dichloroacetic acid has been researched along with Pyruvate Dehydrogenase Complex Deficiency Disease in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bliksrud, YT; Pedersen, S; Ramm-Pettersen, A; Selmer, KK | 1 |
| Buchsbaum, R; Lawson, LA; Nixon, SJ; Prather, RA; Shuster, J; Stacpoole, PW; Thompson, JLPS; Zou, B | 1 |
| Brunetti-Pierri, N; Ferriero, R; Iannuzzi, C; Manco, G | 1 |
| Benelli, C; Boutron, A; Brivet, M; Fouque, F; Marsac, C; Vequaud, C; Zabot, MT | 1 |
| Barnes, C; Bunch, ST; Carney, PR; Felitsyn, NM; Fennell, EM; Gilmore, RL; Greer, M; Henderson, GN; Hutson, AD; Kerr, DS; Neiberger, RE; O'Brien, RG; Perkins, LA; Quisling, RG; Shroads, AL; Shuster, JJ; Silverstein, JH; Stacpoole, PW; Theriaque, DW; Valenstein, E | 1 |
| Berendzen, K; Shuster, J; Stacpoole, PW; Theriaque, DW | 1 |
| Berendzen, K; Chouthai, N; Han, Z; Maina, N; Srivastava, A; Stacpoole, PW; Surolia, I; Zhao, W; Zhong, L | 1 |
| Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E | 1 |
| Hu, CW; Sheu, KF; Utter, MF | 1 |
| Arai, K; Harada, M; Hashimoto, T; Miyoshi, H; Nishitani, H; Tanouchi, M | 1 |
| Barnes, CL; Cannon, SL; Hurbanis, MD; Kerr, DS; Stacpoole, PW | 1 |
| Bachert, P; Langhans, CD; Mayatepek, E; Rating, D; Ruitenbeek, W; Schulze, A | 1 |
| Beattie, P; Brown, GK; Matthews, PM; Morten, KJ | 1 |
| Chen, S; Ito, M; Kuroda, Y; Maehara, M; Naito, E; Saijo, T; Yokota, I | 1 |
| George, JC; Hutson, AD; Neiberger, RE; Perkins, LA; Stacpoole, PW; Theriaque, DW | 1 |
| DeVivo, DC; Haymond, MW; Nelson, JS; Obert, KA; Pagliara, AS | 1 |
| Kobashi, H; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I | 1 |
| Miyabayashi, S; Narisawa, K | 1 |
| MacMillan, H; Petrova-Benedict, R; Robinson, BH; Sherwood, WG | 1 |
2 review(s) available for dichloroacetic acid and Pyruvate Dehydrogenase Complex Deficiency Disease
| Article | Year |
|---|---|
Pyruvate dehydrogenase deficiency.
Topics: Diagnosis, Differential; Dichloroacetic Acid; Diet, Ketogenic; Humans; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Thiamine | 2019 |
Concomitant administration of sodium dichloroacetate and thiamine in west syndrome caused by thiamine-responsive pyruvate dehydrogenase complex deficiency.
Topics: Amino Acid Substitution; Dichloroacetic Acid; DNA Mutational Analysis; Drug Therapy, Combination; Female; Humans; Infant; Lactic Acid; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Sex Factors; Spasms, Infantile; Thiamine | 1999 |
3 trial(s) available for dichloroacetic acid and Pyruvate Dehydrogenase Complex Deficiency Disease
| Article | Year |
|---|---|
Development of a novel observer reported outcome tool as the primary efficacy outcome measure for a rare disease randomized controlled trial.
Topics: Child; Child, Preschool; Cross-Over Studies; Dichloroacetic Acid; Female; Humans; Male; Placebos; Pyruvate Dehydrogenase Complex Deficiency Disease; Rare Diseases; Symptom Assessment; Treatment Outcome | 2018 |
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Lactates; Male; Mitochondrial Diseases; Neurologic Examination; Neuropsychological Tests; Pyruvate Dehydrogenase Complex Deficiency Disease; Quality of Life | 2006 |
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.
Topics: Acidosis, Lactic; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Humans; Infant; Kaplan-Meier Estimate; Lactic Acid; Male; Mitochondrial Encephalomyopathies; Neural Conduction; Pyruvate Dehydrogenase Complex Deficiency Disease | 2008 |
14 other study(ies) available for dichloroacetic acid and Pyruvate Dehydrogenase Complex Deficiency Disease
| Article | Year |
|---|---|
Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate.
Topics: Animals; Binding Sites; Cells, Cultured; Dichloroacetic Acid; Enzyme Activation; Humans; Male; Mice; Mice, Inbred C57BL; Phenylbutyrates; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease | 2015 |
Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.
Topics: Cells, Cultured; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Female; Fibroblasts; Humans; In Vitro Techniques; Infant; Lymphocytes; Male; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Severity of Illness Index | 2003 |
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mitochondria; Models, Biological; Mutation; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease | 2006 |
A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.
Topics: Cells, Cultured; Dependovirus; Dichloroacetic Acid; Fibroblasts; Genetic Therapy; Genetic Vectors; Humans; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex Deficiency Disease; Transduction, Genetic | 2008 |
Pyruvate dehydrogenase complex activity in normal and deficient fibroblasts.
Topics: Acetyl Coenzyme A; Carbon Dioxide; Cell-Free System; Cells, Cultured; Dichloroacetic Acid; Enzyme Activation; Fluorides; Humans; Phosphoprotein Phosphatases; Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Skin | 1981 |
Therapeutic efficacy of a case of pyruvate dehydrogenase complex deficiency monitored by localized proton magnetic resonance spectroscopy.
Topics: Brain; Brain Chemistry; Dichloroacetic Acid; Humans; Infant; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1996 |
Treatment of congenital lactic acidosis with dichloroacetate.
Topics: Acidosis, Lactic; Adolescent; Child; Dichloroacetic Acid; Female; Humans; Infant; Infant, Newborn; Male; Mutation; Pyruvate Dehydrogenase Complex Deficiency Disease | 1997 |
In vivo methods useful for therapy monitoring in lactic acidosis.
Topics: Acidosis, Lactic; Carbon Isotopes; Carbon Radioisotopes; Dichloroacetic Acid; Female; Humans; Infant; Magnetic Resonance Imaging; Monitoring, Physiologic; Pyruvate Dehydrogenase Complex Deficiency Disease | 1998 |
Dichloroacetate stabilizes the mutant E1alpha subunit in pyruvate dehydrogenase deficiency.
Topics: Cell Line; Cells, Cultured; Dichloroacetic Acid; Humans; Immunoblotting; Pyruvate Dehydrogenase Complex Deficiency Disease | 1999 |
Renal manifestations of congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Bicarbonates; Blood Urea Nitrogen; Calcium; Child; Child, Preschool; Creatinine; Dichloroacetic Acid; Female; Humans; Infant; Kidney Diseases; Kidney Tubules; Lactic Acid; Male; Parathyroid Hormone; Phosphates; Pyruvate Dehydrogenase Complex Deficiency Disease; Treatment Outcome; Vitamin D | 2002 |
Defective activation of the pyruvate dehydrogenase complex in subacute necrotizing encephalomyelopathy (Leigh disease).
Topics: Alanine; Blood Glucose; Brain; Brain Diseases; Decarboxylation; Dichloroacetic Acid; Enzyme Activation; Fibroblasts; Humans; In Vitro Techniques; Infant; Liver; Necrosis; Phosphorylation; Pyruvate Dehydrogenase Complex Deficiency Disease; Syndrome | 1979 |
Detection of pyruvate metabolism disorders by culture of skin fibroblasts with dichloroacetate.
Topics: Acetates; Acidosis, Lactic; Cells, Cultured; Child; Dichloroacetic Acid; Enzyme Activation; Female; Fibroblasts; Humans; Infant; Male; Mitochondria; Phosphoprotein Phosphatases; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1988 |
[Clinical and biochemical approach to mitochondrial cytopathy--pyruvate dehydrogenase complex deficiency].
Topics: Child, Preschool; Dichloroacetic Acid; Humans; Infant; Infant, Newborn; Leigh Disease; Microscopy, Electron; Mitochondria, Muscle; Muscles; Prenatal Diagnosis; Pyruvate Dehydrogenase Complex Deficiency Disease | 1987 |
Variable clinical presentation in patients with defective E1 component of pyruvate dehydrogenase complex.
Topics: Acidosis, Lactic; Adolescent; Brain Diseases; Cells, Cultured; Child; Child, Preschool; Dichloroacetic Acid; Fibroblasts; Humans; Infant; Infant, Newborn; Intellectual Disability; Muscle Hypotonia; Pyruvate Dehydrogenase Complex Deficiency Disease; Skin | 1987 |