diclofenac has been researched along with Chemical and Drug Induced Liver Injury in 141 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the influence of diclofenac sodium (DIC) treatment on tilmicosin (TIL) prompted cardiotoxicity, forty albino rats were randomly divided into four equal groups: control, TIL group (single subcutaneous injection of 75 mg/kg BW tilmicosin phosphate 30%), TIL + DIC group (single subcutaneous injection of tilmicosin phosphate 30% and then injection intramuscularly of 13." | 7.88 | Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). ( Derbalah, AE; Oda, SS, 2018) |
| " We estimated 95% confidence interval, Q and 12 criteria, Mantel-Haenszel and DerSimonian-Laird statistics and relative risk of adverse reactions." | 6.46 | [Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review]. ( Koniaeva, EI; Matveev, AV, 2010) |
| "Diclofenac is a Non-Steroidal Anti-inflammatory drug which is used as an analgesic." | 5.48 | Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines. ( Evan Prince, S; Simon, JP, 2018) |
| "Idiosyncratic adverse drug reactions (IADRs) represent an important human health problem, yet animal models for preclinical prediction of these reactions are lacking." | 5.33 | Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Luyendyk, JP; Maddox, JF; Roth, RA; Stachlewitz, RF; Waring, JF, 2006) |
| "Patients > or = 50 years with rheumatoid arthritis or osteoarthritis were randomly assigned to diclofenac (150 mg daily) or etoricoxib (60 or 90 mg daily)." | 5.14 | How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial. ( Cannon, CP; Connors, LG; Curtis, SP; Goldkind, L; Laine, L; Yanqiong, Z, 2009) |
| " As for SCARs, associations of HLA-B*15:02 or HLA-A*31:01 and HLA-B*58:01 have been revealed for carbamazepine- and allopurinol-related Stevens-Johnson syndrome and toxic epidermal neclolysis, respectively." | 4.89 | Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury. ( Kaniwa, N; Saito, Y, 2013) |
| "To assess the influence of diclofenac sodium (DIC) treatment on tilmicosin (TIL) prompted cardiotoxicity, forty albino rats were randomly divided into four equal groups: control, TIL group (single subcutaneous injection of 75 mg/kg BW tilmicosin phosphate 30%), TIL + DIC group (single subcutaneous injection of tilmicosin phosphate 30% and then injection intramuscularly of 13." | 3.88 | Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). ( Derbalah, AE; Oda, SS, 2018) |
| "The risk of a newly diagnosed episode of upper gastrointestinal bleeding, acute liver and renal failure, agranulocytosis, aplastic anemia, severe skin disorders, and anaphylaxis was examined within 30 days after the first prescription for a low dose of diclofenac, naproxen, or ibuprofen in a cohort in the United Kingdom." | 3.70 | Low-dose diclofenac, naproxen, and ibuprofen cohort study. ( Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C, 1999) |
| "This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints." | 3.70 | Diclofenac-associated hepatitis. ( Al-Baghdadi, Y; Bhogaraju, A; Nazeer, S; Patel, N; Rahman, M; Wrestler, F, 1999) |
| " Documentation is derived from clinical trials, post-marketing surveillance, special studies, and spontaneous reports of adverse drug reactions from foreign countries." | 2.66 | Worldwide safety experience with diclofenac. ( Catalano, MA, 1986) |
| "Diclofenac was used to treat back pain associated with an acute exacerbation of a chronic lumbovertebral symptoms reversed." | 2.48 | [Diclofenac induced liver injuries]. ( Krähenbühl, S; Nezic, L; Rätz Bravo, AE, 2012) |
| " We estimated 95% confidence interval, Q and 12 criteria, Mantel-Haenszel and DerSimonian-Laird statistics and relative risk of adverse reactions." | 2.46 | [Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review]. ( Koniaeva, EI; Matveev, AV, 2010) |
| "However, some patients may develop acute liver failure and successful orthotopic liver transplantation may be undertaken in such patients." | 2.42 | Hepatocellular damage from non-steroidal anti-inflammatory drugs. ( Dargan, PI; Jones, AL; O'Connor, N, 2003) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug bearing a carboxylic acid functional group." | 2.42 | The metabolism of diclofenac--enzymology and toxicology perspectives. ( Tang, W, 2003) |
| "But it can produce toxic hepatitis which may be asymptomatic (but this patient was jaundiced) and may take an unforeseeable course." | 2.41 | [Asymptomatic diclofenac-induced acute hepatitis]. ( Dierkes-Globisch, A; Mohr, HH; Schäfer, R, 2000) |
| "Diclofenac is a frequently prescribed nonsteroidal antiinflammatory drug (NSAID)." | 2.38 | Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis. ( Barr, RJ; Clarke, D; Scully, LJ, 1993) |
| "Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally prescribed for the treatment of pain." | 1.91 | Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats. ( Ayna, A; Caglayan, C; Genç, A; Gür, C; Kandemir, FM; Taysı, S; Varışlı, B, 2023) |
| "Diclofenac (DIC) is a phenyl acetic acid derivative which is well known for its analgesic and anti-inflammatory." | 1.62 | Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study. ( Heidarian, E; Nouri, A, 2021) |
| "Metformin (1 mmol/L) was protective against DF-induced apoptosis in hepatocytes." | 1.62 | Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC. ( Alieva, T; Arroyave Ospina, JC; Buist-Homan, M; Cheng, X; Geng, Y; Lezoualc'h, F; Mora, FAA; Moshage, H; Musheshe, N; Rodrigo, JA; Schmidt, M; Soto, JM, 2021) |
| "Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug, but it comes with a high risk of drug-induced liver injury (DILI)." | 1.56 | Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice. ( Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S, 2020) |
| " Long term usage and over-dosage of diclofenac is associated with adverse effects like drug-induced liver injury, gastrointestinal and renal toxicity." | 1.51 | Protective effect of the ethanolic and methanolic leaf extracts of Madhuca longifolia against diclofenac-induced toxicity in female Wistar albino rats. ( Katturaja, R; Namachivayam, A; Nithyanandham, S; Parthasarathy, M; Prince, SE; Simon, JP, 2019) |
| "Diclofenac is a Non-Steroidal Anti-inflammatory drug which is used as an analgesic." | 1.48 | Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines. ( Evan Prince, S; Simon, JP, 2018) |
| "Diclofenac is a widely prescribed NSAID that causes severe idiosyncratic drug induced liver injury (IDILI) in a small part of the patient population." | 1.43 | Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. ( Commandeur, JN; den Braver, MW; Venkataraman, H; Vermeulen, NP; Zhang, Y, 2016) |
| "Diclofenac is a widely prescribed NSAID, which by itself and its reactive metabolites (Phase-I and Phase-II) may be involved in serious idiosyncratic hepatotoxicity." | 1.43 | Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI). ( Hansen, SH; Skonberg, C; Syed, M, 2016) |
| "Diclofenac (DCLF) is a widely used non-steroidal anti-inflammatory drug that is associated with idiosyncratic, drug-induced liver injury (IDILI) in humans." | 1.43 | Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines. ( Breier, AB; Ganey, PE; Maiuri, AR; Roth, RA; Turkus, JD, 2016) |
| " The performed microarray studies informed on > 600 differential expressed genes of which 35, 37 and 50 coded for inflammation, 51, 44 and 61 for immune and 116, 129 and 169 for stress response, respectively after single and repeated dosing for 3 and 14 days." | 1.43 | Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice. ( Borlak, J; Choi, MS; Lee, EH; Oh, JH; Park, SM; Selvaraj, S; Spanel, R; Yoon, S, 2016) |
| "Diclofenac was administered 15 min before sunitinib, mice were euthanized 4 h post-sunitinib dose, and biomarkers and tissue histopathology were assessed." | 1.39 | Potential protective effect of sunitinib after administration of diclofenac: biochemical and histopathological drug-drug interaction assessment in a mouse model. ( Chakravarthi, S; Haleagrahara, N; Judson, JP; Segarra, I; Tan, JR, 2013) |
| "Diclofenac (DF) is a widely used non-steroidal anti-inflammatory drug for the treatment of rheumatic disorders, but is often associated with liver injury." | 1.39 | Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. ( Laarakkers, CM; Masereeuw, R; Pertijs, JC; Russel, FG; van Swelm, RP; Verweij, V, 2013) |
| " First, we established the dosing condition for liver injury in normal mice." | 1.38 | Involvement of immune-related factors in diclofenac-induced acute liver injury in mice. ( Fukami, T; Higuchi, S; Nakajima, M; Tsuneyama, K; Yano, A; Yokoi, T, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Already considered a drug that can reverse the toxic side effects of NSAIDs, BPC 157 (10 μg/kg, 10 ng/kg) was strongly effective throughout the entire experiment when given (i) intraperitoneally immediately after diclofenac or (ii) per-orally in drinking water (0." | 1.37 | Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. ( Blagaic, AB; Brcic, L; Coric, M; Djakovic, Z; Djuzel, V; Drmic, D; Dzidic, S; Filipovic, M; Franjic, S; Gjurasin, M; Ilic, S; Klicek, R; Kolenc, D; Radic, B; Romic, Z; Seiwerth, S; Sever, M; Sikiric, P; Stambolija, V; Stupnisek, M; Zarkovic, K; Zoricic, I, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Diclofenac sodium was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and liver glycogen were assessed." | 1.35 | Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats. ( Chanda, S; Nair, R; Tanna, A, 2009) |
| "Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is associated with idiosyncratic adverse drug reactions in humans." | 1.35 | Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Roth, RA; Sparkenbaugh, EM; Waring, JF, 2008) |
| " The present observations suggest that reduction of the pharmacokinetic parameters may lead to drug accumulation in the regenerating-damaged liver with an attendant possible increase in toxic effects." | 1.34 | Pharmacokinetics of diclofenac in rats intoxicated with CCL4, and in the regenerating liver. ( Castañeda-Hernández, G; Favari, L; Muriel, P; Reyes-Gordillo, K, 2007) |
| "Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is among the most common drugs causing idiosyncratic hepatotoxicity in several recent series with up to 20% mortality in jaundiced subjects." | 1.34 | Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. ( Aithal, GP; Daly, AK; Dang, TS; Day, CP; Leathart, JB; Swainsbury, RA, 2007) |
| "Idiosyncratic adverse drug reactions (IADRs) represent an important human health problem, yet animal models for preclinical prediction of these reactions are lacking." | 1.33 | Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Luyendyk, JP; Maddox, JF; Roth, RA; Stachlewitz, RF; Waring, JF, 2006) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear." | 1.32 | Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. ( Aithal, GP; Alexander, G; Caldwell, J; Daly, AK; Day, CP; Kenna, JG; Leathart, JB; Ramsay, L; Sonchit, N, 2004) |
| " Now, rare adverse reactions to several commonly prescribed medications contribute to the total burden of drug-induced liver injury." | 1.32 | Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. ( Aithal, GP, 2004) |
| "Diclofenac is an anti-inflammatory analgesic which is widely used in the therapy of inflammatory joint pain." | 1.30 | [Diclofenac-associated acute cholestatis hepatitis]. ( Hackstein, H; Mohl, W; Püschel, W; Stallmach, A; Zeitz, M, 1998) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug approved in the United States in 1988 for the treatment of patients with osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis." | 1.29 | Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions. ( Banks, AT; Harter, JG; Ishak, KG; Zimmerman, HJ, 1995) |
| "Diclofenac is a widely used non-steroidal anti-inflammatory drug, being the most commonly prescribed of its kind in the world." | 1.28 | Diclofenac associated hepatitis. ( Chapman, RW; Iveson, TJ; Kelly, PM; McGee, JO; Ryley, NG; Trowell, JM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (10.64) | 18.7374 |
| 1990's | 30 (21.28) | 18.2507 |
| 2000's | 28 (19.86) | 29.6817 |
| 2010's | 54 (38.30) | 24.3611 |
| 2020's | 14 (9.93) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 3 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 3 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Mora, FAA | 1 |
| Musheshe, N | 1 |
| Arroyave Ospina, JC | 1 |
| Geng, Y | 1 |
| Soto, JM | 1 |
| Rodrigo, JA | 1 |
| Alieva, T | 1 |
| Buist-Homan, M | 1 |
| Lezoualc'h, F | 1 |
| Cheng, X | 1 |
| Schmidt, M | 1 |
| Moshage, H | 1 |
| Björnsson, ES | 1 |
| Medina-Caliz, I | 1 |
| Andrade, RJ | 2 |
| Lucena, MI | 1 |
| Sun, C | 1 |
| Zhu, T | 1 |
| Zhu, Y | 1 |
| Li, B | 1 |
| Zhang, J | 1 |
| Liu, Y | 1 |
| Juan, C | 1 |
| Yang, S | 1 |
| Zhao, Z | 1 |
| Wan, R | 1 |
| Lin, S | 1 |
| Yin, B | 1 |
| Kawase, A | 1 |
| Takashima, O | 1 |
| Tanaka, S | 2 |
| Shimada, H | 1 |
| Iwaki, M | 1 |
| Varışlı, B | 1 |
| Caglayan, C | 1 |
| Kandemir, FM | 1 |
| Gür, C | 1 |
| Ayna, A | 1 |
| Genç, A | 1 |
| Taysı, S | 1 |
| Mihaylova, R | 1 |
| Gevrenova, R | 1 |
| Stefanova, A | 1 |
| Zheleva-Dimitrova, D | 1 |
| Balabanova, V | 1 |
| Zengin, G | 1 |
| Simeonova, R | 1 |
| Momekov, G | 1 |
| Darijani, MH | 1 |
| Aminzadeh, A | 1 |
| Rahimi, HR | 1 |
| Mandegary, A | 1 |
| Heidari, MR | 1 |
| Karami-Mohajeri, S | 1 |
| Jafari, E | 1 |
| Simon, JP | 2 |
| Parthasarathy, M | 1 |
| Nithyanandham, S | 1 |
| Katturaja, R | 1 |
| Namachivayam, A | 1 |
| Prince, SE | 1 |
| Arakawa, K | 1 |
| Ikeyama, Y | 1 |
| Sato, T | 1 |
| Segawa, M | 1 |
| Sekine, S | 1 |
| Ito, K | 1 |
| Alhaddad, O | 1 |
| Elsabaawy, M | 1 |
| Abdelsameea, E | 1 |
| Abdallah, A | 1 |
| Shabaan, A | 1 |
| Ehsan, N | 1 |
| Elrefaey, A | 1 |
| Elsabaawy, D | 1 |
| Salama, M | 1 |
| Selvaraj, S | 2 |
| Oh, JH | 2 |
| Borlak, J | 2 |
| Riane, K | 1 |
| Sifour, M | 1 |
| Ouled-Haddar, H | 1 |
| Espinosa, C | 1 |
| Esteban, MA | 1 |
| Lahouel, M | 1 |
| Jiang, W | 1 |
| Dai, T | 1 |
| Xie, S | 1 |
| Ding, L | 1 |
| Huang, L | 1 |
| Dai, R | 1 |
| Jung, SH | 1 |
| Lee, W | 1 |
| Park, SH | 1 |
| Lee, KY | 1 |
| Choi, YJ | 1 |
| Choi, S | 1 |
| Kang, D | 1 |
| Kim, S | 1 |
| Chang, TS | 1 |
| Hong, SS | 1 |
| Lee, BH | 1 |
| Hassan, RA | 1 |
| Hozayen, WG | 1 |
| Abo Sree, HT | 1 |
| Al-Muzafar, HM | 1 |
| Amin, KA | 1 |
| Ahmed, OM | 1 |
| Nouri, A | 2 |
| Heidarian, E | 2 |
| Nikoukar, M | 1 |
| Oda, SS | 1 |
| Derbalah, AE | 1 |
| Ogihara, T | 1 |
| Arakawa, H | 1 |
| Jomura, T | 1 |
| Idota, Y | 1 |
| Koyama, S | 1 |
| Yano, K | 1 |
| Kojima, H | 1 |
| Lazarska, KE | 1 |
| Dekker, SJ | 1 |
| Vermeulen, NPE | 1 |
| Commandeur, JNM | 1 |
| Evan Prince, S | 1 |
| He, Z | 1 |
| Wei, G | 1 |
| Li, N | 1 |
| Niu, M | 1 |
| Gong, S | 1 |
| Wu, G | 1 |
| Wang, T | 1 |
| Jiang, Y | 1 |
| Chen, P | 1 |
| Han, W | 1 |
| Ding, M | 1 |
| Liu, S | 1 |
| Chen, Y | 2 |
| Duan, Z | 1 |
| El-Hadary, AE | 1 |
| Ramadan, MF | 1 |
| van Swelm, RP | 2 |
| Laarakkers, CM | 2 |
| Pertijs, JC | 1 |
| Verweij, V | 1 |
| Masereeuw, R | 2 |
| Russel, FG | 2 |
| Tan, JR | 1 |
| Chakravarthi, S | 1 |
| Judson, JP | 1 |
| Haleagrahara, N | 1 |
| Segarra, I | 1 |
| Kaniwa, N | 1 |
| Saito, Y | 1 |
| Fok, KC | 1 |
| Bell, CJ | 1 |
| Read, RB | 1 |
| Eckstein, RP | 1 |
| Jones, BE | 1 |
| Ramm, S | 2 |
| Mally, A | 2 |
| Hadi, M | 3 |
| Groothuis, GM | 2 |
| Er, A | 1 |
| Dik, B | 1 |
| Corum, O | 1 |
| Cetin, G | 1 |
| Fredriksson, L | 1 |
| Wink, S | 1 |
| Herpers, B | 1 |
| Benedetti, G | 1 |
| de Bont, H | 1 |
| Groothuis, G | 1 |
| Luijten, M | 1 |
| Danen, E | 1 |
| de Graauw, M | 1 |
| Meerman, J | 1 |
| van de Water, B | 1 |
| Besednova, NN | 1 |
| Zaporozhets, TS | 1 |
| Kuznetsova, TA | 1 |
| Kryzhanovskiĭ, SP | 1 |
| Kovalev, NN | 1 |
| Zviagintseva, TN | 1 |
| Kia, R | 1 |
| Kelly, L | 1 |
| Sison-Young, RL | 1 |
| Zhang, F | 1 |
| Pridgeon, CS | 1 |
| Heslop, JA | 1 |
| Metcalfe, P | 1 |
| Kitteringham, NR | 1 |
| Baxter, M | 1 |
| Harrison, S | 1 |
| Hanley, NA | 1 |
| Burke, ZD | 1 |
| Storm, MP | 1 |
| Welham, MJ | 1 |
| Tosh, D | 1 |
| Küppers-Munther, B | 1 |
| Edsbagge, J | 1 |
| Starkey Lewis, PJ | 1 |
| Bonner, F | 1 |
| Harpur, E | 1 |
| Sidaway, J | 1 |
| Bowes, J | 1 |
| Fenwick, SW | 1 |
| Malik, H | 1 |
| Goldring, CE | 1 |
| Park, BK | 1 |
| Morissey, B | 1 |
| Hernandez, B | 1 |
| Rooney, C | 1 |
| Pennington, SR | 1 |
| Akingbasote, JA | 1 |
| Foster, AJ | 1 |
| Wilson, I | 1 |
| Sarda, S | 1 |
| Jones, HB | 1 |
| Maiuri, AR | 1 |
| Breier, AB | 1 |
| Turkus, JD | 1 |
| Ganey, PE | 3 |
| Roth, RA | 3 |
| Syed, M | 1 |
| Skonberg, C | 1 |
| Hansen, SH | 1 |
| Lee, EH | 1 |
| Park, SM | 1 |
| Choi, MS | 1 |
| Spanel, R | 1 |
| Yoon, S | 1 |
| den Braver, MW | 1 |
| Zhang, Y | 1 |
| Venkataraman, H | 1 |
| Vermeulen, NP | 1 |
| Commandeur, JN | 1 |
| Goda, K | 1 |
| Takahashi, T | 1 |
| Kobayashi, A | 1 |
| Shoda, T | 1 |
| Kuno, H | 1 |
| Sugai, S | 1 |
| Oda, S | 1 |
| Shirai, Y | 1 |
| Akai, S | 2 |
| Nakajima, A | 1 |
| Tsuneyama, K | 3 |
| Yokoi, T | 3 |
| Royo, F | 1 |
| Palomo, L | 1 |
| Mleczko, J | 1 |
| Gonzalez, E | 1 |
| Alonso, C | 1 |
| Martínez, I | 1 |
| Pérez-Cormenzana, M | 1 |
| Castro, A | 1 |
| Falcon-Perez, JM | 1 |
| Kang, SW | 1 |
| Haydar, G | 1 |
| Taniane, C | 1 |
| Farrell, G | 1 |
| Arias, IM | 1 |
| Lippincott-Schwartz, J | 1 |
| Fu, D | 1 |
| Petros, Z | 1 |
| Makonnen, E | 1 |
| Aklillu, E | 1 |
| Deng, X | 2 |
| Liguori, MJ | 2 |
| Sparkenbaugh, EM | 1 |
| Waring, JF | 2 |
| Blomme, EA | 2 |
| Tanna, A | 1 |
| Nair, R | 1 |
| Chanda, S | 1 |
| Yerly, G | 1 |
| Cereda, JM | 2 |
| Hinz, B | 1 |
| Renner, B | 1 |
| Cheremina, O | 1 |
| Besz, D | 1 |
| Zolk, O | 1 |
| Brune, K | 2 |
| Laine, L | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of Etoricoxib 90 mg q.d. vs. Diclofenac Sodium 50 mg t.i.d. in Patients With Osteoarthritis[NCT00092703] | Phase 3 | 6,000 participants | Interventional | 2002-06-27 | Completed | ||
| A Randomized, Double-Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of Etoricoxib 90 mg q.d. vs. Diclofenac Sodium 75 mg b.i.d. in Patients With Rheumatoid Arthritis[NCT00092742] | Phase 3 | 4,086 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| A Randomized, Double-Blind, Active-Comparator-Controlled, Parallel-Group Study to Evaluate the Safety of Etoricoxib in Patients With Osteoarthritis or Rheumatoid Arthritis[NCT00250445] | Phase 3 | 23,498 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A 52-week, International, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group Clinical Trial to Compare Retention on Treatment, Safety, Tolerability and Efficacy of Lumiracoxib 100 mg od, Lumiracoxib 100 mg Bid and Celecoxib 200 mg od in [NCT00145301] | Phase 3 | 3,036 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 reviews available for diclofenac and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carba | 2013 |
[Hepatoprotective effects of extracts and polysaccharides from seaweed].
Topics: Acetaminophen; Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2014 |
Drug-induced liver injury in clinical trials: as rare as hens' teeth.
Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Diclofenac; Drug-Related Side Effe | 2009 |
Genetic association studies in drug-induced liver injury.
Topics: Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacteri | 2009 |
[Aceclofenac-induced acute cholestatic lesion].
Topics: Acute Disease; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspartate A | 2010 |
Liver injury caused by drugs: an update.
Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Antitubercular Agents; Apoptosis; Chemic | 2010 |
Mechanisms of drug-induced liver injury: from bedside to bench.
Topics: Acetaminophen; Animals; Azetidines; Benzylamines; Chemical and Drug Induced Liver Injury; Diclofenac | 2011 |
[Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Databases, Factual; | 2010 |
[Diclofenac induced liver injuries].
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; | 2012 |
Latest advances in predicting DILI in human subjects: focus on biomarkers.
Topics: Antitubercular Agents; Apolipoproteins E; Arylamine N-Acetyltransferase; Azetidines; Benzylamines; B | 2012 |
The metabolism of diclofenac--enzymology and toxicology perspectives.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme | 2003 |
Hepatocellular damage from non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; D | 2003 |
Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac | 2003 |
[NSAID-induced hepatotoxicity: aceclofenac and diclofenac].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis; Diclof | 1995 |
[Aceclofenac-induced hepatitis].
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver In | 1995 |
Diclofenac-induced hepatitis: case report and literature review.
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Middle Aged | 1994 |
[Fatal sub-fulminant hepatitis due to diclofenac].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Male; Middle Aged | 1993 |
Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis.
Topics: Aged; Autoimmune Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 1993 |
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injur | 1996 |
Drug-induced hepatic injury.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Aza | 1997 |
Hepatotoxicity of non-narcotic analgesics.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 1998 |
[Asymptomatic diclofenac-induced acute hepatitis].
Topics: Acute Disease; Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; | 2000 |
Liver penetration by a duodenal ulcer in a young woman.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; | 2001 |
Diclofenac hepatitis.
Topics: Aged; Autoantibodies; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Diclofenac; F | 1991 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
3 trials available for diclofenac and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2009 |
Long-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis.
Topics: Aged; Arthralgia; Canada; Cardiovascular Diseases; Celecoxib; Chemical and Drug Induced Liver Injury | 2008 |
Worldwide safety experience with diclofenac.
Topics: Adult; Aged; Aspirin; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Diclo | 1986 |
112 other studies available for diclofenac and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cells, Cultured; Chemical and Drug Induced Liver Injury | 2021 |
Setting up criteria for drug-induced autoimmune-like hepatitis through a systematic analysis of published reports.
Topics: Adalimumab; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Hepatitis A; Hepatitis, Auto | 2022 |
Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chickens; Diclofenac; Mammals; Proteomics; Vitamin | 2022 |
Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Coculture Technique | 2022 |
Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats.
Topics: Animals; Apoptosis; Autophagy; Chemical and Drug Induced Liver Injury; Diclofenac; Endoplasmic Retic | 2023 |
The Phytochemical Profiling, In Vitro Antioxidant, and Hepatoprotective Activity of
Topics: Antioxidants; Asteraceae; Chemical and Drug Induced Liver Injury; Diclofenac; Hep G2 Cells; Humans; | 2023 |
Evaluating the protective effect of metformin against diclofenac-induced oxidative stress and hepatic damage: In vitro and in vivo studies.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diclofenac; Liver; Male; Metformin; O | 2023 |
Protective effect of the ethanolic and methanolic leaf extracts of Madhuca longifolia against diclofenac-induced toxicity in female Wistar albino rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartate Amin | 2019 |
Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Models, Animal; Drug Synergism; | 2019 |
Presentations, Causes and Outcomes of Drug-Induced Liver Injury in Egypt.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Amoxicillin-Potassium Clavulanate Combination; An | 2020 |
An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac.
Topics: Adipokines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury | 2020 |
Effect of probiotic supplementation on oxidative stress markers in rats with diclofenac-induced hepatotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Lipid | 2020 |
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Dru | 2020 |
Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity.
Topics: Autophagy; Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Lysosomes; Oxidative Stress; | 2020 |
Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; | 2021 |
Effects of N-acetyl cysteine on oxidative stress and TNF-α gene expression in diclofenac-induced hepatotoxicity in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Catalase; Chemical | 2017 |
Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity).
Topics: Animals; Apoptosis; Biomarkers; Cardiotoxicity; Caspase 3; Chemical and Drug Induced Liver Injury; D | 2018 |
Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity.
Topics: Alanine Transaminase; Albumins; Aspartate Aminotransferases; Cells, Cultured; Chemical and Drug Indu | 2017 |
Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2018 |
Aqueous leaves extract of Madhuca longifolia attenuate diclofenac-induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytokines; | 2018 |
CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2019 |
Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chemical and Drug Induced Liver Injury | 2021 |
Evaluation of 3D re-cellularized tissue engineering: a drug-induced hepatotoxicity model for hepatoprotectant research.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Diclofenac; Gene Expression; Hep G2 | 2019 |
Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diclofenac; Flavonoids; Glutathione P | 2019 |
Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac | 2013 |
Potential protective effect of sunitinib after administration of diclofenac: biochemical and histopathological drug-drug interaction assessment in a mouse model.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspar | 2013 |
Lumiracoxib-induced cholestatic liver injury.
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Cyclooxygenase 2 Inhibitors; | 2013 |
Role of drug-independent stress factors in liver injury associated with diclofenac intake.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buthionine Sulfoximine; Chem | 2013 |
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Calmodulin; Carbonic Anhydrase III; Chemical and Drug Induced Li | 2014 |
Cardiac safety of diclofenac at a single dose in ram.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Cells; Chemical and Drug Induced | 2013 |
Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.
Topics: Animals; Apoptosis; Carbamazepine; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Synergis | 2014 |
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.
Topics: Acetaminophen; Adenosine Triphosphate; Aged; Cell Differentiation; Cell Survival; Chemical and Drug | 2015 |
Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration.
Topics: Animals; Biomarkers; Blood Proteins; Chemical and Drug Induced Liver Injury; Chromatography, High Pr | 2015 |
Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice.
Topics: Administration, Oral; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Diclofenac | 2016 |
Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium; Chemical and Drug Induced Liver Injury; Cytokines; | 2016 |
Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI).
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced | 2016 |
Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cells, Cultured; Chemical and Drug Ind | 2016 |
Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chemical and Drug Induced Liver Injury; Comp | 2016 |
Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.
Topics: Acetaminophen; Apoptosis; Biological Assay; Biomarkers; Caspase 3; Caspase 7; Cells, Cultured; Chemi | 2016 |
Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Camphanes | 2017 |
Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2017 |
AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.
Topics: Acetaminophen; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Chemic | 2016 |
Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.
Topics: Amoxicillin-Potassium Clavulanate Combination; Cell Adhesion Molecules; Chemical and Drug Induced Li | 2017 |
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Chemical and Drug | 2008 |
Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats.
Topics: Acetone; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemi | 2009 |
Severe hepatitis due to percutaneous diclofenac.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 2008 |
Lumiracoxib inhibits cyclo-oxygenase 2 completely at the 50 mg dose: is liver toxicity avoidable by adequate dosing?
Topics: Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; D | 2009 |
The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cult | 2009 |
Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.
Topics: Androgen Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Li | 2009 |
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, | 2011 |
Severe acute liver injury associated with lumiracoxib.
Topics: Acute Disease; Autoantibodies; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2 Inhibitors; | 2012 |
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; | 2012 |
Case-crossover design: an alternative strategy for detecting drug-induced liver injury.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemica | 2012 |
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Dis | 2011 |
Lessons from Lumiracoxib: are cyclooxygenase-2 inhibitors less hepatotoxic than non-selective non-steroidal anti-inflammatory drugs?
Topics: Chemical and Drug Induced Liver Injury; Cyclooxygenase 2 Inhibitors; Diclofenac; Female; Humans | 2012 |
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.
Topics: Animals; Benzodiazepines; Biomarkers; Carbamazepine; Cell Survival; Chemical and Drug Induced Liver | 2012 |
Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2012 |
Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Chemical and Drug Induced Liver In | 2004 |
Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Separation; Ce | 2004 |
Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chemical and Drug Induced Liver | 2004 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antiviral Agents; Calcium; Chem | 2005 |
Comprehensive analysis of differential gene expression profiles on diclofenac-induced acute mouse liver injury and recovery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac | 2006 |
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Che | 2006 |
Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Chemical and Dr | 2007 |
Pharmacokinetics of diclofenac in rats intoxicated with CCL4, and in the regenerating liver.
Topics: Administration, Oral; Alanine Transaminase; alpha-Fetoproteins; Animals; Anti-Inflammatory Agents, N | 2007 |
[Lumiracoxib taken off the market in Australia. What does that mean for our patients? (interview by Dr. Judith Neumaier)].
Topics: Australia; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Res | 2007 |
Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Chemical and Drug Indu | 2008 |
[Acute fatal hepatitis during treatment with diclofenac (Voltarène)].
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Middle Aged; Phenylacetates | 1984 |
Diclofenac hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Diclofenac; Hepatitis; Humans; Male | 1982 |
[Hepatitis caused by diclofenac].
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Middle Aged; Phenylacetates | 1983 |
Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Diclofenac; | 1995 |
[The hepatotoxic effect of nonsteroidal anti-inflammatory preparations].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Dic | 1994 |
Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Diclofenac; Immunohistochemistry; Liver | 1994 |
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chlorpromazine; | 1994 |
Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis [corrected].
Topics: Arthritis; Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Immunohistochemistry | 1994 |
[Toxic hepatitis caused by aceclofenac].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; | 1996 |
[Hepatic toxicity caused by aceclofenac].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; F | 1997 |
[Acute hepatitis caused by diclofenac].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; | 1997 |
Recovery from diclofenac-induced hypersensitive fulminant hepatitis and prostaglandins.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclof | 1997 |
[Diclofenac-associated acute cholestatis hepatitis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis | 1998 |
Diclofenac-associated hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Amino | 1999 |
Low-dose diclofenac, naproxen, and ibuprofen cohort study.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agen | 1999 |
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Base Sequence; Chemical and Drug Induced Liver Injury; C | 2000 |
[Toxic hepatitis caused by aceclofenac].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; F | 2001 |
Hepatotoxicity to several nonsteroidal anti-inflammatory drugs with diclofenac induced histological changes.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Ind | 1992 |
Liver disease associated with diclofenac, naproxen, and piroxicam.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Diclofenac; Female; Follow-U | 1992 |
[Hepatitis associated with taking diclofenac].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Infant | 1992 |
Diclofenac hepatitis.
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Australia; Chemical and | 1991 |
Reversible hepatitis associated with diclofenac.
Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Liver; Microscopy, | 1991 |
Diclofenac-associated hepatotoxicity.
Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Fibromyalgi | 1990 |
Another side effect of NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; Humans | 1990 |
Diclofenac hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Liver | 1990 |
Diclofenac associated hepatitis.
Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Jaundice; Liver; L | 1990 |
Renal and hepatic impairment in association with diclofenac administration.
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Male; Middle Aged; Nephritis, Interstiti | 1989 |
[Cholestatic hepatitis and acute kidney insufficiency during treatment with diclofenac].
Topics: Acute Kidney Injury; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Diclofenac; Female; | 1989 |
[Fulminating hepatitis in a woman taking glafenine and diclofenac].
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Female; Glafenine; Humans; Middle Aged; ortho-Am | 1985 |
[Drug-induced lesion of the liver].
Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; | 1987 |
[Fatal liver damage during use of diclofenac].
Topics: Adult; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Lupus Erythematosus, Syst | 1987 |
Adverse reactions to nonsteroidal anti-inflammatory drugs. Diclofenac compared with other nonsteroidal anti-inflammatory drugs.
Topics: Aged; Anaphylaxis; Anemia, Aplastic; Anti-Inflammatory Agents; Asthma; Blood Platelets; Chemical and | 1986 |
Fatal hepatitis associated with diclofenac.
Topics: Chemical and Drug Induced Liver Injury; Diclofenac; Humans; Male; Middle Aged | 1986 |
Diclofenac-induced hepatotoxicity.
Topics: Aged; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans; Liver | 1986 |
[Acute hepatitis and diclofenac sodium].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Humans | 1986 |
Adult onset Still's disease in the elderly: a report of two cases.
Topics: Aged; Arthritis; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia | 1985 |