Compounds > dichloroacetic acid

Page last updated: 2024-08-17

dichloroacetic acid and MELAS

dichloroacetic acid has been researched along with MELAS in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (23.08)	18.2507
2000's	9 (69.23)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Stacpoole, PW	1
Matsuda, H; Sasaki, M; Sudo, A; Sugai, K	1
Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T	1
Matsuzaki, M; Mizoguchi, E; Nakano, K; Nakayama, T; Noda, N; Osawa, M; Sasaki, K; Tachikawa, E; Tarashima, M	1
Schaefer, AM	1
De Vivo, DC; DiMauro, S; Engelstad, K; Gooch, CL; Hirano, M; Hong, X; Jhung, S; Kaufmann, P; Mao, X; Millar, WS; Pascual, JM; Sano, MC; Shungu, DC; Stacpoole, PW; Wei, Y	1
Curtò, N; Ferrarese, C; Grassi, MG; Guerra, L; Marzorati, L; Mattavelli, L; Piatti, ML; Tremolizzo, L	1
Savolainen, H	1
Anselm, IA; Darras, BT	1
Ito, M; Iwamoto, H; Kondo, S; Kuroda, Y; Matsuda, J; Miyazaki, M; Mori, K; Naito, E; Saijo, T; Yokota, I; Yoneda, Y	1
Imai, M; Momoi, MY; Mori, Y; Saitoh, S; Yamagata, T	1
Kaplan, GP; Kingsley, PB; Lustbader, D; O'Shea, M; Pavlakis, SG; Stacpoole, PW	1
Barshop, BA; Haas, RH; McGowan, KA; Naviaux, RK; Nyhan, WL; Sheean, G; Spruijt, L	1

Trials

5 trial(s) available for dichloroacetic acid and MELAS

Article	Year
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. Brain & development, 2004, Volume: 26, Issue:7 Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dichloroacetic Acid; Female; Headache; Humans; Hypocalcemia; Lactic Acid; MELAS Syndrome; Mitochondria; Muscle Weakness; Peripheral Nervous System Diseases; Pyruvic Acid; Stroke; Time Factors; Treatment Outcome	2004
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology, 2006, Feb-14, Volume: 66, Issue:3 Topics: Action Potentials; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Humans; MELAS Syndrome; Middle Aged; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; Sural Nerve	2006
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology, 2006, Jul-11, Volume: 67, Issue:1 Topics: Acidosis; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Humans; Lactic Acid; MELAS Syndrome; Middle Aged; Polyneuropathies	2006
Effects of dichloroacetate in three patients with MELAS. Neurology, 1998, Volume: 50, Issue:2 Topics: Adolescent; Calcinosis; Child; Dichloroacetic Acid; Electroencephalography; Evoked Potentials, Auditory, Brain Stem; Female; Hand Strength; Humans; Lactates; MELAS Syndrome	1998
Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. Muscle & nerve, 2001, Volume: 24, Issue:7 Topics: Action Potentials; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Electromyography; Female; Humans; Infant; Male; Median Neuropathy; MELAS Syndrome; Neural Conduction; Neurons, Afferent; Radial Neuropathy; Tibial Neuropathy	2001

Other Studies

8 other study(ies) available for dichloroacetic acid and MELAS

Article	Year
Why are there no proven therapies for genetic mitochondrial diseases? Mitochondrion, 2011, Volume: 11, Issue:5 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Financing, Government; Humans; MELAS Syndrome; Mitochondrial Diseases; Neglected Diseases; Randomized Controlled Trials as Topic; Rare Diseases; Societies, Medical; Ubiquinone; United States	2011
Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adolescent; Dichloroacetic Acid; Female; Frontal Lobe; Humans; Iodine Radioisotopes; Iofetamine; Lactates; Magnetic Resonance Imaging; MELAS Syndrome; Tomography, Emission-Computed, Single-Photon	2004
Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS. Mitochondrion, 2005, Volume: 5, Issue:6 Topics: Blood Platelets; Child; Child, Preschool; Cytochromes c; Dichloroacetic Acid; Female; Humans; Male; MELAS Syndrome; Mitochondria	2005
Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit. Neurology, 2006, Feb-14, Volume: 66, Issue:3 Topics: Dichloroacetic Acid; Humans; MELAS Syndrome; Randomized Controlled Trials as Topic	2006
A case of Melas (A3243G) on chronic dichloroacetate treatment. European neurology, 2006, Volume: 55, Issue:1 Topics: Adolescent; Brain Ischemia; Dichloroacetic Acid; Disease Progression; DNA Mutational Analysis; Dominance, Cerebral; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Lactic Acid; Long-Term Care; Male; MELAS Syndrome; Neuritis; Occipital Lobe; Temporal Lobe; Tomography, Emission-Computed, Single-Photon	2006
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology, 2006, Oct-10, Volume: 67, Issue:7 Topics: Action Potentials; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Humans; MELAS Syndrome; Middle Aged; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; Randomized Controlled Trials as Topic; Sural Nerve	2006
Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome. The Journal of pediatrics, 1997, Volume: 131, Issue:3 Topics: Acidosis, Lactic; Administration, Oral; Child; Dichloroacetic Acid; Drug Monitoring; Drug Therapy, Combination; Humans; Male; MELAS Syndrome; Severity of Illness Index; Thiamine	1997
Magnetic resonance spectroscopy: use in monitoring MELAS treatment. Archives of neurology, 1998, Volume: 55, Issue:6 Topics: Adult; Brain; Cerebrovascular Disorders; Creatine; Dichloroacetic Acid; Female; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Treatment Outcome	1998