dichloroacetic acid has been researched along with Experimental Hepatoma in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 16 (57.14) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carswell, G; Carter, JH; Chorley, BN; DeAngelo, AB; Eldridge, SR; Fisher, A; George, MH; Hester, SD; Olson, GR; Vallanat, B; Wehmas, LC; Wood, CE | 1 |
| Carter, HW; Carter, JH; DeAngelo, AB; Deddens, JA; George, MH; Hurst, BM | 1 |
| Allen, JW; DeAngelo, AB; Fuscoe, JC; George, MH; Thai, SF | 2 |
| Kramer, PM; Li, Y; Pereira, MA; Tao, L; Wang, W | 1 |
| Bull, RJ; Lei, XC; Sasser, LB | 1 |
| Kurtz, DT; McMillan, JM; Walgren, JL | 1 |
| DeAngelo, AB; Ferreira-Gonzalez, A; Garrett, CT; Nasim, S | 1 |
| Anderson, MW; Anna, CH; Foley, JF; Malarkey, DE; Maronpot, RR; Pereira, MA | 1 |
| Bull, RJ; Parker, JC; Templin, MV | 1 |
| Anderson, MW; Anna, CH; Butterworth, BE; Devereux, TR; Lucier, GW; Maronpot, RR | 1 |
| Pereira, MA; Phelps, JB | 1 |
| Kramer, PM; Li, K; Pereira, MA; Tao, L | 1 |
| Kramer, PM; Li, K; Pereira, MA | 1 |
| Bull, RJ; Stauber, AJ; Thrall, BD | 1 |
| Ge, R; Kramer, PM; Pereira, MA; Tao, L | 1 |
| Andersen, ME; Barton, HA; Bull, R; Schultz, I | 1 |
| Bull, RJ; Miller, JH; Minard, K; Orner, GA; Sasser, LB; Wind, RA | 1 |
| Bull, RJ | 1 |
| Chen, CW | 1 |
| Kramer, PM; Pereira, MA; Tao, L; Xie, M; Yang, S | 1 |
| Daniel, FB; DeAngelo, AB; Olson, GR; Page, NP; Stober, JA | 1 |
| Bull, RJ; Larson, JL | 1 |
| Daniel, FB; DeAngelo, AB; Potter, CL; Richmond, RE | 1 |
| Daniel, FB; DeAngelo, AB; Olson, GR; Stober, JA | 1 |
| Bull, RJ; Lansing, AJ; Larson, JL; Nelson, MA; Sanchez, IM | 1 |
| Bull, RJ; Nelson, MA; Sanchez, IM; Sylvester, SR | 1 |
| Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA | 1 |
2 review(s) available for dichloroacetic acid and Experimental Hepatoma
| Article | Year |
|---|---|
Considerations concerning the murine hepatocarcinogenicity of selected chlorinated hydrocarbons.
Topics: Animals; Chloroform; Dichloroacetic Acid; Hydrocarbons, Chlorinated; Liver Neoplasms, Experimental; Male; Methylene Chloride; Mice; Polychlorinated Dibenzodioxins; Tetrachloroethylene; Trichloroethylene | 1995 |
Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.
Topics: Animals; Carcinogens, Environmental; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mutagens; Risk Assessment; Trichloroacetic Acid; Trichloroethylene | 2000 |
26 other study(ies) available for dichloroacetic acid and Experimental Hepatoma
| Article | Year |
|---|---|
Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice.
Topics: Animals; Carcinogens; Dichloroacetic Acid; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Organ Size | 2017 |
A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.
Topics: Adenoma, Acidophil; Adenoma, Basophil; Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glycogen; Linear Models; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Necrosis; Rats; Rats, Inbred F344; Water Pollutants | 2003 |
Altered gene expression in mouse livers after dichloroacetic acid exposure.
Topics: Animals; Dichloroacetic Acid; Gene Expression Regulation; Liver; Liver Neoplasms, Experimental; Male; Mice; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Xenobiotics | 2003 |
Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Topics: 5-Methylcytosine; Animals; Carcinogens; CpG Islands; Dichloroacetic Acid; DNA; DNA Methylation; Female; Immunohistochemistry; Insulin-Like Growth Factor II; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trichloroacetic Acid | 2004 |
Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carcinogens; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Trichloroacetic Acid; Urethane; Water Supply | 2004 |
Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.
Topics: Animals; Apoptosis; Carcinogens, Environmental; Cell Count; Cell Proliferation; Dexamethasone; Dichloroacetic Acid; Epidermal Growth Factor; Glucocorticoids; Hepatocytes; Liver Neoplasms, Experimental; Male; Mitogens; Rats; Rats, Long-Evans; Thymidine; Trichloroacetic Acid | 2005 |
Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
Topics: Animals; Base Sequence; Carcinogens; Dichloroacetic Acid; DNA Primers; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Mice; Molecular Sequence Data; Point Mutation; Trichloroacetic Acid | 1995 |
ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.
Topics: Animals; Base Sequence; Carcinogenicity Tests; Cell Transformation, Neoplastic; Codon; Dichloroacetic Acid; Exons; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Mice, Nude; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Tetrachloroethylene; Trichloroethylene | 1994 |
Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice.
Topics: Animals; Biotransformation; Blood Proteins; Dichloroacetic Acid; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Protein Binding; Trichloroacetic Acid; Trichloroethylene | 1993 |
Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Dichloroacetic Acid; Drug Synergism; Eosine Yellowish-(YS); Female; Hematoxylin; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Staining and Labeling; Trichloroacetic Acid | 1996 |
Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice.
Topics: Animals; Chromosome Deletion; Dichloroacetic Acid; Female; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Trichloroacetic Acid | 1996 |
Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Dichloroacetic Acid; Drug Combinations; Female; Glutathione Transferase; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Organ Size; Time Factors; Trichloroacetic Acid; Water Pollutants, Chemical | 1997 |
Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro.
Topics: Administration, Oral; Animals; Cell Count; Cell Separation; Cells, Cultured; Dichloroacetic Acid; Dose-Response Relationship, Drug; Genes, fos; Genes, jun; Liver; Liver Neoplasms, Experimental; Male; Mice; Neoplastic Stem Cells; Phenotype; Trichloroacetic Acid | 1998 |
Effect of dichloroacetic acid and trichloroacetic acid on DNA methylation in liver and tumors of female B6C3F1 mice.
Topics: 5-Methylcytosine; Adenoma; Animals; Carcinogens; Cytosine; Dichloroacetic Acid; DNA Methylation; Female; Liver; Liver Neoplasms, Experimental; Mice; Trichloroacetic Acid | 1998 |
Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer.
Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Mice; Trichloroethylene | 1999 |
In vivo MRI measurements of tumor growth induced by dichloroacetate: implications for mode of action.
Topics: Animals; Dichloroacetic Acid; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Male; Mice; Regression Analysis | 2000 |
Biologically based dose-response model for liver tumors induced by trichloroethylene.
Topics: Animals; Carcinogens, Environmental; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Models, Biological; Risk Assessment; Trichloroacetic Acid; Trichloroethylene | 2000 |
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Topics: Alkylating Agents; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Dichloroacetic Acid; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Methylnitrosourea; Methyltransferases; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; RNA, Messenger; Trichloroacetic Acid | 2000 |
Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid.
Topics: Animals; Base Sequence; Blotting, Northern; Carcinogens; Cloning, Molecular; Dichloroacetic Acid; DNA Primers; Gene Expression Profiling; Liver; Liver Neoplasms, Experimental; Male; Mice | 2001 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Behavior; Female; Kidney; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Organ Size; Spleen; Testis | 1992 |
Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate.
Topics: Administration, Oral; Algorithms; Animals; Dichloroacetic Acid; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity; Trichloroacetic Acid; Trichloroethylene | 1992 |
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
Topics: Adenoma; Animals; Biomarkers, Tumor; Dichloroacetic Acid; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Mice; Precancerous Conditions | 1991 |
The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse.
Topics: Animals; Body Weight; Carcinogens; Dichloroacetic Acid; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Organ Size; Water Pollutants, Chemical | 1991 |
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate.
Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Hypertrophy; Lipofuscin; Liver Glycogen; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Organ Size; Precancerous Conditions; Trichloroacetic Acid | 1990 |
Increased expression of c-myc and c-Ha-ras in dichloroacetate and trichloroacetate-induced liver tumors in B6C3F1 mice.
Topics: Animals; Dichloroacetic Acid; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, ras; Liver Neoplasms, Experimental; Mice; Nucleic Acid Hybridization; Proto-Oncogenes; RNA, Messenger; RNA, Neoplasm; Trichloroacetic Acid | 1990 |
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Liver Neoplasms, Experimental; Male; Mice; Organ Size; Phenobarbital; Trichloroacetic Acid; Trichloroethylene | 1987 |