diclofenac has been researched along with Anastomotic Leak in 12 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our aim was, for the first time, to analyze the morpho-functional effects of postoperative administration of two commonly used NSAIDs, Diclofenac and Ketorolac, on the healing process of colo-colic anastomoses constructed under condition of fecal peritonitis in a rat model." | 3.96 | Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration. ( Casciani, F; Ghiselli, R; Guerrieri, M; Lucarini, G; Orlando, F; Ortenzi, M; Provinciali, M; Saccomanno, S; Salvolini, E, 2020) |
| "Wildtype, COX-2 knockout and COX-2 heterozygous mice were subjected to a model of colonic anastomotic leakage, and were treated with vehicle, diclofenac, or prostaglandin E2 (PGE2), the most important COX-2 product in the intestine." | 3.85 | Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing. ( Boonen, B; Bosmans, JW; Derikx, JP; Grootjans, J; Hulsewé, KW; Poeze, M; Reisinger, KW; Sastrowijoto, P; Schellekens, DH, 2017) |
| "The results of this study are in line with other comparable studies in the literature, showing an increased risk for anastomotic leakage with diclofenac." | 3.83 | Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program. ( Bakker, N; Cakir, H; Deelder, JD; Doodeman, HJ; Houdijk, AP; Richir, MC; Schreurs, WH, 2016) |
| "Diclofenac treatment could result in an increased proportion of patients with anastomotic leakage after colorectal surgery." | 3.78 | Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. ( Gögenur, I; Klein, M; Rosenberg, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (91.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ghiselli, R | 1 |
| Lucarini, G | 1 |
| Ortenzi, M | 1 |
| Salvolini, E | 1 |
| Saccomanno, S | 1 |
| Orlando, F | 1 |
| Provinciali, M | 1 |
| Casciani, F | 1 |
| Guerrieri, M | 1 |
| Yauw, ST | 2 |
| Hoesseini, A | 1 |
| Lomme, RM | 3 |
| van Goor, H | 2 |
| van der Vijver, RJ | 2 |
| Hendriks, T | 2 |
| van Laarhoven, KJ | 1 |
| Kong, C | 1 |
| Glasbey, J | 1 |
| Mohan, M | 1 |
| McNamee, L | 1 |
| Fitzgerald, JE | 1 |
| Bakker, N | 1 |
| Deelder, JD | 1 |
| Richir, MC | 1 |
| Cakir, H | 1 |
| Doodeman, HJ | 1 |
| Schreurs, WH | 1 |
| Houdijk, AP | 1 |
| Reisinger, KW | 1 |
| Schellekens, DH | 1 |
| Bosmans, JW | 1 |
| Boonen, B | 1 |
| Hulsewé, KW | 1 |
| Sastrowijoto, P | 1 |
| Derikx, JP | 1 |
| Grootjans, J | 1 |
| Poeze, M | 1 |
| Gulcicek, OB | 1 |
| Solmaz, A | 1 |
| Yigitbas, H | 1 |
| Ercetin, C | 1 |
| Yavuz, E | 1 |
| Ozdogan, K | 1 |
| Biricik, A | 1 |
| Akkalp, AK | 1 |
| Uzun, H | 1 |
| Kutnu, M | 1 |
| Celebi, F | 1 |
| Celik, A | 1 |
| Klein, M | 4 |
| Krarup, PM | 2 |
| Burcharth, J | 1 |
| Ågren, MS | 2 |
| Gögenur, I | 3 |
| Jorgensen, LN | 2 |
| Rosenberg, J | 3 |
| Kongsbak, MB | 1 |
| van Laarhoven, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652] | 502 participants (Actual) | Observational [Patient Registry] | 2015-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diclofenac and Anastomotic Leak
| Article | Year |
|---|---|
Postoperative non-steroidal anti-inflammatory drugs and colorectal anastomotic leakage. NSAIDs and anastomotic leakage.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; | 2012 |
11 other studies available for diclofenac and Anastomotic Leak
| Article | Year |
|---|---|
Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Di | 2020 |
Serosal abrasion of bowel ends does not enhance anastomotic healing.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colon; Diclofenac; Male; Random Allocation; Rats, | 2015 |
Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat.
Topics: Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Diclofenac; Male; Rats; R | 2015 |
Caution when interpreting anti-inflammatory drug effects in rat models of gastrointestinal anastomosis.
Topics: Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Diclofenac; Male | 2016 |
Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program.
Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Ster | 2016 |
Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing.
Topics: Anastomosis, Surgical; Anastomotic Leak; Angiogenesis Inducing Agents; Animals; Chi-Square Distribut | 2017 |
Role of diclofenac sodium and paracetamol on colonic anastomosis: An experimental rodent model.
Topics: Acetaminophen; Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Stero | 2018 |
Effect of diclofenac on cyclooxygenase-2 levels and early breaking strength of experimental colonic anastomoses and skin incisions.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Biomechanical Phenomena; Colectomy; Cyclooxygenase | 2011 |
Effect of postoperative diclofenac on anastomotic healing, skin wounds and subcutaneous collagen accumulation: a randomized, blinded, placebo-controlled, experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; | 2012 |
Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data.
Topics: Aged; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colorectal Neoplasm | 2012 |
Diclofenac causes more leakage than naproxen in anastomoses in the small intestine of the rat.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Body Weight; Diclofenac; Hydroxyproline; Ileum; In | 2013 |