dichlororibofuranosylbenzimidazole has been researched along with Multiple Myeloma in 3 studies
Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacCallum, DE | 1 |
| Melville, J | 1 |
| Frame, S | 1 |
| Watt, K | 1 |
| Anderson, S | 1 |
| Gianella-Borradori, A | 1 |
| Lane, DP | 1 |
| Green, SR | 1 |
| Liu, Y | 1 |
| He, X | 1 |
| Sui, Y | 1 |
| Yu, R | 1 |
| Xu, G | 1 |
| Harrold, S | 1 |
| Genovese, C | 1 |
| Kobrin, B | 1 |
| Morrison, SL | 1 |
| Milcarek, C | 1 |
3 other studies available for dichlororibofuranosylbenzimidazole and Multiple Myeloma
| Article | Year |
|---|---|
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Topics: Apoptosis; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Down-Regulation; Enzyme Inhibitors; | 2005 |
Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Dichlororibofuranosylbenzimidazole; HEK293 Cells; Humans | 2015 |
A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors.
Topics: Animals; Cell Death; Cell Line, Transformed; Cytoplasm; Dactinomycin; Dichlororibofuranosylbenzimida | 1991 |