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dichlororibofuranosylbenzimidazole and Breast Cancer

dichlororibofuranosylbenzimidazole has been researched along with Breast Cancer in 5 studies

Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.

Research Excerpts

ExcerptRelevanceReference
"The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients."1.915,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. ( Chang, CH; Hsieh, HC; Hu, MC; Kuo, YH; Lai, TC; Yang, FM, 2023)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Kuo, YH1
Lai, TC1
Chang, CH1
Hsieh, HC1
Yang, FM1
Hu, MC1
Węsierska-Gądek, J1
Gritsch, D1
Zulehner, N1
Komina, O1
Maurer, M1
Davie, JR1
Murphy, LC1
Rutter, JL1
Benbow, U1
Coon, CI1
Brinckerhoff, CE1
Ree, AH1
Knutsen, HK1
Landmark, BF1
Eskild, W1
Hansson, V1

Other Studies

5 other studies available for dichlororibofuranosylbenzimidazole and Breast Cancer

ArticleYear
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression.
    Scientific reports, 2023, 08-03, Volume: 13, Issue:1

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Female; Humans; M

2023
Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Prolifera

2011
Inhibition of transcription selectively reduces the level of ubiquitinated histone H2B in chromatin.
    Biochemical and biophysical research communications, 1994, Aug-30, Volume: 203, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line; Chlorocebus aethiops; CHO Cells; Chromatin; Cricetinae; Dactin

1994
Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fibroblasts and BC-8701 breast cancer cells.
    Journal of cellular biochemistry, 1997, Sep-01, Volume: 66, Issue:3

    Topics: Base Sequence; Breast Neoplasms; Cloning, Molecular; Collagenases; Dichlororibofuranosylbenzimidazol

1997
Down-regulation of messenger ribonucleic acid (mRNA) for the estrogen receptor (ER) by phorbol ester requires ongoing RNA synthesis but not protein synthesis. Is hormonal control of ER mRNA degradation mediated by an RNA molecule?
    Endocrinology, 1992, Volume: 131, Issue:4

    Topics: Breast Neoplasms; Carcinoma; Cycloheximide; Dactinomycin; Dichlororibofuranosylbenzimidazole; Hormon

1992