dichlororibofuranosylbenzimidazole has been researched along with Breast Cancer in 5 studies
Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients." | 1.91 | 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. ( Chang, CH; Hsieh, HC; Hu, MC; Kuo, YH; Lai, TC; Yang, FM, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, YH | 1 |
| Lai, TC | 1 |
| Chang, CH | 1 |
| Hsieh, HC | 1 |
| Yang, FM | 1 |
| Hu, MC | 1 |
| Węsierska-Gądek, J | 1 |
| Gritsch, D | 1 |
| Zulehner, N | 1 |
| Komina, O | 1 |
| Maurer, M | 1 |
| Davie, JR | 1 |
| Murphy, LC | 1 |
| Rutter, JL | 1 |
| Benbow, U | 1 |
| Coon, CI | 1 |
| Brinckerhoff, CE | 1 |
| Ree, AH | 1 |
| Knutsen, HK | 1 |
| Landmark, BF | 1 |
| Eskild, W | 1 |
| Hansson, V | 1 |
5 other studies available for dichlororibofuranosylbenzimidazole and Breast Cancer
| Article | Year |
|---|---|
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dichlororibofuranosylbenzimidazole; Female; Humans; M | 2023 |
Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Prolifera | 2011 |
Inhibition of transcription selectively reduces the level of ubiquitinated histone H2B in chromatin.
Topics: Animals; Breast Neoplasms; Cell Line; Chlorocebus aethiops; CHO Cells; Chromatin; Cricetinae; Dactin | 1994 |
Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fibroblasts and BC-8701 breast cancer cells.
Topics: Base Sequence; Breast Neoplasms; Cloning, Molecular; Collagenases; Dichlororibofuranosylbenzimidazol | 1997 |
Down-regulation of messenger ribonucleic acid (mRNA) for the estrogen receptor (ER) by phorbol ester requires ongoing RNA synthesis but not protein synthesis. Is hormonal control of ER mRNA degradation mediated by an RNA molecule?
Topics: Breast Neoplasms; Carcinoma; Cycloheximide; Dactinomycin; Dichlororibofuranosylbenzimidazole; Hormon | 1992 |