diclofenac has been researched along with Alloxan Diabetes in 8 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to compare the bioavailability and pharmacokinetic parameters of diclofenac sodium and diclofenac potassium in normal and experimentally induced diabetic state in 24 rabbits using a validated reversed phase HPLC method with a washout period of one week." | 1.38 | Comparison of bioavailability and pharmacokinetics of diclofenac sodium and diclofenac potassium in normal and alloxan-diabetic rabbits. ( Ahmad, M; Iqbal, M; Murtaza, G, 2012) |
| "Diclofenac was reported to be metabolized via the hepatic microsomal cytochrome P450 (CYP) 2C11 in male rats." | 1.33 | Pharmacokinetics of diclofenac in rat model of diabetes mellitus induced by alloxan or steptozotocin. ( Kim, SH; Kim, YC; Lee, MG; Oh, EY, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, G | 1 |
| Gaul, MD | 1 |
| Kuo, GH | 1 |
| Du, F | 1 |
| Xu, JZ | 1 |
| Wallace, N | 1 |
| Hinke, S | 1 |
| Kirchner, T | 1 |
| Silva, J | 1 |
| Huebert, ND | 1 |
| Lee, S | 1 |
| Murray, W | 1 |
| Liang, Y | 1 |
| Demarest, K | 1 |
| Miao, GX | 1 |
| Wang, YD | 1 |
| Yan, ZW | 1 |
| Zhang, LY | 1 |
| Cohen, MP | 3 |
| Hud, E | 2 |
| Wu, VY | 2 |
| Shearman, CW | 2 |
| Shea, EA | 1 |
| Ahmad, M | 1 |
| Iqbal, M | 1 |
| Murtaza, G | 1 |
| Kim, YC | 1 |
| Oh, EY | 1 |
| Kim, SH | 1 |
| Lee, MG | 1 |
| Lautenslager, GT | 1 |
| Shea, E | 1 |
| Wang, A | 1 |
| Chen, S | 1 |
| Gutting, BW | 1 |
| Updyke, LW | 1 |
| Amacher, DE | 1 |
8 other studies available for diclofenac and Alloxan Diabetes
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Topics: Administration, Oral; Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Drug De | 2018 |
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relations | 2020 |
Amelioration of diabetes-associated abnormalities in the vitreous fluid by an inhibitor of albumin glycation.
Topics: Animals; Colorimetry; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diclofenac; Eye Protein | 2008 |
Inhibiting low-density lipoprotein glycation ameliorates increased cholesteryl ester synthesis in macrophages and hypercholesterolemia and aortic lipid peroxidation in streptozotocin diabetic rats.
Topics: Animals; Apolipoproteins B; Atherosclerosis; Cholesterol Esters; Diabetes Mellitus, Experimental; Di | 2010 |
Comparison of bioavailability and pharmacokinetics of diclofenac sodium and diclofenac potassium in normal and alloxan-diabetic rabbits.
Topics: Alloxan; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Diabetes Mellitu | 2012 |
Pharmacokinetics of diclofenac in rat model of diabetes mellitus induced by alloxan or steptozotocin.
Topics: Administration, Oral; Alloxan; Animals; Aryl Hydrocarbon Hydroxylases; Bile; Cyclooxygenase Inhibito | 2006 |
Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.
Topics: Albumins; Animals; Collagen Type IV; Creatinine; Diabetes Mellitus, Experimental; Diclofenac; Glycos | 2007 |
Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG(1) and IgE against co-injected TNP-OVA.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diabetes Mellitus, Experimen | 2002 |