diclofenac has been researched along with Disease Models, Animal in 245 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 8.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition." | 8.02 | Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 8.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| "The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats." | 7.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "To assess the influence of diclofenac sodium (DIC) treatment on tilmicosin (TIL) prompted cardiotoxicity, forty albino rats were randomly divided into four equal groups: control, TIL group (single subcutaneous injection of 75 mg/kg BW tilmicosin phosphate 30%), TIL + DIC group (single subcutaneous injection of tilmicosin phosphate 30% and then injection intramuscularly of 13." | 7.88 | Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). ( Derbalah, AE; Oda, SS, 2018) |
| "Nonsteroidal anti-inflammatory drugs, such as diclofenac, are widely used to treat inflammation and pain in several conditions, including sports injuries." | 7.85 | Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway. ( Barcelos, RP; Bresciani, G; Cuevas, MJ; González-Gallego, J; Martínez-Flórez, S; Soares, FAA, 2017) |
| "The aim of the present study was to investigate anti-inflammatory activity of Diclocor in the setting of collagen-induced osteoarthritis in rats in comparison with its active monocomponents-diclofenac sodium and quercetin." | 7.83 | Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis. ( Popov, OS; Shalamay, AS; Shebeko, SK; Zupanets, IA, 2016) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 7.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 7.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 7.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| "This study evaluates the therapeutic effects of iontophoresis using GNPs and diclofenac diethylammonium on inflammatory parameters in rats challenged with traumatic tendinitis." | 7.78 | Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis. ( De Souza, CT; Dohnert, LH; Dohnert, MB; Luciano, TF; Paula, MM; Possato, JC; Venâncio, M; Zeferino, RC; Zugno, AI, 2012) |
| " The aim of this study was to ascertain whether DCL used in combination with the first-line antitubercular antibiotic streptomycin (STM) synergistically augments its efficacy in vitro as well as in a murine tuberculosis infection model." | 7.74 | Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice. ( Dastidar, SG; Dutta, NK; Mazumdar, K; Park, JH, 2007) |
| "This study was aimed to evaluate the anti-inflammatory potential of triterpene alpha, beta-amyrin in rats on acute phase periodontitis." | 7.74 | Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis. ( Chaves, MH; Cunha, GM; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA, 2008) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 7.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "Acanthamoeba keratitis is caused by a protozoal infection of the cornea, with 80% of cases involving the improper use of contact lenses." | 5.56 | Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. ( Heard, CM; Hewitt, M; Kelly, SL; Lewis, PN; Morgan, SR; Morrison, PWJ; Moseley, R; Moses, RL; Parker, JE; Pilia, N; Quantock, AJ; Whitaker, D, 2020) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 5.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "Tendinitis is a painful condition that occurs in tendons in response to repetitive use or direct trauma." | 5.42 | Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats. ( de Souza, CT; Dohnert, LH; Dohnert, MB; Ferreira, GK; Paula, MM; Silveira, PC; Zanoni, ET, 2015) |
| "Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test." | 5.38 | Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 5.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| "Diclofenac was applied with or without gastric acid suppression, in various doses, alone or covalently coupled to albumin, a protein abundant in gastric juices." | 5.36 | Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model. ( Gruber, S; Jensen-Jarolim, E; Kinaciyan, T; Pali-Schöll, I; Riemer, AB; Untersmayr, E, 2010) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 5.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "6 h, oral bioavailability of 37% and 90%) with anti-inflammatory activity (ED 50 = 37 micromol/kg, mouse) and efficacy in pain models (thermal hyperalgesia, ED 50 = 72 micromol/kg, rat)." | 5.35 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. ( Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG, 2008) |
| "Diclofenac was the test NSAID and collagomers--novel vesicular-shaped microparticles based on collagen-lipid conjugates--were the carriers." | 5.35 | A novel Diclofenac-carrier for local treatment of osteoarthritis applying live-animal MRI. ( Biton, IE; Elron-Gross, I; Glucksam, Y; Margalit, R, 2009) |
| "Main parameter was thrombus weight." | 5.32 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004) |
| "The acute pressure reaction after air embolism is mainly mediated via ET-1 by an ETA receptor related mechanism." | 5.30 | The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs. ( Heller, A; Koch, T; Neuhof, H; Patt, B; Schmeck, J; van Ackern, K, 1998) |
| " The effect of 10% AKBA at 20 mg/kg and 40 mg/kg was evaluated in the FCA induced arthritis animal model alone and combined with methotrexate (MTX) at 2 mg/kg b." | 4.12 | Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model. ( Alqahtani, SS; Alshahrani, S; Banji, D; Banji, OJF; Rashida, S, 2022) |
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 4.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition." | 4.02 | Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021) |
| " The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 4.02 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| "We used two well-established mouse models of gastric ulcer (GU) induced by oral administration of EtOH (80% solution in water) or diclofenac (30 mg/kg, p." | 4.02 | AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice. ( Binienda, A; Fichna, J; Kordek, R; Majchrzak, K; Małecka-Panas, E; Salaga, M; Zatorski, H; Zielińska, M, 2021) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 4.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| " The methanolic and aqueous leaves extracts of Croton bonplandianus were exposed to anti-inflammatory activity in the carrageenan induced paw edema against standard diclofenac sodium, followed by the histopathlogical examination." | 4.02 | Anti-inflammatory and histopathological studies of leaves extracts of Croton bonplandianus in Albino rats. ( Abrar, H; Arsalan, A; Bano, R; Fatima, K; Hussain, RA; Islam, M; Jahan, N; Mahmud, S; Yasin, H, 2021) |
| "The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats." | 3.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| " platensis on different types of pain and inflammation in comparison to diclofenac sodium." | 3.96 | Effects of Spirulina platensis on pain and inflammation in long Evans rats. ( Akhter, S; Ali, T; Nipa, NS; Rafiq, K, 2020) |
| "In case of carrageenan mediated inflammation, the combination of 5 mg/kg diclofenac and 200 mg/kg ascorbic acid gave the highest inhibition of 74." | 3.96 | Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid. ( Ahmed, T; Ahsan, CR; Al Shoyaib, A; Archie, SR; Chowdhury, FA; Faruk, A, 2020) |
| " The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug." | 3.91 | A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles ( Nagaraju, B; Prasanna, B; Seelam, N; Shanmukhakumar, JV; Subbaiah, T, 2019) |
| ") administration of acetic acid, a well-established protocol for visceral pain in rodents." | 3.91 | Understanding nociception-related phenotypes in adult zebrafish: Behavioral and pharmacological characterization using a new acetic acid model. ( Costa, FV; Kalueff, AV; Quadros, VA; Rosa, LV; Rosemberg, DB; Santos, ARS, 2019) |
| "The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation." | 3.91 | Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study. ( Cardoso, LCP; Lopes, MJP; Nobre, MEP; Pinto, NB; Pires, GM; Rodrigues, LMR; Silva, MR; Viana, GSB, 2019) |
| "To assess the influence of diclofenac sodium (DIC) treatment on tilmicosin (TIL) prompted cardiotoxicity, forty albino rats were randomly divided into four equal groups: control, TIL group (single subcutaneous injection of 75 mg/kg BW tilmicosin phosphate 30%), TIL + DIC group (single subcutaneous injection of tilmicosin phosphate 30% and then injection intramuscularly of 13." | 3.88 | Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). ( Derbalah, AE; Oda, SS, 2018) |
| " Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels." | 3.88 | Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. ( Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2018) |
| " The synthesized compounds were screened for their in vivo anti-inflammatory activity in carrageenan-induced rat hind paw edema model at dose 20mg/kg body weight using diclofenac sodium as a standard drug." | 3.88 | Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents. ( Chaudhari, PS; Chitlange, SS; Nanda, RK, 2018) |
| " Amongst all the synthesized derivatives, compound 56 showed the significant anti-inflammatory activity in both rat paw edema models with very less ulcerogenic liability in comparison to standard diclofenac, celecoxib, and zileuton." | 3.85 | Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity. ( Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN, 2017) |
| " Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis." | 3.85 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. ( Katselou, MG; Kourounakis, AP; Matralis, AN, 2017) |
| "Wildtype, COX-2 knockout and COX-2 heterozygous mice were subjected to a model of colonic anastomotic leakage, and were treated with vehicle, diclofenac, or prostaglandin E2 (PGE2), the most important COX-2 product in the intestine." | 3.85 | Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing. ( Boonen, B; Bosmans, JW; Derikx, JP; Grootjans, J; Hulsewé, KW; Poeze, M; Reisinger, KW; Sastrowijoto, P; Schellekens, DH, 2017) |
| "Nonsteroidal anti-inflammatory drugs, such as diclofenac, are widely used to treat inflammation and pain in several conditions, including sports injuries." | 3.85 | Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway. ( Barcelos, RP; Bresciani, G; Cuevas, MJ; González-Gallego, J; Martínez-Flórez, S; Soares, FAA, 2017) |
| "The aim of the present study was to investigate anti-inflammatory activity of Diclocor in the setting of collagen-induced osteoarthritis in rats in comparison with its active monocomponents-diclofenac sodium and quercetin." | 3.83 | Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis. ( Popov, OS; Shalamay, AS; Shebeko, SK; Zupanets, IA, 2016) |
| "In the current study, we used 56 female BALB/c mice with induced dry eye syndrome to evaluate the therapeutic effects of formal saline (FS), sodium hyaluronate (SH), diclofenac sodium (DS), olopatadine (OP), retinoic acid (RA), fluoromethanole (FML), cyclosporine A (CsA), and doxycycline hyclate (DH)." | 3.83 | Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome. ( Kilic, S; Kulualp, K, 2016) |
| " Acetic acid-induced writhing test and carrageenan-induced paw edema model were used for evaluation." | 3.83 | Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models. ( Amdekar, S; Singh, V, 2016) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " All the compounds were found to cause less gastric ulceration than the standard drug diclofenac." | 3.83 | Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents. ( Kale, MA; Kuberkar, SV; Nawale, RB; Peharkar, MR, 2016) |
| " Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 3.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 3.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "05) and dosedependent anti-inflammatory activity in carrageenan induced paw oedema models of inflammation and the result was comparable with the standard drug diclofenac." | 3.79 | Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L. ( Gupta, M; Haldar, PK; Mazumder, UK; Naskar, S; Pramanik, G; Saha, P, 2013) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 3.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity." | 3.78 | Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. ( Afzal, M; Afzal, O; Alam, J; Anwar, F; Gupta, G; Gupta, R; Hakeem, KR; Kazmi, I; Pravez, M; Rahman, M, 2012) |
| "This study evaluates the therapeutic effects of iontophoresis using GNPs and diclofenac diethylammonium on inflammatory parameters in rats challenged with traumatic tendinitis." | 3.78 | Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis. ( De Souza, CT; Dohnert, LH; Dohnert, MB; Luciano, TF; Paula, MM; Possato, JC; Venâncio, M; Zeferino, RC; Zugno, AI, 2012) |
| " Anti-inflammatory activity screening of some synthesized compounds utilizing in vivo acute carrageenan-induced paw edema standard method in rats exhibited that the prepared heterocycles possess considerable pharmacological properties especially, 4a, 4b, 10a, and 10b which reveal remarkable activities relative to diclofenac sodium (reference standard)." | 3.77 | Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides. ( Barsoum, FF, 2011) |
| "The aim of the present study was to investigate the preemptive analgesic effects of intraperitoneally administrated midazolam and diclofenac, before acute and inflammatory induced pain in rat model." | 3.77 | Preemptive analgesic effects of midazolam and diclofenac in rat model. ( Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S, 2011) |
| " First, validate PEAP with Complete Freund's Adjuvant (CFA)-induced inflammation for the assessment of the affective component of pain using the reference analgesics celecoxib, diclofenac and duloxetine; fluoxetine and scopolamine were tested as negative controls." | 3.76 | Comparison of mechanical allodynia and the affective component of inflammatory pain in rats. ( Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C, 2010) |
| " The blueberry extract produced a significant decrease in constrictions induced by acetic acid and caused graded inhibition of the second phase of formalin-induced pain." | 3.76 | Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. ( Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR, 2010) |
| "Small intestinal ulceration is a frequent and potentially serious condition associated with nonselective cyclooxygenase 1/2 inhibitors (nonsteroidal anti-inflammatory drugs, NSAIDs) including diclofenac (DCF)." | 3.76 | Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice. ( Boelsterli, UA; Gavillet, B; LoGuidice, A; Proli, A; Ramirez-Alcantara, V, 2010) |
| " EtCD at the dose of 300 mg/kg produced significant decrease in paw volume and pain when compared with reference drug diclofenac and morphine, respectively." | 3.75 | Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. ( Arora, B; Arora, R; Bali, M; Bansal, S; Gill, NS; Muthuraman, A; Sharma, PD; Sood, S, 2009) |
| " The aim of this study was to ascertain whether DCL used in combination with the first-line antitubercular antibiotic streptomycin (STM) synergistically augments its efficacy in vitro as well as in a murine tuberculosis infection model." | 3.74 | Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice. ( Dastidar, SG; Dutta, NK; Mazumdar, K; Park, JH, 2007) |
| "This study was aimed to evaluate the anti-inflammatory potential of triterpene alpha, beta-amyrin in rats on acute phase periodontitis." | 3.74 | Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis. ( Chaves, MH; Cunha, GM; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA, 2008) |
| " Efficacy of lumiracoxib in rat models of hyperalgesia, oedema, pyresis and arthritis was dose-dependent and similar to diclofenac." | 3.73 | Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. ( Berry, C; Dawson, J; Du, Z; Esser, R; Fox, A; Fujimoto, RA; Haston, W; Kimble, EF; Koehler, J; Marshall, PJ; Peppard, J; Quadros, E; Quintavalla, J; Toscano, K; Urban, L; van Duzer, J; Zhang, X; Zhou, S, 2005) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 3.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats." | 3.71 | Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats. ( Cimşit, M; Eroglu, L; Sümen, G, 2001) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| " In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days." | 3.69 | Anti-inflammatory activity of topical nimesulide gel in various experimental models. ( Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T, 1996) |
| "Diclofenac has been used mainly topically, and recent focus has been on intravitreal delivery." | 2.87 | Efficacy of systemic diclofenac sodium on intravitreal concentration. ( Abrishami, M; Hoseini, H; Jadidi, K; Naderi, M; Panahi, Y, 2018) |
| "Misoprostol was not observed to have any protective effect against diclofenac in obstructed kidneys." | 2.80 | Oral misoprostol does not protect the kidneys from diclofenac induced toxicity: data from an unilateral ureteral obstructive rat model. ( Aydogmus, Y; Buyukserbetci, M; Dadali, M; Eroglu, M; Hascicek, AM; Huri, E; Kilinc, AS; Ogus, E; Ozer, E, 2015) |
| "Diclofenac caused the increase in gut damage, enteric bacterial numbers and BT." | 2.71 | Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. ( Jeon, WK; Kim, EJ; Kim, JW, 2005) |
| "Diclofenac sodium (Dc) was found to possess antibacterial activity against both drug-sensitive and drug-resistant clinical isolates of Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Mycobacterium spp." | 2.45 | The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target. ( Dastidar, SG; Dutta, NK; Mazumdar, K; Park, JH, 2009) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "Acanthamoeba keratitis is caused by a protozoal infection of the cornea, with 80% of cases involving the improper use of contact lenses." | 1.56 | Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. ( Heard, CM; Hewitt, M; Kelly, SL; Lewis, PN; Morgan, SR; Morrison, PWJ; Moseley, R; Moses, RL; Parker, JE; Pilia, N; Quantock, AJ; Whitaker, D, 2020) |
| "Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug, but it comes with a high risk of drug-induced liver injury (DILI)." | 1.56 | Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice. ( Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S, 2020) |
| "Osteoarthritis is the most common joint disorder worldwide and one of the leading causes of disability in the elderly." | 1.56 | [Residual Property of SI-613, a Novel Drug for Osteoarthritis, in Knee Joint]. ( Ishii, S; Morita, D; Yoshioka, K, 2020) |
| " But its long-term administration increases the risk of complications of pharmacotherapy." | 1.51 | Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels. ( Beskhmelnitsyna, EA; Kulikov, AL; Peresypkina, AA; Pokrovskii, MV; Varavin, EI, 2019) |
| " This work describes the optimization of the pharmacokinetic properties of a previously published family of triazine lead compounds." | 1.48 | Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives. ( Augustyns, K; Baán, A; Caljon, G; Kiekens, F; Maes, L; Matheeussen, A; Salado, IG; Van der Veken, P; Verdeyen, T, 2018) |
| " The prostate tissue penetration and related pharmacokinetic parameters were evaluated by non-compartmental analysis." | 1.48 | Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue. ( Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK, 2018) |
| "Sepsis was observed in animals with DS and GAS inoculation (group 1 and 2)." | 1.48 | The role of nonsteroidal anti-inflammatory drugs intramuscular injection in the development and severity of deep soft tissue infection in mice. ( Alp, E; Demiraslan, H; Doganay, M; Kontas, O; Ture, Z, 2018) |
| "Left sciatic nerve ligation was used as neuropathic pain model." | 1.48 | Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. ( Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR, 2018) |
| "Aceclofenac is a popular analgesic, antipyretic, and nonsteroidal anti-inflammatory drug (NSAID) used for prolonged treatment (at least three months) in musculoskeletal disorders." | 1.48 | Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations. ( Boatto, G; Burrai, L; Chegaev, K; Cristiano, C; De Caro, C; Gazzano, E; Lazzarato, L; Magliocca, S; Marabello, D; Marini, E; Nieddu, M; Riganti, C; Rimoli, MG; Rolando, B; Russo, R; Sodano, F, 2018) |
| "The knowledge of pharmacokinetic and pharmacodynamic properties of antiepileptic drugs is helpful in optimizing drug therapy for epilepsy." | 1.46 | Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence. ( Kumar, B; Medhi, B; Modi, M; Saikia, B, 2017) |
| "Diclofenac was used for comparison." | 1.46 | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. ( Che Ahmad Tantowi, NA; Hussin, P; Lau, SF; Mohamed, S, 2017) |
| "Diclofenac sodium was chosen as the model drug." | 1.46 | Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac. ( Nguyen, CN; Nguyen, HT; Nguyen, TTT; Tran, TH, 2017) |
| " In the pyridine series, compound 7a was found to be a highly potent and selective EP4 antagonist, with suitable rat and dog pharmacokinetic profiles." | 1.43 | Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile. ( Blanco, MJ; Chambers, M; Chandrasekhar, S; Fisher, MJ; Harvey, A; Lin, C; Mudra, D; Oskins, J; Vetman, T; Wang, XS; Warshawsky, AM; Yu, XP, 2016) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 1.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent." | 1.43 | Antibacterial and Antiinflammatory Properties of Bovine Colostrum. ( Angolkar, T; Buttar, HS; Kaur, G; Yadav, R, 2016) |
| "Diclofenac was used as the standard drug." | 1.43 | Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes). ( Greeshma, P; Janardhanan, KK; Neethu, MN; Pandey, M; Ravikumar, KS; Zuhara, KF, 2016) |
| "Tendinopathy is a common disease with a variety of treatments and therapies." | 1.42 | The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis. ( Arnold, G; Bjordal, JM; Frigo, L; Leal-Junior, EC; Lopes-Martins, RA; Magdalou, J; Marcos, RL; Pallotta, R; Rahouadj, R; Torres-Silva, R, 2015) |
| "Tendinitis is a painful condition that occurs in tendons in response to repetitive use or direct trauma." | 1.42 | Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats. ( de Souza, CT; Dohnert, LH; Dohnert, MB; Ferreira, GK; Paula, MM; Silveira, PC; Zanoni, ET, 2015) |
| "Enhanced oral bioavailability of aceclofenac has been achieved using chitosan cocrystals of aceclofenac and its entrapment into alginate matrix a super saturated drug delivery system (SDDS)." | 1.42 | Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac. ( Ganesh, M; Hemalatha, P; Jang, HT; Jeon, UJ; Peng, MM; Saravanakumar, A; Ubaidulla, U, 2015) |
| "Diclofenac treatment produced dose-related reversal of CRANE at 0." | 1.42 | Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015) |
| "Cancer-induced bone pain is described as dull, aching ongoing pain." | 1.42 | Behavioral and neurochemical analysis of ongoing bone cancer pain in rats. ( King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY, 2015) |
| " The vesicles were characterized for physicochemical properties, ex vivo permeation using human skin and pharmacokinetic parameters and anti-inflammatory activity in rats." | 1.40 | Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation. ( Bhandari, A; Gaur, PK; Kumar, Y; Mishra, S; Purohit, S, 2014) |
| "Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations." | 1.40 | Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres. ( Adedokun, MO; Attama, AA; Kenechukwu, FC; Momoh, MA; Odo, CE, 2014) |
| "Inflammation was induced by carrageen and Freund's complete adjuvant in plantar surface of the rats." | 1.39 | Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model. ( Bhatia, M; Garg, LN; Gupta, S; Kumar, S, 2013) |
| "Cancer pain is one of the most severe types of chronic pain, and the most common cancer pain is bone cancer pain." | 1.38 | Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. ( Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ, 2012) |
| " First, we established the dosing condition for liver injury in normal mice." | 1.38 | Involvement of immune-related factors in diclofenac-induced acute liver injury in mice. ( Fukami, T; Higuchi, S; Nakajima, M; Tsuneyama, K; Yano, A; Yokoi, T, 2012) |
| " The results obtained in this study suggest that 84 days of continuous oral treatment of three different dosages of Polycan led to lesser degrees of articular stiffness and histological cartilage damage compared with OA controls 91 days after OA inducement, suggesting that the optimal Polycan dosage to treat OA is 42." | 1.38 | Efficacy test of Polycan, a beta-glucan originated from Aureobasidium pullulans SM-2001, on anterior cruciate ligament transection and partial medial meniscectomy-induced-osteoarthritis rats. ( Cho, HR; Kim, JW; Ku, SK, 2012) |
| "Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test." | 1.38 | Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012) |
| "Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group." | 1.38 | Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012) |
| "Similar pharmacokinetic behavior of diclofenac was found both in normal and FCA-induced arthritic rats." | 1.38 | Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats. ( Guo, HF; Li, P; Liu, L; Liu, XD; Zhang, J, 2012) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 1.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| "Diclofenac was administered before peanut feeding." | 1.37 | Diclofenac enhances allergic responses in a mouse peanut allergy model. ( Bleumink, R; Bol-Schoenmakers, M; Hassing, I; Ludwig, I; Marcondes Rezende, M; Mouser, E; Pieters, RH; Smit, JJ, 2011) |
| "Already considered a drug that can reverse the toxic side effects of NSAIDs, BPC 157 (10 μg/kg, 10 ng/kg) was strongly effective throughout the entire experiment when given (i) intraperitoneally immediately after diclofenac or (ii) per-orally in drinking water (0." | 1.37 | Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. ( Blagaic, AB; Brcic, L; Coric, M; Djakovic, Z; Djuzel, V; Drmic, D; Dzidic, S; Filipovic, M; Franjic, S; Gjurasin, M; Ilic, S; Klicek, R; Kolenc, D; Radic, B; Romic, Z; Seiwerth, S; Sever, M; Sikiric, P; Stambolija, V; Stupnisek, M; Zarkovic, K; Zoricic, I, 2011) |
| " Collagen and U46619 caused in vivo thrombus formation with the former, but not latter, sensitive to oral dosing with aspirin." | 1.37 | Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. ( Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN, 2011) |
| "Diclofenac was applied with or without gastric acid suppression, in various doses, alone or covalently coupled to albumin, a protein abundant in gastric juices." | 1.36 | Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model. ( Gruber, S; Jensen-Jarolim, E; Kinaciyan, T; Pali-Schöll, I; Riemer, AB; Untersmayr, E, 2010) |
| "Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals." | 1.36 | Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models. ( Aslan, A; Aygun, H; Cakir, A; Halici, Z; Odabasoglu, F; Suleyman, H; Tanas, S, 2010) |
| " A first-order model, including lag time and decreased relative bioavailability as a function of the dose, described the absorption process." | 1.36 | Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats. ( Castañeda-Hernández, G; Ortiz, MI; Salazar-Morales, UE; Trocóniz, IF; Vásquez-Bahena, DA, 2010) |
| "Diclofenac treatment resulted in a significant reduction in COX-2 expression and its activity." | 1.36 | Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. ( Kaur, J; Sanyal, SN, 2010) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 1.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "6 h, oral bioavailability of 37% and 90%) with anti-inflammatory activity (ED 50 = 37 micromol/kg, mouse) and efficacy in pain models (thermal hyperalgesia, ED 50 = 72 micromol/kg, rat)." | 1.35 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. ( Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG, 2008) |
| "Acute renal failure was caused by D." | 1.35 | The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. ( Balal, M; Besen, A; Dogan, A; Gonlusen, G; Inal, T; Kibar, M; Kose, F; Paydas, S, 2009) |
| "Diclofenac was the test NSAID and collagomers--novel vesicular-shaped microparticles based on collagen-lipid conjugates--were the carriers." | 1.35 | A novel Diclofenac-carrier for local treatment of osteoarthritis applying live-animal MRI. ( Biton, IE; Elron-Gross, I; Glucksam, Y; Margalit, R, 2009) |
| "Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)." | 1.35 | Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat. ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009) |
| "Eyes treated with ketorolac and diclofenac demonstrated reduced aqueous leucocyte concentrations of 62% and 64% respectively, compared with untreated controls (p<0." | 1.35 | Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation. ( Barañano, DE; Durairaj, C; Edelhauser, HF; Handa, JT; Kim, SJ; Kompella, UB, 2009) |
| "Hydrogen sulfide (H(2)S) is a naturally occurring gas that has been shown to be a potent vasodilator." | 1.35 | Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury. ( Bhatia, M; Moore, PK; Sidhapuriwala, JN; Sparatore, A, 2008) |
| "Peridural fibrosis is one of the more frequent complications of lumbar surgery." | 1.35 | Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs. ( Hernandez-Vaquero, D; Sandoval, MA, 2008) |
| "Pain was inferred from impairment of gait and stance." | 1.34 | Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis. ( Arborelius, L; Berge, OG; Brodin, E; Heilborn, U, 2007) |
| "Carrageenan induced significant mechanical allodynia, thermal hyperalgesia and paw oedema at 6 h post-carrageenan, while paw incision surgery induced significant mechanical allodynia and thermal hyperalgesia at 6 and 24 h post-surgery." | 1.34 | Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain. ( Biddlestone, L; Corbett, AD; Dolan, S, 2007) |
| "Naloxone pretreatment had no effect on the antinociceptive effects of intradermal diclofenac, ketorolac, lysine acetyl salicylate, and sodium salicylate." | 1.34 | The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. ( Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC, 2007) |
| "However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
| "Treatment with aspirin (200 mg/kg, p." | 1.33 | Influence of protein malnutrition on induction and treatment of inflammation in mice. ( Bassiouny, K; Hamed, MR; Hassanein, NM; Talaat, RM, 2006) |
| "Treatment with diclofenac sodium extending past the acute inflammatory phase was no more effective than short and timely treatment in this model of skeletal muscle damage." | 1.32 | Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats. ( Côté, CH; Frémont, P; Lapointe, BM, 2003) |
| "Chronic pain resulting from metastatic bone cancer remains poorly understood and resistant to treatment." | 1.32 | Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. ( Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L, 2004) |
| "Main parameter was thrombus weight." | 1.32 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004) |
| "Diclofenac did not inhibit corneal haze formation significantly." | 1.31 | Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy. ( Amano, S; Kaji, Y; Obata, H; Ohashi, T; Oshika, T; Sakai, H; Shirasawa, E; Tsuru, T; Yamashita, H, 2000) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "This hyperalgesia was observed only in the period before the development of fever which started 120-135 min after the LPS injection." | 1.31 | Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. ( Abe, M; Hori, T; Oka, T; Takahashi, S, 2001) |
| "Diclofenac is a non-steroidal anti-inflammatory drug, commonly used by reproductive age women for the treatment of a variety of conditions." | 1.31 | A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model. ( Chan, LY; Chiu, PY; Lau, TK; Siu, SS, 2001) |
| "The acute pressure reaction after air embolism is mainly mediated via ET-1 by an ETA receptor related mechanism." | 1.30 | The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs. ( Heller, A; Koch, T; Neuhof, H; Patt, B; Schmeck, J; van Ackern, K, 1998) |
| "Misoprostol treatment resulted in a significant reduction in the extent of indomethacin-induced antral ulceration, but ranitidine had no effect." | 1.29 | Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. ( McKnight, GW; Wallace, JL, 1993) |
| "Diclofenac inhibits the increase in both pulmonary arterial pressure and EVLW during reperfusion and reventilation of LLL." | 1.29 | Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion. ( Albrecht, DM; Krieter, H; Segiet, W; Stieber, C; van Ackern, K, 1995) |
| "Treatment with diclofenac sodium tended to normalize this activity but there was no significant histological improvement." | 1.29 | Modulation of murine osteoarthritis. ( Bitensky, L; Chambers, MG; Chayen, J, 1996) |
| " Initial evaluation in the lipoidalamine (LA) arthritis model in rats (5-day dosing protocol) resulted in an oral ED50 of 4." | 1.28 | Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. ( Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.63) | 18.7374 |
| 1990's | 12 (4.90) | 18.2507 |
| 2000's | 78 (31.84) | 29.6817 |
| 2010's | 126 (51.43) | 24.3611 |
| 2020's | 25 (10.20) | 2.80 |
| Authors | Studies |
|---|---|
| Stock, N | 1 |
| Munoz, B | 1 |
| Wrigley, JD | 1 |
| Shearman, MS | 1 |
| Beher, D | 1 |
| Peachey, J | 1 |
| Williamson, TL | 1 |
| Bain, G | 1 |
| Chen, W | 1 |
| Jiang, X | 1 |
| St-Jacques, R | 1 |
| Prasit, P | 1 |
| Cowart, MD | 1 |
| Altenbach, RJ | 1 |
| Liu, H | 1 |
| Hsieh, GC | 3 |
| Drizin, I | 1 |
| Milicic, I | 1 |
| Miller, TR | 1 |
| Witte, DG | 1 |
| Wishart, N | 1 |
| Fix-Stenzel, SR | 1 |
| McPherson, MJ | 1 |
| Adair, RM | 1 |
| Wetter, JM | 1 |
| Bettencourt, BM | 1 |
| Marsh, KC | 1 |
| Sullivan, JP | 1 |
| Honore, P | 2 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Abdel-Aziz, AA | 1 |
| ElTahir, KE | 1 |
| Asiri, YA | 1 |
| Blanco, MJ | 1 |
| Vetman, T | 1 |
| Chandrasekhar, S | 1 |
| Fisher, MJ | 1 |
| Harvey, A | 1 |
| Chambers, M | 1 |
| Lin, C | 1 |
| Mudra, D | 1 |
| Oskins, J | 1 |
| Wang, XS | 1 |
| Yu, XP | 1 |
| Warshawsky, AM | 1 |
| Frost, JM | 1 |
| DeGoey, DA | 1 |
| Shi, L | 1 |
| Gum, RJ | 1 |
| Fricano, MM | 1 |
| Lundgaard, GL | 1 |
| El-Kouhen, OF | 1 |
| Neelands, T | 1 |
| Matulenko, MA | 1 |
| Daanen, JF | 1 |
| Pai, M | 1 |
| Ghoreishi-Haack, N | 1 |
| Zhan, C | 1 |
| Zhang, XF | 1 |
| Kort, ME | 1 |
| Muthukaman, N | 1 |
| Tambe, M | 1 |
| Shaikh, M | 1 |
| Pisal, D | 1 |
| Deshmukh, S | 1 |
| Tondlekar, S | 1 |
| Sarode, N | 1 |
| Narayana, L | 1 |
| Gajera, JM | 1 |
| Kattige, VG | 1 |
| Honnegowda, S | 1 |
| Karande, V | 1 |
| Kulkarni, A | 1 |
| Behera, D | 1 |
| Jadhav, SB | 1 |
| Gudi, GS | 1 |
| Khairatkar-Joshi, N | 1 |
| Gharat, LA | 1 |
| Shrivastava, SK | 1 |
| Srivastava, P | 1 |
| Bandresh, R | 1 |
| Tripathi, PN | 1 |
| Tripathi, A | 1 |
| Katselou, MG | 1 |
| Matralis, AN | 1 |
| Kourounakis, AP | 1 |
| Salado, IG | 1 |
| Baán, A | 1 |
| Verdeyen, T | 1 |
| Matheeussen, A | 1 |
| Caljon, G | 1 |
| Van der Veken, P | 1 |
| Kiekens, F | 1 |
| Maes, L | 1 |
| Augustyns, K | 1 |
| Xue, ST | 1 |
| Zhang, L | 1 |
| Xie, ZS | 1 |
| Jin, J | 1 |
| Guo, HF | 2 |
| Yi, H | 1 |
| Liu, ZY | 1 |
| Li, ZR | 1 |
| Chen, LZ | 1 |
| Shu, HY | 1 |
| Wu, J | 1 |
| Yu, YL | 1 |
| Ma, D | 1 |
| Huang, X | 2 |
| Liu, MM | 1 |
| Liu, XH | 1 |
| Shi, JB | 1 |
| Chávez-Riveros, A | 1 |
| Hernández-Vázquez, E | 1 |
| Ramírez-Trinidad, Á | 1 |
| Nieto-Camacho, A | 1 |
| Miranda, LD | 1 |
| Banji, D | 1 |
| Banji, OJF | 1 |
| Rashida, S | 1 |
| Alshahrani, S | 1 |
| Alqahtani, SS | 1 |
| Arai, T | 1 |
| Suzuki-Narita, M | 1 |
| Takeuchi, J | 1 |
| Tajiri, I | 1 |
| Inage, K | 1 |
| Kawarai, Y | 1 |
| Eguchi, Y | 1 |
| Shiga, Y | 1 |
| Hozumi, T | 1 |
| Kim, G | 1 |
| Tsuchiya, R | 1 |
| Otagiri, T | 1 |
| Mukaihata, T | 1 |
| Hishiya, T | 1 |
| Toshi, N | 1 |
| Okuyama, K | 1 |
| Tokeshi, S | 1 |
| Furuya, T | 1 |
| Maki, S | 1 |
| Matsuura, Y | 1 |
| Suzuki, T | 1 |
| Nakamura, J | 1 |
| Hagiwara, S | 1 |
| Ohtori, S | 1 |
| Orita, S | 1 |
| Erdogan, A | 2 |
| Erdogan, MA | 2 |
| Gurgul, S | 2 |
| Erbas, O | 2 |
| Almehizia, AA | 1 |
| Khattab, AEA | 1 |
| Darwish, AM | 1 |
| Al-Omar, MA | 1 |
| Naglah, AM | 1 |
| Bhat, MA | 1 |
| Kalmouch, A | 1 |
| Madzuki, IN | 1 |
| Lau, SF | 3 |
| Mohamad Shalan, NAA | 1 |
| Mohd Ishak, NI | 1 |
| Mohamed, S | 3 |
| Khayyal, MT | 2 |
| Wadie, W | 1 |
| Abd El-Haleim, EA | 1 |
| Ahmed, KA | 1 |
| Kelber, O | 1 |
| Ammar, RM | 1 |
| Abdel-Aziz, H | 1 |
| Arakawa, K | 1 |
| Ikeyama, Y | 1 |
| Sato, T | 1 |
| Segawa, M | 1 |
| Sekine, S | 1 |
| Ito, K | 2 |
| Nagaraju, B | 1 |
| Shanmukhakumar, JV | 1 |
| Seelam, N | 1 |
| Subbaiah, T | 1 |
| Prasanna, B | 1 |
| Morgan, SR | 1 |
| Pilia, N | 1 |
| Hewitt, M | 1 |
| Moses, RL | 1 |
| Moseley, R | 1 |
| Lewis, PN | 1 |
| Morrison, PWJ | 1 |
| Kelly, SL | 1 |
| Parker, JE | 1 |
| Whitaker, D | 1 |
| Quantock, AJ | 1 |
| Heard, CM | 1 |
| Dos Santos Haupenthal, DP | 1 |
| Zortea, D | 1 |
| Zaccaron, RP | 2 |
| de Bem Silveira, G | 1 |
| Corrêa, MEAB | 1 |
| Mendes, C | 1 |
| de Roch Casagrande, L | 1 |
| Duarte, MB | 1 |
| Pinho, RA | 1 |
| Feuser, PE | 1 |
| Machado-de-Ávila, RA | 1 |
| Silveira, PCL | 2 |
| Tantowi, NACA | 1 |
| Hussin, P | 2 |
| Ailincai, D | 1 |
| Mititelu-Tartau, L | 1 |
| Marin, L | 2 |
| Jiang, W | 1 |
| Dai, T | 1 |
| Xie, S | 1 |
| Ding, L | 1 |
| Huang, L | 1 |
| Dai, R | 1 |
| Kudsi, SQ | 1 |
| Antoniazzi, CTD | 1 |
| Camponogara, C | 1 |
| Brum, EDS | 1 |
| Brusco, I | 1 |
| Peres, DS | 1 |
| Fischer, SPM | 1 |
| Dalenogare, DP | 1 |
| Stein, CDS | 1 |
| Moresco, RN | 1 |
| Oliveira, SM | 1 |
| Trevisan, G | 1 |
| Ishii, S | 1 |
| Yoshioka, K | 1 |
| Morita, D | 1 |
| Ha, W | 1 |
| Wang, ZH | 1 |
| Zhao, XB | 1 |
| Shi, YP | 1 |
| Chao, G | 1 |
| Wang, Z | 1 |
| Yang, C | 1 |
| Qian, Y | 1 |
| Zhang, S | 1 |
| Xu, N | 1 |
| Zhang, C | 1 |
| Jing, L | 1 |
| Mou, S | 1 |
| Cao, X | 1 |
| Yu, Z | 1 |
| Wen, X | 1 |
| Wu, H | 1 |
| Abdou, RM | 1 |
| El-Maadawy, WH | 1 |
| Hassan, M | 1 |
| El-Dine, RS | 1 |
| Aboushousha, T | 1 |
| El-Tanbouly, ND | 1 |
| El-Sayed, AM | 1 |
| Nipa, NS | 1 |
| Ali, T | 1 |
| Akhter, S | 1 |
| Rafiq, K | 1 |
| Gowayed, MA | 1 |
| Abdel-Bary, A | 1 |
| El-Tahan, RA | 1 |
| Zatorski, H | 1 |
| Salaga, M | 1 |
| Zielińska, M | 1 |
| Majchrzak, K | 1 |
| Binienda, A | 1 |
| Kordek, R | 1 |
| Małecka-Panas, E | 1 |
| Fichna, J | 1 |
| Ventura-Martínez, R | 1 |
| Déciga-Campos, M | 1 |
| Bustamante-Marquina, A | 1 |
| Ángeles-López, GE | 1 |
| Aviles-Herrera, J | 1 |
| González-Trujano, ME | 1 |
| Navarrete-Vázquez, G | 1 |
| Yasin, H | 1 |
| Mahmud, S | 1 |
| Abrar, H | 1 |
| Arsalan, A | 1 |
| Jahan, N | 1 |
| Fatima, K | 1 |
| Bano, R | 1 |
| Hussain, RA | 1 |
| Islam, M | 1 |
| Kumar, B | 1 |
| Modi, M | 1 |
| Saikia, B | 1 |
| Medhi, B | 1 |
| Oda, SS | 1 |
| Derbalah, AE | 1 |
| Che Ahmad Tantowi, NA | 1 |
| Nguyen, CN | 1 |
| Nguyen, TTT | 1 |
| Nguyen, HT | 1 |
| Tran, TH | 1 |
| Katara, R | 2 |
| Sachdeva, S | 2 |
| Majumdar, DK | 2 |
| Tsagareli, MG | 1 |
| Nozadze, I | 1 |
| Tsiklauri, N | 1 |
| Gurtskaia, G | 1 |
| Yellepeddi, VK | 1 |
| Radhakrishnan, J | 1 |
| Radhakrishnan, R | 1 |
| Ture, Z | 1 |
| Demiraslan, H | 1 |
| Kontas, O | 1 |
| Alp, E | 1 |
| Doganay, M | 1 |
| Prasad, GS | 1 |
| Govardhan, P | 1 |
| Deepika, G | 1 |
| Vakdevi, V | 1 |
| Sashidhar, RB | 1 |
| Ibrahim, MA | 1 |
| Abdelzaher, WY | 1 |
| Rofaeil, RR | 1 |
| Abdelwahab, S | 1 |
| Ohmichi, Y | 1 |
| Ohmichi, M | 1 |
| Murai, N | 1 |
| Yasui, M | 1 |
| Takeshita, N | 1 |
| Oshibuchi, H | 1 |
| Naito, M | 1 |
| Nakano, T | 1 |
| Sato, J | 1 |
| Zamudio-Cuevas, Y | 1 |
| Fernández-Torres, J | 1 |
| Martínez-Nava, GA | 1 |
| Martínez-Flores, K | 1 |
| López-Reyes, A | 1 |
| Magliocca, S | 1 |
| De Caro, C | 1 |
| Lazzarato, L | 1 |
| Russo, R | 1 |
| Rolando, B | 1 |
| Chegaev, K | 1 |
| Marini, E | 1 |
| Nieddu, M | 1 |
| Burrai, L | 1 |
| Boatto, G | 1 |
| Cristiano, C | 1 |
| Marabello, D | 1 |
| Gazzano, E | 1 |
| Riganti, C | 1 |
| Sodano, F | 1 |
| Rimoli, MG | 1 |
| Chaudhari, PS | 1 |
| Chitlange, SS | 1 |
| Nanda, RK | 1 |
| Costa, FV | 1 |
| Rosa, LV | 1 |
| Quadros, VA | 1 |
| Santos, ARS | 1 |
| Kalueff, AV | 1 |
| Rosemberg, DB | 1 |
| Craciun, AM | 1 |
| Mititelu Tartau, L | 1 |
| Pinteala, M | 1 |
| Andreev, YA | 1 |
| Osmakov, DI | 1 |
| Koshelev, SG | 1 |
| Maleeva, EE | 1 |
| Logashina, YA | 1 |
| Palikov, VA | 1 |
| Palikova, YA | 1 |
| Dyachenko, IA | 1 |
| Kozlov, SA | 1 |
| Ter Heegde, F | 1 |
| Luiz, AP | 1 |
| Santana-Varela, S | 1 |
| Chessell, IP | 1 |
| Welsh, F | 1 |
| Wood, JN | 1 |
| Chenu, C | 1 |
| Cardoso, LCP | 1 |
| Pinto, NB | 1 |
| Nobre, MEP | 1 |
| Silva, MR | 1 |
| Pires, GM | 1 |
| Lopes, MJP | 1 |
| Viana, GSB | 1 |
| Rodrigues, LMR | 1 |
| Beskhmelnitsyna, EA | 1 |
| Pokrovskii, MV | 1 |
| Kulikov, AL | 1 |
| Peresypkina, AA | 1 |
| Varavin, EI | 1 |
| Shimada, S | 1 |
| Tanigawa, T | 1 |
| Watanabe, T | 1 |
| Nakata, A | 1 |
| Sugimura, N | 1 |
| Itani, S | 1 |
| Higashimori, A | 1 |
| Nadatani, Y | 1 |
| Otani, K | 3 |
| Taira, K | 1 |
| Hosomi, S | 1 |
| Nagami, Y | 1 |
| Tanaka, F | 1 |
| Kamata, N | 1 |
| Yamagami, H | 1 |
| Shiba, M | 1 |
| Fujiwara, Y | 1 |
| Ahmed, T | 1 |
| Archie, SR | 1 |
| Faruk, A | 1 |
| Chowdhury, FA | 1 |
| Al Shoyaib, A | 1 |
| Ahsan, CR | 1 |
| Zagorchev, PI | 1 |
| Apostolova, EG | 1 |
| Pilicheva, BA | 1 |
| Draganova-Filipova, MN | 1 |
| Kokova, VY | 1 |
| Lukanov, JB | 1 |
| Jana, S | 3 |
| Das, A | 1 |
| Nayak, AK | 2 |
| Sen, KK | 4 |
| Basu, SK | 2 |
| Gaur, PK | 1 |
| Purohit, S | 1 |
| Kumar, Y | 1 |
| Mishra, S | 1 |
| Bhandari, A | 1 |
| Valle, BL | 1 |
| D'Souza, T | 1 |
| Becker, KG | 1 |
| Wood, WH | 1 |
| Zhang, Y | 1 |
| Wersto, RP | 1 |
| Morin, PJ | 1 |
| Torres-López, JE | 1 |
| Carmona-Díaz, E | 1 |
| Cortés-Peñaloza, JL | 1 |
| Guzmán-Priego, CG | 1 |
| Rocha-González, HI | 1 |
| Ercan, N | 1 |
| Uludag, MO | 1 |
| Agis, ER | 1 |
| Demirel-Yilmaz, E | 1 |
| Momoh, MA | 1 |
| Kenechukwu, FC | 1 |
| Adedokun, MO | 1 |
| Odo, CE | 1 |
| Attama, AA | 1 |
| Tamaddonfard, E | 1 |
| Farshid, AA | 1 |
| Eghdami, K | 1 |
| Samadi, F | 1 |
| Erfanparast, A | 1 |
| de Souza, AH | 1 |
| da Costa Lopes, AM | 1 |
| Castro, CJ | 1 |
| Pereira, EM | 1 |
| Klein, CP | 1 |
| da Silva, CA | 1 |
| da Silva, JF | 1 |
| Ferreira, J | 1 |
| Gomez, MV | 1 |
| Chaudhary, H | 1 |
| Kohli, K | 1 |
| Kumar, V | 1 |
| Sawazaki, R | 1 |
| Ishihara, T | 1 |
| Usui, S | 1 |
| Hayashi, E | 1 |
| Tahara, K | 1 |
| Hoshino, T | 1 |
| Higuchi, A | 1 |
| Nakamura, S | 1 |
| Tsubota, K | 1 |
| Mizushima, T | 1 |
| Krishnan, K | 1 |
| Mathew, LE | 1 |
| Vijayalakshmi, NR | 1 |
| Helen, A | 1 |
| Torres-Silva, R | 1 |
| Lopes-Martins, RA | 1 |
| Bjordal, JM | 1 |
| Frigo, L | 1 |
| Rahouadj, R | 1 |
| Arnold, G | 1 |
| Leal-Junior, EC | 1 |
| Magdalou, J | 1 |
| Pallotta, R | 1 |
| Marcos, RL | 1 |
| Dhokchawle, BV | 1 |
| Bhandari, AB | 1 |
| Dohnert, MB | 2 |
| Ferreira, GK | 1 |
| Silveira, PC | 1 |
| Zanoni, ET | 1 |
| Dohnert, LH | 2 |
| de Souza, CT | 2 |
| Paula, MM | 2 |
| Somagoni, J | 1 |
| Boakye, CH | 1 |
| Godugu, C | 1 |
| Patel, AR | 1 |
| Mendonca Faria, HA | 1 |
| Zucolotto, V | 1 |
| Singh, M | 1 |
| Ganesh, M | 1 |
| Jeon, UJ | 1 |
| Ubaidulla, U | 1 |
| Hemalatha, P | 1 |
| Saravanakumar, A | 1 |
| Peng, MM | 1 |
| Jang, HT | 1 |
| Zhu, CZ | 2 |
| Bannon, AW | 2 |
| Joshi, SK | 2 |
| Raju, YP | 1 |
| Haritha, K | 1 |
| Satyanarayana, RP | 1 |
| Vandana, KR | 1 |
| Bindu, DT | 1 |
| Vinesha, V | 1 |
| Chowdary, VH | 1 |
| Datar, PA | 1 |
| Limaye, SA | 1 |
| Ramm, S | 1 |
| Morissey, B | 1 |
| Hernandez, B | 1 |
| Rooney, C | 1 |
| Pennington, SR | 1 |
| Mally, A | 1 |
| Remeniuk, B | 1 |
| Sukhtankar, D | 1 |
| Okun, A | 1 |
| Navratilova, E | 1 |
| Xie, JY | 1 |
| King, T | 1 |
| Porreca, F | 2 |
| Gupta, AK | 1 |
| Parasar, D | 1 |
| Sagar, A | 1 |
| Choudhary, V | 1 |
| Chopra, BS | 1 |
| Garg, R | 1 |
| Khatri, N | 1 |
| Buyukserbetci, M | 1 |
| Dadali, M | 1 |
| Aydogmus, Y | 1 |
| Huri, E | 1 |
| Hascicek, AM | 1 |
| Ozer, E | 1 |
| Ogus, E | 1 |
| Kilinc, AS | 1 |
| Eroglu, M | 1 |
| Teixeira, GQ | 1 |
| Boldt, A | 1 |
| Nagl, I | 1 |
| Pereira, CL | 1 |
| Benz, K | 1 |
| Wilke, HJ | 1 |
| Ignatius, A | 1 |
| Barbosa, MA | 1 |
| Gonçalves, RM | 1 |
| Neidlinger-Wilke, C | 1 |
| Zupanets, IA | 1 |
| Shebeko, SK | 1 |
| Popov, OS | 1 |
| Shalamay, AS | 1 |
| Yadav, R | 1 |
| Angolkar, T | 1 |
| Kaur, G | 1 |
| Buttar, HS | 1 |
| Kilic, S | 1 |
| Kulualp, K | 1 |
| Reisinger, KW | 1 |
| Schellekens, DH | 1 |
| Bosmans, JW | 1 |
| Boonen, B | 1 |
| Hulsewé, KW | 1 |
| Sastrowijoto, P | 1 |
| Derikx, JP | 1 |
| Grootjans, J | 1 |
| Poeze, M | 1 |
| Amdekar, S | 1 |
| Singh, V | 1 |
| Liao, AH | 1 |
| Chung, HY | 1 |
| Chen, WS | 1 |
| Yeh, MK | 1 |
| Mikusic, NLR | 1 |
| Roson, MI | 1 |
| Penna, SLD | 1 |
| Choi, MR | 1 |
| Gorzalczany, S | 1 |
| Zotta, E | 1 |
| Toblli, JE | 1 |
| Fernandez, BE | 1 |
| Greeshma, P | 1 |
| Ravikumar, KS | 1 |
| Neethu, MN | 1 |
| Pandey, M | 1 |
| Zuhara, KF | 1 |
| Janardhanan, KK | 1 |
| Huang, J | 1 |
| Nguyen, V | 1 |
| Tang, X | 1 |
| Wei, J | 1 |
| Lin, X | 1 |
| Lai, Z | 1 |
| Doan, V | 1 |
| Xie, Q | 1 |
| Huang, R | 1 |
| Pandey, A | 1 |
| Kumar, VL | 1 |
| Türkmen, AP | 1 |
| Kaplan, S | 2 |
| Aksoy, A | 1 |
| Altunkaynak, B | 1 |
| Yurt, K | 1 |
| Elibol, E | 1 |
| Çokluk, C | 1 |
| Onger, M | 1 |
| Vieira, V | 1 |
| Glassmann, D | 1 |
| Marafon, P | 1 |
| Pereira, P | 1 |
| Gomez, R | 1 |
| Coitinho, AS | 1 |
| Manzhulo, IV | 1 |
| Ogurtsova, OS | 1 |
| Kipryushina, YO | 1 |
| Latyshev, NA | 1 |
| Kasyanov, SP | 1 |
| Dyuizen, IV | 1 |
| Tyrtyshnaia, AA | 1 |
| Banerjee, A | 1 |
| Maiti, S | 1 |
| Kale, MA | 1 |
| Nawale, RB | 1 |
| Peharkar, MR | 1 |
| Kuberkar, SV | 1 |
| El-Shafei, RA | 1 |
| Saleh, RM | 1 |
| Panahi, Y | 1 |
| Naderi, M | 1 |
| Jadidi, K | 1 |
| Hoseini, H | 1 |
| Abrishami, M | 1 |
| Krügel, U | 1 |
| Straub, I | 1 |
| Beckmann, H | 1 |
| Schaefer, M | 1 |
| Barcelos, RP | 1 |
| Bresciani, G | 1 |
| Cuevas, MJ | 1 |
| Martínez-Flórez, S | 1 |
| Soares, FAA | 1 |
| González-Gallego, J | 1 |
| Hosni, HM | 1 |
| Abdulla, MM | 1 |
| Hassanein, NM | 1 |
| Talaat, RM | 1 |
| Bassiouny, K | 1 |
| Hamed, MR | 1 |
| Mythilypriya, R | 1 |
| Shanthi, P | 1 |
| Sachdanandam, P | 1 |
| Besen, A | 1 |
| Kose, F | 1 |
| Paydas, S | 1 |
| Gonlusen, G | 1 |
| Inal, T | 1 |
| Dogan, A | 1 |
| Kibar, M | 1 |
| Balal, M | 1 |
| Richard, V | 1 |
| Solans, V | 1 |
| Favre, J | 1 |
| Henry, JP | 1 |
| Lallemand, F | 1 |
| Thuillez, C | 1 |
| Marie, I | 1 |
| Elron-Gross, I | 1 |
| Glucksam, Y | 1 |
| Biton, IE | 1 |
| Margalit, R | 1 |
| Füredi, R | 1 |
| Bölcskei, K | 1 |
| Szolcsányi, J | 1 |
| Petho, G | 1 |
| Capuano, A | 1 |
| De Corato, A | 1 |
| Treglia, M | 1 |
| Tringali, G | 1 |
| Dello Russo, C | 1 |
| Navarra, P | 1 |
| Eter, EG | 1 |
| Khazzaka, A | 1 |
| Mneimneh, W | 1 |
| Karam-Sarkis, D | 1 |
| Haddad, A | 1 |
| Sarkis, R | 1 |
| Walker, TD | 1 |
| Alagarsamy, V | 4 |
| Shankar, D | 2 |
| Solomon, VR | 1 |
| Sheorey, RV | 1 |
| Parthiban, P | 2 |
| Mazumdar, K | 2 |
| Dastidar, SG | 2 |
| Park, JH | 2 |
| Dutta, NK | 2 |
| Cohen, MP | 1 |
| Shearman, CW | 1 |
| Niazi, J | 1 |
| Singh, P | 1 |
| Bansal, Y | 1 |
| Goel, RK | 1 |
| Barañano, DE | 1 |
| Kim, SJ | 1 |
| Edelhauser, HF | 1 |
| Durairaj, C | 1 |
| Kompella, UB | 1 |
| Handa, JT | 1 |
| Dolan, S | 2 |
| Gunn, MD | 1 |
| Biddlestone, L | 2 |
| Nolan, AM | 1 |
| Boyce-Rustay, JM | 1 |
| Zhong, C | 2 |
| Kohnken, R | 1 |
| Baker, SJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Novel Technique of Pneumatic Posterior Capsulorhexis for Treatment and Prevention of Posterior Capsular Opacification[NCT04007965] | 100 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| Effects of Colostrum Supplement on Inflammatory and Growth Factors, Immune System Function and Clinical Outcomes in Hospitalized Patients With Enteral Feeding in Intensive Care Unit[NCT03019250] | 200 participants (Actual) | Interventional | 2017-01-15 | Completed | |||
| Effects of Colostrum Supplement on Intestinal Permeability in Hospitalized Patients With Enteral Feeding in Intensive Care Unit[NCT03186716] | 70 participants (Actual) | Interventional | 2017-06-11 | Completed | |||
| Analysis of Effect of Low Level Laser Therapy in Spinal Surgery[NCT02529657] | 48 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
Emergent nanotherapies in microcrystal-induced arthritis.
Topics: Animals; Calcium Phosphates; Chitosan; Chondrocalcinosis; Crystal Arthropathies; Diclofenac; Disease | 2018 |
Pharmacological attempts to reduce posterior capsule opacification after cataract surgery--a review.
Topics: Animals; Cataract Extraction; Corneal Opacity; Dexamethasone; Diclofenac; Disease Models, Animal; Hu | 2008 |
The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Diclo | 2009 |
The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Diclofenac; Disease Models, Animal; Human | 2010 |
3 trials available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
Oral misoprostol does not protect the kidneys from diclofenac induced toxicity: data from an unilateral ureteral obstructive rat model.
Topics: Administration, Oral; Animals; Diclofenac; Disease Models, Animal; Female; Kidney; Misoprostol; Rats | 2015 |
Efficacy of systemic diclofenac sodium on intravitreal concentration.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, | 2018 |
Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Adhesion; Bacterial Translocation; Cattl | 2005 |
Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Adhesion; Bacterial Translocation; Cattl | 2005 |
Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Adhesion; Bacterial Translocation; Cattl | 2005 |
Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Adhesion; Bacterial Translocation; Cattl | 2005 |
238 other studies available for diclofenac and Disease Models, Animal
| Article | Year |
|---|---|
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, N | 2006 |
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Topics: Amines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Histamine Antagonists; Ligands; M | 2008 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Cyclooxygenas | 2011 |
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Topics: Animals; Benzoic Acid; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Half-Life; Humans | 2016 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Ev | 2016 |
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
Topics: A549 Cells; Administration, Oral; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease | 2017 |
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhi | 2017 |
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Mod | 2017 |
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.
Topics: Animals; Disease Models, Animal; Humans; Mice; Structure-Activity Relationship; Triazines; Tropolone | 2018 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Respo | 2020 |
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dos | 2021 |
Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Artemia; Cell Survival; Diphenylamine; Disease Mod | 2021 |
Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bilirubin; Biological Availability; Boswellia; Diclofe | 2022 |
Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Diclofenac; Disease Models, Animal; Hyaluronic | 2022 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease | 2023 |
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from
Topics: Aging; Animals; Bone Development; Cartilage; Chondrocytes; Diclofenac; Disease Models, Animal; Estro | 2019 |
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Duodenal Ulcer | 2019 |
Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Drug Synergism; | 2019 |
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coordination Complexes; Cyclization; Diclofenac; Dis | 2019 |
Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Ophthalmic; Animals; Contact Lenses, Hydrophil | 2020 |
Effects of phonophoresis with diclofenac linked gold nanoparticles in model of traumatic muscle injury.
Topics: Animals; Catalase; Diclofenac; Disease Models, Animal; Glutathione; Gold; Hyperalgesia; Metal Nanopa | 2020 |
Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model.
Topics: Administration, Oral; Animals; Apigenin; Cytokines; Diclofenac; Disease Models, Animal; Dose-Respons | 2020 |
Citryl-imine-PEG-ylated chitosan hydrogels - Promising materials for drug delivery applications.
Topics: Animals; Chitosan; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Hydrogels; Pain; Polye | 2020 |
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Dru | 2020 |
Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Ani | 2020 |
[Residual Property of SI-613, a Novel Drug for Osteoarthritis, in Knee Joint].
Topics: Animals; Cartilage; Diclofenac; Disease Models, Animal; Hyaluronic Acid; Injections, Intra-Articular | 2020 |
Reinforced Supramolecular Hydrogels from Attapulgite and Cyclodextrin Pseudopolyrotaxane for Sustained Intra-Articular Drug Delivery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Regeneration; Cyclodextrins; Diclofenac; Dise | 2021 |
Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity.
Topics: Abdominal Injuries; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, An | 2021 |
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Claudin-1; Cytokines; Diclofenac; Disease | 2021 |
Development of a novel intraarticular injection of diclofenac for the treatment of arthritis: a preclinical study in the rabbit model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Precipitation; D | 2021 |
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study.
Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; C | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldeh | 2020 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Dic | 2021 |
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice.
Topics: Administration, Oral; Animals; Catalase; Diclofenac; Disease Models, Animal; Ethanol; Male; Mice; Om | 2021 |
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis; Diclofenac; Dis | 2021 |
Anti-inflammatory and histopathological studies of leaves extracts of Croton bonplandianus in Albino rats.
Topics: Animals; Anti-Inflammatory Agents; Croton; Diclofenac; Disease Models, Animal; Dose-Response Relatio | 2021 |
Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbon Tetrachl | 2017 |
Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity).
Topics: Animals; Apoptosis; Biomarkers; Cardiotoxicity; Caspase 3; Chemical and Drug Induced Liver Injury; D | 2018 |
Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Cartilage; Collagen Type II; Diclofenac; | 2017 |
Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, | 2017 |
Enhancement of ocular efficacy of aceclofenac using biodegradable PLGA nanoparticles: formulation and characterization.
Topics: Administration, Ophthalmic; Animals; Arachidonic Acid; Calorimetry, Differential Scanning; Chemistry | 2017 |
Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Disease Models, | 2018 |
Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Celecoxib; | 2018 |
The role of nonsteroidal anti-inflammatory drugs intramuscular injection in the development and severity of deep soft tissue infection in mice.
Topics: Abscess; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Bacterial Load; Diclofenac; D | 2018 |
Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Computer Simulation; Cyclooxygenase 1; Cyclooxygenas | 2018 |
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; D | 2018 |
Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
Topics: Animals; Chronic Pain; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Muscle, | 2018 |
Design, characterization, and evaluation of aceclofenac-loaded Eudragit RS 100 nanoparticulate system for ocular delivery.
Topics: Acrylic Resins; Administration, Ophthalmic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell M | 2019 |
Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations.
Topics: Acute Pain; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avail | 2018 |
Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Carrageenan; Diclofenac; Disease Models, Anim | 2018 |
Understanding nociception-related phenotypes in adult zebrafish: Behavioral and pharmacological characterization using a new acetic acid model.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-St | 2019 |
Nitrosalicyl-imine-chitosan hydrogels based drug delivery systems for long term sustained release in local therapy.
Topics: Animals; Chitosan; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Hydrogels; Imines; Mal | 2019 |
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Biol | 2018 |
Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Behavior, Animal; Cartilag | 2019 |
Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 2019 |
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Diclofenac; D | 2019 |
Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Diclofenac; Diet, Gluten-Free; Dis | 2019 |
Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Atorvastatin; Diclofenac; Disease Mo | 2020 |
In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations.
Topics: Acrylic Resins; Analgesics; Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibi | 2018 |
Aceclofenac-loaded unsaturated esterified alginate/gellan gum microspheres: in vitro and in vivo assessment.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Mat | 2013 |
Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceramides; Chemistry, P | 2014 |
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumo | 2013 |
Antinociceptive synergy between diclofenac and morphine after local injection into the inflamed site.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; | 2013 |
The anti-inflammatory effect of diclofenac is considerably augmented by topical capsaicinoids-containing patch in carrageenan-induced paw oedema of rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Capsicum; Carrageenan; Diclofenac; Dise | 2013 |
Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres.
Topics: Acrylic Resins; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2014 |
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carotenoids; Carrageenan; Cyclohexenes; Diclofenac; D | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
A novel nano-carrier transdermal gel against inflammation.
Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Ca | 2014 |
Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Diclofenac; Disease Models, Anima | 2014 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, An | 2014 |
The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagenases; Cyclooxygenase 2; D | 2015 |
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Inflammatory cytokines content in Achilles tendinopathy after phonophoresis treatment combined with gold nanoparticles and diclophenac diethylammonium in rats.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Gold; Inflam | 2015 |
Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Capsaicin; Cell Proliferation; Diclofenac; Dise | 2014 |
Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chitosan; Crys | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxy | 2015 |
Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Disea | 2015 |
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
Topics: Acetic Acid; Analgesics; Animals; Benzimidazoles; Diclofenac; Disease Models, Animal; Drug Evaluatio | 2015 |
Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration.
Topics: Animals; Biomarkers; Blood Proteins; Chemical and Drug Induced Liver Injury; Chromatography, High Pr | 2015 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Stero | 2015 |
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, | 2015 |
A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Diclofenac; Disease Models, Animal; Equipment De | 2016 |
Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Diclofenac; Disease Models, Animal; Drug | 2016 |
Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cattle | 2016 |
Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome.
Topics: Animals; Anti-Inflammatory Agents; Blinking; Cyclosporine; Diclofenac; Disease Models, Animal; Dry E | 2016 |
Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing.
Topics: Anastomosis, Surgical; Anastomotic Leak; Angiogenesis Inducing Agents; Animals; Chi-Square Distribut | 2017 |
Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Diclofenac; Dise | 2016 |
Efficacy of Combined Ultrasound-and-Microbubbles-Mediated Diclofenac Gel Delivery to Enhance Transdermal Permeation in Adjuvant-Induced Rheumatoid Arthritis in the Rat.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental | 2016 |
Synthesis and Biological Evaluation of New N-(4-Substituted phenyl)glycine Derivatives as Potential Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Drug Design; Dru | 2016 |
Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes).
Topics: Agaricales; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Benzothiazoles; | 2016 |
Protection from diclofenac-induced liver injury by Yulangsan polysaccharide in a mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; Disease Models, Animal; Liv | 2016 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, | 2016 |
Effects of diclofenac sodium on the hippocampus of rats with acute subdural hematoma: histological, stereological, and molecular approach.
Topics: Animals; Diclofenac; Disease Models, Animal; Hematoma, Subdural, Acute; Hippocampus; Immunohistochem | 2016 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Dicl | 2016 |
Gelatin-carboxymethyl tamarind gum biocomposites: In vitro characterization & anti-inflammatory pharmacodynamics.
Topics: Animals; Anti-Inflammatory Agents; Calorimetry, Differential Scanning; Diclofenac; Disease Models, A | 2016 |
Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Diclofenac; Disease Models, Animal; | 2016 |
Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cytoprotection; Diclofenac; D | 2016 |
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; | 2017 |
Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway.
Topics: Animals; Cyclooxygenase 2; Diclofenac; Disease Models, Animal; Inflammation; Interleukin-1beta; Inte | 2017 |
Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Carrageenan; Diclofenac; Disease Mode | 2008 |
Influence of protein malnutrition on induction and treatment of inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Diclofenac; Diet, Protein-Re | 2006 |
Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cotton Fiber; Diclofenac; D | 2008 |
The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, | 2009 |
Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1.
Topics: Acetylcholine; Animals; Bosentan; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dos | 2008 |
A novel Diclofenac-carrier for local treatment of osteoarthritis applying live-animal MRI.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen Type I; Delayed-Action Preparations; Dicl | 2009 |
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, An | 2009 |
Antinociceptive activity of buprenorphine and lumiracoxib in the rat orofacial formalin test: a combination analysis study.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, | 2009 |
Does diclofenac increase the risk of cervical necrotizing fasciitis in a rat model?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fasciitis, Nec | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; F | 2009 |
Reduction of Abeta42 in brains of transgenic APPswe mice by 2-3-chlorophenylaminophenylacetate.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Diclofenac | 2009 |
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea | 2009 |
Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; | 2009 |
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.
Topics: Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzhydryl Compounds; Carra | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclo | 2010 |
Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociceptors in the knee joint of the rat.
Topics: Action Potentials; Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2009 |
Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Citrus; Diclofenac; Dise | 2009 |
Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model.
Topics: Animals; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antigen-Antibody Reactions; | 2010 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclof | 2010 |
Effect of COX-2 inhibitor after TNBS-induced colitis in Wistar rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Inflammatory Bowel Disease | 2009 |
Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.
Topics: Administration, Oral; Analgesics; Animals; Biological Availability; Carrageenan; Cyclooxygenase 2 In | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal | 2010 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Fa | 2010 |
Induction of apoptosis as a potential chemopreventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Chemoprevention; Colon; Co | 2010 |
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Ca | 2010 |
Pharmacologic targeting or genetic deletion of mitochondrial cyclophilin D protects from NSAID-induced small intestinal ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclophilins; Cyclospori | 2010 |
Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrage | 2010 |
Diclofenac enhances allergic responses in a mouse peanut allergy model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Female; Immune | 2011 |
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase | 2011 |
Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Arginase; Cell Proliferation; Di | 2010 |
The influence of irradiation on the potential chondroprotective effect of aqueous extract of propolis in rats.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Exper | 2011 |
Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis.
Topics: Adhesiveness; Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Del | 2010 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl | 2011 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; H | 2011 |
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, | 2011 |
Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.
Topics: Analysis of Variance; Animals; Caco-2 Cells; Cell Shape; Coculture Techniques; Culture Media, Condit | 2011 |
Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model.
Topics: Analgesics; Animals; Cattle; Diclofenac; Disease Models, Animal; Intervertebral Disc Displacement; L | 2010 |
Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis.
Topics: Amphiregulin; Animals; Animals, Newborn; Blotting, Western; Butadienes; Cell Proliferation; Cells, C | 2011 |
Preemptive analgesic effects of midazolam and diclofenac in rat model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fo | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cycl | 2011 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; E | 2012 |
Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model.
Topics: 4-Aminopyridine; Activating Transcription Factor 3; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2012 |
Synthesis and anti-inflammatory activity of some benzofuran and benzopyran-4-one derivatives.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzopyrans; Binding Sites; Carrageenan; Catalytic D | 2012 |
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Efficacy test of Polycan, a beta-glucan originated from Aureobasidium pullulans SM-2001, on anterior cruciate ligament transection and partial medial meniscectomy-induced-osteoarthritis rats.
Topics: Administration, Oral; Animals; Anterior Cruciate Ligament; Anti-Inflammatory Agents, Non-Steroidal; | 2012 |
Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Diclofenac; Disease Models, Animal; Injection | 2012 |
Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Cyclooxygenase Inhibitors; | 2012 |
Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Int | 2012 |
Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Diclofena | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo | 2012 |
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Dis | 2011 |
Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Cocos; Diclofenac; Disease Models, Anim | 2013 |
Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Diclofenac; Disease Mo | 2012 |
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Brain Neoplasms; Cell Cycle Che | 2013 |
Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; | 2012 |
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxyl | 2012 |
Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Female; | 2012 |
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model.
Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory A | 2013 |
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinopro | 2012 |
Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2012 |
Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carrageenan; C | 2013 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; | 2003 |
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Monoamines; Brain Chemistry; Corpus Stria | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ster | 2003 |
The effects of antipyretics on influenza virus encephalitis in mice and chicks.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Diclofenac; Disease Models, Ani | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyc | 2004 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; | 2003 |
Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives.
Topics: Acetates; Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofena | 2004 |
Effects of thalidomide, cyclosporine, and diclofenac on skin allograft survival in rabbits.
Topics: Animals; Cyclosporine; Diclofenac; Disease Models, Animal; Graft Survival; Immunosuppressive Agents; | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, D | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxy | 2004 |
Ultrastructural alterations in renal tissues of rabbits induced by diclofenac sodium (Voltaren).
Topics: Animals; Biopsy, Needle; Diclofenac; Disease Models, Animal; Immunohistochemistry; Kidney Glomerulus | 2004 |
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; A | 2005 |
Effect of diclofenac on experimental pleurodesis induced by tetracycline in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fibrosis; Male | 2005 |
Oral administration of lumiracoxib reduces choroidal neovascular membrane development in the rat laser-trauma model.
Topics: Administration, Oral; Animals; Choroidal Neovascularization; Cyclooxygenase 2 Inhibitors; Diclofenac | 2005 |
Influence of antiinflammatory drugs (methylprednisolone and diclofenac sodium) on experimental pleurodesis induced by silver nitrate or talc.
Topics: Animals; Diclofenac; Disease Models, Animal; Female; Male; Methylprednisolone; Pleural Diseases; Ple | 2005 |
Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats.
Topics: Adjuvants, Immunologic; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2006 |
Comparison of ketorolac tromethamine, diclofenac sodium, and loteprednol etabonate in an animal model of ocular inflammation.
Topics: Androstadienes; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Endophthalmit | 2006 |
Increased prostanoid dependency of arterial relaxation in Chlamydia pneumoniae-infected mice.
Topics: Animals; Aorta, Thoracic; Chlamydophila Infections; Chlamydophila pneumoniae; Cyclooxygenase Inhibit | 2006 |
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; D | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoproston | 2006 |
Effects of ototopic steroid and NSAIDS in clearing middle ear effusion in an animal model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diclofenac; Disease Models, Animal; | 2006 |
Effect of prenatal exposure to an anti-inflammatory drug on neuron number in cornu ammonis and dentate gyrus of the rat hippocampus: a stereological study.
Topics: Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Differentiation; Cel | 2007 |
[Efficiency of anti-inflammatory therapy for experimental tuberculosis in genetically tuberculosis-sensitive mice].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Mice; Mice, In | 2006 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Eva | 2007 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Bone repair in rats treated with sodic diclofenac and calcitonin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Bone Regeneratio | 2006 |
Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Carrage | 2007 |
Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dis | 2007 |
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease | 2007 |
COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.
Topics: Animals; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Dose-R | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Mod | 2007 |
Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Diclofenac; Disease Models, Animal; Hy | 2008 |
Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Pro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varians.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotaxis, Leukocyte; Dexamethasone; D | 2008 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents; Burseraceae; Dexamethasone; | 2008 |
Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Connective Tissue; Diclofenac; Disease M | 2008 |
Nanoemulsions as vehicles for transdermal delivery of aceclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, | 2007 |
[The treatment of acute periodontitis using sodium diclofenac experimentally].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofen | 1995 |
[The experimental treatment of chronic periodontitis using ortofen].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Disease Models, Anima | 1995 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response | 1993 |
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dogs; | 1995 |
Modulation of murine osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Densitometry; Diclofenac; Disease Model | 1996 |
Anti-inflammatory activity of topical nimesulide gel in various experimental models.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1996 |
Combined non-steroidal therapy in experimental corneal injury.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Cornea; | 1997 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Emboli | 1998 |
Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; | 1998 |
Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Collagen; | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Antiulcer activity of Mikania cordata.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Diclofenac; Disease Models, Animal; Male; Plant Extracts; Pl | 2000 |
Interaction of acetylcholine and endothelin-1 in the modulation of pulmonary arterial pressure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Cyclooxy | 2000 |
Diclofenac-induced gastric mucosal fluorescence in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Chromatography, High | 2001 |
Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofena | 2001 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
Effects of diclofenac and ketoprofen on nerve conduction velocity in experimental nerve root compression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Injections, In | 2001 |
A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous Syste | 2001 |
Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Combined Modality Therapy; Diclofenac | 2001 |
Nucleus pulposus-induced nerve root injury: effects of diclofenac and ketoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Intervertebral | 2002 |
Neostigmine interactions with non steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Diclofenac; Disease Mod | 2002 |
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collage | 1992 |
Localization of the central antinociceptive effects of diclofenac in the rat.
Topics: Animals; Brain; Diclofenac; Disease Models, Animal; Male; Microinjections; Pain; Periaqueductal Gray | 1992 |
[Analgesic action of sodium diclofenac: behavioral and electrophysiological study in normal and polyarthritic rats].
Topics: Animals; Arthritis; Behavior, Animal; Diclofenac; Disease Models, Animal; Dose-Response Relationship | 1988 |
Pathogenesis of osteoarthritis and use of diclofenac in the treatment of experimental models.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Diclofenac; Disease Models, Animal; Dogs; E | 1985 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |
Effects of topical diclofenac sodium in a rabbit model of ocular inflammation and leukotaxis.
Topics: Administration, Topical; Animals; Chemotaxis, Leukocyte; Diclofenac; Disease Models, Animal; Endopht | 1986 |