dichloroacetic acid has been researched along with Liver Neoplasms in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, Y; Choi, DH; Kim, SY; Kim, TS; Lee, CY; Lee, M; Park, M; Shim, MS | 1 |
| Chen, A; Dong, J; Li, B; Meng, G; Wei, J; Wu, J; Xu, T; Yu, D; Zhang, H; Zheng, M | 1 |
| Chen, A; Chen, L; Chen, S; Dai, X; He, F; Huang, C; Jiang, Y; Li, S; Li, T; Lian, J; Sun, L; Xiang, L; Xiao, H; Yan, X; Yang, M; Zhang, Y | 1 |
| Dai, Y; Huang, G; Liu, J; Qin, W; Sheng, S; Wang, H; Xiong, X | 1 |
| Carswell, G; Chorley, BN; Deangelo, AB; Fisher, A; Gaillard, ET; George, MH; Hester, SD; Lake, AD; Moore, TM; Okerberg, CV; Ren, H; Vallanat, B; Ward, W; Wood, CE | 1 |
| Corton, JC | 1 |
| Boorman, GA; Hejtmancik, MR; Herbert, RA; Johnson, JD; Kissling, GE; Malarkey, DE; Vallant, MK | 1 |
| Bull, RJ; Cheng, RS; Lingohr, MK; Orner, GA; Sasser, LB; Stauber, AJ; Stillwell, L; Thrall, BD | 1 |
| Kramer, PM; Pereira, MA; Tao, L; Wang, W | 1 |
| Caldwell, JC; Keshava, N | 1 |
| Fields, AL; Halperin, ML; Wolman, SL | 1 |
| Carter, HW; Carter, JH; Daniel, FB; DeAngelo, AB; Richmond, RE | 1 |
| Bull, RJ; Larson, JL; Stevens, DK; Templin, M | 1 |
| Pereira, MA | 1 |
| Daniel, FB; DeAngelo, AB; Most, BM; Olson, GR | 1 |
| Bull, RJ; Stauber, AJ | 1 |
| DeAngelo, AB; Mass, MJ; Schroeder, M | 1 |
| DeAngelo, AB; George, MH; House, DE | 1 |
| Bull, RJ | 1 |
| Chen, CW | 1 |
| Bull, RJ; Lingohr, MK; Thrall, BD | 1 |
| Conran, PB; Kramer, PM; Pereira, MA; Tao, L | 1 |
| Bull, RJ; Lansing, AJ; Larson, JL; Nelson, MA; Sanchez, IM | 1 |
3 review(s) available for dichloroacetic acid and Liver Neoplasms
| Article | Year |
|---|---|
Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.
Topics: Animals; Dichloroacetic Acid; Environmental Pollutants; Liver Neoplasms; Mice; Peroxisome Proliferator-Activated Receptors; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene | 2008 |
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States | 2006 |
Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.
Topics: Animals; Carcinogens, Environmental; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mutagens; Risk Assessment; Trichloroacetic Acid; Trichloroethylene | 2000 |
20 other study(ies) available for dichloroacetic acid and Liver Neoplasms
| Article | Year |
|---|---|
Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Flow Cytometry; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Phosphatidylinositol 3-Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Transcription Factors | 2021 |
Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dichloroacetic Acid; Glycolysis; Humans; Immunotherapy; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Newcastle disease virus; Oncolytic Virotherapy; Oncolytic Viruses; Oxygen; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Transfection; Tumor Burden; Virus Replication; Xenograft Model Antitumor Assays | 2020 |
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |
Dichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levels.
Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Doxorubicin; Humans; Liver Neoplasms; Male; Mice; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2014 |
Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice.
Topics: Animals; Dichloroacetic Acid; DNA Methylation; Dose-Response Relationship, Drug; Eating; Environmental Pollutants; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Male; Mice, Inbred Strains; MicroRNAs; Phenobarbital; RNA, Messenger | 2015 |
Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Dichloroacetic Acid; Disease Models, Animal; Female; Liver Neoplasms; Male; Mice; Mice, Transgenic; Neoplasms; Papilloma; Skin Neoplasms; Vacuoles; Water; Water Supply | 2009 |
Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
Topics: Animals; Blotting, Western; Dichloroacetic Acid; DNA, Neoplasm; Drug Interactions; Genes, jun; Genes, ras; Liver Neoplasms; Male; Mice; Mutation; Polymerase Chain Reaction; Random Allocation; Sequence Analysis, DNA; Solvents; Trichloroacetic Acid; Trichloroethylene | 2002 |
Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice.
Topics: Adenoma, Liver Cell; Animals; Chlorine; Dichloroacetic Acid; DNA Methylation; Drug Combinations; Female; Glycogen; Hepatocytes; Liver Neoplasms; Methionine; Mice; Mice, Inbred Strains; Organ Size; Peroxisome Proliferators; Peroxisomes; Water Purification | 2004 |
Chronic lactic acidosis in a patient with cancer: therapy and metabolic consequences.
Topics: Acidosis; Bicarbonates; Cachexia; Dichloroacetic Acid; Glycolysis; Humans; Lactates; Liver Neoplasms; Male; Middle Aged; Sodium Bicarbonate | 1981 |
Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats.
Topics: Aldehyde Dehydrogenase; alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Division; Dichloroacetic Acid; Glutathione Transferase; Immunoenzyme Techniques; Liver Neoplasms; Male; Oncogene Protein p21(ras); Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred F344 | 1995 |
The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene.
Topics: Animals; Dichloroacetic Acid; Liver Neoplasms; Mice; Mice, Inbred Strains; Rats; Trichloroethylene | 1993 |
Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms; Mice; Time Factors; Trichloroacetic Acid | 1996 |
The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat.
Topics: Administration, Oral; Animals; Body Weight; Carcinogenicity Tests; Dichloroacetic Acid; Liver; Liver Neoplasms; Male; Mitotic Index; Organ Size; Palmitoyl Coenzyme A; Rats; Rats, Inbred F344; Water Supply | 1996 |
Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).
Topics: Administration, Oral; Animals; Cell Count; Cell Division; Dichloroacetic Acid; Drinking; Immunohistochemistry; Liver; Liver Neoplasms; Male; Mice; Phenotype; Precancerous Conditions; Trichloroacetic Acid | 1997 |
Dichloroacetic acid reduces Ha-ras codon 61 mutations in liver tumors from female B6C3F1 mice.
Topics: Animals; Dichloroacetic Acid; DNA; Female; Genes, ras; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Sex Factors | 1997 |
Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: dose-response determination and modes of action.
Topics: Analysis of Variance; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Dichloroacetic Acid; Dose-Response Relationship, Drug; Kidney; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Organ Size; Specific Pathogen-Free Organisms; Spleen; Survival Analysis; Testis; Time Factors; Water Pollutants | 1999 |
Biologically based dose-response model for liver tumors induced by trichloroethylene.
Topics: Animals; Carcinogens, Environmental; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Models, Biological; Risk Assessment; Trichloroacetic Acid; Trichloroethylene | 2000 |
Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.
Topics: Animals; Blotting, Western; Carcinogens; Dichloroacetic Acid; Hepatocytes; Insulin; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction | 2001 |
Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.
Topics: Animals; Carcinogens; Chloroform; Dichloroacetic Acid; DNA Methylation; Dose-Response Relationship, Drug; Drug Interactions; Female; Gene Expression; Genes, myc; Hepatocytes; Kidney Neoplasms; Liver Neoplasms; Mice; RNA, Messenger; Trichloroacetic Acid | 2001 |
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate.
Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Hypertrophy; Lipofuscin; Liver Glycogen; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Organ Size; Precancerous Conditions; Trichloroacetic Acid | 1990 |