dichloroacetic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Falk, MJ; Haroon, S; Herman, E; Lavorato, M; Mathew, ND; Nakamaru-Ogiso, E; Seiler, C; Shah, N; Xiao, R | 1 |
| Horne, LP; James, MO; Mareus, R; Squirewell, EJ; Stacpoole, PW | 1 |
| Horne, LP; James, MO; Rowland-Faux, L; Smeltz, MG; Squirewell, EJ; Stacpoole, PW | 1 |
| Horne, LP; James, MO; Joseph, S; Keller-Wood, M; Langaee, T; Sharma, A; Stacpoole, PW; Wood, CE | 1 |
| Coats, BS; Langaee, T; McDonough, CW; Shroads, AL; Stacpoole, PW | 1 |
| Hu, Z; Jahn, SC; James, MO; Smeltz, MG; Stacpoole, PW; Zhong, G | 1 |
| Kerr, DS | 1 |
| Hayashi, J; Nakada, K; Ogasawara, E | 1 |
| Stacpoole, PW | 1 |
| Chinnery, PF; Majamaa, K; Pfeffer, G; Thorburn, D; Turnbull, DM | 1 |
| Fukumizu, M; Hanaoka, S; Hirayama, Y; Izumi, M; Kaga, M; Murayama, K; Sasaki, M; Sugai, K | 1 |
| Kawai, M; Ogawa, M; Oishi, K; Oya, Y; Ozawa, R; Yamamoto, T; Yoshioka, M | 1 |
| Goto, Y; Momoi, M | 1 |
| Duncan, GE; Neiberger, RE; Perkins, LA; Stacpoole, PW; Theriaque, DW | 1 |
| Chinnery, P; Majamaa, K; Thorburn, D; Turnbull, D | 1 |
| Barnes, C; Bunch, ST; Carney, PR; Felitsyn, NM; Fennell, EM; Gilmore, RL; Greer, M; Henderson, GN; Hutson, AD; Kerr, DS; Neiberger, RE; O'Brien, RG; Perkins, LA; Quisling, RG; Shroads, AL; Shuster, JJ; Silverstein, JH; Stacpoole, PW; Theriaque, DW; Valenstein, E | 1 |
| Kuroda, Y; Naito, E; Touda, Y | 1 |
6 review(s) available for dichloroacetic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Topics: Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Hypertension, Pulmonary; Mitochondrial Diseases; Neoplasms; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase | 2017 |
Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.
Topics: Arginine; Clinical Trials as Topic; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Randomized Controlled Trials as Topic; Treatment Outcome; Ubiquinone | 2010 |
Treatment for mitochondrial disorders.
Topics: Creatine; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Randomized Controlled Trials as Topic; Sarcosine; Thioctic Acid; Ubiquinone | 2012 |
[Treatment for mitochondrial diseases].
Topics: Antioxidants; Arginine; Child; Dichloroacetic Acid; DNA, Mitochondrial; Humans; Mitochondrial Diseases; Mutation; Ubiquinone; Vitamins | 2004 |
Treatment for mitochondrial disorders.
Topics: Creatine; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Sarcosine; Ubiquinone | 2006 |
[Drug therapy for mitochondrial diseases].
Topics: Carnitine; Coenzymes; Cytochrome c Group; Cytochromes c; Dichloroacetic Acid; Drug Combinations; Drug Therapy, Combination; Flavin Mononucleotide; Humans; Mitochondrial Diseases; Succinic Acid; Thiamine; Thiamine Pyrophosphate; Ubiquinone | 2002 |
3 trial(s) available for dichloroacetic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Topics: Acetone; Adolescent; Adult; Aminolevulinic Acid; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Genetic Diseases, Inborn; Glutathione Transferase; Haplotypes; Humans; Infant; Kinetics; Male; Maleates; Mitochondrial Diseases; Polymorphism, Single Nucleotide; Tyrosine; Young Adult | 2015 |
Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.
Topics: Adult; Child; Child, Preschool; Dichloroacetic Acid; Energy Metabolism; Exercise; Female; Humans; Lactic Acid; Male; Middle Aged; Mitochondria; Mitochondrial Diseases; Oxygen Consumption | 2004 |
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Lactates; Male; Mitochondrial Diseases; Neurologic Examination; Neuropsychological Tests; Pyruvate Dehydrogenase Complex Deficiency Disease; Quality of Life | 2006 |
8 other study(ies) available for dichloroacetic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models.
Topics: Animals; Caenorhabditis elegans; Dichloroacetic Acid; F-Box Proteins; Humans; Mitochondria; Mitochondrial Diseases; Ubiquitin-Protein Ligases; Zebrafish | 2022 |
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
Topics: Administration, Oral; Adult; Age Factors; Animals; Child; Dichloroacetic Acid; Dose-Response Relationship, Drug; Energy Metabolism; Female; Glutathione; Glutathione Transferase; Humans; Liver; Male; Mitochondrial Diseases; Models, Animal; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Rats; Up-Regulation | 2020 |
Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
Topics: Adult; Age Factors; Animals; Child; Dichloroacetic Acid; Dose-Response Relationship, Drug; Energy Metabolism; Epoxy Compounds; Female; Glutathione Transferase; Humans; Liver; Male; Mitochondrial Diseases; Models, Animal; Nitrophenols; Rats | 2020 |
Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Drugs, Investigational; Female; Fetal Blood; Glutathione Transferase; Maternal-Fetal Exchange; Metabolic Networks and Pathways; Mitochondrial Diseases; Obstetric Labor Complications; Placental Circulation; Pregnancy; Sheep | 2020 |
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex IV; Female; Gene Expression; Genes, Mitochondrial; Humans; Lactic Acid; Male; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Diseases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sequence Deletion; Trans-Activators; Transcription Factors | 2010 |
Why are there no proven therapies for genetic mitochondrial diseases?
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Financing, Government; Humans; MELAS Syndrome; Mitochondrial Diseases; Neglected Diseases; Randomized Controlled Trials as Topic; Rare Diseases; Societies, Medical; Ubiquinone; United States | 2011 |
[Adverse effects of dichloroacetate in a girl with mitochondrial disorder].
Topics: Administration, Oral; Central Nervous System; Child, Preschool; Dichloroacetic Acid; Dose-Response Relationship, Drug; Electroencephalography; Female; Hepatomegaly; Humans; Hypokinesia; Lactic Acid; Mitochondrial Diseases | 2003 |
[Dichloroacetate treatment for adult patients with mitochondrial disease].
Topics: Adult; Consciousness Disorders; Dichloroacetic Acid; Female; Humans; Male; Middle Aged; Mitochondrial Diseases; Peripheral Nervous System Diseases; Treatment Outcome | 2003 |