Page last updated: 2024-08-17

dichloroacetic acid and Neoplasms

dichloroacetic acid has been researched along with Neoplasms in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.96)	18.7374
1990's	2 (3.92)	18.2507
2000's	8 (15.69)	29.6817
2010's	36 (70.59)	24.3611
2020's	4 (7.84)	2.80

Authors

Authors	Studies
Han, HW; Lin, HY; Lu, GH; Qi, JL; Sun, WX; Tang, CY; Wang, XM; Yang, YH; Yang, YS	1
Berridge, BR; Jahnke, GD; Lunn, RM; Mehta, SS; Wang, A; Wolfe, MS	1
Chen, H; Hou, C; Liang, K; Piao, HL	1
Guo, Z; Li, H; Liu, T; Liu, Y; She, W; Wang, Z	1
Cheng, M; Cui, S; Hou, Z; Liu, Y; Luan, W; Sun, J; Wang, S; Wei, G	1
Brusa, D; Corbet, C; Feron, O; Gallez, B; Joudiou, N; Schoonjans, CA	1
Piccoli, C; Tataranni, T	1
Stacpoole, PW	1
Cao, Q; Gan, Z; Hao, L; Ji, LN; Li, Z; Mao, ZW; Tong, YX; Yang, J; Zhang, H; Zhou, D	1
Chang, YJ; Chien, CS; Fang, HW; Kan, PC; Su, CY	1
Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA	1
An, X; Chen, J; Ding, D; Feng, S; Gao, Y; Ge, J; Guo, L; Huang, X; Jiang, Q; Li, M; Luo, Y; Meng, X; Ning, X; Sun, L; Wang, X; Xu, Y; Zhang, J; Zhang, Y	1
Dhar, S; Harn, DA; Marrache, S; Pathak, RK	1
Chan, GL; Li, N; Liu, L; Sun, H; Wu, XR; Zhang, B; Zhang, ZF	1
Kankotia, S; Stacpoole, PW	1
An, W; Li, H; Pan, S; Su, M; Yang, M; Zhang, J	1
Karagiannis, TC; Ngo, H; Tortorella, SM; Ververis, K	1
Boichuk, IV; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI	1
Chu, QS; Mackey, JR; McEwan, AJ; Michelakis, ED; Sangha, R; Spratlin, J; Venner, P; Vos, LJ	1
Bhat, TA; Chandra, D; Chaudhary, AK; Kumar, S; Yadav, N	1
Chmelik, R; Collakova, J; Dostal, Z; Kollarova, V; Krizova, A; Slaba, M; Vesely, P	1
Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG	1
Brisson, L; Danhier, P; De Preter, G; Gallez, B; Jordan, BF; Neveu, MA; Payen, VL; Porporato, PE; Sonveaux, P	1
Hebanowska, A; Rybakowska, I; Sein Anand, J; Senderowska, Z	1
Jahn, SC; James, MO; Langaee, T; Lorenzo, RJ; Solayman, MH; Stacpoole, PW	1
James, MO; Stacpoole, PW	1
Chen, X; Huang, Y; Jing, X; Liu, S; Qi, Y; Xie, Z; Zhang, Z; Zhou, D	1
Del Mazo-Monsalvo, I; Marín-Hernández, Á; Moreno-Sánchez, R; Rodríguez-Enríquez, S; Saavedra, E	1
Hu, Z; Jahn, SC; James, MO; Smeltz, MG; Stacpoole, PW; Zhong, G	1
Mackey, JR; Michelakis, ED; Webster, L	1
Boorman, GA; Hejtmancik, MR; Herbert, RA; Johnson, JD; Kissling, GE; Malarkey, DE; Vallant, MK	1
Cairns, R; Chen, Y; Denko, NC; Koong, A; Papandreou, I	1
Li, X; Niu, N; Qian, J; Wang, Y; Xiao, L; Xie, G	1
Boos, J; Brauckmann, C; Heshe, D; Hoogestraat, S; Karst, U; Lanvers-Kaminsky, C	1
Beijnen, JH; Boogerd, W; Brandsma, D; Dorlo, TP; Haanen, JH	1
Garber, K	1
Juzeniene, A; Kwitniewski, M; Moan, J	1
Pereira, Rde S	1
Palmer, AF; Zhang, N	1
Cifra, M; Coček, A; Havelka, D; Jandová, A; Jelínek, F; Kobilková, J; Kučera, O; Nedbalová, M; Pokorný, J; Vrba, J	1
Buffa, F; Devlin, CM; Gee, HE; Harris, AL; Huffman, M; Ivan, M; Kumar, K; Leek, R; Li, JL; Silver, J; Singleton, D; Sinn, AL; Turley, H; Wigfield, S	1
Gan, W; Guo, W; He, Y; Liang, Y; Liu, W; Liu, Y; Mo, J; Yang, X	1
Allalunis-Turner, J; Andrade, MA; Archer, SL; Beaulieu, C; Bonnet, S; Haromy, A; Harry, G; Hashimoto, K; Lee, CT; Lopaschuk, GD; Michelakis, ED; Porter, CJ; Puttagunta, L; Thebaud, B; Thompson, R	1
Pearson, H	1
Mak, TW; Pan, JG	1
Campbell, JL; Fisher, JW; Keys, DA; Li, T; Schultz, I	1
Kreisberg, RA	1
Henderson, GN; James, MO; Stacpoole, PW; Yan, Z	1
Ishida, T; Kajikawa, T; Kawanishi, K; Tada, S	1

Reviews

12 review(s) available for dichloroacetic acid and Neoplasms

Article	Year
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications. Oxidative medicine and cellular longevity, 2019, Volume: 2019 Topics: Animals; Antineoplastic Agents; Dichloroacetic Acid; Humans; Neoplasms; Neoplastic Stem Cells	2019
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer. Journal of the National Cancer Institute, 2017, 11-01, Volume: 109, Issue:11 Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Biomimetics; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glycolysis; Humans; Isoenzymes; Mitochondria; NAD; Neoplasms; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid	2017
Dichloroacetate and cancer: new home for an orphan drug? Biochimica et biophysica acta, 2014, Volume: 1846, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dichloroacetic Acid; Humans; Neoplasms; Orphan Drug Production	2014
The Warburg effect: molecular aspects and therapeutic possibilities. Molecular biology reports, 2015, Volume: 42, Issue:4 Topics: Antineoplastic Agents; Dichloroacetic Acid; Epigenesis, Genetic; Genes; Glycolysis; Humans; Lactic Acid; Neoplasms; Pyruvates	2015
Restoration of mitochondria function as a target for cancer therapy. Drug discovery today, 2015, Volume: 20, Issue:5 Topics: Animals; Antineoplastic Agents; Dichloroacetic Acid; Drug Design; Energy Metabolism; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms; Oxidative Phosphorylation; Signal Transduction	2015
[Dichloroacetate--a healing toxin or a toxic drug?]. Przeglad lekarski, 2015, Volume: 72, Issue:9 Topics: Antineoplastic Agents; Brain; Carcinogens; Dichloroacetic Acid; Humans; Hypertension, Pulmonary; Liver; Mitochondria; Neoplasms	2015
Pharmacogenetic considerations with dichloroacetate dosing. Pharmacogenomics, 2016, Volume: 17, Issue:7 Topics: Amino Acid Sequence; Animals; Biotransformation; Chlorides; Dichloroacetic Acid; Glutathione Transferase; Humans; In Vitro Techniques; Liver; Metabolic Diseases; Neoplasms; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase	2016
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacology & therapeutics, 2017, Volume: 170 Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Hypertension, Pulmonary; Mitochondrial Diseases; Neoplasms; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase	2017
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. British journal of cancer, 2008, Oct-07, Volume: 99, Issue:7 Topics: Apoptosis; Dichloroacetic Acid; Glycolysis; Humans; Neoplasms; Positron-Emission Tomography	2008
Mitochondrial metabolism - neglected link of cancer transformation and treatment. Prague medical report, 2012, Volume: 113, Issue:2 Topics: Adenosine Triphosphate; Cell Transformation, Neoplastic; Dichloroacetic Acid; Electrophysiological Phenomena; Energy Metabolism; Guanosine Triphosphate; Humans; Microtubules; Mitochondria; Neoplasms	2012
Lactate homeostasis and lactic acidosis. Annals of internal medicine, 1980, Volume: 92, Issue:2 Pt 1 Topics: Acidosis; Animals; Diabetic Ketoacidosis; Dichloroacetic Acid; Ethanol; Homeostasis; Humans; Hypoglycemia; Kidney; Lactates; Liver; Liver Diseases; Neoplasms; Phenformin; Renal Dialysis; Salicylates; Seizures; Vasodilator Agents	1980
[Lactate metabolism and lactic acidosis]. Rinsho byori. The Japanese journal of clinical pathology, 1998, Volume: 46, Issue:8 Topics: Acidosis, Lactic; Alcoholism; Cardiovascular Diseases; Diabetes Complications; Dichloroacetic Acid; Female; Humans; Insulin; Lactates; Male; Neoplasms; Sodium Bicarbonate; Tromethamine	1998

Trials

1 trial(s) available for dichloroacetic acid and Neoplasms

Article	Year
A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors. Investigational new drugs, 2015, Volume: 33, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms	2015

Other Studies

38 other study(ies) available for dichloroacetic acid and Neoplasms

Article	Year
Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors. European journal of medicinal chemistry, 2018, Jan-20, Volume: 144 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Drug Design; Glycolysis; HeLa Cells; Humans; Mitosis; Naphthoquinones; Neoplasms; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tubulin; Tubulin Modulators	2018
Cancer Hazard Evaluations for Contemporary Needs: Highlights From New National Toxicology Program Evaluations and Methodological Advancements. Journal of the National Cancer Institute, 2022, 11-14, Volume: 114, Issue:11 Topics: Animals; Carcinogens; Dichloroacetic Acid; Humans; Neoplasms; Program Evaluation	2022
Dichloroacetic acid and rapamycin synergistically inhibit tumor progression. Journal of Zhejiang University. Science. B, 2023, May-15, Volume: 24, Issue:5 Topics: Dichloroacetic Acid; Humans; Mechanistic Target of Rapamycin Complex 1; Neoplasms; Pyruvate Dehydrogenase Complex; Sirolimus; TOR Serine-Threonine Kinases	2023
Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy. Journal of medicinal chemistry, 2023, 11-09, Volume: 66, Issue:21 Topics: Dichloroacetic Acid; Energy Metabolism; Humans; Neoplasms; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase	2023
Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy. Journal of medicinal chemistry, 2019, 10-10, Volume: 62, Issue:19 Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Dichloroacetic Acid; Drug Design; Drug Synergism; Energy Metabolism; Female; Ferroptosis; Humans; Macrophages; Mice; Mice, Nude; Mitochondria; Neoplasms; Protein Kinase Inhibitors; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Saponins	2019
Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. Cancer letters, 2020, 02-01, Volume: 470 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Drug Synergism; Female; Glutaminase; Glutamine; Glycolysis; Humans; Hydrogen-Ion Concentration; Mice; Neoplasms; Pentose Phosphate Pathway; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sulfides; Thiadiazoles; Xenograft Model Antitumor Assays	2020
Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate. Biomaterials, 2018, Volume: 176 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Coordination Complexes; Dichloroacetic Acid; Embryo, Nonmammalian; Fluorescent Dyes; Glucose; Glycolysis; Humans; Mice, Nude; Mitochondria; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Optical Imaging; Oxidation-Reduction; Rhenium; Theranostic Nanomedicine; Zebrafish	2018
Coupling Dichloroacetate Treatment with Curcumin Significantly Enhances Anticancer Potential. Anticancer research, 2018, Volume: 38, Issue:11 Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Dichloroacetic Acid; Drug Synergism; Humans; Mitochondria; Neoplasms; Oxidative Stress	2018
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. Medical hypotheses, 2019, Volume: 122 Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroacetic Acid; Evidence-Based Medicine; Glioblastoma; Heart; Humans; Ketones; Lactic Acid; Models, Theoretical; Neoplasms; Oxygen; Perfusion; Rats	2019
Synergistic Amplification of Oxidative Stress-Mediated Antitumor Activity via Liposomal Dichloroacetic Acid and MOF-Fe Small (Weinheim an der Bergstrasse, Germany), 2019, Volume: 15, Issue:24 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dichloroacetic Acid; Drug Synergism; Ferrous Compounds; Humans; Liposomes; Metal-Organic Frameworks; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Neoplasms; Oxidative Stress; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate. ACS chemical biology, 2014, May-16, Volume: 9, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dichloroacetic Acid; Drug Carriers; Drug Delivery Systems; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Neoplasms; Organophosphorus Compounds; Protein Kinase Inhibitors	2014
Selective protection of normal cells during chemotherapy by RY4 peptides. Molecular cancer research : MCR, 2014, Volume: 12, Issue:10 Topics: Animals; Antineoplastic Agents; Antioxidants; Carboplatin; Catalase; Cell Line, Tumor; Cell Survival; Cytoprotection; Dichloroacetic Acid; Doxorubicin; Humans; Mice, Nude; Myocardium; Neoplasms; Oxidative Stress; Peptides; Protein Binding; Proteomics; Rats; Xenograft Model Antitumor Assays	2014
Cancer risk assessment on trihalomethanes and haloacetic acids in drinking water of China using disability-adjusted life years. Journal of hazardous materials, 2014, Sep-15, Volume: 280 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; China; Dichloroacetic Acid; Humans; Infant; Middle Aged; Neoplasms; Risk Assessment; Trichloroacetic Acid; Trihalomethanes; Uncertainty; Water Pollutants, Chemical; Young Adult	2014
Hypoxia enhances antitumor activity of dichloroacetate. Experimental oncology, 2014, Volume: 36, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Glioma; Humans; Hyperoxia; Hypoxia; Inhibitory Concentration 50; Lactic Acid; Necrosis; Neoplasms; Reactive Oxygen Species	2014
TRICHLOROETHYLENE, TETRACHLOROETHYLENE, AND SOME OTHER CHLORINATED AGENTS. IARC monographs on the evaluation of carcinogenic risks to humans, 2014, Volume: 106 Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Chloral Hydrate; Dichloroacetic Acid; Ethane; Humans; Hydrocarbons, Chlorinated; Neoplasms; Risk Assessment; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene	2014
Coherence-controlled holographic microscopy enabled recognition of necrosis as the mechanism of cancer cells death after exposure to cytopathic turbid emulsion. Journal of biomedical optics, 2015, Volume: 20, Issue:11 Topics: Cell Death; Cell Line, Tumor; Cytological Techniques; Dichloroacetic Acid; Holography; Humans; Microscopy; Necrosis; Neoplasms; Phospholipids	2015
Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3 Topics: Acidosis; Aldehyde Dehydrogenase; Dichloroacetic Acid; Formaldehyde; Glutathione; Humans; Hydrogen-Ion Concentration; Lactic Acid; Neoplasms; Pain; Pain Management; Quality of Life; Resveratrol; Sodium Bicarbonate; Stilbenes	2015
Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation. Oncotarget, 2016, Jan-19, Volume: 7, Issue:3 Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Glucose; Glucosephosphate Dehydrogenase; Glycolysis; Humans; Mice; Mitochondria; Neoplasms; Oxidation-Reduction; Oxygen Consumption; Pentose Phosphate Pathway; RNA Interference; RNA, Small Interfering	2016
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate. Biochimica et biophysica acta, 2016, Volume: 1860, Issue:6 Topics: Cell Survival; Chlorides; Dichloroacetic Acid; Drug Resistance, Neoplasm; Glutathione Transferase; Hep G2 Cells; Humans; MicroRNAs; Neoplasms	2016
Time-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery. Journal of controlled release : official journal of the Controlled Release Society, 2016, 08-10, Volume: 235 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Delivery Systems; Drug Liberation; Drug Synergism; Humans; Mice; Microscopy, Electron, Scanning; Nanofibers; Neoplasm Recurrence, Local; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Tissue Distribution	2016
Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism. Biochimica et biophysica acta. General subjects, 2017, Volume: 1861, Issue:1 Pt A Topics: Aminooxyacetic Acid; Animals; Antineoplastic Agents; Cell Line, Tumor; Computer Simulation; Dichloroacetic Acid; Dihydroxyacetone Phosphate; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Kinetics; Mice; Mitochondria, Heart; Models, Molecular; NADP; Neoplasms; Oxamic Acid; Oxidative Phosphorylation; Rats, Wistar; Sus scrofa	2017
Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1 Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Dichloroacetic Acid; Disease Models, Animal; Female; Liver Neoplasms; Male; Mice; Mice, Transgenic; Neoplasms; Papilloma; Skin Neoplasms; Vacuoles; Water; Water Supply	2009
Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PloS one, 2009, Sep-15, Volume: 4, Issue:9 Topics: Adenosine Triphosphate; Cell Line, Tumor; Dichloroacetic Acid; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Hypoxia; Ion Channels; Mitochondrial Proteins; Neoplasms; Oxidative Phosphorylation; Oxygen; Oxygen Consumption; Pancreatic Neoplasms; Ribosomal Proteins; Uncoupling Protein 1	2009
Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24. Molecular and cellular biochemistry, 2010, Volume: 340, Issue:1-2 Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Separation; Combined Modality Therapy; Cytopathogenic Effect, Viral; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Flow Cytometry; HCT116 Cells; HeLa Cells; Humans; Interleukins; Neoplasms; Oncolytic Virotherapy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Time Factors; Viral Vaccines	2010
Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs. Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:3 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Dacarbazine; Dichloroacetic Acid; Doxorubicin; Drug Delivery Systems; Drug Interactions; Drug Stability; Glucose; HEK293 Cells; Humans; Membrane Potential, Mitochondrial; Neoplasms; Temozolomide	2011
Severe encephalopathy and polyneuropathy induced by dichloroacetate. Journal of neurology, 2010, Volume: 257, Issue:12 Topics: Antineoplastic Agents; Dichloroacetic Acid; Humans; Male; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Neurotoxins; Polyneuropathies	2010
Oncology's energetic pipeline. Nature biotechnology, 2010, Volume: 28, Issue:9 Topics: Animals; Antineoplastic Agents; Dichloroacetic Acid; Drug Industry; Energy Metabolism; Glutamine; Glycolysis; Humans; Neoplasms	2010
Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:1 Topics: Cell Line, Tumor; Dichloroacetic Acid; Humans; Light; Neoplasms; Photochemotherapy; Photosensitizing Agents; Phthalic Acids	2011
Developing new anti-cancer drugs. Recent patents on anti-cancer drug discovery, 2011, Volume: 6, Issue:1 Topics: Acetates; Antineoplastic Agents; Dichloroacetic Acid; Drug Design; Drug Discovery; Drugs, Investigational; Humans; Melanoma; Models, Biological; Neoplasms; Skin Neoplasms	2011
Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic. Biotechnology and bioengineering, 2011, Volume: 108, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Drug Delivery Systems; Haptoglobins; Hemoglobin A; Humans; Macrophages; Monocytes; Neoplasms; Protein Binding	2011
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts. Journal of molecular medicine (Berlin, Germany), 2013, Volume: 91, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Humans; Hypoxia; Mice; Mice, SCID; Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays	2013
The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multipathway cancer risk assessment. The Science of the total environment, 2013, Mar-01, Volume: 447 Topics: China; Chloroform; Cities; Dichloroacetic Acid; Disinfectants; Disinfection; Drinking Water; Humans; Neoplasms; Public Health; Risk Assessment; Rivers; Seasons; Trichloroacetic Acid; Trihalomethanes; Water Pollutants, Chemical	2013
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer cell, 2007, Volume: 11, Issue:1 Topics: Animals; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Humans; Immunoblotting; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria; Neoplasms; NFATC Transcription Factors; Patch-Clamp Techniques; Potassium Channels; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Nude; Reverse Transcriptase Polymerase Chain Reaction	2007
Cancer patients opt for unapproved drug. Nature, 2007, Mar-29, Volume: 446, Issue:7135 Topics: Animals; Clinical Trials as Topic; Dichloroacetic Acid; Drug Approval; Humans; Neoplasms; Patients; Rats; Time Factors	2007
Metabolic targeting as an anticancer strategy: dawn of a new era? Science's STKE : signal transduction knowledge environment, 2007, Apr-10, Volume: 2007, Issue:381 Topics: Adenosine Triphosphate; Citric Acid Cycle; Dichloroacetic Acid; Drug Delivery Systems; Enzyme Inhibitors; Glycolysis; Humans; Mitochondria; Neoplasms; Oxygen; Oxygen Consumption	2007
Trials and tribulations. Nature reviews. Drug discovery, 2007, Volume: 6, Issue:5 Topics: Antineoplastic Agents; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Dichloroacetic Acid; Neoplasms; United States; United States Food and Drug Administration	2007
Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation. Toxicology, 2008, Mar-12, Volume: 245, Issue:1-2 Topics: Administration, Oral; Biotransformation; Dichloroacetic Acid; Female; Humans; Infusions, Intravenous; Male; Models, Biological; Neoplasms; Predictive Value of Tests; Risk; Water Pollutants, Chemical	2008
Clinical pharmacology and toxicology of dichloroacetate. Environmental health perspectives, 1998, Volume: 106 Suppl 4 Topics: Animals; Child; Dichloroacetic Acid; Energy Metabolism; Environmental Exposure; Humans; Liver; Neoplasms; Pyruvate Dehydrogenase Complex; Rats; Toxicity Tests; Xenobiotics	1998