dichloroacetic acid has been researched along with Disease Models, Animal in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.26) | 18.7374 |
| 1990's | 7 (12.96) | 18.2507 |
| 2000's | 8 (14.81) | 29.6817 |
| 2010's | 29 (53.70) | 24.3611 |
| 2020's | 5 (9.26) | 2.80 |
| Authors | Studies |
|---|---|
| Aicher, TD; Brand, LJ; Damon, RE; Gao, J; Kaplan, EL; Koletar, J; Mann, WR; Shetty, SS; Vinluan, CC | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Dai, Q; Huang, S; Li, R; Li, S; Mo, Y; Ni, X; Wang, J; Zhang, A; Zhao, X | 1 |
| Edison, AS; Horne, L; Joseph, S; Keller-Wood, M; Li, M; Stacpoole, PW; Wohlgemuth, SE; Wood, C; Zhang, S | 1 |
| Des Rosiers, C; Isern, NG; Kajimoto, M; Nuri, M; Portman, MA; Robillard-Frayne, I | 1 |
| Ahmad, SF; Carter, R; Greaves, E; Hogg, C; Horne, AW; Morton, NM; Saunders, PTK; Simitsidellis, I | 1 |
| Fujiwara, H; Furukawa, T; Hata, M; Hayakawa, Y; Hayata, Y; Hirata, Y; Kinoshita, H; Koike, K; Kon, S; Konishi, M; Kurokawa, K; Muranishi, Y; Nakagawa, H; Oya, Y; Tateishi, K; Tomita, H; Tsuboi, M; Wang, TC; Worthley, DL | 1 |
| Buechler, N; Furdui, C; Key, CC; Long, D; Mainali, R; Martinez, J; McCall, CE; Parks, JS; Quillen, E; Quinn, MA; Stacpoole, PW; Zabalawi, M; Zhu, X | 1 |
| Cressman, ENK; Guo, C | 1 |
| Borges, K; Durie, D; McDonald, TS | 1 |
| Akabudike, N; Enomoto-Iwamoto, M; Hast, MW; Iwamoto, M; Izumi, S; Nissim, I; Philp, NJ; Shetye, S; Soslowsky, LJ; Usami, Y; Zhang, K | 1 |
| Arts, RJW; Buechler, NL; Liu, T; Long, DL; Martin, A; McCall, CE; Netea, M; Stacpoole, PW; Vachharajani, V; Yoza, BK; Zabalawi, M | 1 |
| Barbeito, L; Cassina, A; Cassina, P; Lagos-Rodríguez, V; Martínez-Palma, L; Miquel, E | 1 |
| Dong, G; Dong, Z; Huo, Y; Su, J; Wei, Q; Zhang, M | 1 |
| Chitjian, C; Fanelli, A; Kashkin, A; Ovcharenko, D; Ovcharenko, V | 1 |
| Domoto, S; Hara, H; Nakamura, S; Ohba, T; Shimazawa, M; Tanaka, M | 1 |
| Bach, K; Fischer, JW; Gorges, K; Gorski, DJ; Grandoch, M; Kretschmer, I; Reichert, C; Reiners, O; Twarock, S | 1 |
| Aboagye, EO; Ashek, A; Barnes, G; Cotroneo, E; Cupitt, J; Dabral, S; Dubois, O; El-Bahrawy, MA; Fang, W; Gibbs, JS; Gsell, W; He, JG; Howard, LS; Jones, H; Nguyen, QD; Pullamsetti, SS; Tomasi, G; Wang, L; Wilkins, MR; Zhao, L | 1 |
| Hayashi, K; Itoh, H; Mitsuishi, M; Miyashita, K; Tamaki, M; Wakino, S | 1 |
| Blankenberg, S; Bolaños, JP; Deuse, T; Eschenhagen, T; Haddad, F; Heeren, J; Hua, X; Ikeno, F; Itagaki, R; Kiefmann, R; Klein, C; Länger, F; Maegdefessel, L; Rakovic, A; Reichenspurner, H; Robbins, RC; Scheja, L; Schrepfer, S; Schulte-Uentrop, L; Spin, JM; Stoehr, A; Stubbendorff, M; Tsao, PS; Velden, J; Wang, D; Yeung, A; Zeller, T | 1 |
| Li, B; Liu, Y; Ma, Z; Shen, Y; Yan, J | 1 |
| Dutta, SK; Ghosh, M; Saha, S | 1 |
| Alavian, KN; Ashek, A; Bozorgi, S; Busbridge, M; Cotroneo, E; Dubois, O; Wang, L; Wharton, J; Wilkins, MR; Zhao, L | 1 |
| Dilda, PJ; Hau, E; Joshi, S; McDonald, KL; Shen, H | 1 |
| Boychuk, IV; Dasyukevich, OI; Fedorchuk, AG; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI | 1 |
| Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
| Jan Bogaard, H; Jiang, R; Jing, ZC; Sun, XQ; Wang, L; Wang, XJ; Yuan, P; Zhang, HD; Zhang, R; Zhao, QH | 1 |
| Blomgren, K; Li, T; Sun, Y; Wang, X; Xie, C; Zhang, Y; Zhou, K; Zhu, C | 1 |
| Boorman, GA; Hejtmancik, MR; Herbert, RA; Johnson, JD; Kissling, GE; Malarkey, DE; Vallant, MK | 1 |
| Inuzuka, Y; Iwanaga, Y; Kato, T; Kawashima, T; Kimura, T; Kita, T; Matsuda, T; Narazaki, M; Niizuma, S; Okuda, J; Shioi, T; Soga, T; Tamaki, Y | 1 |
| Beresewicz, A; Skierczynska, A | 1 |
| Hayashi, J; Nakada, K; Ogasawara, E | 1 |
| Martin, NK; Robey, IF | 1 |
| Barbeito, L; Bolatto, C; Cassina, A; Cassina, P; Gandelman, M; Martínez-Palma, L; Miquel, E; Radi, R; Trías, E | 1 |
| Beltran, JA; Charney, R; Chomicova, O; Cirillo, K; El-Khodor, BF; Marino, T; Mushlin, R; Ramboz, S; Winberg, ML | 1 |
| Constantin-Teodosiu, D; Davies, WJ; Glaves, PD; Greenhaff, PL; Mallinson, JE; Martin, EA; Sidaway, JE; Westwood, FR | 1 |
| Kudej, AB; Kudej, RK; Lewandowski, ED; Vatner, SF; White, LT | 1 |
| Back, MR; Bandyk, DF; Bowser, A; Johnson, BL; Kline, JA; Parker, JL; Rushing, G; Wilson, JS | 1 |
| Archer, SL; McMurtry, MS; Michelakis, ED; Sonnenberg, B | 1 |
| Donovan, K; McDonald, T; Sian, K; Tong, W; Tyner, TR; Yamaguchi, KT | 1 |
| Calabrese, EJ; Leonard, DA | 1 |
| Hayek, A; Woodside, WF | 2 |
| Caretti, D; De Garavilla, L; Durkot, MJ; Francesconi, R | 1 |
| Dimlich, RV; Marangos, PJ | 1 |
| Bajaj, N; Chapman, D; Holloway, PA; Knox, K; Krishna, S; O'Brien, R; Stacpoole, PW; White, NJ | 1 |
| Bernard, M; Cozzone, P; El Banani, H; Feuvray, D; James, F | 1 |
| Chandy, MJ; Ravindra, J | 1 |
| Allard, MF; Brownsey, RW; Lopaschuk, GD; Wambolt, RB | 1 |
| Andreassen, OA; Beal, MF; Borchelt, DR; Dedeoglu, A; Ferrante, KL; Ferrante, RJ; Gibson, GE; Huang, HM; Kwon, J; Park, L; Ross, CA | 1 |
| Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR | 1 |
| Holloway, PA; Krishna, S; White, NJ | 1 |
| Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF | 1 |
| Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF | 1 |
2 review(s) available for dichloroacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.
Topics: Administration, Inhalation; Administration, Oral; Animals; Arginine; Dichloroacetic Acid; Disease Models, Animal; Humans; Hypertension, Pulmonary; Models, Biological; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Potassium Channels; Pulmonary Circulation; Purines; Rats; Sildenafil Citrate; Sulfones | 2003 |
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Food; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1989 |
1 trial(s) available for dichloroacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
51 other study(ies) available for dichloroacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK).
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Diterpenes; Mice; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triterpenes | 1999 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Cells, Cultured; Dichloroacetic Acid; Disease Models, Animal; Endothelial Cells; Glycolysis; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Reperfusion Injury; Signal Transduction | 2021 |
Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.
Topics: Animals; Cushing Syndrome; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Female; Fetal Distress; Fetal Heart; Heart Rate, Fetal; Hydrocortisone; Labor, Obstetric; Lipid Metabolism; Metabolome; Mitochondria, Heart; Pregnancy; Sheep, Domestic | 2022 |
Metabolic Response to Stress by the Immature Right Ventricle Exposed to Chronic Pressure Overload.
Topics: Animals; Animals, Newborn; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Activators; Heart Ventricles; Hypertrophy, Right Ventricular; Ligation; Male; Pulmonary Artery; Pyruvate Dehydrogenase Complex; Sus scrofa; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2019 |
Repurposing dichloroacetate for the treatment of women with endometriosis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Dichloroacetic Acid; Disease Models, Animal; Drug Repositioning; Endometriosis; Extracellular Space; Female; Glycolysis; Humans; Mice; Peritoneum | 2019 |
GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Topics: Animals; Azetidines; Cell Communication; Cell Differentiation; Cell Lineage; Chief Cells, Gastric; Dichloroacetic Acid; Disease Models, Animal; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Intercellular Signaling Peptides and Proteins; Metaplasia; Mice; Mice, Knockout; Piperazines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Estrogen; Receptors, G-Protein-Coupled; Stem Cells; Tamoxifen | 2020 |
Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction.
Topics: Animals; Citric Acid Cycle; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidation-Reduction; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sepsis | 2021 |
First In Vivo Test of Thermoembolization: Turning Tissue Against Itself Using Transcatheter Chemistry in a Porcine Model.
Topics: Animals; Computed Tomography Angiography; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Embolization, Therapeutic; Ethiodized Oil; Feasibility Studies; Hepatic Artery; Humans; Liver; Necrosis; Swine | 2018 |
The effect of dichloroacetate in mouse models of epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Dichloroacetic Acid; Disease Models, Animal; Electric Stimulation; Epilepsy; Flurothyl; Ketone Oxidoreductases; Male; Mice; Mitochondria; Pilocarpine | 2018 |
Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.
Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Collagen; Dichloroacetic Acid; Disease Models, Animal; Female; Glucose; Glycolysis; Lactates; Mice; Mice, Inbred C57BL; Random Allocation; Tendon Injuries; Wound Healing | 2018 |
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
Topics: Animals; Cells, Cultured; Dichloroacetic Acid; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; Homeostasis; Humans; Kaplan-Meier Estimate; Male; Mice; Mitochondria; Monocytes; Primary Cell Culture; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Sepsis; Signal Transduction; Treatment Outcome | 2018 |
Mitochondrial Modulation by Dichloroacetate Reduces Toxicity of Aberrant Glial Cells and Gliosis in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Dichloroacetic Acid; Disease Models, Animal; Gliosis; Mitochondria; Neuroglia; Rats; Spinal Cord; Superoxide Dismutase | 2019 |
Glycolysis inhibitors suppress renal interstitial fibrosis via divergent effects on fibroblasts and tubular cells.
Topics: Animals; Apoptosis; Cell Line; Dichloroacetic Acid; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Extracellular Matrix; Fibroblasts; Fibrosis; Glycolysis; Kidney Diseases; Kidney Tubules; Macrophages; Male; Mice; Mice, Inbred C57BL; Naphthoquinones; Signal Transduction; Ureteral Obstruction | 2019 |
Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mitochondria; Xenograft Model Antitumor Assays | 2019 |
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.
Topics: Animals; Behavior, Animal; Dichloroacetic Acid; Disease Models, Animal; Fatigue Syndrome, Chronic; Ketone Oxidoreductases; Male; Mice, Inbred ICR; Mitochondria, Muscle; Muscle, Skeletal; Swimming | 2019 |
Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Matrix; Humans; Hyaluronic Acid; Hymecromone; Male; Mice; Mice, Nude; Mitochondria; Molecular Structure; Neoplasms, Experimental; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Chronic kidney disease reduces muscle mitochondria and exercise endurance and its exacerbation by dietary protein through inactivation of pyruvate dehydrogenase.
Topics: Animals; Cytokines; Dichloroacetic Acid; Dietary Proteins; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Exercise Tolerance; Inflammation Mediators; Male; Mice, Inbred C57BL; Mitochondria, Muscle; Mitochondrial Turnover; Muscle Strength; Muscle, Skeletal; Oxidative Stress; Pyruvate Dehydrogenase Complex; Renal Insufficiency, Chronic; Running; Signal Transduction; Time Factors | 2014 |
Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
Topics: Angioplasty, Balloon; Animals; Aorta; Apoptosis; Arteries; Cell Proliferation; Constriction, Pathologic; Coronary Vessels; Dichloroacetic Acid; Disease Models, Animal; Enzyme Activation; Gene Knockdown Techniques; Humans; Hyperplasia; Iliac Artery; Mammary Arteries; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rabbits; Rats; Secondary Prevention; Stents; Swine; Tunica Intima | 2014 |
Dichloroacetate prevents but not reverses the formation of neointimal lesions in a rat model of severe pulmonary arterial hypertension.
Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Endothelium, Vascular; Hemodynamics; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Kv1.5 Potassium Channel; Lung; Male; Neointima; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Disease Models, Animal; Drug Synergism; Esters; Female; Humans; Inhibitory Concentration 50; Lung Neoplasms; Melanoma; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mitochondria; NIH 3T3 Cells; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Triterpenes | 2015 |
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Benzamides; Cell Proliferation; Deficiency Diseases; Dichloroacetic Acid; Disease Models, Animal; Erythropoiesis; Ferric Compounds; Ferritins; Glycolysis; Hematinics; Homeostasis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Iron; Iron Deficiencies; Liver; Male; Maltose; Piperazines; Pulmonary Artery; Pyrimidines; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Transferrin; Vascular Remodeling | 2015 |
Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.
Topics: Animals; Carbohydrate Metabolism; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Disease Models, Animal; Female; Glioblastoma; Glucose; Glycolysis; Mice; Mitochondria; Oxidative Phosphorylation; Phenotype; Radiation Tolerance; Radiotherapy; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2015 |
Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma.
Topics: Aconitine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Dichloroacetic Acid; Disease Models, Animal; Drug Synergism; Humans; Lactate Dehydrogenases; Lactic Acid; Mice; Nitric Oxide; Reactive Oxygen Species; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis.
Topics: Animals; Apoptosis; Arterial Pressure; Dichloroacetic Acid; Disease Models, Animal; Heart Ventricles; Hemodynamics; Male; Mitochondria; Monocrotaline; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2016 |
Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice.
Topics: Acetyl Coenzyme A; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Injuries; Caspases; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Hypoxia-Ischemia, Brain; Male; Mice, Inbred C57BL; Mitochondria; Mitochondrial Dynamics; Neuroprotective Agents; Organelle Biogenesis; Pyruvate Dehydrogenase Complex; Time Factors | 2016 |
Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Dichloroacetic Acid; Disease Models, Animal; Female; Liver Neoplasms; Male; Mice; Mice, Transgenic; Neoplasms; Papilloma; Skin Neoplasms; Vacuoles; Water; Water Supply | 2009 |
Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.
Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Fatty Acids; Glucose; Heart Failure; Hypertrophy, Left Ventricular; Male; Metabolome; Rats; Rats, Inbred Dahl; Ventricular Remodeling | 2010 |
Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.
Topics: Animals; Coronary Circulation; Dichloroacetic Acid; Disease Models, Animal; Dobutamine; Fatty Acids; Glucose; Glycolysis; Male; Myocardial Ischemia; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Trimetazidine | 2010 |
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex IV; Female; Gene Expression; Genes, Mitochondrial; Humans; Lactic Acid; Male; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Diseases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sequence Deletion; Trans-Activators; Transcription Factors | 2010 |
Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bicarbonates; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Dichloroacetic Acid; Disease Models, Animal; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lung Neoplasms; Mice; Mice, SCID; Sodium Bicarbonate; Survival Analysis; Tumor Burden; Tumor Microenvironment | 2011 |
Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Death; Cell Survival; Cells, Cultured; Dichloroacetic Acid; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Mitochondria; Motor Neurons; Oxidation-Reduction; Phosphorylation; Pyruvate Dehydrogenase Complex; Rats; Superoxide Dismutase; Superoxide Dismutase-1 | 2012 |
Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Computer Simulation; Dichloroacetic Acid; Disease Models, Animal; Disease Progression; Female; Genotype; Humans; Lactic Acid; Male; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy, Spinal; Mutation; Predictive Value of Tests; Survival Analysis; Survival of Motor Neuron 2 Protein | 2012 |
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Topics: Acetylcarnitine; Animals; Body Weight; Carbohydrate Metabolism; Cathepsin L; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme Activation; Enzyme Activators; Female; Forkhead Transcription Factors; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Necrosis; Oxidation-Reduction; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; SKP Cullin F-Box Protein Ligases; Time Factors | 2012 |
Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs.
Topics: Animals; Blood Flow Velocity; Carbohydrate Metabolism; Consciousness; Coronary Circulation; Coronary Stenosis; Dichloroacetic Acid; Disease Models, Animal; Enzyme Inhibitors; Glucose; Heart; Hemodynamics; Injections, Intra-Arterial; Myocardial Contraction; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Oxidation-Reduction; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Recovery of Function; Swine; Time | 2002 |
The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.
Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Female; Hindlimb; Ischemia; Lactic Acid; Muscle, Skeletal; Necrosis; Oxygen; Rabbits; Regional Blood Flow; Reperfusion | 2003 |
Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model.
Topics: Analysis of Variance; Animals; Dichloroacetic Acid; Disease Models, Animal; Graft Rejection; Graft Survival; Male; Necrosis; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Rectus Abdominis; Risk Factors; Sensitivity and Specificity; Surgical Flaps | 2006 |
The effects of di- and trichloroacetic acid on sheep erythrocytes: an animal model with a glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; In Vitro Techniques; Methemoglobinemia; Sheep; Trichloroacetic Acid | 1984 |
Short-term influences of dichloroacetate on genetically hyperlipemic rats.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Fatty Acids, Nonesterified; Glucagon; Hyperlipidemias; Hypoglycemia; Insulin; Ketone Bodies; Obesity; Rats; Triglycerides | 1980 |
Long-term dichloroacetate administration to genetically hyperlipemic rats.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Obesity; Rats | 1981 |
The effects of dichloroacetate on lactate accumulation and endurance in an exercising rat model.
Topics: Acidosis, Lactic; Animals; Body Temperature Regulation; Dichloroacetic Acid; Disease Models, Animal; Enzyme Activation; Glycogen; Lactates; Liver; Male; Muscle Fatigue; Muscle, Skeletal; Oxidation-Reduction; Physical Endurance; Physical Exertion; Pyruvate Dehydrogenase Complex; Pyruvates; Rats; Rats, Sprague-Dawley; Running; Time Factors | 1995 |
Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia.
Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Gerbillinae; Hippocampus; Lactates; Lactic Acid; Male; Motor Activity; Neurons; Pyramidal Cells | 1994 |
Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis.
Topics: Acidosis, Lactic; Anemia; Animals; Blood Glucose; Dichloroacetic Acid; Disease Models, Animal; Drug Therapy, Combination; Hematocrit; Lactates; Logistic Models; Malaria; Male; Parasitemia; Plasmodium berghei; Quinine; Random Allocation; Rats; Rats, Wistar | 1995 |
Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury.
Topics: Acetylcarnitine; Animals; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Fatty Acids; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure | 1998 |
Effect of dichloracetate on infarct size in a primate model of focal cerebral ischaemia.
Topics: Acidosis, Lactic; Animals; Brain Ischemia; Cerebral Cortex; Dichloroacetic Acid; Disease Models, Animal; Female; Infarction, Middle Cerebral Artery; Macaca radiata; Male; Pyruvate Dehydrogenase Complex | 2000 |
Dichloroacetate improves postischemic function of hypertrophied rat hearts.
Topics: Animals; Cardiomegaly; Dichloroacetic Acid; Disease Models, Animal; Glucose; Glycogen; Glycolysis; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Ventricular Function | 2000 |
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.
Topics: Animals; Behavior, Animal; Dichloroacetic Acid; Disease Models, Animal; Huntington Disease; Male; Mice; Mice, Transgenic; Time Factors | 2001 |
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Animal; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Water | 1992 |
Plasmodium berghei: lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Carbon Dioxide; Dichloroacetic Acid; Disease Models, Animal; Glucose; Hematocrit; Hypoglycemia; Infusions, Intravenous; Insulin; Lactates; Malaria; Male; Oxygen; Plasmodium berghei; Pyruvates; Quinine; Rats; Rats, Inbred Strains | 1991 |
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Humans; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1989 |