Page last updated: 2024-08-17

dichloroacetic acid and Carcinoma, Squamous Cell of Head and Neck

dichloroacetic acid has been researched along with Carcinoma, Squamous Cell of Head and Neck in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Black, LJ; Bleeker, JS; Dib, EG; Ellison, CA; Geeraerts, LH; Jensen, AW; Lee, JH; Lohr, MM; Mazurczak, M; McGraw, SC; Miskimins, WK; Powell, SF; Puumala, SE; Reed, VJ; Spanos, WC; Tinguely, M	1
Fan, Z; Li, X; Lu, H; Lu, Y; Qiu, S; Xie, Y	1
Fan, Z; Li, X; Lu, H; Lu, Y; Qiu, S	1

Trials

1 trial(s) available for dichloroacetic acid and Carcinoma, Squamous Cell of Head and Neck

Article	Year
Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma. Investigational new drugs, 2022, Volume: 40, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Dichloroacetic Acid; Head and Neck Neoplasms; Humans; Oxidoreductases; Pyruvates; Squamous Cell Carcinoma of Head and Neck	2022

Article

Year

Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma.

Investigational new drugs, 2022, Volume: 40, Issue:3

Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Dichloroacetic Acid; Head and Neck Neoplasms; Humans; Oxidoreductases; Pyruvates; Squamous Cell Carcinoma of Head and Neck

2022

Other Studies

2 other study(ies) available for dichloroacetic acid and Carcinoma, Squamous Cell of Head and Neck

Article	Year
Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI insight, 2019, 10-03, Volume: 4, Issue:19 Topics: Amino Acid Transport System ASC; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cetuximab; Dichloroacetic Acid; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Mice, Nude; Minor Histocompatibility Antigens; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays	2019
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer letters, 2016, 10-10, Volume: 381, Issue:1 Topics: Amino Acid Transport System ASC; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Dichloroacetic Acid; Down-Regulation; Endocytosis; ErbB Receptors; Gefitinib; Glutamine; Glutathione; Head and Neck Neoplasms; Humans; Minor Histocompatibility Antigens; Oxidative Stress; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Quinazolines; Reactive Oxygen Species; RNA Interference; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Time Factors; Transfection	2016

Article

Year

Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma.

JCI insight, 2019, 10-03, Volume: 4, Issue:19

Topics: Amino Acid Transport System ASC; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cetuximab; Dichloroacetic Acid; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Mice, Nude; Minor Histocompatibility Antigens; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays

2019

ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.

Cancer letters, 2016, 10-10, Volume: 381, Issue:1

Topics: Amino Acid Transport System ASC; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Dichloroacetic Acid; Down-Regulation; Endocytosis; ErbB Receptors; Gefitinib; Glutamine; Glutathione; Head and Neck Neoplasms; Humans; Minor Histocompatibility Antigens; Oxidative Stress; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Quinazolines; Reactive Oxygen Species; RNA Interference; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Time Factors; Transfection

2016