dichlorphenamide has been researched along with Intraocular Pressure in 28 studies
Dichlorphenamide: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
diclofenamide : A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, blind clinical study, we tested the effect of timolol and Daranide against placebo medications among patients who had intraocular pressures greater than 30 mm Hg on the first postoperative day after aphakic keratoplasty." | 9.04 | Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty. ( Kaufman, HE; Olson, RJ; Zimmerman, TJ, 1979) |
| "Dichlorphenamide as well as Diamox lowers intraocular pressure." | 9.04 | [Dichlorphenamide treatment in acute glaucoma (author's transl)]. ( Bleckmann, H, 1976) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 7.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 7.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| " For prevention of postoperative intraocular pressure (IOP) elevation, carbachol 0." | 5.08 | [Minimally inflammatory cataract surgery]. ( Hessemer, V; Schartner, H; Schmidt, KG, 1996) |
| "In a randomized, blind clinical study, we tested the effect of timolol and Daranide against placebo medications among patients who had intraocular pressures greater than 30 mm Hg on the first postoperative day after aphakic keratoplasty." | 5.04 | Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty. ( Kaufman, HE; Olson, RJ; Zimmerman, TJ, 1979) |
| "Dichlorphenamide as well as Diamox lowers intraocular pressure." | 5.04 | [Dichlorphenamide treatment in acute glaucoma (author's transl)]. ( Bleckmann, H, 1976) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 3.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 3.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "A single topical instillation (50 microliter) of the water soluble sodium salt of dichlorphenamide (10%) produced a pronounced and prolonged lowering of intraocular pressure (IOP), compared to suspensions of its free acid, in rabbits with alpha-chymotrypsin-induced ocular hypertension." | 3.67 | Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. ( Gautheron, PD; Lotti, VJ; Schmitt, CJ, 1984) |
| "Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles." | 3.66 | Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979) |
| "Methazolamide was next." | 2.64 | Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978) |
| "Such an agent would be useful in the treatment of glaucoma." | 1.28 | Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (71.43) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, SL | 2 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 1 |
| Best, DB | 1 |
| Christy, ME | 1 |
| Freedman, MB | 1 |
| Gautheron, P | 1 |
| Habecker, CN | 1 |
| Hoffman, JM | 2 |
| Woltersdorf, OW | 1 |
| Schwam, H | 1 |
| Bicking, JB | 1 |
| Brown, SL | 1 |
| deSolms, SJ | 1 |
| Fishman, DR | 1 |
| Gautheron, PD | 2 |
| Larson, RD | 1 |
| Scozzafava, A | 6 |
| Menabuoni, L | 2 |
| Mincione, F | 5 |
| Briganti, F | 1 |
| Mincione, G | 1 |
| Supuran, CT | 6 |
| Casini, A | 5 |
| Ilies, MA | 1 |
| Winum, JY | 1 |
| Starnotti, M | 3 |
| Montero, JL | 1 |
| Weber, A | 1 |
| Heine, A | 1 |
| Kuhn, D | 1 |
| Klebe, G | 1 |
| de Leval, X | 1 |
| Ilies, M | 1 |
| Dogné, JM | 1 |
| Masini, E | 2 |
| Bacciottini, L | 1 |
| Scrivanti, C | 1 |
| Vullo, D | 1 |
| GONZALES-JIMENEZ, E | 1 |
| LEOPOLD, IH | 1 |
| SCHIMEK, RA | 1 |
| BALLAN, JV | 1 |
| LEPLEY, FJ | 1 |
| OTTUM, JA | 1 |
| SLEZAK, H | 1 |
| TOJO, H | 1 |
| TSUJI, M | 1 |
| Luntz, MH | 1 |
| Lotti, VJ | 1 |
| Schmitt, CJ | 1 |
| Hessemer, V | 1 |
| Schmidt, KG | 1 |
| Schartner, H | 1 |
| Hasegawa, T | 1 |
| Doki, K | 1 |
| Yanase, J | 1 |
| Gelatt, KN | 1 |
| Gum, G | 1 |
| Williams, LW | 1 |
| Gwin, RM | 1 |
| Olson, RJ | 1 |
| Kaufman, HE | 1 |
| Zimmerman, TJ | 1 |
| Lichter, PR | 1 |
| Newman, LP | 1 |
| Wheeler, NC | 1 |
| Beall, OV | 1 |
| Bleckmann, H | 1 |
| Evans, SC | 1 |
| Sevcik, J | 1 |
| Levcik, A | 1 |
| Breffeilh, LA | 1 |
| Bietti, GB | 1 |
| Virno, M | 2 |
| Pecori-Giraldi, J | 2 |
| Pivetti-Pezzi, P | 2 |
| Leonardi, E | 1 |
| Burberi, P | 1 |
| Piccinelli, D | 1 |
| Silvestrini, B | 1 |
| Kanski, JJ | 1 |
| McDonald, TO | 1 |
| Hodges, JW | 1 |
| Borgmann, AR | 1 |
| Leaders, FE | 1 |
5 trials available for dichlorphenamide and Intraocular Pressure
| Article | Year |
|---|---|
GLAUCOMA TREATED WITH DARANIDE A CLINICAL TRIAL.
Topics: Acetazolamide; Aged; Carbonic Anhydrase Inhibitors; Chronic Disease; Dichlorphenamide; Drug Therapy, | 1961 |
[Minimally inflammatory cataract surgery].
Topics: Adult; Aged; Aged, 80 and over; Blood-Aqueous Barrier; Carbachol; Dexamethasone; Dichlorphenamide; D | 1996 |
Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty.
Topics: Adult; Aged; Aphakia, Postcataract; Carbonic Anhydrase Inhibitors; Cornea; Dichlorphenamide; Female; | 1979 |
Patient tolerance to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation | 1978 |
[Dichlorphenamide treatment in acute glaucoma (author's transl)].
Topics: Acetazolamide; Acid-Base Equilibrium; Acute Disease; Clinical Trials as Topic; Dichlorphenamide; Dru | 1976 |
23 other studies available for dichlorphenamide and Intraocular Pressure
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao | 1989 |
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Cornea; Ethox | 1989 |
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2000 |
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul | 2000 |
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Glaucoma; | 2004 |
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
Topics: Animals; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Celecoxib; Crystallograp | 2004 |
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In | 2004 |
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, | 2005 |
Effect of dichlorphenamide on the intraocular pressure of humans.
Topics: Acetazolamide; Dichlorphenamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular | 1958 |
Evaluation of dichlorphenamide as an ocular hypotensive agent.
Topics: Acetazolamide; Antihypertensive Agents; Dichlorphenamide; Eye; Glaucoma; Humans; Intraocular Pressur | 1958 |
[On the influence of dichlorphenamide on intraocular pressure in glaucoma].
Topics: Dichlorphenamide; Diuretics; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocular | 1959 |
[A CASE OF GLAUCOMA WITH LARGE DIURNAL VARIATION OF INTRAOCULAR PRESSURE].
Topics: Acetazolamide; Circadian Rhythm; Dichlorphenamide; Drug Therapy; Eye Diseases; Glaucoma; Humans; Int | 1964 |
Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits.
Topics: Administration, Topical; Animals; Aqueous Humor; Chromatography, Gas; Chymotrypsin; Dichlorphenamide | 1984 |
Long-term management of a glaucomatous eye in a dog treated with medical therapy alone.
Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog Diseases; | 2001 |
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D | 1979 |
Ophthalmic nutrition and prevention of eye disorder and blindness.
Topics: Adolescent; Adult; Africa, Western; Age Factors; Aged; Avitaminosis; Blindness; Child; Dichlorphenam | 1977 |
[Effect of Oratrol on the dynamics of aqueous humor].
Topics: Acid-Base Equilibrium; Aqueous Humor; Dichlorphenamide; Humans; Intraocular Pressure | 1975 |
Reformation of the anterior chamber of the eye.
Topics: Acetazolamide; Anterior Chamber; Anxiety; Aqueous Humor; Cataract Extraction; Corneal Injuries; Dich | 1968 |
[Blood acidosis and intraocular hypotension].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Animals; Aqueous Humor; Ascorbic Acid; Bicarbonates; | 1972 |
[Ocular hypotonic effect of hematic acidifying agents: carbonic anhydrase inhibitors].
Topics: Acetazolamide; Animals; Aqueous Humor; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; | 1970 |
Effects of systemically administered drugs on intraocular pressure in rabbits.
Topics: Acetazolamide; Amphetamine; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressu | 1970 |
Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Glaucoma; Humans; Intraocular Pressu | 1968 |
The water-loading test in rabbits. A method to detect potential ocular hypotensive drugs.
Topics: Acetazolamide; Animals; Atropine; Carbachol; Dichlorphenamide; Epinephrine; Glaucoma; Hexamethonium | 1969 |