Page last updated: 2024-10-26

diclofenac and Acute Kidney Injury

diclofenac has been researched along with Acute Kidney Injury in 68 studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
"Diclofenac (DIC)-induced acute kidney injury (AKI) causes high morbidity and mortality."8.126-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2022)
"Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition."8.02Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021)
"To evaluate the nephro-protective effects of berberine and/or pentoxifylline on the reduction of diclofenac-induced acute kidney injury in rats."7.91Berberine and Pentoxifylline: A novel combination in amelioration of acute kidney injury. ( Al-Gareeb, AI; Al-Kuraishy, HM; Hussien, NR, 2019)
"The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group."7.88Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief. ( Banh, HL; Cave, A; Li, YY; Luo, JQ; Wang, Q; Xiao, YW; Xu, P; Zhou, YG; Zhu, Y, 2018)
"Methotrexate is one of the most commonly used drugs in autoimmune disorders like rheumatoid arthritis."7.88Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury. ( Biju, IK; Manappallil, RG; Peringat, J; Prasan, D, 2018)
"In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis."5.38Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. ( Leicht-Biener, U; Mucsi, I; Seitz, K; Wagner, R, 2012)
"Acute renal failure was present in three of the 9 new patients and in 20 of 37 published patients."5.33Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review. ( Ahrens, N; Genth, R; Kiesewetter, H; Salama, A, 2006)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; 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Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"Diclofenac (DIC)-induced acute kidney injury (AKI) causes high morbidity and mortality."4.126-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2022)
" Spironolactone, furosemide, and trimethoprim with sulfamethoxazole are medicines that, in particular, need to be used carefully and monitored closely in patients in the community at risk of acute kidney injury."4.12Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care. ( Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE, 2022)
"Chronic administration of diclofenac (DIC) has been reported to cause acute kidney injury (AKI), which is a serious health condition."4.02Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study. ( Abdou, RM; Aboushousha, T; El-Dine, RS; El-Maadawy, WH; El-Sayed, AM; El-Tanbouly, ND; Hassan, M, 2021)
"To assess the reno-protective effect of berberine on diclofenac-induced acute kidney injury in rats."3.91Reno-protective effect of berberine. ( Al-Gareeb, AI; Al-Kuraishy, HM; Hussien, NR, 2019)
"To evaluate the nephro-protective effects of berberine and/or pentoxifylline on the reduction of diclofenac-induced acute kidney injury in rats."3.91Berberine and Pentoxifylline: A novel combination in amelioration of acute kidney injury. ( Al-Gareeb, AI; Al-Kuraishy, HM; Hussien, NR, 2019)
"The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group."3.88Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief. ( Banh, HL; Cave, A; Li, YY; Luo, JQ; Wang, Q; Xiao, YW; Xu, P; Zhou, YG; Zhu, Y, 2018)
"Methotrexate is one of the most commonly used drugs in autoimmune disorders like rheumatoid arthritis."3.88Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury. ( Biju, IK; Manappallil, RG; Peringat, J; Prasan, D, 2018)
"Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by multiple adverse effects, including renal toxicity leading to acute kidney injury."3.78Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury. ( Bao, H; Dworkin, LD; Ge, Y; Gong, R; Liu, Z; Zhuang, S, 2012)
"We report a case of severe metabolic acidosis associated with acute renal failure and septicaemia following treatment with maximal therapeutic doses of metformin and diclofenac."3.73Intensive care treatment of severe mixed metabolic acidosis. ( Akeson, J; Christensson, A; Schmidt, A, 2005)
"We report a case of neonatal transient renal failure after maternal ingestion of diclofenac, paracetamol, and nimesulide during pregnancy."3.72In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. ( Benini, D; Cuzzolin, L; Fanos, V; Tatò, L, 2004)
"The risk of a newly diagnosed episode of upper gastrointestinal bleeding, acute liver and renal failure, agranulocytosis, aplastic anemia, severe skin disorders, and anaphylaxis was examined within 30 days after the first prescription for a low dose of diclofenac, naproxen, or ibuprofen in a cohort in the United Kingdom."3.70Low-dose diclofenac, naproxen, and ibuprofen cohort study. ( Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C, 1999)
"Ketorolac is approved for the relief of postoperative pain but concerns have been raised over a possible risk of serious adverse effects and death."2.70Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. ( Abdalla, M; Bianchi, PG; Bonnet, F; Camu, F; Ebrahim, S; Escolar, G; Forrest, JB; Greer, IA; Heitlinger, E; Jage, J; Kehlet, H; Langman, MJ; Pocock, S; Samama, MM; Velo, G, 2002)
"Diclofenac (DIC) is a non-steroidal anti-inflammatory drug with a potential nephrotoxic effect."1.91Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect. ( Alhindi, A; Almalki, H; Badr, A; Hasan, IH; Mostafa, HS, 2023)
"Diclofenac, one of the most commonly used non-steroidal anti-inflammatory drugs, leads to severe adverse effects on the kidneys."1.62Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats. ( Abdel-Razek, NS; Salem, HA; Wadie, W, 2021)
"Treatment of many inflammatory diseases involves a chronic use of NSAIDs in large doses increasing acute kidney injury risk."1.51Gum Acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways. ( Abu-Elsaad, N; El-Karef, A; Ibrahim, T; Shafeek, F, 2019)
"Diclofenac (DIC) can cause nephrotoxicity in humans."1.51Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study. ( Heidarian, E; Nouri, A, 2019)
"However, a primary presentation of acute kidney failure due to lymphoma localization is extremely rare."1.46Clinical case report: a rare cause of acute kidney failure - tissue is the issue. ( Claes, K; Evenepoel, P; Heggermont, WA; Lerut, E; Sprangers, B; Tousseyn, T; Verhoef, G, 2017)
"In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis."1.38Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. ( Leicht-Biener, U; Mucsi, I; Seitz, K; Wagner, R, 2012)
"Acute renal failure was caused by D."1.35The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. ( Balal, M; Besen, A; Dogan, A; Gonlusen, G; Inal, T; Kibar, M; Kose, F; Paydas, S, 2009)
"Acute renal failure was present in three of the 9 new patients and in 20 of 37 published patients."1.33Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review. ( Ahrens, N; Genth, R; Kiesewetter, H; Salama, A, 2006)
" This drug, therefore affects the bioavailability of two major respiratory complex I substrates which would normally contribute substantially to supplying the reducing equivalents for mitochondrial electron transport for generation of ATP in the renal cell."1.33Action of diclofenac on kidney mitochondria and cells. ( Halliwell, B; Ng, LE; Vincent, AS; Wong, KP, 2006)
"We concluded that in our patient acute renal insufficiency aggravated by diclofenac treatment probably associated with an inadvertent withdrawal could have been the precipitating factor for transient protein C deficiency."1.32Coumarin necrosis induced by renal insufficiency. ( Ferreres, JR; Giménez, S; Marcoval, J; Moreno, A; Muniesa, C; Peyrí, J; Sánchez, J, 2004)
"The progressive septic state with acute renal failure was verified by elevation of creatinine concentration and decrease of leukocyte values in the second case (from 10/nl to 2,5/nl) shortly after admission."1.31[Diagnosis and treatment of streptococcal myositis]. ( Bechtold, H; Eckmann, C; Krüger, S; Kujath, P, 2002)
"Electrolyte disorders and acute renal failure are observed more frequently in patients with risk factors."1.31[Renal tolerance of selective inhibitors of cyclooxygenase type 2]. ( Deray, G, 2001)
"In critically ill patients, acute renal failure is mostly multifactorial in origin."1.29Transient post-renal obstruction may protect the kidney against nephrotoxic damage--a case report. ( Baur, C; de Jong, PE; Navis, GJ; Rommes, JH, 1995)
" We suggest that the immune complex mechanism could have induced these adverse reactions."1.29Serious adverse effects induced by simultaneous administration of two nonsteroidal anti-inflammatory drugs. ( Awaya, N; Handa, M; Matsuyama, M; Ogino, M; Okada, H; Saruta, T; Suzuki, H; Toya, S, 1993)
"2 cases of acute renal failure associated with diclofenac therapy are reported."1.27Diclofenac-associated acute renal failure. Report of 2 cases. ( Cavalieri, F; Dall'Aglio, PP; Ferraccioli, GF; Menta, R; Migone, L; Rossi, E, 1985)

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-199011 (16.18)18.7374
1990's10 (14.71)18.2507
2000's19 (27.94)29.6817
2010's20 (29.41)24.3611
2020's8 (11.76)2.80

Authors

AuthorsStudies
El-Maadawy, WH2
Hassan, M2
Abdou, RM2
El-Dine, RS2
Aboushousha, T2
El-Tanbouly, ND2
El-Sayed, AM2
Roughead, EE1
Kerr, M1
Moffat, A1
Kassie, GM1
Pratt, N1
Hasan, IH1
Badr, A1
Almalki, H1
Alhindi, A1
Mostafa, HS1
Naya, Y1
Hata, N1
Kobayash, M1
Thuyuki, M1
Koyama, Y1
Ogihara, K1
Hussien, NR2
Al-Kuraishy, HM2
Al-Gareeb, AI2
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J1
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J6
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Li, Y6
Xu, T1
Li, C2
Ji, F1
Ming, F1
Zhao, Y2
Cheng, J1
Wang, Y3
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C1
Wu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C3
Lin, Y1
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y3
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Yang, K2
Zhai, C1
Yang, M1
Lao, X1
Sun, J1
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
Mathews, D1
Agnese, W1
Apple, S1
Meloncelli, S1
Divizia, M1
Germani, G1
Adefegha, SA1
Bottari, NB1
Leal, DB1
de Andrade, CM1
Schetinger, MR1
Martínez-Velasco, A1
Perez-Ortiz, AC1
Antonio-Aguirre, B1
Martínez-Villaseñor, L1
Lira-Romero, E1
Palacio-Pastrana, C1
Zenteno, JC1
Ramirez, I1
Zepeda-Palacio, C1
Mendoza-Velásquez, C1
Camacho-Ordóñez, A1
Ortiz Bibriesca, DM1
Estrada-Mena, FJ1
Martin, BL1
Thompson, LC1
Kim, YH2
Snow, SJ1
Schladweiler, MC1
Phillips, P1
Harmon, M1
King, C1
Richards, J1
George, I1
Haykal-Coates, N1
Gilmour, MI1
Kodavanti, UP1
Hazari, MS1
Farraj, AK1
Shen, Z1
Zou, Y1
Gao, K1
Lazar, S1
Wurtzel, JGT1
Ma, P1
Goldfinger, LE1
Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
Chen, J2
Xun, J1
Hu, Z1
Huang, Q2
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Guo, X1
Cao, Y1
Jia, X1
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
Wang, YF1
Cong, WL1
Liu, LP1
Li, XX1
Zhou, CL1
Chen, WM1
Wei, KL1
Tung, SY1
Shen, CH1
Chang, TS1
Yen, CW1
Hsieh, YY1
Chiu, WN1
Hu, JH1
Lu, SN1
Hung, CH1
Alakavuklar, MA1
Fuqua, C1
Luo, KL1
Underwood, RS1
Greenwald, I1
Elashiry, MM1
Elashiry, M1
Zeitoun, R1
Elsayed, R1
Tian, F1
Saber, SE1
Elashry, SH1
Tay, FR1
Cutler, CW1
O'Dowd, A1
Maciel, M1
Poole, ST1
Jobling, MG1
Rollenhagen, JE1
Woods, CM1
Sincock, SA1
McVeigh, AL1
Gregory, MJ1
Maves, RC1
Prouty, MG1
Holmes, RK1
Savarino, SJ1
Mor, MK1
Palevsky, PM1
Kaufman, JS1
Thiessen Philbrook, H1
Weisbord, SD1
Parikh, CR1
John, CM1
Phillips, NJ1
Jarvis, GA1
Zhu, Y2
Kilburn, S1
Kapoor, M1
Chaturvedi, S1
Shaw, KJ1
Chaturvedi, V1
Kong, X1
Zhang, T1
Xiao, H1
Feng, X1
Tu, H1
Feng, J1
Sabet, M1
Tarazi, Z1
Griffith, DC1
Nguyen, F1
Guan, P1
Guerrero, DT1
Kolla, V1
Naraparaju, K1
Perry, LM1
Soberman, D1
Pressly, BB1
Alferiev, IS1
Chorny, M1
Brodeur, GM1
Gao, X2
Cheng, YH1
Enten, GA1
DeSantis, AJ1
Gaponenko, V1
Majetschak, M1
Kim, DY1
Choi, MJ1
Ko, TK1
Lee, NH1
Kim, OH1
Cheon, HG1
Cai, H1
Yip, V1
Lee, MV1
Wong, S1
Saad, O1
Ma, S1
Ljumanovic, N1
Khojasteh, SC1
Kamath, AV1
Shen, BQ1
Cuypers, ML1
Chanteux, H1
Gillent, E1
Bonnaillie, P1
Saunders, K1
Beckers, C1
Delatour, C1
Dell'Aiera, S1
Ungell, AL1
Nicolaï, J1
Knapp, AK1
Chen, A1
Griffin-Nolan, RJ1
Baur, LE1
Carroll, CJW1
Gray, JE1
Hoffman, AM1
Li, X4
Post, AK1
Slette, IJ1
Collins, SL1
Luo, Y1
Smith, MD1
Temitayo, GI1
Olawande, B1
Emmanuel, YO1
Timothy, AT1
Kehinde, O1
Susan, LF1
Ezra, L1
Joseph, OO1
Lev, S1
Desmarini, D1
Liuwantara, D1
Sorrell, TC1
Hawthorne, WJ1
Djordjevic, JT1
Verso, MG1
Costantino, C1
Marrella, A1
Immordino, P1
Vitale, F1
Amodio, E1
Wang, YD1
Yao, WL1
Xin, ZM1
Han, TT1
Wang, ZG1
Chen, L1
Cai, C1
Zhang, Y4
Ba, D1
Wen, S1
Tian, Q1
Lv, W1
Cheng, G1
Li, N1
Yue, XY1
Chu, WJ1
Chen, Q1
Choi, ES1
Zhao, X3
Zhou, HD1
Sun, XF1
Sharma, S2
Chhoker, S1
Xie, C1
Ong, EWY1
Tan, ZK1
Evans, S1
Weinheimer, CJ1
Kovacs, A1
Williams, JW1
Randolph, GJ1
Jiang, W1
Barger, PM1
Mann, DL1
Liu, J2
Huang, Y1
Kong, L1
Yu, X1
Feng, B1
Liu, D1
Zhao, B1
Mendes, GC1
Yuan, P1
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Li, P1
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Chang, EF1
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Shanmugam, S1
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Yu, HJ1
Li, XQ1
Yang, AD1
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Palaparthi, A1
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González, MA1
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García-Pérez, AL1
Jatt, LP1
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Zhao, Q1
Tong, W1
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Zhao, D1
Norbäck, D1
Li, B1
Zhao, Z1
Huang, C1
Zhang, X1
Qian, H1
Yang, X1
Sun, Y1
Sundell, J1
Deng, Q1
Kim, HJ1
Jeon, JW1
Hwang, SM1
Chu, KI1
Cha, YH1
Kwak, YD1
Choi, SD1
Aslam, M1
Kim, CG1
Zhou, J1
Yang, E1
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Mazzuco, TL2
Casagrande, R2
Verri, WA2
Xu, P1
Wang, Q1
Luo, JQ1
Xiao, YW1
Li, YY1
Zhou, YG1
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Jung, O1
Colak, S1
Kutlucan, L1
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Ribas, OS1
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Reis, LA1
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Zhuang, S1
Dworkin, LD1
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Gong, R1
Fuchs, T1
Puellmann, K1
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Kruth, J1
Schulze, TJ1
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Beham, AW1
Kaminski, WE1
Gerber, L1
Gaspert, A1
Bleisch, JA1
Kujath, P1
Krüger, S1
Bechtold, H1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056]Phase 4200 participants (Anticipated)Interventional2022-02-08Recruiting
Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173]Phase 4550 participants (Anticipated)Interventional2020-07-22Recruiting
Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174]50 participants (Actual)Observational2016-06-01Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for diclofenac and Acute Kidney Injury

ArticleYear
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
[Nephrotic syndrome and oligo-anuria complicating treatment with diclofenac].
    Annales de medecine interne, 2000, Volume: 151, Issue:1

    Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclof

2000
Diclofenac-induced thrombocytopenic purpura with renal and hepatic involvement.
    Journal of internal medicine, 1991, Volume: 230, Issue:6

    Topics: Acute Kidney Injury; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Jaundice; Middle Aged; Purpu

1991
Diclofenac-associated interstitial mucinosis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1991, Volume: 6, Issue:8

    Topics: Acute Kidney Injury; Adult; Anemia; Biopsy; Blood Sedimentation; Coombs Test; Diclofenac; Extracellu

1991
[Acute reversible renal insufficiency during treatment with diclofenac].
    La Clinica terapeutica, 1989, Jan-31, Volume: 128, Issue:2

    Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Pros

1989
Scleroderma renal crisis without hypertension.
    The Journal of rheumatology, 1989, Volume: 16, Issue:5

    Topics: Acute Kidney Injury; Diclofenac; Female; Humans; Middle Aged; Scleroderma, Systemic

1989

Trials

2 trials available for diclofenac and Acute Kidney Injury

ArticleYear
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico

2002

Other Studies

61 other studies available for diclofenac and Acute Kidney Injury

ArticleYear
6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways.
    Environmental toxicology and pharmacology, 2022, Volume: 91

    Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Autophagy; Diclofenac; Guaiacol; Inflam

2022
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
    Drug safety, 2022, Volume: 45, Issue:11

    Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia;

2022
Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect.
    Life sciences, 2023, Oct-01, Volume: 330

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Curcumin; Cystatin C; Diclofenac; Lipopolysa

2023
Pathological study of proximal tubule mitochondria in diclofenac-induced acute kidney injury model mice.
    Tissue & cell, 2023, Volume: 84

    Topics: Acute Kidney Injury; Animals; Autophagy; Diclofenac; Kidney Tubules, Proximal; Mice; Mitochondria

2023
Reno-protective effect of berberine.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69(Suppl 3), Issue:8

    Topics: Acute Kidney Injury; Animals; Antioxidants; Berberine; Biomarkers; Cystatin C; Diclofenac; Glomerula

2019
Berberine and Pentoxifylline: A novel combination in amelioration of acute kidney injury.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69(Suppl 3), Issue:8

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Berberine; Biomarkers; Creatinine; Cystatin C; D

2019
Thymoquinone alleviates mitochondrial viability and apoptosis in diclofenac-induced acute kidney injury (AKI) via regulating Mfn2 and miR-34a mRNA expressions.
    Environmental science and pollution research international, 2021, Volume: 28, Issue:8

    Topics: Acute Kidney Injury; Animals; Apoptosis; Benzoquinones; Diclofenac; Kidney; MicroRNAs; Oxidative Str

2021
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study.
    Journal of ethnopharmacology, 2021, Jun-12, Volume: 273

    Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; C

2021
Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats.
    Life sciences, 2021, Jul-15, Volume: 277

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cilostazol; Creatinine; Diclofenac; Kidney; Male;

2021
Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice.
    Pharmacological research, 2017, Volume: 120

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cytokines; Diclofe

2017
Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Presch

2018
Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018, Volume: 43, Issue:9

    Topics: Acute Kidney Injury; Animals; Diclofenac; Dinoprostone; Flavonoids; Garcinia kola; Kidney; Male; Oxi

2018
Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury.
    BMJ case reports, 2018, Jun-05, Volume: 2018

    Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis,

2018
Pyrrolidine dithiocarbamate inhibits mouse acute kidney injury induced by diclofenac by targeting oxidative damage, cytokines and NF-κB activity.
    Life sciences, 2018, Sep-01, Volume: 208

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Dicl

2018
Gum Acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 129

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biom

2019
Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study.
    Journal of food biochemistry, 2019, Volume: 43, Issue:8

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Biomarkers; Creatinine; Diclofenac; Humans; Kidney; Ma

2019
Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration.
    HIV medicine, 2013, Volume: 14, Issue:10

    Topics: Acute Kidney Injury; Adenine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Inter

2013
Acute kidney failure associated with anaphylactic shock caused by diclofenac sodium.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2015, Volume: 25, Issue:4

    Topics: Acute Kidney Injury; Anaphylaxis; Cyclooxygenase Inhibitors; Diclofenac; Humans; Injections, Intramu

2015
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy.
    BMC nephrology, 2016, Mar-15, Volume: 17

    Topics: Acute Disease; Acute Kidney Injury; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal;

2016
Clinical case report: a rare cause of acute kidney failure - tissue is the issue.
    Acta clinica Belgica, 2017, Volume: 72, Issue:3

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Murine-Derived

2017
Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Acute Kidney Injury; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cytoprotection; Diclofenac; D

2016
The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide.
    International urology and nephrology, 2009, Volume: 41, Issue:4

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy,

2009
Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.
    Clinical nephrology, 2009, Volume: 71, Issue:5

    Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diag

2009
Corosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 56, Issue:2

    Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Nephropathi

2010
Preconditioning induced by gentamicin protects against acute kidney injury: the role of prostaglandins but not nitric oxide.
    Toxicology and applied pharmacology, 2011, May-15, Volume: 253, Issue:1

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Diclofenac; Gentamicins; Male; NG-Nit

2011
Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica.
    Scandinavian journal of urology and nephrology, 2012, Volume: 46, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C

2012
Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury.
    Kidney international, 2012, Volume: 81, Issue:7

    Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt

2012
An autoimmune double attack.
    Lancet (London, England), 2012, Apr-07, Volume: 379, Issue:9823

    Topics: Acute Kidney Injury; Aged; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents, Non-Steroidal; A

2012
[Calcified].
    Praxis, 2012, May-23, Volume: 101, Issue:11

    Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Calcinosis; Cathartics;

2012
[Diagnosis and treatment of streptococcal myositis].
    Deutsche medizinische Wochenschrift (1946), 2002, Nov-22, Volume: 127, Issue:47

    Topics: Acute Kidney Injury; Adult; Arthroscopy; Biopsy; Diclofenac; Extremities; Humans; Injections, Intram

2002
In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.
    Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fema

2004
Nonsteroidal antiinflammatory-induced acute renal failure detected on bone scintigraphy.
    Clinical nuclear medicine, 2004, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Diclofenac; Humans; Ib

2004
Coumarin necrosis induced by renal insufficiency.
    The British journal of dermatology, 2004, Volume: 151, Issue:2

    Topics: Acenocoumarol; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; D

2004
[Acute renal failure caused by analgesics. Successful treatment of knee pain, but patient died].
    MMW Fortschritte der Medizin, 2004, Aug-19, Volume: 146, Issue:33-34

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Nephropathies; Diagnosis, Dif

2004
[Acute renal failure--"a well meant present from a friend"].
    Therapeutische Umschau. Revue therapeutique, 2004, Volume: 61, Issue:12

    Topics: Acute Kidney Injury; Administration, Cutaneous; Administration, Oral; Aged; Anti-Inflammatory Agents

2004
Intensive care treatment of severe mixed metabolic acidosis.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:3

    Topics: Abdominal Abscess; Acidosis; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blo

2005
[Rhabdomyolysis after administration of diclofenac].
    Der Unfallchirurg, 2005, Volume: 108, Issue:5

    Topics: Acute Kidney Injury; Adult; Creatine Kinase; Diclofenac; Humans; Male; Myoglobin; Rhabdomyolysis

2005
Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review.
    American journal of hematology, 2006, Volume: 81, Issue:2

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anemia, Hemolytic, Autoimmune; Antibodies; Coombs Test

2006
A Friday afternoon case of apparent anti-glomerular basement nephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Animals; Anti-Glomerular Basement Membrane Disease;

2006
Action of diclofenac on kidney mitochondria and cells.
    Biochemical and biophysical research communications, 2006, Sep-22, Volume: 348, Issue:2

    Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Aspartic Acid; Benzimidazoles; Carbocyanines;

2006
Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2006, Volume: 12, Issue:5

    Topics: Acute Kidney Injury; Adult; Anthraquinones; Appetite Depressants; Diclofenac; Drugs, Chinese Herbal;

2006
[Reversible nephrotic syndrome and acute renal failure associated with alclofenac administration].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1982, Jul-27, Volume: 71, Issue:30

    Topics: Acute Kidney Injury; Diclofenac; Eosinophilia; Humans; Kidney; Male; Middle Aged; Nephrotic Syndrome

1982
[Acute renal insufficiency caused by clometacin. Relapse with diclofenac. Inhibition of the synthesis of prostaglandins].
    La Revue de medecine interne, 1982, Volume: 3, Issue:4

    Topics: Acute Kidney Injury; Analgesics; Diclofenac; Female; Humans; Indoleacetic Acids; Middle Aged; Phenyl

1982
Transient post-renal obstruction may protect the kidney against nephrotoxic damage--a case report.
    Intensive care medicine, 1995, Volume: 21, Issue:7

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Hypotensio

1995
Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
    Journal of toxicology. Clinical toxicology, 1995, Volume: 33, Issue:2

    Topics: Acute Kidney Injury; Adolescent; Adult; Alcoholic Intoxication; Creatinine; Diclofenac; Drug Interac

1995
[Renal and systemic changes caused by non-steroidal anti-inflammatory agents].
    Medicina clinica, 1994, Jun-11, Volume: 103, Issue:2

    Topics: Acute Kidney Injury; Diclofenac; Humans; Lymphatic Diseases; Male; Middle Aged; Proteinuria

1994
Serious adverse effects induced by simultaneous administration of two nonsteroidal anti-inflammatory drugs.
    Southern medical journal, 1993, Volume: 86, Issue:11

    Topics: Acute Kidney Injury; Agranulocytosis; Anemia, Hemolytic; Diclofenac; Drug Therapy, Combination; Fema

1993
Low-dose diclofenac, naproxen, and ibuprofen cohort study.
    Pharmacotherapy, 1999, Volume: 19, Issue:7

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agen

1999
Injection of diclofenac precipitating oliguric acute renal failure in a patient with kidney myeloma.
    Nephron, 2000, Volume: 85, Issue:1

    Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Diclofenac;

2000
Recurrence of Arthrotec-associated nephrotic syndrome with re-challenge.
    Clinical nephrology, 2000, Volume: 53, Issue:6

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Combinations; Humans;

2000
[Renal tolerance of selective inhibitors of cyclooxygenase type 2].
    Presse medicale (Paris, France : 1983), 2001, Oct-20, Volume: 30, Issue:30

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroida

2001
[Acute renal failure and nephrotic syndrome associated with treatment with diclofenac].
    Revista clinica espanola, 1992, Volume: 191, Issue:5

    Topics: Acute Kidney Injury; Aged; Diclofenac; Humans; Male; Nephrotic Syndrome

1992
Morphine intoxication during acute reversible renal insufficiency.
    Journal of palliative care, 1992,Summer, Volume: 8, Issue:2

    Topics: Acute Kidney Injury; Aged; Bone Neoplasms; Diclofenac; Drug Therapy, Combination; Humans; Male; Morp

1992
Morphine intoxication during acute reversible renal insufficiency.
    Journal of palliative care, 1991,Winter, Volume: 7, Issue:4

    Topics: Acute Kidney Injury; Aged; Bone Neoplasms; Diclofenac; Humans; Male; Morphine; Pain; Poisoning; Pros

1991
[Evolution of enzymuria in the course of acute renal insufficiency caused by non-steroidal anti-inflammatory agents].
    Revue du rhumatisme et des maladies osteo-articulaires, 1989, Volume: 56, Issue:1

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Aged; Aged, 80 and over; Aminopeptidases; Anti-Inflammat

1989
[Cholestatic hepatitis and acute kidney insufficiency during treatment with diclofenac].
    Annales de gastroenterologie et d'hepatologie, 1989, Volume: 25, Issue:6

    Topics: Acute Kidney Injury; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Diclofenac; Female;

1989
Enhancement of cyclosporine A nephrotoxicity by diclofenac.
    Clinical nephrology, 1987, Volume: 27, Issue:4

    Topics: Acute Kidney Injury; Back Pain; Cyclosporins; Diclofenac; Drug Synergism; Humans; Male; Middle Aged;

1987
Acute renal failure associated with diclofenac treatment in an elderly woman.
    Journal of the American Geriatrics Society, 1988, Volume: 36, Issue:5

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Diclofenac; Female; Humans; Kidney Failure, Chronic

1988
[Two cases of acute renal failure and nephrotic syndrome induced by nonsteroidal anti-inflammatory drugs].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1988, Volume: 77, Issue:1

    Topics: Acute Kidney Injury; Adolescent; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female;

1988
Acute tubular necrosis associated with acute pyelonephritis and concomitant diclofenac therapy.
    Clinical nephrology, 1987, Volume: 28, Issue:2

    Topics: Acute Kidney Injury; Aged; Diclofenac; Female; Humans; Kidney Tubular Necrosis, Acute; Pyelonephriti

1987
Diclofenac-associated acute renal failure. Report of 2 cases.
    Nephron, 1985, Volume: 40, Issue:4

    Topics: Acute Kidney Injury; Aged; Diclofenac; Female; Humans; Male; Middle Aged; Phenylacetates

1985