dichlorphenamide has been researched along with Ocular Hypertension in 3 studies
Dichlorphenamide: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
diclofenamide : A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Ocular Hypertension: A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In an animal model of ocular hypertension, one of the new compounds was twice more effective than dorzolamide in reducing elevated intraocular pressure characteristic of this disease, anticipating their potential for the treatment of glaucoma." | 3.77 | Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action. ( Benedini, F; Biondi, S; Cecchi, A; Formicola, G; Masini, E; Mincione, F; Pacileo, I; Scozzafava, A; Supuran, CT; Temperini, C, 2011) |
| "A single topical instillation (50 microliter) of the water soluble sodium salt of dichlorphenamide (10%) produced a pronounced and prolonged lowering of intraocular pressure (IOP), compared to suspensions of its free acid, in rabbits with alpha-chymotrypsin-induced ocular hypertension." | 3.67 | Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. ( Gautheron, PD; Lotti, VJ; Schmitt, CJ, 1984) |
| "Such an agent would be useful in the treatment of glaucoma." | 1.28 | Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, SL | 1 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 1 |
| Best, DB | 1 |
| Christy, ME | 1 |
| Freedman, MB | 1 |
| Gautheron, P | 1 |
| Habecker, CN | 1 |
| Hoffman, JM | 1 |
| Mincione, F | 1 |
| Benedini, F | 1 |
| Biondi, S | 1 |
| Cecchi, A | 1 |
| Temperini, C | 1 |
| Formicola, G | 1 |
| Pacileo, I | 1 |
| Scozzafava, A | 1 |
| Masini, E | 1 |
| Supuran, CT | 1 |
| Lotti, VJ | 1 |
| Schmitt, CJ | 1 |
| Gautheron, PD | 1 |
3 other studies available for dichlorphenamide and Ocular Hypertension
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao | 1989 |
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Topics: Animals; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Disease Models, Animal; Glaucoma; Hu | 2011 |
Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits.
Topics: Administration, Topical; Animals; Aqueous Humor; Chromatography, Gas; Chymotrypsin; Dichlorphenamide | 1984 |