diclofenac has been researched along with Anesthesia in 10 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additional measures included NPRS scores at predefined times over 48 hours, the summed pain intensity difference over 48 hours (SPID48), the time-weighted sum of pain relief scores over the first 8 hours, the mean dosing interval (the time from dosing to the time rescue medication or the next dose of study medication was administered, whichever was less), the proportion of patients requiring rescue medication, and the onset of perceptible and meaningful pain relief (2-stopwatch method)." | 2.74 | Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days. ( Boesing, SE; Diamond, E; Duckor, S; Gottlieb, I; Raymond, G; Riff, DS; Soulier, S, 2009) |
| "With fentanyl, pain scores were reduced also, but the effect was not statistically significant." | 2.67 | Diclofenac for day-care arthroscopy surgery: comparison with a standard opioid therapy. ( Boules, Z; Fee, JP; McKinney, MS; McLoughlin, C, 1990) |
| " Vt and total plasma clearance were higher than in adults but the elimination half-life was similar." | 1.28 | Pharmacokinetics of intravenous diclofenac sodium in children. ( Korpela, R; Olkkola, KT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeiner, S | 1 |
| Haider, T | 1 |
| Zotti, O | 1 |
| Thüringer, K | 1 |
| Höbart, P | 1 |
| Kimberger, O | 1 |
| Knolle, E | 1 |
| Riff, DS | 1 |
| Duckor, S | 1 |
| Gottlieb, I | 1 |
| Diamond, E | 1 |
| Soulier, S | 1 |
| Raymond, G | 1 |
| Boesing, SE | 1 |
| Ericsson, E | 1 |
| Wadsby, M | 1 |
| Hultcrantz, E | 1 |
| van den Berg, AA | 1 |
| Bamber, MJ | 1 |
| Tweedie, IE | 1 |
| Breeze, C | 1 |
| Williams, NE | 1 |
| Fang, JY | 1 |
| Sung, KC | 1 |
| Lin, HH | 1 |
| Fang, CL | 1 |
| Seymour, RA | 1 |
| Moore, U | 1 |
| Hawkesford, J | 1 |
| Coulthard, P | 1 |
| Jackson-Leech, D | 1 |
| Thomas, D | 1 |
| Hill, M | 1 |
| Combs, ML | 1 |
| Renton, T | 1 |
| McGurk, M | 1 |
| Schmidt, A | 1 |
| Björkman, S | 1 |
| Akeson, J | 1 |
| McLoughlin, C | 1 |
| McKinney, MS | 1 |
| Fee, JP | 1 |
| Boules, Z | 1 |
| Korpela, R | 1 |
| Olkkola, KT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery[NCT00366444] | Phase 3 | 201 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain intensity scores were measured using an 11-point numerical pain rating scale (NPRS) with 0=no pain to 10=worst possible pain (NCT00366444)
Timeframe: Over 48 hours after bunionectomy
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 2.5 |
| Placebo | 5.6 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 70.2 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 26.0 |
| Placebo | 22.2 |
(NCT00366444)
Timeframe: Day 1
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 40 |
| Placebo | 87 |
(NCT00366444)
Timeframe: Day 2
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 22 |
| Placebo | 64 |
Day 3 data reflect the use of rescue medication only up to the time of discharge (NCT00366444)
Timeframe: Day 3
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 5 |
| Placebo | 29 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 62 |
| Placebo | 40 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 58 |
| Placebo | 35 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 84 |
| Placebo | 69 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 60 |
Pain relief was rated using a 5-point categorial scale (0=none, 1=a little, 2=some, 3=a lot, and 4=complete) at time of dose (time=0) and over 15 time points afterwards (10, 15, 20, 30, 45, and 60 minutes and at 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after the initial dose on Day 1 or until time of re-medication). A score of 0 across all time points would be the lowest (worst) and a score of 60 (4 X 15 time points) would be the highest (best) possible score. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 8.2 |
| Placebo | 2.6 |
7 trials available for diclofenac and Anesthesia
| Article | Year |
|---|---|
Intravenous diclofenac and orphenadrine for the treatment of postoperative pain after remifentanil-based anesthesia : A double-blinded, randomized, placebo-controlled study.
Topics: Analgesics; Analgesics, Opioid; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dou | 2023 |
Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; An | 2009 |
Pre-surgical child behavior ratings and pain management after two different techniques of tonsil surgery.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Anti-Inflammato | 2006 |
Premedication with controlled release diclofenac sodium reduces post-operative pain after minor gynaecological surgery.
Topics: Analgesics, Non-Narcotic; Anesthesia; Delayed-Action Preparations; Diclofenac; Double-Blind Method; | 1997 |
An investigation into the efficacy of intravenous diclofenac in post-operative dental pain.
Topics: Adult; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; | 2000 |
Preoperative rectal diclofenac versus paracetamol for tonsillectomy: effects on pain and blood loss.
Topics: Acetaminophen; Administration, Rectal; Adult; Analgesics, Non-Narcotic; Anesthesia; Anti-Inflammator | 2001 |
Diclofenac for day-care arthroscopy surgery: comparison with a standard opioid therapy.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Anesthesia; Anesthesia Recovery | 1990 |
3 other studies available for diclofenac and Anesthesia
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory drugs, opioids, and routine anesthesia.
Topics: Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fentanyl; Humans; Nalbuphine; Narco | 1995 |
Transdermal iontophoretic delivery of diclofenac sodium from various polymer formulations: in vitro and in vivo studies.
Topics: Administration, Cutaneous; Anesthesia; Animals; Cellulose; Chemistry, Pharmaceutical; Diclofenac; Dr | 1999 |
Pharmacokinetics of intravenous diclofenac sodium in children.
Topics: Anesthesia; Child, Preschool; Diclofenac; Half-Life; Humans; Infusions, Intravenous; Premedication | 1990 |