diclofenac and Colonic Diseases studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).

Research Excerpts

Excerpt	Relevance	Reference
"Diclofenac sodium is a widely used enteric-coated nonsteroidal anti-inflammatory drug."	5.28	'Diaphragmlike' stricture and ulcer of the colon during diclofenac treatment. ( Becich, MJ; Evans, BA; Martin, SP; Trellis, DR; Whitcomb, DC, 1992)
" In this review we also report 9 cases of colonic ulcers and 7 cases of diaphragm disease of the ascending colon, most of them associated with the long-term intake of slow release diclofenac."	2.39	[Nonsteroidal antirheumatic drugs and acetylsalicylic acid: adverse effects distal to the duodenum]. ( Gut, A; Halter, F; Ruchti, C, 1996)
" Their adverse effects on the upper gastrointestinal (GI) tract are well documented and well known among clinicians and often mitigated against by coprescribing proton pump inhibitors."	1.39	Lower gastrointestinal adverse effects of NSAIDS: an extreme example of a common problem. ( Conway, C; Elton, C; Mandegaran, R, 2013)
"A report is presented of five aged patients with hemorrhagic colon ulcer, which was strongly suspected to be a side effect of non steroidal anti-inflammatory drugs (NSAID)."	1.30	[Hemorrhagic colon ulcer as a side effect of non-steroidal anti-inflammatory drugs in five aged patients]. ( Kusakabe, N; Matsui, I; Matsui, Y; Matsumura, Y; Morimoto, S; Ogihara, T; Takahashi, E, 1997)
"Diclofenac sodium is a widely used enteric-coated nonsteroidal anti-inflammatory drug."	1.28	'Diaphragmlike' stricture and ulcer of the colon during diclofenac treatment. ( Becich, MJ; Evans, BA; Martin, SP; Trellis, DR; Whitcomb, DC, 1992)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (33.33)	18.2507
2000's	14 (38.89)	29.6817
2010's	9 (25.00)	24.3611
2020's	1 (2.78)	2.80

Authors	Studies
Kamboj, AK	1
Moreira, RK	1
Sweetser, S	1
Bronswijk, M	1
Christiaens, P	1
Van Olmen, A	1
Mandegaran, R	1
Conway, C	1
Elton, C	1
Küttner Magalhães, R	1
Ferreira, JM	1
Pedroto, I	1
Kratt, T	1
Lange, J	1
Königsrainer, A	1
Malek, N	1
Adam, P	1
Bösmüller, H	1
Goetz, M	1
Seon, KA	1
Tseng, SH	1
Weng, CC	1
Chen, Y	1
Nguyen, VQ	1
Grider, DJ	1
Yeaton, P	1
Schmidtko, J	1
Truninger, K	1
Gugger, M	1
Cottagnoud, P	1
Stucki, A	1
Klein, M	2
Andersen, LP	1
Harvald, T	2
Rosenberg, J	3
Gogenur, I	1
Aftab, AR	1
Donnellan, F	1
Zeb, F	1
Kevans, D	1
Cullen, G	1
Courtney, G	1
Rahme, E	1
Bernatsky, S	1
Linnemann, D	1
Wan, A	1
Wong, J	1
Maitra, R	1
Keating, JP	2
Khan, AZ	1
George, K	1
DeFriend, DJ	1
Ihara, E	1
Ochiai, T	1
Sasaki, I	1
Shiga, N	1
Honda, K	1
Matsumoto, M	1
Koyanagi, N	1
Harada, N	1
Kabemura, T	1
Ervens, J	1
Schiffmann, L	2
Berger, G	2
Hoffmeister, B	1
Kahrau, S	1
Buhr, HJ	1
Gargot, D	1
Chaussade, S	1
d'Alteroche, L	2
Desbazeille, F	1
Grandjouan, S	1
Louvel, A	1
Douvin, J	1
Causse, X	1
Festin, D	1
Chapuis, Y	1
Bourlier, P	1
Barre, I	1
Metman, EH	1
Benoit, R	2
Blanchi, A	1
Roubin, C	1
Chapeau, MC	1
Robinson, MH	1
Wheatley, T	1
Leach, IH	1
McIlwaine, J	1
Halter, F	2
Weber, B	1
Huber, T	1
Eigenmann, F	1
Frey, MP	1
Ruchti, C	2
Gut, A	1
Kirsch, M	1
Matsui, Y	1
Matsui, I	1
Kusakabe, N	1
Matsumura, Y	1
Takahashi, E	1
Morimoto, S	1
Ogihara, T	1
Weinstock, LB	1
Hammoud, Z	1
Brandwin, L	1
Michell, NP	1
Routledge, H	1
Chesner, IM	1
Kehrer, G	1
Bosseckert, H	1
Koppe, P	1
Lutz, B	1
Will, U	1
Zinsser, E	1
Adhiyaman, V	1
Asghar, M	1
White, AD	1
Yamaura, T	1
Tsugane, E	1
Sakaguchi, M	1
Rokuhara, A	1
Kiyosawa, K	1
Akamatsu, T	1
Grobost, O	1
Crepeau, T	1
Israel, LH	1
Koea, JB	1
Stewart, ID	1
Wright, CL	1
Frankish, PD	1
Whitcomb, DC	1
Martin, SP	1
Trellis, DR	1
Evans, BA	1
Becich, MJ	1
Carson, J	1
Notis, WM	1
Orris, ES	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded C[NCT04804761]				20 participants (Anticipated)	Interventional	2023-01-01	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Nonsteroidal anti-inflammatory drug-induced colonic strictures: two cases and literature review. The American journal of gastroenterology, 1995, Volume: 90, Issue:11 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonoscopy; Con	1995
[Singular diaphragm-like colonic stricture and short-term administration of a non-steroidal anti-inflammatory drug]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colitis, Ulcerative; Colonic Diseases; Col	1994
Nonsteroidal antiinflammatory drug-induced colonic stricture. An unusual cause of large bowel obstruction and perforation. Digestive diseases and sciences, 1995, Volume: 40, Issue:2 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Colonic Diseases; Delayed-Ac	1995
[Nonsteroidal antirheumatic drugs and acetylsalicylic acid: adverse effects distal to the duodenum]. Schweizerische medizinische Wochenschrift, 1996, Apr-13, Volume: 126, Issue:15 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colitis, Ulcerative; Colonic Diseases; Co	1996
[A case of multiple colonic ulcerations and megacolon associated with nonsteroidal antiinflammatory drugs]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2001, Volume: 98, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Female; Humans; Megacolon; Mi	2001
[Diaphragm-like strictures of the colon from diclofenac]. Presse medicale (Paris, France : 1983), 2001, Jun-30, Volume: 30, Issue:22 Topics: Abdominal Pain; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases;	2001

Article	Year
NSAID-Induced Colopathy. Mayo Clinic proceedings, 2021, Volume: 96, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonoscopy; Diclofenac; Humans; Ma	2021
Circumferential Ulcerations in the Ascending Colon. Gastroenterology, 2019, Volume: 157, Issue:3 Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colon; Colonic Diseases; Colonoscopy; Di	2019
Lower gastrointestinal adverse effects of NSAIDS: an extreme example of a common problem. BMJ case reports, 2013, Feb-20, Volume: 2013 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colon; Colonic Diseases; D	2013
Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy with diaphragm-like strictures. Journal of gastrointestinal and liver diseases : JGLD, 2014, Volume: 23, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonoscopy; Diclofenac; Female; Hu	2014
Successful Hemospray treatment for recurrent diclofenac-induced severe diffuse lower gastrointestinal bleeding avoiding the need for colectomy. Endoscopy, 2014, Volume: 46 Suppl 1 UCTN Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonoscopy; Diclofenac; Female; Ga	2014
Colonic perforation after nonsteroidal anti-inflammatory drug use in a 2.7-year-old boy. Journal of pediatric gastroenterology and nutrition, 2015, Volume: 60, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Colonic Diseases; Diclofenac; Humans; Int	2015
A Rare Cause of Colonic Stricture. Gastroenterology, 2017, Volume: 152, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colon; Colonic Diseases; Colonoscopy; Constriction,	2017
[What is your diagnosis? Diaphragma disease]. Praxis, 2008, Feb-06, Volume: 97, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Diseases; Diagnosis, Differential; Diclofe	2008
Increased risk of anastomotic leakage with diclofenac treatment after laparoscopic colorectal surgery. Digestive surgery, 2009, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Colonic Diseases; Cyclooxygenase Inhibitors; Diclofe	2009
NSAID-induced colopathy. A case series. Journal of gastrointestinal and liver diseases : JGLD, 2010, Volume: 19, Issue:1 Topics: Aged; Anemia, Iron-Deficiency; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colon; Colonic Disea	2010
NSAIDs and risk of lower gastrointestinal bleeding. Lancet (London, England), 2010, Jul-17, Volume: 376, Issue:9736 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Celecoxib; Coloni	2010
Non-steroidal anti-inflammatory drug-induced colopathy. BMJ case reports, 2011, Feb-08, Volume: 2011 Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Female; Humans; Middle Aged	2011
Diaphragm disease of the large bowel due to non steroidal anti inflammatory drugs. The New Zealand medical journal, 2002, Jun-21, Volume: 115, Issue:1156 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Female; Humans	2002
Nonsteroidal anti-inflammatory drug-induced colonic stenosis: an unusual cause of a right-sided colonic mass: report of a case. Diseases of the colon and rectum, 2003, Volume: 46, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cecal Neoplasms; Colonic Diseases; Colonoscopy; Constrictio	2003
[Two cases of non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy presenting ileal perforation or ileo-colonic fistula]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Fema	2003
Colon perforation with acute peritonitis after taking clindamycin and diclofenac following wisdom tooth removal. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2004, Volume: 32, Issue:5 Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clindamycin; Colonic Dis	2004
Colon perforation in an adolescent after short-term diclofenac intake. ANZ journal of surgery, 2005, Volume: 75, Issue:8 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Female; Humans; I	2005
Severe complications with diclofenac after colonic resection. Diseases of the colon and rectum, 2007, Volume: 50, Issue:5 Topics: Anastomosis, Surgical; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Colonic Dis	2007
[Are right colonic lesions specific to sustained-release NSAID preparations?]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:11 Topics: Aged; Arthritis, Rheumatoid; Cecal Diseases; Colonic Diseases; Delayed-Action Preparations; Diclofen	1994
Simultaneous small and large bowel ulceration associated with short term NSAID use. The New Zealand medical journal, 1993, Oct-13, Volume: 106, Issue:965 Topics: Aged; Aged, 80 and over; Colonic Diseases; Diclofenac; Humans; Ileal Diseases; Intestinal Perforatio	1993
Diaphragm disease of the ascending colon. Association with sustained-release diclofenac. Journal of clinical gastroenterology, 1993, Volume: 16, Issue:1 Topics: Aged; Colonic Diseases; Colonoscopy; Constriction, Pathologic; Delayed-Action Preparations; Diclofen	1993
Nonsteroidal antiinflammatory drug colopathy: mimicry of Crohn's disease and colon carcinoma. Journal of clinical gastroenterology, 1997, Volume: 24, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonic Neoplasms; Crohn Disease; Diagnos	1997
[Hemorrhagic colon ulcer as a side effect of non-steroidal anti-inflammatory drugs in five aged patients]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1997, Volume: 34, Issue:9 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diabetes Complications; Diclofenac;	1997
Nonsteroidal anti-inflammatory drug-induced colonic stricture and ulceration treated with balloon dilatation and prednisone. Gastrointestinal endoscopy, 1999, Volume: 50, Issue:4 Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Colonic Di	1999
A case of intestinal obstruction. Postgraduate medical journal, 2000, Volume: 76, Issue:893 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Drug Combinations; Fema	2000
Unusual negative side effects of non-steroidal anti-inflammatory drugs in the proximal colon. Zeitschrift fur Gastroenterologie, 2000, Volume: 38, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Diseases; Diagnos	2000
Colonic perforation associated with slow-release diclofenac sodium. International journal of clinical practice, 2000, Volume: 54, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Fatal Outcome; Female;	2000
Nonsteroidal anti-inflammatory drug-induced strictures of the colon: report of a case and review of the literature. Diseases of the colon and rectum, 2001, Volume: 44, Issue:9 Topics: Anemia; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Constriction, Pathologic; Diagnos	2001
'Diaphragmlike' stricture and ulcer of the colon during diclofenac treatment. Archives of internal medicine, 1992, Volume: 152, Issue:11 Topics: Anemia, Hypochromic; Biopsy; Colon; Colonic Diseases; Constriction, Pathologic; Delayed-Action Prepa	1992
Colonic ulceration and bleeding during diclofenac therapy. The New England journal of medicine, 1990, Jul-12, Volume: 323, Issue:2 Topics: Aged; Colonic Diseases; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Tablet	1990

diclofenac and Colonic Diseases

Research Excerpts

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

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