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dichlorodiphenyl dichloroethylene and Alzheimer Disease

dichlorodiphenyl dichloroethylene has been researched along with Alzheimer Disease in 11 studies

Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"Both DDT and DDE increase amyloid precursor protein levels, providing mechanistic plausibility for the association of DDE exposure with AD."1.40Elevated serum pesticide levels and risk for Alzheimer disease. ( Buckley, B; Gearing, M; German, DC; Hossain, MM; Levey, AI; Richardson, JR; Roy, A; Shalat, SL; von Stein, RT, 2014)
"Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1,1'-(2,2-dichloroethenyl diene)-bis(4-chlorobenzene) (p,p-DDE) and total Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD substantia nigra when these concentrations were compared with those of CLBD."1.31Organochlorine insecticides in substantia nigra in Parkinson's disease. ( Corrigan, FM; Daniel, SE; Mann, D; Shore, RF; Wienburg, CL, 2000)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's9 (81.82)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Eid, A1
Mhatre-Winters, I1
Sammoura, FM1
Edler, MK1
von Stein, R1
Hossain, MM2
Han, Y1
Lisci, M1
Carney, K1
Konsolaki, M1
Hart, RP1
Bennett, JW1
Richardson, JR5
Dekosky, ST2
Gandy, S2
Roy, A1
Shalat, SL1
von Stein, RT1
Buckley, B1
Gearing, M1
Levey, AI2
German, DC2
Bible, E1
German, D1
Levey, A1
Bernard, A1
Martins, R1
Carruthers, M1
Corrigan, FM1
Wienburg, CL1
Shore, RF1
Daniel, SE1
Mann, D1

Other Studies

11 other studies available for dichlorodiphenyl dichloroethylene and Alzheimer Disease

ArticleYear
Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk.
    Environmental health perspectives, 2022, Volume: 130, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; DDT; Dichlorodiph

2022
Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns?
    JAMA neurology, 2014, Volume: 71, Issue:3

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Elevated serum pesticide levels and risk for Alzheimer disease.
    JAMA neurology, 2014, Volume: 71, Issue:3

    Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E3; Apoli

2014
Alzheimer disease: High serum levels of the pesticide metabolite DDE--a potential environmental risk factor for Alzheimer disease.
    Nature reviews. Neurology, 2014, Volume: 10, Issue:3

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Alzheimer disease risk factors.
    JAMA neurology, 2014, Volume: 71, Issue:8

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Alzheimer disease risk factors--reply.
    JAMA neurology, 2014, Volume: 71, Issue:8

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Elevated serum DDE and risk for Alzheimer disease.
    JAMA neurology, 2014, Volume: 71, Issue:8

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Elevated serum DDE and risk for Alzheimer disease--reply.
    JAMA neurology, 2014, Volume: 71, Issue:8

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease.
    JAMA neurology, 2014, Volume: 71, Issue:9

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease--reply.
    JAMA neurology, 2014, Volume: 71, Issue:9

    Topics: Alzheimer Disease; Apolipoprotein E4; Dichlorodiphenyl Dichloroethylene; Female; Humans; Insecticide

2014
Organochlorine insecticides in substantia nigra in Parkinson's disease.
    Journal of toxicology and environmental health. Part A, 2000, Feb-25, Volume: 59, Issue:4

    Topics: Alzheimer Disease; Case-Control Studies; Chromatography, Gas; Dichlorodiphenyl Dichloroethylene; Die

2000