diclofenac has been researched along with Arrhythmias, Cardiac in 6 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole-heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis." | 4.12 | Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model. ( Bäumer, S; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Leitz, PR; Wegner, F; Willy, K; Wolfes, J, 2022) |
| "Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and does not increase the risk of arrhythmia in normal heart." | 3.78 | Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. ( Baczkó, I; Biliczki, P; Husti, Z; Jost, N; Juhász, V; Kohajda, Z; Koncz, I; Kristóf, A; Papp, JG; Szél, T; Varró, A; Virág, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Wolfes, J | 1 |
| Ellermann, C | 1 |
| Bäumer, S | 1 |
| Fehr, M | 1 |
| Willy, K | 1 |
| Wegner, F | 1 |
| Leitz, PR | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Carr, DB | 1 |
| McDonnell Moorehead, T | 1 |
| Bouchard, A | 1 |
| Sprenger, CR | 1 |
| Hamilton, DA | 1 |
| Lang, E | 1 |
| Madden, D | 1 |
| Lacouture, PG | 1 |
| Wright, C | 1 |
| Schmidt, JJ | 1 |
| Ramazan, L | 1 |
| Bockemeyer, C | 1 |
| Günter, HH | 1 |
| Martens-Lobenhoffer, J | 1 |
| Ganzenmüller, T | 1 |
| Bode-Böger, SM | 1 |
| Kielstein, JT | 1 |
| Kristóf, A | 1 |
| Husti, Z | 1 |
| Koncz, I | 1 |
| Kohajda, Z | 1 |
| Szél, T | 1 |
| Juhász, V | 1 |
| Biliczki, P | 1 |
| Jost, N | 1 |
| Baczkó, I | 1 |
| Papp, JG | 1 |
| Varró, A | 1 |
| Virág, L | 1 |
| Alva, JP | 1 |
| Kotian, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-Dose, Comparative, Positive and Placebo Controlled, Four-Way, Four Period, Cross-Over Study to Evaluate the Effect of DIC075V on QTc Intervals in Healthy Subjects[NCT01812538] | Phase 1 | 70 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diclofenac and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
1 trial available for diclofenac and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Effects of injectable HPβCD-diclofenac on the human delayed rectifier potassium channel current in vitro and on proarrhythmic QTc in vivo.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arrhy | 2013 |
4 other studies available for diclofenac and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Cardiac E | 2022 |
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy.
Topics: Acute Disease; Acute Kidney Injury; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2016 |
Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cyclooxygenase Inhibitors; Diclofenac; Dogs; Heart | 2012 |
Diclofenac induced renal dysfunction presenting as cardiac arrhythmia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Diclofenac; Electrocardiography; Huma | 2001 |