diclofenac has been researched along with Cancer of Colon in 24 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to investigate the effect of diclofenac (DCF), a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells." | 4.02 | Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. ( Aslan, M; Çeker, T; Köksoy, S; Yilmaz, Ç, 2021) |
| "The results of this study are in line with other comparable studies in the literature, showing an increased risk for anastomotic leakage with diclofenac." | 3.83 | Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program. ( Bakker, N; Cakir, H; Deelder, JD; Doodeman, HJ; Houdijk, AP; Richir, MC; Schreurs, WH, 2016) |
| "Diclofenac is a preferential cyclooxygenase 2 inhibitor (COX-2) and member of non-steroidal anti-inflammatory drugs (NSAIDs)." | 1.48 | Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells. ( Arisan, ED; Bozdağ, G; Çoker-Gürkan, A; Coşkun, D; Ergül, Z; Obakan-Yerlikaya, P; Palavan-Ünsal, N; Rencüzoğulları, Ö, 2018) |
| "Diclofenac treatment resulted in a significant reduction in COX-2 expression and its activity." | 1.36 | Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. ( Kaur, J; Sanyal, SN, 2010) |
| " Related to the salicin content of the willow bark extract, a higher dosage of ASA was needed." | 1.36 | In vitro anti-proliferative effects of the willow bark extract STW 33-I. ( Bonaterra, GA; Kelber, O; Kinscherf, R; Metz, J; Weiser, D, 2010) |
| "Diclofenac treatment ameliorated the elevated delta psi M and its associated events to exert its chemopreventive action against early stages of colon cancer." | 1.36 | Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopreventive effect of diclofenac in colon cancer. ( Kaur, J; Sanyal, SN, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 17 (70.83) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, JJ | 1 |
| Yu, WW | 1 |
| Hu, LL | 1 |
| Liu, WJ | 1 |
| Lin, XH | 1 |
| Wang, W | 1 |
| Zhang, Q | 1 |
| Wang, PL | 1 |
| Tang, SW | 1 |
| Wang, X | 1 |
| Liu, M | 1 |
| Lu, W | 1 |
| Zhang, HK | 1 |
| Yilmaz, Ç | 1 |
| Köksoy, S | 1 |
| Çeker, T | 1 |
| Aslan, M | 1 |
| Jain, S | 2 |
| Ghanghas, P | 2 |
| Rana, C | 4 |
| Sanyal, SN | 11 |
| Arisan, ED | 1 |
| Ergül, Z | 1 |
| Bozdağ, G | 1 |
| Rencüzoğulları, Ö | 1 |
| Çoker-Gürkan, A | 1 |
| Obakan-Yerlikaya, P | 1 |
| Coşkun, D | 1 |
| Palavan-Ünsal, N | 1 |
| Smirnova, AV | 1 |
| Lazebnik, LB | 1 |
| Trubitsina, IE | 1 |
| Tkachenko, EV | 1 |
| Varvarina, GG | 1 |
| Drozdov, VN | 1 |
| Kim, VA | 1 |
| Baryshnikova, AIu | 1 |
| Sokolova, ZA | 1 |
| Bonaterra, GA | 2 |
| Kelber, O | 2 |
| Weiser, D | 2 |
| Kinscherf, R | 2 |
| Lee, J | 1 |
| Burke, DT | 1 |
| Piplani, H | 2 |
| Vaish, V | 2 |
| Nehru, B | 2 |
| Bakker, N | 1 |
| Deelder, JD | 1 |
| Richir, MC | 1 |
| Cakir, H | 1 |
| Doodeman, HJ | 1 |
| Schreurs, WH | 1 |
| Houdijk, AP | 1 |
| Wang, LC | 1 |
| Ching, LM | 1 |
| Paxton, JW | 1 |
| Kestell, P | 1 |
| Sutherland, R | 1 |
| Zhuang, L | 1 |
| Baguley, BC | 1 |
| Kaur, J | 7 |
| Metz, J | 1 |
| Cho, M | 1 |
| Gwak, J | 1 |
| Park, S | 1 |
| Won, J | 1 |
| Kim, DE | 1 |
| Yea, SS | 1 |
| Cha, IJ | 1 |
| Kim, TK | 1 |
| Shin, JG | 1 |
| Oh, S | 1 |
| Kirsch, M | 1 |
| Seed, MP | 2 |
| Brown, JR | 2 |
| Freemantle, CN | 2 |
| Papworth, JL | 2 |
| Colville-Nash, PR | 2 |
| Willis, D | 1 |
| Somerville, KW | 2 |
| Asculai, S | 1 |
| Willoughby, DA | 2 |
| Alam, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652] | 502 participants (Actual) | Observational [Patient Registry] | 2015-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for diclofenac and Cancer of Colon
| Article | Year |
|---|---|
Discovery and Characterization of 1
Topics: Animals; Calcium; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Drug Disc | 2020 |
Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2 | 2021 |
Role of GSK-3β in Regulation of Canonical Wnt/β-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Celecoxib; Cell Transformation, | 2017 |
Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colon; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; D | 2018 |
[Antiproliferative activity of diclofenac at tumor cell cultures].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Di | 2012 |
Mechanisms of the anti-proliferative and anti-inflammatory effects of the herbal fixed combination STW 5 (Iberogast®) on colon adenocarcinoma (HT29) cells in vitro.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; bcl-2-Associated X Prot | 2013 |
Lower gastrointestinal bleeding associated with diclofenac topical patch in a patient with colonic mass and on antiplatelet therapy for atrial fibrillation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Clopidogrel; Colonic Neoplasms; | 2014 |
Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Apoptosis; Colon; Colonic Neoplasms; Curcumin | 2015 |
Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin | 2015 |
Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program.
Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Ster | 2016 |
Chemoprevention of Colon Cancer through Inhibition of Angiogenesis and Induction of Apoptosis by Nonsteroidal Anti-Inflammatory Drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Celecoxib; Col | 2016 |
Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Cycloo | 2009 |
Alterations in membrane fluidity and dynamics in experimental colon cancer and its chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, C | 2010 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Fa | 2010 |
Induction of apoptosis as a potential chemopreventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Chemoprevention; Colon; Co | 2010 |
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Ca | 2010 |
In vitro anti-proliferative effects of the willow bark extract STW 33-I.
Topics: Apoptosis; Aspirin; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Diclofe | 2010 |
Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopreventive effect of diclofenac in colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Ap | 2010 |
Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF.
Topics: 1,2-Dimethylhydrazine; Animals; Blotting, Western; Carcinogens; Chemokine CCL2; Chemokine CCL3; Colo | 2011 |
Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Calcium | 2011 |
Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; beta Catenin; Calcium-Binding Protei | 2005 |
Nonsteroidal antiinflammatory drug colopathy: mimicry of Crohn's disease and colon carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Colonic Neoplasms; Crohn Disease; Diagnos | 1997 |
The inhibition of colon-26 adenocarcinoma development and angiogenesis by topical diclofenac in 2.5% hyaluronan.
Topics: Adenocarcinoma; Administration, Topical; Animals; Apoptosis; Cell Survival; Colonic Neoplasms; Cyclo | 1997 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |