diclofenac has been researched along with Anoxemia in 13 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The measurements were performed during normoxia and hypoxia before and after sublingual administration of the NO donor nitroglycerin, and were repeated on a second study day after topical administration of the COX-inhibitor diclofenac." | 7.83 | Lack of effect of nitroglycerin on the diameter response of larger retinal arterioles in normal persons during hypoxia. ( Bek, T; Kaya, MY; Petersen, L, 2016) |
| "Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation." | 7.71 | Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002) |
| "Diclofenac has been shown to activate aryl hydrocarbon receptor (AHR), which induces transcription in the metabolic enzyme cytochrome P450 1a (cyp1a)." | 5.42 | Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback. ( Götting, M; Kanerva, M; Lubiana, P; McCairns, RJ; Nikinmaa, M; Prokkola, JM, 2015) |
| "The diameter of retinal arterioles showed no significant change during hypoxia or L-NMMA infusion, or after topical application of diclofenac (p > 0." | 5.22 | The diameter response of retinal arterioles in diabetic maculopathy is reduced during hypoxia and is unaffected by the inhibition of cyclo-oxygenase and nitric oxide synthesis. ( Bek, T; Petersen, L, 2016) |
| " The measurements were performed during normoxia and hypoxia before and after sublingual administration of the NO donor nitroglycerin, and were repeated on a second study day after topical administration of the COX-inhibitor diclofenac." | 3.83 | Lack of effect of nitroglycerin on the diameter response of larger retinal arterioles in normal persons during hypoxia. ( Bek, T; Kaya, MY; Petersen, L, 2016) |
| "Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation." | 3.71 | Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002) |
| "Diclofenac has been shown to activate aryl hydrocarbon receptor (AHR), which induces transcription in the metabolic enzyme cytochrome P450 1a (cyp1a)." | 1.42 | Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback. ( Götting, M; Kanerva, M; Lubiana, P; McCairns, RJ; Nikinmaa, M; Prokkola, JM, 2015) |
| "Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is associated with idiosyncratic adverse drug reactions in humans." | 1.35 | Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury. ( Blomme, EA; Deng, X; Ganey, PE; Liguori, MJ; Roth, RA; Sparkenbaugh, EM; Waring, JF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petersen, L | 5 |
| Bek, T | 5 |
| Prokkola, JM | 1 |
| Nikinmaa, M | 1 |
| Lubiana, P | 1 |
| Kanerva, M | 1 |
| McCairns, RJ | 1 |
| Götting, M | 1 |
| Kaya, MY | 1 |
| Aleksandrova, NP | 1 |
| Danilova, GA | 1 |
| Aleksandrov, VG | 1 |
| Deng, X | 1 |
| Liguori, MJ | 1 |
| Sparkenbaugh, EM | 1 |
| Waring, JF | 1 |
| Blomme, EA | 1 |
| Ganey, PE | 1 |
| Roth, RA | 1 |
| Boussery, K | 1 |
| Delaey, C | 1 |
| Van de Voorde, J | 1 |
| Ray, CJ | 1 |
| Abbas, MR | 1 |
| Coney, AM | 1 |
| Marshall, JM | 1 |
| Palayoor, ST | 1 |
| Tofilon, PJ | 1 |
| Coleman, CN | 1 |
| Nishida, N | 1 |
| Blood, AB | 1 |
| Hunter, CJ | 1 |
| Bragg, S | 1 |
| Williams, J | 1 |
| Pearce, WJ | 1 |
| Power, GG | 1 |
| Nakhostine, N | 1 |
| Lamontagne, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diameter Changes of Retinal Vessels During Hypoxia[NCT01689090] | 58 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for diclofenac and Anoxemia
| Article | Year |
|---|---|
Post-hypoxic constriction of retinal arterioles is impaired during nitric oxide and cyclo-oxygenase inhibition and in diabetic patients without retinopathy.
Topics: Adult; Arterioles; Cyclooxygenase Inhibitors; Diabetic Retinopathy; Diclofenac; Drug Therapy, Combin | 2017 |
The diameter response of retinal arterioles in diabetic maculopathy is reduced during hypoxia and is unaffected by the inhibition of cyclo-oxygenase and nitric oxide synthesis.
Topics: Adult; Aged; Arterioles; Cyclooxygenase Inhibitors; Diabetic Retinopathy; Diclofenac; Female; Follow | 2016 |
11 other studies available for diclofenac and Anoxemia
| Article | Year |
|---|---|
Diameter changes of retinal arterioles during acute hypoxia in vivo are modified by the inhibition of nitric oxide and prostaglandin synthesis.
Topics: Acute Disease; Adult; Arterioles; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Inhibitors; Exercise | 2015 |
Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback.
Topics: Animals; Biotransformation; Circadian Rhythm; Cytochrome P-450 CYP1A1; Diclofenac; Enzyme Activation | 2015 |
Lack of effect of nitroglycerin on the diameter response of larger retinal arterioles in normal persons during hypoxia.
Topics: Administration, Topical; Adult; Arterioles; Blood Pressure; Cyclooxygenase Inhibitors; Diclofenac; E | 2016 |
Preserved Pressure Autoregulation but Disturbed Cyclo-Oxygenase and Nitric Oxide Effects on Retinal Arterioles during Acute Hypoxia in Diabetic Patients without Retinopathy.
Topics: Adult; Arterial Pressure; Arterioles; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Diabetic | 2016 |
Interleukin-1beta suppresses the ventilatory hypoxic response in rats via prostaglandin-dependent pathways.
Topics: Animals; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypoxia; Interleuk | 2017 |
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Chemical and Drug | 2008 |
Rat retinal tissue releases a vasorelaxing factor.
Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; D | 2002 |
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies.
Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indo | 2002 |
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tu | 2003 |
Role of prostanoids in the regulation of cerebral blood flow during normoxia and hypoxia in the fetal sheep.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2006 |
Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cyclic AMP; Diclofenac; Epoprostenol; Heart; Hypoxia; My | 1994 |