Compounds > diclofenac
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diclofenac and Colitis

diclofenac has been researched along with Colitis in 21 studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"We report a case of severe colitis from diclofenac (Voltaren), one of a number of nonsteroidal anti-inflammatory drugs (NSAIDs) that can cause colonic injury."7.69A case of diclofenac-induced colitis with focal granulomatous change. ( Baert, F; Blackstone, MO; Hart, J, 1995)
"We report a case of severe colitis from diclofenac (Voltaren), one of a number of nonsteroidal anti-inflammatory drugs (NSAIDs) that can cause colonic injury."3.69A case of diclofenac-induced colitis with focal granulomatous change. ( Baert, F; Blackstone, MO; Hart, J, 1995)
"Two women, aged 21 and 44 years, developed ileocolitis and proctocolitis, respectively, lasting for several weeks after taking non-steroidal anti-inflammatory drugs (Diclofenac; Pyrazinebutazone)."3.67[Side effects of non-steroidal antirheumatic agents on the lower intestinal tract]. ( Filippini, L; Ritschard, T, 1986)
" In this review we also report 9 cases of colonic ulcers and 7 cases of diaphragm disease of the ascending colon, most of them associated with the long-term intake of slow release diclofenac."2.39[Nonsteroidal antirheumatic drugs and acetylsalicylic acid: adverse effects distal to the duodenum]. ( Gut, A; Halter, F; Ruchti, C, 1996)
"Peptic gastroduodenal lesions due to nonsteroidal antiinflammatory drugs (NSAID) are well known, but not the adverse effects of these preparations in the lower GI tract."2.37[Side effects of non-steroidal antirheumatic agents in the lower gastrointestinal tract]. ( Güller, R, 1987)
"Diclofenac slow release was the most commonly involved drug."1.31Clinical, endoscopic, and histologic spectrum of nonsteroidal anti-inflammatory drug-induced lesions in the colon. ( Kiener, HP; Oberhuber, G; Püspök, A, 2000)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's7 (33.33)18.2507
2000's8 (38.10)29.6817
2010's3 (14.29)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Almehizia, AA1
Khattab, AEA1
Darwish, AM1
Al-Omar, MA1
Naglah, AM1
Bhat, MA1
Kalmouch, A1
Ahmad, H1
Verma, S1
Kumar, VL1
Breganó, JW1
Dichi, JB1
Barbosa, DS1
El Kadri, MZ1
Matsuo, T1
Rodrigues, MA1
Cecchini, R1
Dichi, I1
Alexandropoulou, K1
O'Donohue, J1
Sherid, M1
Ehrenpreis, ED1
Paiotti, AP1
Ribeiro, DA1
Silva, RM1
Marchi, P1
Oshima, CT1
Neto, RA1
Miszputen, SJ1
Franco, M1
Al-Ghamdi, MY1
Malatjalian, DA1
Veldhuyzen van Zanten, S1
Zuber-Jerger, I1
Drexel, H1
Vieth, M1
Bielsa Martín, S1
Porcel Pérez, JM1
Madroñero Vuelta, AB1
Planella Rubinat, MJ1
Zijlstra, FJ1
Van Dijk, JP1
Wilson, JH1
Baert, F1
Hart, J1
Blackstone, MO1
Reuter, BK1
Cirino, G1
Wallace, JL1
Rodríguez Carballeira, M1
Coll Roldua, I1
Muñoz Rodríguez, FJ1
Bastus Piulats, R1
Cirera Noguera, L1
Espinós Pérez, JC1
Gut, A1
Halter, F1
Ruchti, C1
González-Huix, F1
Condom, E1
Constantopoulos, A1
Püspök, A1
Kiener, HP1
Oberhuber, G1
Kanda, K1
Kume, K1
Yoshikawa, I1
Kai, R1
Nagata, K1
Tamura, M1
Yamasaki, T1
Otsuki, M1
Güller, R1
Ritschard, T1
Filippini, L1

Reviews

3 reviews available for diclofenac and Colitis

ArticleYear
Types of colitis based on histology.
    Disease-a-month : DM, 2011, Volume: 57, Issue:9

    Topics: Angiogenesis Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies,

2011
[Nonsteroidal antirheumatic drugs and acetylsalicylic acid: adverse effects distal to the duodenum].
    Schweizerische medizinische Wochenschrift, 1996, Apr-13, Volume: 126, Issue:15

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colitis, Ulcerative; Colonic Diseases; Co

1996
[Side effects of non-steroidal antirheumatic agents in the lower gastrointestinal tract].
    Schweizerische medizinische Wochenschrift, 1987, Oct-03, Volume: 117, Issue:40

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Female; Humans; Male; Mefenamic

1987

Other Studies

18 other studies available for diclofenac and Colitis

ArticleYear
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease

2023
Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018, Volume: 67, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Edema;

2018
Decreased total antioxidant capacity in plasma, but not tissue, in experimental colitis.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:4

    Topics: Animals; Antioxidants; Biomarkers; Colitis; Colon; Cyclooxygenase Inhibitors; Diclofenac; Male; Oxid

2009
A rare case of diarrhoea. Colonic complications of NSAIDs.
    Gut, 2008, Volume: 57, Issue:11

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Colonoscopy; Diarrhea; Dicl

2008
Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
    Journal of molecular histology, 2012, Volume: 43, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2

2012
Causation: Recurrent collagenous colitis following repeated use of NSAIDs.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2002, Volume: 16, Issue:12

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Collagen; Diarrhea; Diclo

2002
Aphthous colitis induced by non-steroidal antirheumatic drugs.
    Swiss medical weekly, 2003, Oct-11, Volume: 133, Issue:39-40

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Colitis

2003
[NSAID-colonopathy].
    Der Pathologe, 2006, Volume: 27, Issue:1

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Diagnosis, Differentia

2006
[Acute colitis by diclofenac].
    Revista espanola de enfermedades digestivas, 2006, Volume: 98, Issue:3

    Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Humans; Male

2006
Increased platelet activating factor synthesis in experimental colitis after diclofenac and 5-amino-salicylic acid.
    European journal of pharmacology, 1993, Nov-02, Volume: 249, Issue:1

    Topics: Aminosalicylic Acid; Animals; Colitis; Dextrans; Diclofenac; Diterpenes; Female; Ginkgolides; Lacton

1993
A case of diclofenac-induced colitis with focal granulomatous change.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:10

    Topics: Aged; Colitis; Crohn Disease; Diagnosis, Differential; Diclofenac; Female; Granuloma; Humans

1995
Markedly reduced intestinal toxicity of a diclofenac derivative.
    Life sciences, 1994, Volume: 55, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Dose-Response Relationship, D

1994
[Colitis induced by non-steroidal anti-inflammatory agents].
    Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:10

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Colitis; Diarrhea; Diclofenac; Humans

1995
[Diarrhea lasting 8 weeks in a 48-year-old woman].
    Medicina clinica, 1996, Jul-06, Volume: 107, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colon; Diagnosis, Differential; Diarrhea;

1996
Colitis induced by interaction of cyclosporine A and non-steroidal anti-inflammatory drugs.
    Pediatrics international : official journal of the Japan Pediatric Society, 1999, Volume: 41, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Child; Colitis; Cyclosporine; Diclof

1999
Clinical, endoscopic, and histologic spectrum of nonsteroidal anti-inflammatory drug-induced lesions in the colon.
    Diseases of the colon and rectum, 2000, Volume: 43, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colonoscopy; Delay

2000
[A case of non-steroidal anti-inflammatory drug-induced colitis with granulomas].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2002, Volume: 99, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Female; Granu

2002
[Side effects of non-steroidal antirheumatic agents on the lower intestinal tract].
    Deutsche medizinische Wochenschrift (1946), 1986, Oct-10, Volume: 111, Issue:41

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Diclofenac; Female; Humans;

1986