dichlorphenamide has been researched along with Glaucoma in 45 studies
Dichlorphenamide: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
diclofenamide : A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, blind clinical study, we tested the effect of timolol and Daranide against placebo medications among patients who had intraocular pressures greater than 30 mm Hg on the first postoperative day after aphakic keratoplasty." | 9.04 | Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty. ( Kaufman, HE; Olson, RJ; Zimmerman, TJ, 1979) |
| "Dichlorphenamide as well as Diamox lowers intraocular pressure." | 9.04 | [Dichlorphenamide treatment in acute glaucoma (author's transl)]. ( Bleckmann, H, 1976) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 7.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 7.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses." | 7.67 | Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. ( Baird, IM; Cowan, RA; Hartnell, GG; Leak, AM; Lowdell, CP, 1984) |
| "In a randomized, blind clinical study, we tested the effect of timolol and Daranide against placebo medications among patients who had intraocular pressures greater than 30 mm Hg on the first postoperative day after aphakic keratoplasty." | 5.04 | Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty. ( Kaufman, HE; Olson, RJ; Zimmerman, TJ, 1979) |
| "Dichlorphenamide as well as Diamox lowers intraocular pressure." | 5.04 | [Dichlorphenamide treatment in acute glaucoma (author's transl)]. ( Bleckmann, H, 1976) |
| " In an animal model of ocular hypertension, one of the new compounds was twice more effective than dorzolamide in reducing elevated intraocular pressure characteristic of this disease, anticipating their potential for the treatment of glaucoma." | 3.77 | Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action. ( Benedini, F; Biondi, S; Cecchi, A; Formicola, G; Masini, E; Mincione, F; Pacileo, I; Scozzafava, A; Supuran, CT; Temperini, C, 2011) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 3.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 3.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses." | 3.67 | Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. ( Baird, IM; Cowan, RA; Hartnell, GG; Leak, AM; Lowdell, CP, 1984) |
| "Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles." | 3.66 | Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979) |
| "Methazolamide was next." | 2.64 | Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978) |
| "Such an agent would be useful in the treatment of glaucoma." | 1.28 | Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (75.56) | 18.7374 |
| 1990's | 1 (2.22) | 18.2507 |
| 2000's | 9 (20.00) | 29.6817 |
| 2010's | 1 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, SL | 1 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 1 |
| Best, DB | 1 |
| Christy, ME | 1 |
| Freedman, MB | 1 |
| Gautheron, P | 1 |
| Habecker, CN | 1 |
| Hoffman, JM | 1 |
| Scozzafava, A | 8 |
| Menabuoni, L | 3 |
| Mincione, F | 7 |
| Briganti, F | 1 |
| Mincione, G | 1 |
| Supuran, CT | 8 |
| Casini, A | 4 |
| Ilies, MA | 1 |
| Winum, JY | 1 |
| Starnotti, M | 3 |
| Montero, JL | 1 |
| de Leval, X | 1 |
| Ilies, M | 1 |
| Dogné, JM | 1 |
| Masini, E | 3 |
| Vullo, D | 2 |
| Innocenti, A | 1 |
| Nishimori, I | 1 |
| Pastorek, J | 1 |
| Pastoreková, S | 1 |
| Bacciottini, L | 1 |
| Scrivanti, C | 1 |
| Benedini, F | 1 |
| Biondi, S | 1 |
| Cecchi, A | 1 |
| Temperini, C | 1 |
| Formicola, G | 1 |
| Pacileo, I | 1 |
| GONZALES-JIMENEZ, E | 1 |
| LEOPOLD, IH | 1 |
| SCHIMEK, RA | 1 |
| BALLAN, JV | 1 |
| LEPLEY, FJ | 1 |
| OTTUM, JA | 1 |
| HENRY, MM | 1 |
| LEE, PF | 1 |
| BERNARD, P | 1 |
| SLEZAK, H | 1 |
| MOSQUERA, JM | 1 |
| URRETS ZAVALIA, A | 1 |
| PECZON, JD | 1 |
| PALMIERI, L | 1 |
| GRAZIANO, FM | 1 |
| FREZZOTTI, R | 1 |
| GENTILI, MC | 1 |
| HOSHIWARA, I | 1 |
| TOJO, H | 1 |
| TSUJI, M | 1 |
| Boeve, M | 1 |
| Bult, W | 1 |
| Luntz, MH | 1 |
| Shoji, Y | 1 |
| Cowan, RA | 1 |
| Hartnell, GG | 1 |
| Lowdell, CP | 1 |
| Baird, IM | 1 |
| Leak, AM | 1 |
| Hasegawa, T | 1 |
| Doki, K | 1 |
| Yanase, J | 1 |
| Gelatt, KN | 1 |
| Gum, G | 1 |
| Williams, LW | 1 |
| Gwin, RM | 1 |
| Olson, RJ | 1 |
| Kaufman, HE | 1 |
| Zimmerman, TJ | 1 |
| Lichter, PR | 1 |
| Newman, LP | 1 |
| Wheeler, NC | 1 |
| Beall, OV | 1 |
| Bleckmann, H | 1 |
| van Rens, JW | 1 |
| Evans, SC | 1 |
| Wakabayashi, Y | 1 |
| Fraunfelder, FT | 1 |
| Meyer, SM | 1 |
| Bagby, GC | 1 |
| Dreis, MW | 1 |
| Wallace, MR | 1 |
| MacDiarmid, J | 1 |
| Reeder, J | 1 |
| Breffeilh, LA | 1 |
| Selchau, M | 1 |
| Bietti, GB | 2 |
| Virno, M | 2 |
| Pecori-Giraldi, J | 2 |
| Pivetti-Pezzi, P | 2 |
| Evans, PJ | 1 |
| Leonardi, E | 1 |
| Weekers, R | 1 |
| Kanski, JJ | 1 |
| McDonald, TO | 1 |
| Hodges, JW | 1 |
| Borgmann, AR | 1 |
| Leaders, FE | 1 |
| Quaranta, CA | 1 |
1 review available for dichlorphenamide and Glaucoma
| Article | Year |
|---|---|
[Diuretics. 47].
Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen | 1970 |
4 trials available for dichlorphenamide and Glaucoma
| Article | Year |
|---|---|
GLAUCOMA TREATED WITH DARANIDE A CLINICAL TRIAL.
Topics: Acetazolamide; Aged; Carbonic Anhydrase Inhibitors; Chronic Disease; Dichlorphenamide; Drug Therapy, | 1961 |
Effects of timolol and Daranide on elevated intraocular pressure after aphakic keratoplasty.
Topics: Adult; Aged; Aphakia, Postcataract; Carbonic Anhydrase Inhibitors; Cornea; Dichlorphenamide; Female; | 1979 |
Patient tolerance to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation | 1978 |
[Dichlorphenamide treatment in acute glaucoma (author's transl)].
Topics: Acetazolamide; Acid-Base Equilibrium; Acute Disease; Clinical Trials as Topic; Dichlorphenamide; Dru | 1976 |
40 other studies available for dichlorphenamide and Glaucoma
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao | 1989 |
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2000 |
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul | 2000 |
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chelating Agents; Chloroform; Chromatog | 2002 |
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Glaucoma; | 2004 |
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In | 2004 |
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Glaucoma; Hu | 2005 |
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, | 2005 |
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Topics: Animals; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Disease Models, Animal; Glaucoma; Hu | 2011 |
Effect of dichlorphenamide on the intraocular pressure of humans.
Topics: Acetazolamide; Dichlorphenamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular | 1958 |
Evaluation of dichlorphenamide as an ocular hypotensive agent.
Topics: Acetazolamide; Antihypertensive Agents; Dichlorphenamide; Eye; Glaucoma; Humans; Intraocular Pressur | 1958 |
Clinical comparison of dichlorphenamide, chlorothiazide and sulocarbilate with acetazolamide in control of glaucoma.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Chlorothiazide; Dichlorphenamide; Glaucoma; Humans | 1959 |
[Use of daranide per os, as antiglaucomatous agent].
Topics: Administration, Oral; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Glaucoma; Humans | 1960 |
[On the influence of dichlorphenamide on intraocular pressure in glaucoma].
Topics: Dichlorphenamide; Diuretics; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocular | 1959 |
[Pharmacology and administration of antiglaucoma medication].
Topics: Acetazolamide; Dichlorphenamide; Epinephrine; Glaucoma; Humans; Miotics; Parasympathomimetics | 1963 |
FIXED, DILATED PUPIL, IRIS ATROPHY AND SECONDARY GLAUCOMA.
Topics: Acetazolamide; Atrophy; Atropine; Corneal Transplantation; Dichlorphenamide; Glaucoma; Humans; Iris; | 1963 |
CLINICAL EVALUATION OF DIGITALIZATION IN GLAUCOMA.
Topics: Dichlorphenamide; Digitalis Glycosides; Digoxin; Epinephrine; Glaucoma; Humans; Parasympathomimetics | 1964 |
[ACTION OF ORAL GLYCEROL IN ACUTE GLAUCOMA].
Topics: Dichlorphenamide; Glaucoma; Glaucoma, Angle-Closure; Glycerol; Humans; Miotics | 1963 |
MEDICAL THERAPY ATTEMPTS IN MALIGNANT GLAUCOMA, REPORT OF THREE CASES.
Topics: Acetazolamide; Atropine; Chlorothiazide; Dichlorphenamide; Geriatrics; Glaucoma; Humans; Phenylephri | 1964 |
BILATERAL MALIGNANT GLAUCOMA. CASE REPORT OF SIMULTANEOUS MALIGNANT GLAUCOMA OCCURRING THREE YEARS AFTER GLAUCOMA SURGERY.
Topics: Acetazolamide; Anterior Chamber; Aqueous Humor; Atropine; Dichlorphenamide; Echothiophate Iodide; Ep | 1964 |
[A CASE OF GLAUCOMA WITH LARGE DIURNAL VARIATION OF INTRAOCULAR PRESSURE].
Topics: Acetazolamide; Circadian Rhythm; Dichlorphenamide; Drug Therapy; Eye Diseases; Glaucoma; Humans; Int | 1964 |
[Diclofenamide].
Topics: Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Glaucoma | 2005 |
[Side effects of opthalmic drugs].
Topics: Acetazolamide; Adolescent; Adult; Aged; Cortisone; Dichlorphenamide; Epinephrine; Eye Diseases; Fema | 1966 |
Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function.
Topics: Acetazolamide; Acidosis; Adult; Arthritis; Aspirin; Carbonic Anhydrase Inhibitors; Child; Dichlorphe | 1984 |
Long-term management of a glaucomatous eye in a dog treated with medical therapy alone.
Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog Diseases; | 2001 |
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D | 1979 |
[Glaucoma simplex in general practice (a cause for blindness which usually can be prevented)].
Topics: Acetazolamide; Blindness; Dichlorphenamide; Glaucoma; Humans; Tonometry, Ocular | 1977 |
Ophthalmic nutrition and prevention of eye disorder and blindness.
Topics: Adolescent; Adult; Africa, Western; Age Factors; Aged; Avitaminosis; Blindness; Child; Dichlorphenam | 1977 |
Hyperkalaemia induced by carbonic anhydrase inhibitor.
Topics: Acidosis; Acute Kidney Injury; Aged; Aged, 80 and over; Aldosterone; Dichlorphenamide; Glaucoma; Hum | 1991 |
Hematologic reactions to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Agranulocytosis; Anemia, Aplastic; Carbonic Anhydrase Inhibitors; Dichlorphenamide; G | 1985 |
Exacerbation of nephrolithiasis by a carbonic anhydrase inhibitor.
Topics: Calcium; Citrates; Colorimetry; Dichlorphenamide; Glaucoma; Humans; Kidney Calculi; Male; Middle Age | 1974 |
Reformation of the anterior chamber of the eye.
Topics: Acetazolamide; Anterior Chamber; Anxiety; Aqueous Humor; Cataract Extraction; Corneal Injuries; Dich | 1968 |
[Blood acidosis and intraocular hypotension].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Animals; Aqueous Humor; Ascorbic Acid; Bicarbonates; | 1972 |
Modern problems in glaucoma.
Topics: Acetazolamide; Acute Disease; Aged; Bicarbonates; Chronic Disease; Ciliary Body; Dichlorphenamide; E | 1971 |
[Ocular hypotonic effect of hematic acidifying agents: carbonic anhydrase inhibitors].
Topics: Acetazolamide; Animals; Aqueous Humor; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; | 1970 |
[Treatment of open angle glaucoma (synonym: chronic simple glaucoma)].
Topics: Acetazolamide; Acetylcholine; Carbonic Anhydrase Inhibitors; Chronic Disease; Dichlorphenamide; Echo | 1968 |
Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Glaucoma; Humans; Intraocular Pressu | 1968 |
The water-loading test in rabbits. A method to detect potential ocular hypotensive drugs.
Topics: Acetazolamide; Animals; Atropine; Carbachol; Dichlorphenamide; Epinephrine; Glaucoma; Hexamethonium | 1969 |
Oral drugs for glaucoma.
Topics: Acetazolamide; Dichlorphenamide; Glaucoma; Humans | 1965 |
[Considerations on the therapy of certain forms of "cortisone glaucoma" with special reference to surgery by means of goniotomy].
Topics: Adolescent; Adult; Dichlorphenamide; Epinephrine; Female; Glaucoma; Glucocorticoids; Humans; Hyaluro | 1966 |