diclofenac has been researched along with Diabetic Retinopathy in 19 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients preoperatively treated with diclofenac had significantly lower intraocular levels of IL-12 and a lower increase in CFT, which indicates that a combination of preoperative and postoperative treatment with a topical NSAID may lower the incidence of postoperative macular edema in patients with diabetic retinopathy." | 9.24 | Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial. ( Jukić, T; Matas, A; Medić, A; Sapunar, A; Vukojević, K; Znaor, L, 2017) |
| "The purpose of the study is to compare single injection of intravitreal diclofenac (IVD) with intravitreal bevacizumab (IVB) in the treatment of eyes with naïve diabetic macular edema (DME)." | 9.20 | Intravitreal diclofenac versus intravitreal bevacizumab in naive diabetic macular edema: a randomized double-masked clinical trial. ( Karimi, S; Montahai, T; Peyman, GA; Ramezani, A; Soheilian, M; Soheilian, R; Yaseri, M, 2015) |
| "To compare the efficacy and safety of intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema." | 9.15 | Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema. ( Elbendary, AM; Shahin, MM, 2011) |
| "This study compares the effect of topical diclofenac with that of betamethasone against postoperative cystoid macular edema (CME) following cataract surgery in patients with non- and mild nonproliferative diabetic retinopathy." | 9.12 | Diclofenac prevents an early event of macular thickening after cataract surgery in patients with diabetes. ( Nakazawa, T; Nishida, K; Shimura, M; Yasuda, K, 2007) |
| "1% diclofenac eye drops for the management of postoperative inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy and in normal controls." | 7.78 | A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy. ( Miyazawa, A; Shimura, M; Yasuda, K, 2012) |
| "Patients preoperatively treated with diclofenac had significantly lower intraocular levels of IL-12 and a lower increase in CFT, which indicates that a combination of preoperative and postoperative treatment with a topical NSAID may lower the incidence of postoperative macular edema in patients with diabetic retinopathy." | 5.24 | Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial. ( Jukić, T; Matas, A; Medić, A; Sapunar, A; Vukojević, K; Znaor, L, 2017) |
| "The diameter of retinal arterioles showed no significant change during hypoxia or L-NMMA infusion, or after topical application of diclofenac (p > 0." | 5.22 | The diameter response of retinal arterioles in diabetic maculopathy is reduced during hypoxia and is unaffected by the inhibition of cyclo-oxygenase and nitric oxide synthesis. ( Bek, T; Petersen, L, 2016) |
| "The purpose of the study is to compare single injection of intravitreal diclofenac (IVD) with intravitreal bevacizumab (IVB) in the treatment of eyes with naïve diabetic macular edema (DME)." | 5.20 | Intravitreal diclofenac versus intravitreal bevacizumab in naive diabetic macular edema: a randomized double-masked clinical trial. ( Karimi, S; Montahai, T; Peyman, GA; Ramezani, A; Soheilian, M; Soheilian, R; Yaseri, M, 2015) |
| "Long-term prospective studies are needed to study the effect of topical treatment with latanoprost on the consequences of retinal hyperperfusion in retinal vascular diseases such as diabetic retinopathy." | 5.16 | Topical treatment for 1 week with latanoprost but not diclofenac reduces the diameter of dilated retinal arterioles in patients with type 1 diabetes mellitus and mild retinopathy. ( Bek, T; Tilma, KK, 2012) |
| "To compare the efficacy and safety of intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema." | 5.15 | Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema. ( Elbendary, AM; Shahin, MM, 2011) |
| "To investigate the effect of pretreatment oral and topical diclofenac on pain reduction during panretinal laser photocoagulation (PRP) for proliferative diabetic retinopathy (PDR)." | 5.14 | Oral versus topical diclofenac for pain prevention during panretinal photocoagulation. ( Lam, WC; O'Donnell, HL; Zakrzewski, PA, 2009) |
| "This study compares the effect of topical diclofenac with that of betamethasone against postoperative cystoid macular edema (CME) following cataract surgery in patients with non- and mild nonproliferative diabetic retinopathy." | 5.12 | Diclofenac prevents an early event of macular thickening after cataract surgery in patients with diabetes. ( Nakazawa, T; Nishida, K; Shimura, M; Yasuda, K, 2007) |
| "1% diclofenac eye drops for the management of postoperative inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy and in normal controls." | 3.78 | A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy. ( Miyazawa, A; Shimura, M; Yasuda, K, 2012) |
| "We made TPD ophthalmic solution by combining Tropicamide solution(Mydrin-P: T), Phenylephrine Hydrochloride(Neosynesin Kowa solution: P) and Diclofenac Sodium(Diclod solution: D), and evaluated its efficiency in terms of corneal epithelial damage in patients with diabetic retinopathy." | 3.71 | [Availability of TPD ophthalmic solution (mixture of Mydrin-P solution, Neosynesin Kowa solution, and Diclod solution) in regard to the corneal barrier function--clinical evaluation for vitrectomy in patients with diabetic retinopathy]. ( Hirowatari, T; Kamei, Y; Matsubara, M; Miyazaki, Y; Tokuda, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramezani, A | 3 |
| Entezari, M | 2 |
| Shahbazi, MM | 1 |
| Semnani, Y | 1 |
| Nikkhah, H | 2 |
| Yaseri, M | 3 |
| Petersen, L | 3 |
| Bek, T | 4 |
| Soheilian, M | 1 |
| Karimi, S | 1 |
| Montahai, T | 1 |
| Soheilian, R | 1 |
| Peyman, GA | 1 |
| Ghanbari, H | 1 |
| Kianersi, F | 1 |
| Sonbolestan, SA | 1 |
| Abtahi, MA | 1 |
| Akbari, M | 1 |
| Abtahi, ZA | 1 |
| Abtahi, SH | 1 |
| Medić, A | 1 |
| Jukić, T | 1 |
| Matas, A | 1 |
| Vukojević, K | 1 |
| Sapunar, A | 1 |
| Znaor, L | 1 |
| Cohen, MP | 1 |
| Hud, E | 1 |
| Wu, VY | 1 |
| Shearman, CW | 1 |
| Zakrzewski, PA | 1 |
| O'Donnell, HL | 1 |
| Lam, WC | 1 |
| de Faria Rodrigues, A | 1 |
| Messias, AM | 1 |
| Da Silva, JA | 1 |
| Ribeiro, JA | 1 |
| Jorge, R | 1 |
| Scott, IU | 1 |
| Tilma, KK | 1 |
| Elbendary, AM | 1 |
| Shahin, MM | 1 |
| Yasuda, K | 2 |
| Miyazawa, A | 1 |
| Shimura, M | 2 |
| Kim, SJ | 1 |
| Tokuda, K | 2 |
| Hirowatari, T | 2 |
| Kamei, Y | 2 |
| Miyazaki, Y | 2 |
| Matsubara, M | 2 |
| Nakazawa, T | 1 |
| Nishida, K | 1 |
| Weinberger, D | 1 |
| Ron, Y | 1 |
| Lichter, H | 1 |
| Rosenblat, I | 1 |
| Axer-Siegel, R | 1 |
| Yassur, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diameter Changes of Retinal Vessels During Hypoxia[NCT01689090] | 58 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Patient Comfort Using Green (532 nm) Versus Yellow (577 nm) Laser Indirect Ophthalmoscopy Panretinal Photocoagulation for Proliferative Diabetic Retinopathy[NCT02995629] | 40 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| An Observational Prospective Study of Comparing Pain Responses With Pattern Laser Platform and Conventional Laser System During the Panretinal Photocoagulation in Proliferative Diabetic Retinopathy[NCT02645383] | 30 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 trials available for diclofenac and Diabetic Retinopathy
| Article | Year |
|---|---|
Analgesic Effect of Topical Sodium Diclofenac before Retinal Photocoagulation for Diabetic Retinopathy: A Randomized Double-masked Placebo-controlled Intraindividual Crossover Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; D | 2017 |
Post-hypoxic constriction of retinal arterioles is impaired during nitric oxide and cyclo-oxygenase inhibition and in diabetic patients without retinopathy.
Topics: Adult; Arterioles; Cyclooxygenase Inhibitors; Diabetic Retinopathy; Diclofenac; Drug Therapy, Combin | 2017 |
Intravitreal diclofenac versus intravitreal bevacizumab in naive diabetic macular edema: a randomized double-masked clinical trial.
Topics: Adult; Aged; Analysis of Variance; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
The effect of topical sodium diclofenac on macular thickness in diabetic eyes after phacoemulsification: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; Diclofenac; | 2017 |
The diameter response of retinal arterioles in diabetic maculopathy is reduced during hypoxia and is unaffected by the inhibition of cyclo-oxygenase and nitric oxide synthesis.
Topics: Adult; Aged; Arterioles; Cyclooxygenase Inhibitors; Diabetic Retinopathy; Diclofenac; Female; Follow | 2016 |
Intravitreal Diclofenac plus Bevacizumab versus Bevacizumab alone in treatment-naive diabetic macular edema: a randomized double-blind clinical trial.
Topics: Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Bevacizumab; Diabetic Retinopathy; | 2017 |
Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Aqueous Hu | 2017 |
Oral versus topical diclofenac for pain prevention during panretinal photocoagulation.
Topics: Administration, Oral; Administration, Topical; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; D | 2009 |
Oral versus topical diclofenac for pain prevention during panretinal photocoagulation.
Topics: Administration, Oral; Administration, Topical; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; D | 2009 |
Oral versus topical diclofenac for pain prevention during panretinal photocoagulation.
Topics: Administration, Oral; Administration, Topical; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; D | 2009 |
Oral versus topical diclofenac for pain prevention during panretinal photocoagulation.
Topics: Administration, Oral; Administration, Topical; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; D | 2009 |
Topical treatment for 1 week with latanoprost but not diclofenac reduces the diameter of dilated retinal arterioles in patients with type 1 diabetes mellitus and mild retinopathy.
Topics: Administration, Topical; Adult; Antihypertensive Agents; Arterioles; Blood Glucose; Blood Pressure; | 2012 |
Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; Diclofenac; Female; Glucocorti | 2011 |
Evaluation of a new preoperative ophthalmic solution.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diabet | 2005 |
Diclofenac prevents an early event of macular thickening after cataract surgery in patients with diabetes.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents | 2007 |
Analgesic effect of topical sodium diclofenac 0.1% drops during retinal laser photocoagulation.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diabetic Retinopathy; Diclo | 2000 |
6 other studies available for diclofenac and Diabetic Retinopathy
| Article | Year |
|---|---|
Preserved Pressure Autoregulation but Disturbed Cyclo-Oxygenase and Nitric Oxide Effects on Retinal Arterioles during Acute Hypoxia in Diabetic Patients without Retinopathy.
Topics: Adult; Arterial Pressure; Arterioles; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Diabetic | 2016 |
Amelioration of diabetes-associated abnormalities in the vitreous fluid by an inhibitor of albumin glycation.
Topics: Animals; Colorimetry; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diclofenac; Eye Protein | 2008 |
Diclofenac for panretinal photocoagulation pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; Diclofenac; Female; Fluorescein Angio | 2010 |
A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Case-Control Studies; Cataract; Cataract Extracti | 2012 |
“Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema”.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; Diclofenac; Female; Glucocorticoids; | 2012 |
[Availability of TPD ophthalmic solution (mixture of Mydrin-P solution, Neosynesin Kowa solution, and Diclod solution) in regard to the corneal barrier function--clinical evaluation for vitrectomy in patients with diabetic retinopathy].
Topics: Adult; Aged; Diabetic Retinopathy; Diclofenac; Drug Combinations; Epithelium, Corneal; Female; Human | 2002 |