dichlororibofuranosylbenzimidazole has been researched along with Astrocytoma in 1 studies
Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin." | 3.66 | Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis. ( Barovsky, K; Brooker, G; Pedone, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brooker, G | 1 |
| Pedone, C | 1 |
| Barovsky, K | 1 |
1 other study available for dichlororibofuranosylbenzimidazole and Astrocytoma
| Article | Year |
|---|---|
Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis.
Topics: Animals; Astrocytoma; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dichlororibofu | 1983 |