diclofenac has been researched along with Abnormalities, Drug-Induced in 5 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the safety of diclofenac during pregnancy." | 9.14 | First trimester diclofenac exposure and pregnancy outcome. ( Berkovitch, M; Cassina, M; Cesari, E; Clementi, M; De Santis, M; Di Gianantonio, E; Eleftheriou, G; Raffagnato, F; van Eijkeren, M, 2010) |
| "To assess the safety of diclofenac during pregnancy." | 5.14 | First trimester diclofenac exposure and pregnancy outcome. ( Berkovitch, M; Cassina, M; Cesari, E; Clementi, M; De Santis, M; Di Gianantonio, E; Eleftheriou, G; Raffagnato, F; van Eijkeren, M, 2010) |
| "Diclofenac treatment exerted a teratogenic effect on Xenopus embryos with a teratogenic index (TI) value of 2." | 1.42 | Evaluation of developmental toxicity and teratogenicity of diclofenac using Xenopus embryos. ( Chae, JP; Hwang, YS; Kim, SH; Lee, HS; Min, BH; Park, MJ; Park, MS, 2015) |
| "Diclofenac is a non-steroidal anti-inflammatory drug, commonly used by reproductive age women for the treatment of a variety of conditions." | 1.31 | A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model. ( Chan, LY; Chiu, PY; Lau, TK; Siu, SS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chae, JP | 1 |
| Park, MS | 1 |
| Hwang, YS | 1 |
| Min, BH | 1 |
| Kim, SH | 1 |
| Lee, HS | 1 |
| Park, MJ | 1 |
| Cardoso-Vera, JD | 1 |
| Islas-Flores, H | 1 |
| SanJuan-Reyes, N | 1 |
| Montero-Castro, EI | 1 |
| Galar-Martínez, M | 1 |
| García-Medina, S | 1 |
| Elizalde-Velázquez, A | 1 |
| Dublán-García, O | 1 |
| Gómez-Oliván, LM | 1 |
| Cassina, M | 1 |
| De Santis, M | 1 |
| Cesari, E | 1 |
| van Eijkeren, M | 1 |
| Berkovitch, M | 1 |
| Eleftheriou, G | 1 |
| Raffagnato, F | 1 |
| Di Gianantonio, E | 1 |
| Clementi, M | 1 |
| Shintaku, K | 1 |
| Hori, S | 1 |
| Satoh, H | 1 |
| Tsukimori, K | 1 |
| Nakano, H | 1 |
| Fujii, T | 1 |
| Taketani, Y | 1 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
| Chan, LY | 1 |
| Chiu, PY | 1 |
| Siu, SS | 1 |
| Lau, TK | 1 |
1 trial available for diclofenac and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
First trimester diclofenac exposure and pregnancy outcome.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; | 2010 |
4 other studies available for diclofenac and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Evaluation of developmental toxicity and teratogenicity of diclofenac using Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Embryo, N | 2015 |
Comparative study of diclofenac-induced embryotoxicity and teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX).
Topics: Abnormalities, Drug-Induced; Animals; Diclofenac; Embryo, Nonmammalian; Mexico; Rana catesbeiana; Te | 2017 |
Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Di | 2012 |
A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous Syste | 2001 |