diclofenac has been researched along with Depression in 8 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " diclofenac monotherapy in reducing symptoms of mild to moderate depression among patients with chronic pain." | 9.22 | Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial. ( Afarideh, M; Agah, E; Akhondzadeh, S; Arbabi, M; Ghajar, A; Jafarinia, M; Noorbala, AA; Saravi, MA; Tafakhori, A, 2016) |
| "Here, we aimed to compare the efficacy and safety of celecoxib, a selective inhibitor of COX-2, with diclofenac, a nonselective inhibitor of both COX-1 and COX-2 in reducing depressive symptoms and pain in breast cancer patients." | 9.20 | Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial. ( Akhondzadeh, S; Arya, P; Emami, SA; Esfandbod, M; Kashani, L; Kaviani, A; Mohammadinejad, P; Najafi, M; Zeinoddini, A, 2015) |
| "There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid." | 5.48 | Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018) |
| " diclofenac monotherapy in reducing symptoms of mild to moderate depression among patients with chronic pain." | 5.22 | Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial. ( Afarideh, M; Agah, E; Akhondzadeh, S; Arbabi, M; Ghajar, A; Jafarinia, M; Noorbala, AA; Saravi, MA; Tafakhori, A, 2016) |
| "Here, we aimed to compare the efficacy and safety of celecoxib, a selective inhibitor of COX-2, with diclofenac, a nonselective inhibitor of both COX-1 and COX-2 in reducing depressive symptoms and pain in breast cancer patients." | 5.20 | Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial. ( Akhondzadeh, S; Arya, P; Emami, SA; Esfandbod, M; Kashani, L; Kaviani, A; Mohammadinejad, P; Najafi, M; Zeinoddini, A, 2015) |
| "There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid." | 1.48 | Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018) |
| "Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence." | 1.46 | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. ( Abagyan, R; Atayee, R; Cohen, IV; Makunts, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Li, X | 1 |
| Li, J | 2 |
| Huang, Y | 1 |
| Gong, Q | 1 |
| Fu, Y | 1 |
| Xu, Y | 1 |
| Huang, J | 1 |
| You, H | 1 |
| Zhang, D | 2 |
| Mao, F | 1 |
| Zhu, J | 1 |
| Wang, H | 1 |
| Zhang, H | 1 |
| Cohen, IV | 2 |
| Makunts, T | 2 |
| Atayee, R | 1 |
| Abagyan, R | 2 |
| Lee, KC | 1 |
| Mohammadinejad, P | 1 |
| Arya, P | 1 |
| Esfandbod, M | 1 |
| Kaviani, A | 1 |
| Najafi, M | 1 |
| Kashani, L | 1 |
| Zeinoddini, A | 1 |
| Emami, SA | 1 |
| Akhondzadeh, S | 2 |
| Jafarinia, M | 1 |
| Afarideh, M | 1 |
| Tafakhori, A | 1 |
| Arbabi, M | 1 |
| Ghajar, A | 1 |
| Noorbala, AA | 1 |
| Saravi, MA | 1 |
| Agah, E | 1 |
| De La Garza, R | 1 |
| Asnis, GM | 1 |
| Iohom, G | 1 |
| Abdalla, H | 1 |
| O'Brien, J | 1 |
| Szarvas, S | 1 |
| Larney, V | 1 |
| Buckley, E | 1 |
| Butler, M | 1 |
| Shorten, GD | 1 |
1 review available for diclofenac and Depression
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
3 trials available for diclofenac and Depression
| Article | Year |
|---|---|
Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial.
Topics: Analgesics; Antidepressive Agents; Breast Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Cycloox | 2015 |
Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial.
Topics: Administration, Oral; Adult; Antidepressive Agents; Chronic Pain; Depression; Diclofenac; Double-Bli | 2016 |
The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anxiety; Breast Neoplasms; Bupivacaine; Celecoxib; Chronic Di | 2006 |
4 other studies available for diclofenac and Depression
| Article | Year |
|---|---|
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antidepressive Agents; Binding Sites; Brain; Choli | 2022 |
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications.
Topics: Adverse Drug Reaction Reporting Systems; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents | 2017 |
Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain.
Topics: Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Anxiety; Cohort | 2018 |
The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Monoamines; Brain Chemistry; Corpus Stria | 2003 |