Compounds > dichloroacetic acid
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dichloroacetic acid and Colorectal Neoplasms

dichloroacetic acid has been researched along with Colorectal Neoplasms in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (69.23)24.3611
2020's4 (30.77)2.80

Authors

AuthorsStudies
Gaiddon, C; Gross, I; Gu, Y; Hou, L; Hou, Y; Huang, X; Li, L; Li, Y; Liang, Y; Luo, M; Meng, X; Wang, J; Wang, Y; Weng, X; Wu, T; Yao, M; Zhu, D; Zhu, L; Zou, H1
Gu, Y; Hou, L; Huang, X; Li, L; Liang, Y; Luo, M; Meng, X; Wang, J; Wang, Y; Zhou, C; Zhu, D; Zhu, L1
Cheng, X; Dou, W; Liu, J; Pan, S; Shi, X; Sun, J; Wang, L1
Alboghobeish, S; Behmanesh, B; Khodayar, MJ; Mahdavinia, M; Nikravesh, H; Teimoori, A; Zeidooni, L1
Aleksander-Krasko, J; Jarmalaitė, S; Sarapinienė, I; Skeberdytė, A; Stankevičius, V; Sužiedėlis, K1
Huang, Y; Jing, X; Liu, D; Wang, F; Yue, J1
Andrejeva, G; Boult, JK; Chung, YL; Eykyn, TR; Fong, AC; Griffiths, JR; Hill, DK; Jafar, M; Judson, IR; Koh, DM; Leach, MO; Lin, G; Orton, MR; Panek, R; Parkes, HG; Robinson, SP; Troy, H1
Coomber, BL; Delaney, LM; Farias, NR; Ho, N; Morrison, J; Mosser, DD1
Coomber, BL; Ho, N1
Bennett, N; Donohoe, DR; Han, A; Johnstone, M; MacDonald, A; Whelan, J1
Hughes, TA; Jayne, DG; Madhok, BM; Perry, SL; Yeluri, S1
Adamcic, U; Coomber, BL; Lacombe, K; Minhas, K; Shahrzad, S1
He, J; Li, J; Liang, H; Pan, F; Tong, J; Xie, G1

Other Studies

13 other study(ies) available for dichloroacetic acid and Colorectal Neoplasms

ArticleYear
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
    Oncogene, 2020, Volume: 39, Issue:2

    Topics: Animals; Apoptosis; Base Sequence; Colorectal Neoplasms; Dichloroacetic Acid; Drug Resistance, Neoplasm; Fluorouracil; Glucose; HCT116 Cells; Humans; Male; Mice; MicroRNAs; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tumor Suppressor Protein p53

2020
MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
    British journal of cancer, 2020, Volume: 122, Issue:5

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium-Binding Proteins; Colorectal Neoplasms; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; HCT116 Cells; HEK293 Cells; Heterografts; Humans; Male; Mice; Mice, Nude; MicroRNAs; Molecular Targeted Therapy; Oxaliplatin; Phosphorylation; Protein Kinases; Random Allocation; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation

2020
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes.
    Environmental toxicology, 2021, Volume: 36, Issue:4

    Topics: Cell Movement; Cell Survival; Colorectal Neoplasms; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ferroptosis; HCT116 Cells; HT29 Cells; Humans; Iron; Lysosomes; Neoplastic Stem Cells; Sequestering Agents

2021
The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis.
    BMC cancer, 2021, Aug-07, Volume: 21, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dichloroacetic Acid; Drug Synergism; Fluorouracil; Glucose; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Metabolic Networks and Pathways; Mitochondria; Models, Biological; Pyruvates

2021
Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines.
    Scientific reports, 2018, 12-10, Volume: 8, Issue:1

    Topics: Cell Culture Techniques; Cell Line, Tumor; Colorectal Neoplasms; Cytotoxins; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; HCT116 Cells; Humans; Pyrans

2018
Metabolism targeting therapy of dichloroacetate-loaded electrospun mats on colorectal cancer.
    Drug delivery, 2015, Volume: 22, Issue:1

    Topics: Animals; Colorectal Neoplasms; Dichloroacetic Acid; Drug Delivery Systems; Energy Metabolism; Mice; Mice, Inbred BALB C; Polyesters; Quaternary Ammonium Compounds

2015
Dichloroacetate induces autophagy in colorectal cancer cells and tumours.
    British journal of cancer, 2014, Jul-15, Volume: 111, Issue:2

    Topics: Animals; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Dichloroacetic Acid; Female; HCT116 Cells; HT29 Cells; Humans; Lactic Acid; Mice; Mice, Nude; Microscopy, Electron; NAD; Random Allocation; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand; TOR Serine-Threonine Kinases

2014
Dichloroacetate affects proliferation but not survival of human colorectal cancer cells.
    Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:1

    Topics: Antimetabolites; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Cysteine Proteinase Inhibitors; Dichloroacetic Acid; Gene Knockout Techniques; HCT116 Cells; Humans; Leupeptins; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Tumor Suppressor Protein p53

2015
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
    Experimental cell research, 2015, Feb-01, Volume: 331, Issue:1

    Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Glucose; Humans; Hypoxia; Ketone Oxidoreductases; Lactic Acid; Mitochondria; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2015
Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells.
    Journal of cellular physiology, 2016, Volume: 231, Issue:8

    Topics: Acetylation; Antineoplastic Agents; Butyric Acid; Carnitine; Carnitine O-Palmitoyltransferase; Colorectal Neoplasms; Dichloroacetic Acid; Dose-Response Relationship, Drug; Energy Metabolism; HCT116 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Organic Cation Transport Proteins; Oxidation-Reduction; Phosphorylation; Pyruvate Dehydrogenase Complex; RNA Interference; Signal Transduction; Solute Carrier Family 22 Member 5; Time Factors; Transfection

2016
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.
    British journal of cancer, 2010, Jun-08, Volume: 102, Issue:12

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Enzyme Inhibitors; G2 Phase; Humans; Lactic Acid; Oxygen; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase

2010
Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.
    Cancer letters, 2010, Nov-01, Volume: 297, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Caspase 3; Cell Hypoxia; Colorectal Neoplasms; Cytoprotection; Dichloroacetic Acid; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Necrosis; Oxygen; Proto-Oncogene Proteins c-akt; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2010
Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer.
    Journal of biomedicine & biotechnology, 2011, Volume: 2011

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dichloroacetic Acid; Drug Synergism; Fluorouracil; Humans; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase

2011