diclofenac has been researched along with Arrhythmia in 6 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole-heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis." | 4.12 | Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model. ( Bäumer, S; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Leitz, PR; Wegner, F; Willy, K; Wolfes, J, 2022) |
| "Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and does not increase the risk of arrhythmia in normal heart." | 3.78 | Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. ( Baczkó, I; Biliczki, P; Husti, Z; Jost, N; Juhász, V; Kohajda, Z; Koncz, I; Kristóf, A; Papp, JG; Szél, T; Varró, A; Virág, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Wolfes, J | 1 |
| Ellermann, C | 1 |
| Bäumer, S | 1 |
| Fehr, M | 1 |
| Willy, K | 1 |
| Wegner, F | 1 |
| Leitz, PR | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Carr, DB | 1 |
| McDonnell Moorehead, T | 1 |
| Bouchard, A | 1 |
| Sprenger, CR | 1 |
| Hamilton, DA | 1 |
| Lang, E | 1 |
| Madden, D | 1 |
| Lacouture, PG | 1 |
| Wright, C | 1 |
| Schmidt, JJ | 1 |
| Ramazan, L | 1 |
| Bockemeyer, C | 1 |
| Günter, HH | 1 |
| Martens-Lobenhoffer, J | 1 |
| Ganzenmüller, T | 1 |
| Bode-Böger, SM | 1 |
| Kielstein, JT | 1 |
| Kristóf, A | 1 |
| Husti, Z | 1 |
| Koncz, I | 1 |
| Kohajda, Z | 1 |
| Szél, T | 1 |
| Juhász, V | 1 |
| Biliczki, P | 1 |
| Jost, N | 1 |
| Baczkó, I | 1 |
| Papp, JG | 1 |
| Varró, A | 1 |
| Virág, L | 1 |
| Alva, JP | 1 |
| Kotian, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-Dose, Comparative, Positive and Placebo Controlled, Four-Way, Four Period, Cross-Over Study to Evaluate the Effect of DIC075V on QTc Intervals in Healthy Subjects[NCT01812538] | Phase 1 | 70 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diclofenac and Arrhythmia
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
1 trial available for diclofenac and Arrhythmia
| Article | Year |
|---|---|
Effects of injectable HPβCD-diclofenac on the human delayed rectifier potassium channel current in vitro and on proarrhythmic QTc in vivo.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arrhy | 2013 |
4 other studies available for diclofenac and Arrhythmia
| Article | Year |
|---|---|
Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Cardiac E | 2022 |
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy.
Topics: Acute Disease; Acute Kidney Injury; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2016 |
Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cyclooxygenase Inhibitors; Diclofenac; Dogs; Heart | 2012 |
Diclofenac induced renal dysfunction presenting as cardiac arrhythmia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Diclofenac; Electrocardiography; Huma | 2001 |