diclofenac has been researched along with Delayed Effects, Prenatal Exposure in 22 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diclofenac is a non-steroidal anti-inflammatory drug widely used by the general population and, although generally contraindicated during pregnancy, it is also used by some pregnant women." | 3.96 | Prenatal diclofenac exposure delays pubertal development and induces behavioral changes in rats. ( Curi, TZ; da Silva, GN; Dos Santos, AC; Grechi, N; Hey, GS; Krebs Ribeiro, DC; Martino-Andrade, AJ; Meldola, H; Passoni, MT; Ramos, ATA; Souza, RIC; Spercoski, KM; Tolouei, SEL, 2020) |
| "Diclofenac sodium (DS) can cross the placental barrier and affect the fetus, and its consumption during pregnancy may cause developmental malformation of embryos." | 3.81 | Effects of prenatally exposed diclofenac sodium on rat heart tissue: a stereological and histological study. ( Fikret, G; Hüseyin, A; Mikail, K; Murat Cetin, R, 2015) |
| " If given during pregnancy, diclofenac sodium (DS), an NSAID, is given during the pregnancy, may also affect the development of the central nervous system (CNS) or related structures." | 3.79 | The effect of prenatal exposure of a non-steroidal anti-inflammatory drug on the optic nerve of female rats: a stereological, histological, and electron microscopic study. ( Aktaş, A; Altunkaynak, ME; Eşrefoglu, M; Gül, M; Kaplan, S; Onger, ME; Ragbetli, MÇ; Ulkay, MB, 2013) |
| " Both mothers had been administered diclofenac during pregnancy." | 3.78 | Maternal ingestion of diclofenac leading to renal failure in newborns. ( Bhardwaj, S; Kanhere, S; Phadke, V; Sahoo, B, 2012) |
| "We aimed to investigate the possible postnatal effects on the lung tissues of the rat offspring treated with diclofenac sodium (DS) during pregnancy." | 3.77 | A histological investigation concerning the effects of diclofenac sodium to the lung in 4- and 20-week-old rats treated prenatally. ( Aydinlioğlu, A; Ilhan, F; Kara, M; Ragbetli, C; Ragbetli, MC, 2011) |
| "Diclofenac sodium (DS) may affect the number of Purkinje cells in the developing cerebellum since DS can easily be transported from the maternal to the fetal physiological system during the pregnancy." | 3.76 | Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: a stereological study. ( Aslan, H; Cihan, OF; Kaplan, S; Odaci, E; Ragbetli, MC, 2010) |
| "We report a case of neonatal transient renal failure after maternal ingestion of diclofenac, paracetamol, and nimesulide during pregnancy." | 3.72 | In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. ( Benini, D; Cuzzolin, L; Fanos, V; Tatò, L, 2004) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug that nonselectively inhibits constitutive and inducible isoenzymes of cyclooxygenase." | 2.44 | [Prenatal tolerability evaluation of diclofenac]. ( Burdan, F; Kiś, J; Przybylski, P, 2007) |
| "Melatonin (Mel) has strong antioxidant properties since it is a direct scavenger of oxygen-based free radicals and related species." | 1.48 | The neuroprotective effect of melatonin on the hippocampus exposed to diclofenac sodium during the prenatal period. ( Kaplan, S; Kıvrak, EG; Yurt, KK, 2018) |
| " Immunophenotyping analysis using flow cytometry (FCM) indicated that the proportion and number of CD45RA(+) cells increased, and the proportion of CD3(-) NKR-P1A(+) cells decreased in males when dosed with IND at 1." | 1.34 | Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult rats. ( Fujiwara, M; Furusawa, S; Kushima, K; Oda, K; Sakuma, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Krebs Ribeiro, DC | 1 |
| Passoni, MT | 1 |
| Meldola, H | 1 |
| Curi, TZ | 1 |
| da Silva, GN | 1 |
| Tolouei, SEL | 1 |
| Hey, GS | 1 |
| Grechi, N | 1 |
| Dos Santos, AC | 1 |
| Souza, RIC | 1 |
| Spercoski, KM | 1 |
| Ramos, ATA | 1 |
| Martino-Andrade, AJ | 1 |
| Ragbetli, MÇ | 10 |
| Kara, M | 2 |
| Çölçimen, N | 1 |
| Koyun, N | 1 |
| Çakmak, G | 1 |
| Akyol, V | 1 |
| Deniz, OG | 1 |
| Yurt, KK | 4 |
| Kaplan, S | 13 |
| Kıvrak, EG | 2 |
| Güven, D | 1 |
| Altunkaynak, BZ | 6 |
| Ayranci, E | 2 |
| Bildircin, FD | 1 |
| Kesim, Y | 1 |
| Aktaş, A | 5 |
| Eşrefoglu, M | 1 |
| Gül, M | 1 |
| Onger, ME | 3 |
| Altunkaynak, ME | 2 |
| Ulkay, MB | 3 |
| Çolakoğlu, S | 2 |
| Raimondo, S | 1 |
| Türkmen, AP | 3 |
| Odacı, E | 3 |
| Geuna, S | 2 |
| Keskin, I | 1 |
| Kalkan, S | 1 |
| Sutcu, M | 1 |
| Esener, OB | 2 |
| Fikret, G | 1 |
| Mikail, K | 1 |
| Murat Cetin, R | 1 |
| Hüseyin, A | 1 |
| Khoshvakhti, H | 1 |
| Elibol, E | 2 |
| Aydın, I | 1 |
| Arslan, H | 1 |
| Canan, S | 1 |
| Ayyildiz, M | 1 |
| Cihan, OF | 1 |
| Aslan, H | 3 |
| Ragbetli, C | 1 |
| Ilhan, F | 1 |
| Aydinlioğlu, A | 1 |
| Phadke, V | 1 |
| Bhardwaj, S | 1 |
| Sahoo, B | 1 |
| Kanhere, S | 1 |
| Zengin, H | 1 |
| Tümkaya, L | 1 |
| Yilmaz, O | 1 |
| Benini, D | 1 |
| Fanos, V | 1 |
| Cuzzolin, L | 1 |
| Tatò, L | 1 |
| Gokcimen, A | 2 |
| Baş, O | 1 |
| Tunc, AT | 1 |
| Yazici, AC | 1 |
| Kushima, K | 1 |
| Oda, K | 1 |
| Sakuma, S | 1 |
| Furusawa, S | 1 |
| Fujiwara, M | 1 |
| Przybylski, P | 1 |
| Kiś, J | 1 |
| Burdan, F | 1 |
| Ozyurt, B | 1 |
| Sahin, B | 1 |
| Alexandrov, VA | 1 |
| Bespalov, VG | 1 |
| Petrov, AS | 1 |
| Troyan, DN | 1 |
1 review available for diclofenac and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
[Prenatal tolerability evaluation of diclofenac].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anuria; Cyclooxygenase Inhibitors; Diclofenac; Duc | 2007 |
21 other studies available for diclofenac and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal diclofenac exposure delays pubertal development and induces behavioral changes in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Female; Male; Matern | 2020 |
Prenatal exposure to low-dose diclofenac sodium does not affect total neuron numbers in spinal segment T13 in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Motor Neurons; Pregnancy; Pren | 2018 |
The neuroprotective effect of melatonin on the hippocampus exposed to diclofenac sodium during the prenatal period.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Female; Hippocampus; Mal | 2018 |
Stereological and histopathological evaluation of ovary and uterine horns of female rats prenatally exposed to diclofenac sodium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Ovary; Pregnancy; Prenatal Exp | 2013 |
Prenatal exposure of diclofenac sodium affects morphology but not axon number of the median nerve of rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Diclofenac; Female; Male; Median Nerve; Pre | 2013 |
The effect of prenatal exposure of a non-steroidal anti-inflammatory drug on the optic nerve of female rats: a stereological, histological, and electron microscopic study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Evaluation, Preclinical; Female; | 2013 |
Effects of prenatal exposure to diclofenac sodium and saline on the optic nerve of 4- and 20-week-old male rats: a stereological and histological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Diclofenac; Female; Male; Myelin Sheath; Op | 2014 |
Evaluation of neuroprotection by melatonin against adverse effects of prenatal exposure to a nonsteroidal anti-inflammatory drug during peripheral nerve development.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroida | 2015 |
Effects of prenatally exposed diclofenac sodium on rat heart tissue: a stereological and histological study.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Heart; M | 2015 |
Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Female; Kidney Glomerulu | 2015 |
Effects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study.
Topics: Animals; Diclofenac; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sertoli Cells | 2016 |
Prenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Cell Size; Diclofenac; Female; Image Cytome | 2008 |
Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: a stereological study.
Topics: Aging; Animals; Cell Proliferation; Diclofenac; Female; Photogrammetry; Pregnancy; Prenatal Exposure | 2010 |
A histological investigation concerning the effects of diclofenac sodium to the lung in 4- and 20-week-old rats treated prenatally.
Topics: Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationshi | 2011 |
Maternal ingestion of diclofenac leading to renal failure in newborns.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anuria; Diclofenac; Fatal Outcome; Female; Gestation | 2012 |
Effect of prenatal exposure to diclofenac sodium on the male rat arteries: a stereological and histopathological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteries; Diclofenac; Female; Fetus; Male; Neovasc | 2013 |
In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fema | 2004 |
Effect of prenatal exposure to an anti-inflammatory drug on neuron number in cornu ammonis and dentate gyrus of the rat hippocampus: a stereological study.
Topics: Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Differentiation; Cel | 2007 |
Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Diclofenac; Enzyme-Li | 2007 |
Effect of prenatal exposure to diclofenac sodium on Purkinje cell numbers in rat cerebellum: a stereological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cerebellum; Diclofenac; Female; Male; | 2007 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous S | 1996 |