dichloroacetic acid has been researched along with Hypoxia in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (29.63) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mittal, R; Rath, S; Reddy, MM; Sradhanjali, S; Tripathy, D | 1 |
| Battiprolu, PK; Rodnick, KJ | 1 |
| Coomber, BL; Ho, N | 1 |
| Boichuk, IV; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI | 1 |
| Abe, H; Asagiri, M; Choi, H; Cowburn, AS; Goda, N; Honda, K; Isagawa, T; Jenkins, DM; Johnson, RS; Katoh, M; Kim, JW; Komuro, I; Koyama, K; Manabe, I; Miura, M; Miyazawa, H; Nagai, R; Sayama, K; Semba, H; Soma, K; Sugiura, Y; Takeda, N; Wake, M; Yamaguchi, Y | 1 |
| Cairns, R; Chen, Y; Denko, NC; Koong, A; Papandreou, I | 1 |
| Buffa, F; Devlin, CM; Gee, HE; Harris, AL; Huffman, M; Ivan, M; Kumar, K; Leek, R; Li, JL; Silver, J; Singleton, D; Sinn, AL; Turley, H; Wigfield, S | 1 |
| Bicego, KC; Branco, LG; Gargaglioni, LH; Steiner, AA | 2 |
| Andrade-Navarro, MA; Archer, SL; Bonnet, S; Haromy, A; Harry, G; McMurtry, MS; Michelakis, ED; Moudgil, R; Porter, CJ; Thébaud, B; Weir, EK | 1 |
| Diamond, MP; Saed, G | 1 |
| Arieff, AI; Park, R | 1 |
| Bolling, SF; Ullrich, K; Wahr, JA | 1 |
| Aaron, EA; Forster, HV; Korducki, MJ; Lowry, TF; Ohtake, PJ | 1 |
| Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL | 1 |
| Archer, SL; Dyck, JR; Hopkins, TA; Lopaschuk, GD; McMurtry, MS; Michelakis, ED; Moudgil, R; Puttagunta, L; Waite, R; Wu, XC | 1 |
| Bagger, JP; Frøbert, O; Gravholt, CH; Mikkelsen, EO | 1 |
| Loubatieres, A; Loubatieres-Mariani, MM; Ribes, G; Rondot, AM; Valette, G | 1 |
| Bagby, GJ; Burns, A; deBoisblanc, BP; Meszaros, K; Nelson, S; Summer, WR | 1 |
| Arieff, AI | 1 |
| Anthonisen, NR; Berezanski, D; Georgopoulos, D | 1 |
| Sahlin, K | 1 |
| Kemmotsu, O; Nakata, F; Tanaka, R | 2 |
| Abu Romen, S; Tannen, RL | 1 |
| Edelman, NH; Melton, JE; Neubauer, JA | 1 |
| Edelman, NH; Neubauer, JA; Simone, A | 1 |
2 review(s) available for dichloroacetic acid and Hypoxia
| Article | Year |
|---|---|
Lactic acidosis: current concepts.
Topics: Acidosis; Animals; Bicarbonates; Diabetes Mellitus; Dichloroacetic Acid; Gluconeogenesis; Glycolysis; Heart; Homeostasis; Humans; Hypoxia; Lactates; Liver; Models, Biological; Phenformin; Regional Blood Flow | 1983 |
Indications for use of bicarbonate in patients with metabolic acidosis.
Topics: Acidosis; Animals; Bicarbonates; Buffers; Carbon Dioxide; Carbonates; Dichloroacetic Acid; Drug Combinations; Fluid Therapy; Humans; Hypoxia; Oxygen; Sodium; Sodium Bicarbonate; Tromethamine | 1991 |
2 trial(s) available for dichloroacetic acid and Hypoxia
| Article | Year |
|---|---|
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Glycogen; Glycolysis; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylases; Physical Exertion; Pyruvate Dehydrogenase Complex; Respiratory Function Tests | 2000 |
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults.
Topics: Adult; Brain; Dichloroacetic Acid; Female; Humans; Hypoxia; Lactates; Lactic Acid; Male; Respiration; Tidal Volume | 1990 |
23 other study(ies) available for dichloroacetic acid and Hypoxia
| Article | Year |
|---|---|
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dichloroacetic Acid; Drug Synergism; Gene Expression; Humans; Hypoxia; Immunohistochemistry; Lactic Acid; Molecular Targeted Therapy; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; Retinoblastoma | 2017 |
Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow trout.
Topics: Animals; Calcium; Cardiac Pacing, Artificial; Citric Acid; Dichloroacetic Acid; Energy Metabolism; Enzyme Activation; Enzyme Activators; Female; Glucose; Heart Ventricles; Hypoxia; Lactic Acid; Male; Myocardial Contraction; Myocardium; Oncorhynchus mykiss; Phenotype; Pyruvate Dehydrogenase (Lipoamide); Sex Factors; Ventricular Dysfunction; Ventricular Function | 2014 |
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Glucose; Humans; Hypoxia; Ketone Oxidoreductases; Lactic Acid; Mitochondria; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2015 |
Hypoxia enhances antitumor activity of dichloroacetate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Glioma; Humans; Hyperoxia; Hypoxia; Inhibitory Concentration 50; Lactic Acid; Necrosis; Neoplasms; Reactive Oxygen Species | 2014 |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Topics: Animals; Cell Line, Tumor; Cell Movement; Dichloroacetic Acid; Electron Transport Complex IV; Glucose; Glycolysis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Mice, Inbred C57BL; Primary Cell Culture; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase | 2016 |
Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.
Topics: Adenosine Triphosphate; Cell Line, Tumor; Dichloroacetic Acid; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Hypoxia; Ion Channels; Mitochondrial Proteins; Neoplasms; Oxidative Phosphorylation; Oxygen; Oxygen Consumption; Pancreatic Neoplasms; Ribosomal Proteins; Uncoupling Protein 1 | 2009 |
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Humans; Hypoxia; Mice; Mice, SCID; Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Is lactate a mediator of hypoxia-induced anapyrexia?
Topics: Animals; Body Temperature; Body Temperature Regulation; Dichloroacetic Acid; Fever; Hypoxia; Lactic Acid; Male; Oxygen; Rats; Rats, Wistar | 2002 |
Lactate as a modulator of hypoxia-induced hyperventilation.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Pulmonary Ventilation; Rats; Rats, Wistar; Respiration | 2003 |
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Topics: Animals; Cardiac Catheterization; Chromosome Aberrations; Chromosomes, Human, Pair 1; Dichloroacetic Acid; Echocardiography, Doppler; Electron Transport Complex IV; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mitochondria; Muscle, Smooth, Vascular; Oxygen; Potassium Channels; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Vasoconstriction | 2006 |
Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts.
Topics: Cyclooxygenase 2 Inhibitors; Dichloroacetic Acid; Female; Fibroblasts; Humans; Hypoxia; Nitrobenzenes; Peritoneal Diseases; Peritoneum; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; PPAR-beta; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tissue Adhesions | 2007 |
The use of dichloroacetate in the treatment of overwhelming hypoxic acidosis.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Pressure; Cardiac Output; Cause of Death; Coronary Circulation; Dichloroacetic Acid; Dogs; Heart; Hemodynamics; Hydrogen-Ion Concentration; Hypoxia; Lactates; Myocardium; Oxygen Consumption; Renal Circulation; Sodium; Sodium Chloride; Stroke Volume; Vascular Resistance | 1994 |
Effect of dichloroacetate on PaCO2 responses to hypoxia in awake goats.
Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Chemoreceptor Cells; Dichloroacetic Acid; Female; Goats; Hydrogen-Ion Concentration; Hypoxia; Respiratory Mechanics; Wakefulness | 1996 |
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Topics: Animals; Cells, Cultured; CHO Cells; Chronic Disease; Cricetinae; Delayed Rectifier Potassium Channels; Dichloroacetic Acid; Electric Conductivity; Enzyme Inhibitors; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Immunoblotting; Male; Muscle, Smooth, Vascular; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Shab Potassium Channels | 2002 |
Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.
Topics: Animals; Coronary Vessels; Dichloroacetic Acid; Dose-Response Relationship, Drug; Extracellular Space; Glucose; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Lactic Acid; Pressure; Swine; Vasodilation | 2002 |
[Sodium dichloracetate: its application to the therapeutics of experimental hyperiactatemia (author's transl)].
Topics: Acetates; Animals; Blood; Dichloroacetic Acid; Dogs; Hydrogen-Ion Concentration; Hypoxia; Lactates; Phenformin; Pyruvates | 1978 |
Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle.
Topics: Animals; Diaphragm; Dichloroacetic Acid; Electric Stimulation; Glucose; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Toxemia | 1992 |
Lactate formation and tissue hypoxia.
Topics: Acetates; Dichloroacetic Acid; Exercise; Humans; Hypoxia; Lactates | 1989 |
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Sodium; Sodium Bicarbonate | 1987 |
Therapeutic benefit of dichloroacetate in experimentally induced hypoxic lactic acidosis.
Topics: Acetates; Acidosis; Animals; Blood Pressure; Carbon Dioxide; Dichloroacetic Acid; Hypoxia; Kinetics; Lactates; Male; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains | 1986 |
CO2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression.
Topics: Animals; Carbon Dioxide; Cats; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Phrenic Nerve; Respiration | 1988 |
Role of brain lactic acidosis in hypoxic depression of respiration.
Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Oxygen; Phrenic Nerve; Respiration | 1988 |
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid | 1986 |