dichloroacetic acid has been researched along with Hypertension, Pulmonary in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aboagye, EO; Ashek, A; Barnes, G; Cotroneo, E; Cupitt, J; Dabral, S; Dubois, O; El-Bahrawy, MA; Fang, W; Gibbs, JS; Gsell, W; He, JG; Howard, LS; Jones, H; Nguyen, QD; Pullamsetti, SS; Tomasi, G; Wang, L; Wilkins, MR; Zhao, L | 1 |
| Li, B; Liu, Y; Ma, Z; Shen, Y; Yan, J | 1 |
| Alavian, KN; Ashek, A; Bozorgi, S; Busbridge, M; Cotroneo, E; Dubois, O; Wang, L; Wharton, J; Wilkins, MR; Zhao, L | 1 |
| Hebanowska, A; Rybakowska, I; Sein Anand, J; Senderowska, Z | 1 |
| Aronow, WS; Lanier, GM; Shen, M; Tariq, S; Valerio, MG; Velayati, A | 1 |
| Hu, Z; Jahn, SC; James, MO; Smeltz, MG; Stacpoole, PW; Zhong, G | 1 |
| Davidson, A; Gibbs, JS; Rhodes, CJ; Wharton, J; Wilkins, MR | 1 |
| Adnot, S; Dewachter, L; Eddahibi, S; Fadel, E; Guignabert, C; Humbert, M; Izikki, M; Tu, L; Zadigue, P | 1 |
| Bo, K; Fan, XM; Huang, JB; Liu, YL; Lv, XD; Sun, PW | 1 |
| Archer, SL; Fang, YH; Hong, Z; Kutty, S; Lopaschuk, GD; Morrow, E; Parikh, KS; Piao, L; Ryan, JJ; Sidhu, VK; Toth, PT | 1 |
| Archer, SL; McMurtry, MS; Michelakis, ED; Sonnenberg, B | 1 |
| Bonnet, S; Dyck, JR; Haromy, A; Hashimoto, K; McMurtry, MS; Michelakis, ED; Wu, X | 1 |
| Klinger, JR; Martin, KB; Rounds, SI | 1 |
| Andrade-Navarro, MA; Archer, SL; Bonnet, S; Haromy, A; Harry, G; McMurtry, MS; Michelakis, ED; Moudgil, R; Porter, CJ; Thébaud, B; Weir, EK | 1 |
| Archer, SL; Michelakis, ED | 1 |
| Gurbanov, E; Shiliang, X | 1 |
| Archer, SL; Dyck, JR; Hopkins, TA; Lopaschuk, GD; McMurtry, MS; Michelakis, ED; Moudgil, R; Puttagunta, L; Waite, R; Wu, XC | 1 |
9 review(s) available for dichloroacetic acid and Hypertension, Pulmonary
| Article | Year |
|---|---|
[Dichloroacetate--a healing toxin or a toxic drug?].
Topics: Antineoplastic Agents; Brain; Carcinogens; Dichloroacetic Acid; Humans; Hypertension, Pulmonary; Liver; Mitochondria; Neoplasms | 2015 |
Update on pulmonary arterial hypertension pharmacotherapy.
Topics: Calcium Channel Blockers; Dichloroacetic Acid; Drug Therapy, Combination; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Phosphodiesterase 5 Inhibitors; Protein Kinase Inhibitors; Pulmonary Artery; Pyrazoles; Pyrimidines; Receptors, Epoprostenol; Registries; rho-Associated Kinases; Soluble Guanylyl Cyclase | 2016 |
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Hypertension, Pulmonary; Mitochondrial Diseases; Neoplasms; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase | 2017 |
Therapeutic targets in pulmonary arterial hypertension.
Topics: Adrenomedullin; Animals; Bone Morphogenetic Protein Receptors; Cyclic GMP; Dichloroacetic Acid; Drug Discovery; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; NFATC Transcription Factors; Pancreatic Elastase; Pneumonia; Receptor Protein-Tyrosine Kinases; rho-Associated Kinases; Serotonin; Stem Cells; Vasoactive Intestinal Peptide | 2009 |
Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis.
Topics: Animals; Apoptosis; Cell Proliferation; Dichloroacetic Acid; Humans; Hypertension, Pulmonary; Lung; Mice; Muscle, Smooth, Vascular; Pancreatic Elastase; Potassium Channels; Proto-Oncogene Proteins c-bcl-2; Pulmonary Artery; Rats; rho-Associated Kinases; Vasodilator Agents | 2010 |
The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.
Topics: Administration, Inhalation; Administration, Oral; Animals; Arginine; Dichloroacetic Acid; Disease Models, Animal; Humans; Hypertension, Pulmonary; Models, Biological; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Potassium Channels; Pulmonary Circulation; Purines; Rats; Sildenafil Citrate; Sulfones | 2003 |
Pulmonary arterial hypertension: new insights and new hope.
Topics: Animals; Dichloroacetic Acid; Drug Design; Drugs, Investigational; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Potassium Channels; Serotonin Antagonists; Simvastatin; Vascular Resistance; Vasodilator Agents | 2006 |
An evidence-based approach to the management of pulmonary arterial hypertension.
Topics: Antihypertensive Agents; Benzamides; Bosentan; Calcium Channel Blockers; Comorbidity; Dichloroacetic Acid; Drug Therapy, Combination; Epoprostenol; Evidence-Based Medicine; Fluoxetine; Humans; Hypertension, Pulmonary; Iloprost; Imatinib Mesylate; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins, Synthetic; Pulmonary Artery; Purines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Simvastatin; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents | 2006 |
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.
Topics: Apoptosis; Dichloroacetic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lovastatin; MAP Kinase Kinase Kinase 5; Microtubule-Associated Proteins; Muscle, Smooth, Vascular; Neoplasm Proteins; Pancreatic Elastase; PPAR gamma; Protein Serine-Threonine Kinases; Pulmonary Circulation; Receptor, Bradykinin B2; rho-Associated Kinases; Simvastatin; Survivin; Thrombosis; Vasoconstriction | 2006 |
1 trial(s) available for dichloroacetic acid and Hypertension, Pulmonary
| Article | Year |
|---|---|
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
7 other study(ies) available for dichloroacetic acid and Hypertension, Pulmonary
| Article | Year |
|---|---|
Dichloroacetate prevents but not reverses the formation of neointimal lesions in a rat model of severe pulmonary arterial hypertension.
Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Endothelium, Vascular; Hemodynamics; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Kv1.5 Potassium Channel; Lung; Male; Neointima; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Benzamides; Cell Proliferation; Deficiency Diseases; Dichloroacetic Acid; Disease Models, Animal; Erythropoiesis; Ferric Compounds; Ferritins; Glycolysis; Hematinics; Homeostasis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Iron; Iron Deficiencies; Liver; Male; Maltose; Piperazines; Pulmonary Artery; Pyrimidines; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Transferrin; Vascular Remodeling | 2015 |
Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Dichloroacetic Acid; Female; Fluoxetine; Gene Expression Regulation; Hypertension, Pulmonary; Kv1.5 Potassium Channel; Male; Mice; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NFATC Transcription Factors; Pulmonary Artery; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2009 |
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Topics: Animals; Dichloroacetic Acid; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose; Humans; Hypertension, Pulmonary; Oxidation-Reduction; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Up-Regulation; Ventricular Dysfunction, Right | 2013 |
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.
Topics: Animals; Apoptosis; Cell Division; Cells, Cultured; Dichloroacetic Acid; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kv1.5 Potassium Channel; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Specificity; Oxidative Phosphorylation; Potassium Channels, Voltage-Gated; Pulmonary Artery; Rats; Shab Potassium Channels; Vascular Resistance | 2004 |
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Topics: Animals; Cardiac Catheterization; Chromosome Aberrations; Chromosomes, Human, Pair 1; Dichloroacetic Acid; Echocardiography, Doppler; Electron Transport Complex IV; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mitochondria; Muscle, Smooth, Vascular; Oxygen; Potassium Channels; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Vasoconstriction | 2006 |
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Topics: Animals; Cells, Cultured; CHO Cells; Chronic Disease; Cricetinae; Delayed Rectifier Potassium Channels; Dichloroacetic Acid; Electric Conductivity; Enzyme Inhibitors; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Immunoblotting; Male; Muscle, Smooth, Vascular; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Shab Potassium Channels | 2002 |