites; Carrageenan; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Diclofenac; Dinoprostone; Disease Models, Animal; Edema; Gene Expression Regulation; Male; Rats; Rats, Wistar | 2012 |
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Injections, Intraperitoneal; Interleukin-17; Interleukin-1beta; Kupffer Cells; Liver; Mice; Mice, Inbred BALB C; Necrosis; RNA, Messenger; Th17 Cells; Time Factors | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Efficacy test of Polycan, a beta-glucan originated from Aureobasidium pullulans SM-2001, on anterior cruciate ligament transection and partial medial meniscectomy-induced-osteoarthritis rats.
Topics: Administration, Oral; Animals; Anterior Cruciate Ligament; Anti-Inflammatory Agents, Non-Steroidal; Ascomycota; beta-Glucans; Cartilage; Diclofenac; Disease Models, Animal; Histocytochemistry; Menisci, Tibial; Microscopy; Osteoarthritis; Rats; Treatment Outcome | 2012 |
Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Diclofenac; Disease Models, Animal; Injections, Intra-Articular; Injections, Subcutaneous; Lidocaine; Male; Morphine; Movement; Nociception; Osteoarthritis; Pain Measurement; Rats; Rats, Wistar | 2012 |
Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Fluorescent Dyes; Gastric Mucosa; Gastrins; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Proteomics; Stomach Ulcer; Tandem Mass Spectrometry | 2012 |
Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Male; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution | 2012 |
Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Diclofenac; Disease Models, Animal; Diterpenes; Edema; Female; Flavones; Inflammation; Kalanchoe; Male; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Spinal; Neural Pathways; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats; Spinal Cord; Time Factors | 2012 |
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Glycyrrhiza; Liver Function Tests; Male; Plant Extracts; Protective Agents; Rats; Reperfusion Injury | 2011 |
Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Cocos; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Pain; Plant Extracts; Rats | 2013 |
Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Diclofenac; Disease Models, Animal; Gold; Humans; Interleukin-1beta; Iontophoresis; Male; Metal Nanoparticles; Nanomedicine; Rats; Rats, Wistar; Tendinopathy; Tumor Necrosis Factor-alpha | 2012 |
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Diclofenac; Disease Models, Animal; Female; Glioma; Imidazoles; Immune Tolerance; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-2 Receptor alpha Subunit; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phosphorylation; T-Lymphocytes, Regulatory; Transcriptional Activation; Up-Regulation | 2013 |
Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; Disease Models, Animal; Freund's Adjuvant; Immunoenzyme Techniques; Lipopolysaccharides; Male; Models, Biological; Rats; Rats, Sprague-Dawley | 2012 |
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neuroglia; Prostaglandins; Spine; Time Factors; Treatment Outcome | 2012 |
Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Female; Formaldehyde; Injections; Injections, Spinal; Models, Biological; Nonlinear Dynamics; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors; Up-Regulation | 2012 |
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model.
Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Methotrexate; Plant Extracts; Plant Leaves; Prednisolone; Rats; Rats, Wistar; Solvents | 2013 |
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinoprostone; Disease Models, Animal; Edema; Leukocytes; Male; Mice; Molecular Structure; Peritoneal Cavity; Prodrugs; Rats; Stomach Ulcer | 2012 |
Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Diclofenac; Disease Models, Animal; Glutathione; Hydroxylation; In Vitro Techniques; Lipopolysaccharides; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2012 |
Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carrageenan; Chitosan; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Edema; Glutaral; In Vitro Techniques; Male; Microspheres; Polymers; Polysaccharides; Rats; Rats, Sprague-Dawley; Seeds; Spectroscopy, Fourier Transform Infrared; Tamarindus | 2013 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; Diclofenac; Dipyrone; Disease Models, Animal; Edema; Formaldehyde; Granuloma, Foreign-Body; Histamine; Male; Mice; Pain; Rats; Rats, Sprague-Dawley | 2002 |
Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Inflammation; Isometric Contraction; Myositis; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Wistar; Recovery of Function; Time Factors; Treatment Outcome | 2003 |
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Female; Furans; Lipopolysaccharides; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Quinazolines; Sepsis; Sulfonamides | 2003 |
The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Monoamines; Brain Chemistry; Corpus Striatum; Depression; Diclofenac; Disease Models, Animal; Drug Interactions; Hippocampus; Interferon-alpha; Male; Prefrontal Cortex; Rats; Rats, Wistar; Swimming | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Glucosamine; Ibuprofen; Indomethacin; Ketoprofen; Mice; Pain; Piroxicam | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Drug Administration Schedule; Female; Foot; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Male; Microbial Sensitivity Tests; Norfloxacin; Oxazines; Pain; Pain Measurement; Quinazolines; Rats; Rats, Wistar; Time Factors | 2003 |
The effects of antipyretics on influenza virus encephalitis in mice and chicks.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Diclofenac; Disease Models, Animal; Encephalitis, Viral; Histological Techniques; Immunohistochemistry; Influenza A virus; Influenza in Birds; Mice; Mice, Inbred BALB C | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured | 2004 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; Benzopyrans; Bromobenzenes; Conjunctivitis, Allergic; Diclofenac; Dinoprostone; Disease Models, Animal; Evans Blue; Exudates and Transudates; Eye; Guinea Pigs; Histamine; Histamine Release; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Ketotifen; Male; Ovalbumin; Propionates; Prostaglandin D2; Pruritus; Therapeutic Irrigation | 2003 |
Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives.
Topics: Acetates; Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Diseases; Lipid Peroxidation; Malondialdehyde; Pain; Protective Agents; Rats; Thiadiazoles | 2004 |
Effects of thalidomide, cyclosporine, and diclofenac on skin allograft survival in rabbits.
Topics: Animals; Cyclosporine; Diclofenac; Disease Models, Animal; Graft Survival; Immunosuppressive Agents; Rabbits; Skin Transplantation; Thalidomide; Time Factors | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Facial Pain; Female; Formaldehyde; Grooming; Hyperalgesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Nimodipine; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis | 2004 |
Ultrastructural alterations in renal tissues of rabbits induced by diclofenac sodium (Voltaren).
Topics: Animals; Biopsy, Needle; Diclofenac; Disease Models, Animal; Immunohistochemistry; Kidney Glomerulus; Kidney Tubules; Male; Microscopy, Electron; Rabbits; Risk Factors; Sensitivity and Specificity | 2004 |
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; Blood Platelets; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Female; Fever; Fibroblasts; Humans; Hyperalgesia; Male; Membrane Proteins; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Skin; Thromboxane B2 | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemokine CCL2; Chemokine CXCL10; Chemokines; Chemokines, CXC; Diclofenac; Disease Models, Animal; Hindlimb; Hot Temperature; Hyperalgesia; Indomethacin; Injections, Intravenous; Interleukin-8; Macrophages; Male; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Single-Blind Method | 2005 |
Effect of diclofenac on experimental pleurodesis induced by tetracycline in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fibrosis; Male; Pleura; Pleurodesis; Rabbits; Sclerosing Solutions; Tetracycline | 2005 |
Oral administration of lumiracoxib reduces choroidal neovascular membrane development in the rat laser-trauma model.
Topics: Administration, Oral; Animals; Choroidal Neovascularization; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Fluorescein Angiography; Laser Coagulation; Male; Optic Disk; Organic Chemicals; Rats; Rats, Inbred BN | 2005 |
Influence of antiinflammatory drugs (methylprednisolone and diclofenac sodium) on experimental pleurodesis induced by silver nitrate or talc.
Topics: Animals; Diclofenac; Disease Models, Animal; Female; Male; Methylprednisolone; Pleural Diseases; Pleurodesis; Probability; Reference Values; Risk Assessment; Sclerosing Solutions; Sensitivity and Specificity; Silver Nitrate; Statistics, Nonparametric; Talc; Tissue Adhesions | 2005 |
Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats.
Topics: Adjuvants, Immunologic; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Cell Count; Diclofenac; Disease Models, Animal; Freund's Adjuvant; Hindlimb; Injections, Intra-Articular; Lumbar Vertebrae; Male; Nitric Oxide Synthase; Pain Measurement; Phonophoresis; Rats; Rats, Wistar; Spinal Cord; Ultrasonic Therapy | 2006 |
Comparison of ketorolac tromethamine, diclofenac sodium, and loteprednol etabonate in an animal model of ocular inflammation.
Topics: Androstadienes; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Endophthalmitis; Ketorolac Tromethamine; Loteprednol Etabonate; Rabbits | 2006 |
Increased prostanoid dependency of arterial relaxation in Chlamydia pneumoniae-infected mice.
Topics: Animals; Aorta, Thoracic; Chlamydophila Infections; Chlamydophila pneumoniae; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Enzyme Inhibitors; Female; Methacholine Chloride; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prostaglandins; Vasoconstrictor Agents; Vasodilation | 2006 |
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Pain Measurement; Rats; Rats, Wistar | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
Effects of ototopic steroid and NSAIDS in clearing middle ear effusion in an animal model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; Disease Models, Animal; Glucocorticoids; Lipopolysaccharides; Otitis Media with Effusion; Rats; Rats, Sprague-Dawley | 2006 |
Effect of prenatal exposure to an anti-inflammatory drug on neuron number in cornu ammonis and dentate gyrus of the rat hippocampus: a stereological study.
Topics: Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Diclofenac; Disease Models, Animal; Female; Hippocampus; Male; Nervous System Malformations; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Stem Cells | 2007 |
[Efficiency of anti-inflammatory therapy for experimental tuberculosis in genetically tuberculosis-sensitive mice].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Mice; Mice, Inbred Strains; Treatment Outcome; Tuberculosis, Pulmonary | 2006 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Flowers; Formaldehyde; Injections, Intraperitoneal; Male; Mice; Morphine; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Reaction Time; Solanaceae; Treatment Outcome | 2007 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Male; Mice; Molecular Structure; Pain Measurement; Pain Threshold; Quinazolinones; Rats; Rats, Wistar; Stomach Ulcer | 2007 |
Bone repair in rats treated with sodic diclofenac and calcitonin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Bone Regeneration; Calcitonin; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Rats; Rats, Wistar | 2006 |
Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Carrageenan; Chi-Square Distribution; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Mice; Mice, Inbred Strains; Morphine; Narcotics; Pain; Pain Measurement; Time Factors | 2007 |
Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Ginkgo biloba; Hindlimb; Hyperalgesia; Inflammation; Injections, Intradermal; Male; Pain; Pain Measurement; Pain, Postoperative; Plant Extracts; Rats; Rats, Wistar | 2007 |
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intradermal; Injections, Intraperitoneal; Ketorolac; Lysine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Reaction Time; Sodium Salicylate; Tail; Time Factors | 2007 |
COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.
Topics: Animals; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-10; Lactones; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Sulfones; T-Box Domain Proteins; T-Lymphocytes; Time Factors | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Inflammation; Male; Mice; Pain Measurement; Quinazolinones; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hindlimb; Hydrogen Sulfide; Injections; Male; Neutrophils; Nitrates; Nitrites; Peroxidase; Rats; Rats, Wistar; Thiones | 2007 |
Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Diclofenac; Disease Models, Animal; Hydrogen Sulfide; Lung; Lung Injury; Male; Mice; Pancreatitis, Acute Necrotizing; Thiones | 2008 |
Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Lung; Male; Mice; Microbial Sensitivity Tests; Microbial Viability; Mycobacterium tuberculosis; Spleen; Streptomycin; Survival Analysis; Tuberculosis | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Depression, Chemical; Diastole; Diclofenac; Disease Models, Animal; Glyburide; In Vitro Techniques; Indomethacin; Myocardial Contraction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitrobenzenes; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Reperfusion Injury; Research Design; Sulfonamides; Systole; Time Factors | 2007 |
Pro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varians.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotaxis, Leukocyte; Dexamethasone; Diclofenac; Disease Models, Animal; Edema; Inflammation; Lectins; Macrophages, Peritoneal; Mice; Mice, Inbred Strains; Peritonitis; Porifera; Pyrazoles; Sulfonamides | 2008 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofenac; Dinoprostone; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2007 |
Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents; Burseraceae; Dexamethasone; Diclofenac; Disease Models, Animal; Gingiva; Gingivitis; Isomerism; Male; Molecular Structure; Neutrophil Infiltration; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Periodontitis; Peroxidase; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2008 |
Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Connective Tissue; Diclofenac; Disease Models, Animal; Dura Mater; Epidural Space; Fibroblasts; Fibrosis; Inflammation; Laminectomy; Lumbar Vertebrae; Postoperative Complications; Rabbits; Spinal Canal; Tissue Adhesions; Treatment Outcome | 2008 |
Nanoemulsions as vehicles for transdermal delivery of aceclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Diclofenac; Diffusion Chambers, Culture; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Stability; Edema; Emulsions; Excipients; Kinetics; Male; Mice; Nanoparticles; Oils; Particle Size; Permeability; Rats; Rats, Wistar; Skin; Skin Absorption; Skin Irritancy Tests; Surface Properties; Technology, Pharmaceutical; Temperature; Viscosity; Water | 2007 |
[The treatment of acute periodontitis using sodium diclofenac experimentally].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Ointments; Periodontitis; Periodontium; Quaternary Ammonium Compounds; Time Factors | 1995 |
[The experimental treatment of chronic periodontitis using ortofen].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Ointments; Periodontitis; Periodontium; Time Factors | 1995 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Indomethacin; Male; Misoprostol; Pyloric Antrum; Rabbits; Ranitidine; Stomach Ulcer | 1993 |
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Extravascular Lung Water; Hemodynamics; Premedication; Pulmonary Embolism; Pulmonary Wedge Pressure; Reperfusion Injury | 1995 |
Modulation of murine osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Densitometry; Diclofenac; Disease Models, Animal; Drug Combinations; Glycosides; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Osteoarthritis | 1996 |
Anti-inflammatory activity of topical nimesulide gel in various experimental models.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Disease Models, Animal; Edema; Female; Gels; Male; Piroxicam; Rats; Rats, Wistar; Sulfonamides | 1996 |
Combined non-steroidal therapy in experimental corneal injury.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Cornea; Corneal Injuries; Dexamethasone; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Eye Burns; Free Radical Scavengers; Glucocorticoids; Indomethacin; Ophthalmic Solutions; Rabbits; Thiourea; Wound Healing | 1997 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Female; Ileum; Indans; Indomethacin; Intestinal Diseases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Ulcer | 1998 |
The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Embolism, Air; Endothelin Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; In Vitro Techniques; Oligopeptides; Perfusion; Phenylpropionates; Piperidines; Pulmonary Artery; Pulmonary Embolism; Pyrimidines; Rabbits; Radioimmunoassay; Thromboxane A2; Time Factors; Vascular Resistance | 1998 |
Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Female; Granulocytes; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Perfusion; Phenylpropionates; Prospective Studies; Pulmonary Artery; Pyrimidines; Rabbits; Random Allocation; Respiratory Distress Syndrome; Thromboxane A2; Thromboxane B2; Vascular Resistance | 1998 |
Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Collagen; Conjunctivitis; Cornea; Corneal Opacity; Diclofenac; Disease Models, Animal; Lasers, Excimer; Male; Ophthalmic Solutions; Photorefractive Keratectomy; Postoperative Complications; Rabbits; Wound Healing | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Morphine; Neuralgia; Neurons, Afferent; Pain | 2000 |
Antiulcer activity of Mikania cordata.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Diclofenac; Disease Models, Animal; Male; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Long-Evans; Stomach Ulcer | 2000 |
Interaction of acetylcholine and endothelin-1 in the modulation of pulmonary arterial pressure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Female; Hypertension, Pulmonary; In Vitro Techniques; Male; Peptides, Cyclic; Pulmonary Circulation; Pulmonary Wedge Pressure; Rabbits; Thromboxane A2; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2000 |
Diclofenac-induced gastric mucosal fluorescence in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Chromatography, High Pressure Liquid; Diclofenac; Disease Models, Animal; Fluorescence; Free Radical Scavengers; Gastric Mucosa; Gastritis; Lipid Peroxidation; Male; Piperidines; Porphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence | 2001 |
Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofenac; Disease Models, Animal; Indomethacin; Iodoacetates; Knee Joint; Male; Osteoarthritis, Knee; Propionates; Rats; Rats, Sprague-Dawley | 2001 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamus; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Nitrobenzenes; Pain Measurement; Pain Threshold; Preoptic Area; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Reaction Time; Septal Nuclei; Sulfonamides | 2001 |
Effects of diclofenac and ketoprofen on nerve conduction velocity in experimental nerve root compression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Injections, Intramuscular; Ketoprofen; Nerve Compression Syndromes; Neural Conduction; Radiculopathy; Spinal Nerve Roots; Swine | 2001 |
A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Culture Techniques; Diclofenac; Disease Models, Animal; Embryo, Mammalian; Embryonic and Fetal Development; Female; Hindlimb; Pregnancy; Rats; Rats, Sprague-Dawley | 2001 |
Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Combined Modality Therapy; Diclofenac; Disease Models, Animal; Edema; Hindlimb; Hyperbaric Oxygenation; Inflammation; Male; Rats; Rats, Sprague-Dawley | 2001 |
Nucleus pulposus-induced nerve root injury: effects of diclofenac and ketoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Intervertebral Disc; Ketoprofen; Neural Conduction; Radiculopathy; Swine | 2002 |
Neostigmine interactions with non steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Diclofenac; Disease Models, Animal; Drug Synergism; Ketoprofen; Meloxicam; Mice; Neostigmine; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Thiazines; Thiazoles | 2002 |
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collagen; Diamines; Diclofenac; Dinoprostone; Disease Models, Animal; Female; Interleukin-1; Leukotriene B4; Male; Naproxen; Oxazines; Phenols; Piroxicam; Rats; Rats, Inbred Lew; Thromboxane B2 | 1992 |
Localization of the central antinociceptive effects of diclofenac in the rat.
Topics: Animals; Brain; Diclofenac; Disease Models, Animal; Male; Microinjections; Pain; Periaqueductal Gray; Preoptic Area; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Thalamus | 1992 |
[Analgesic action of sodium diclofenac: behavioral and electrophysiological study in normal and polyarthritic rats].
Topics: Animals; Arthritis; Behavior, Animal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Rats; Rats, Inbred Strains; Vocalization, Animal | 1988 |
Pathogenesis of osteoarthritis and use of diclofenac in the treatment of experimental models.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Diclofenac; Disease Models, Animal; Dogs; Extracellular Matrix; Humans; Microbial Collagenase; Osteoarthritis; Proteoglycans; Synovial Membrane | 1985 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid Peroxidation; Luminescent Measurements; Male; Malondialdehyde; Piroxicam; Prednisolone; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Effects of topical diclofenac sodium in a rabbit model of ocular inflammation and leukotaxis.
Topics: Administration, Topical; Animals; Chemotaxis, Leukocyte; Diclofenac; Disease Models, Animal; Endophthalmitis; Male; Prostaglandins; Rabbits | 1986 |