Compounds > dichloroacetic acid
Page last updated: 2024-08-17

dichloroacetic acid and Breast Neoplasms

dichloroacetic acid has been researched along with Breast Neoplasms in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (90.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Danker, K; Eickholt, B; Klein, A; Parczyk, J; Ruhnau, J1
Corbet, C; de Mey, S; De Ridder, M; Dufait, I; Feron, O; Gevaert, T; Jiang, H; Kerkhove, L; Law, KL; Van De Gucht, M; Vandenplas, H; Wang, H1
Hu, Y; Jiang, J; Liao, C; Wang, M1
Aime, S; Anemone, A; Cavallo, F; Consolino, L; Conti, L; Longo, DL; Reineri, F1
Al-Anbaky, QA; Ali, N; Alkarakooly, Z; Kannan, K1
Brown, A; Culf, AS; Cuperlovic-Culf, M; Lefort, N; Lloyd, V; Ouellette, R; Touaibia, M1
Bahng, A; Black, A; Britten, CD; Christofk, HR; Crabtree, MJ; Dubinett, SM; Garon, EB; Hong, CS; Hosmer, W; Kabbinavar, F; Kamranpour, N; Michelakis, ED; Patel, C; Pitts, S; Slamon, DJ; von Euw, E1
Choi, YW; Lim, IK1
Coppock, JD; Haugrud, AB; Miskimins, WK; Zhuang, Y1
Choe, TB; Hong, SE; Hwang, CS; Hwang, SG; Jin, HO; Kim, EK; Kim, HA; Kim, JI; Lee, JK; Lee, YH; Noh, WC; Park, IC; Seo, SK; Shin, KS; Yun, SM1
Blackburn, AC; Dilda, PJ; Gang, BP; Hogg, PJ1
Hu, X; Tam, KY; Zhang, SL; Zhang, W1
Misra, SK; Ostadhossein, F; Pan, D; Ye, M1
Hwang, SG; Kim, EK; Kim, HA; Lee, JK; Noh, WC; Park, IC; Park, Y; Seo, SK; Seong, MK; Song, JY; Woo, SH1
An, S; Hong, J; Hong, SE; Hwang, SG; Jin, HO; Kim, CS; Kim, HA; Kim, JI; Lee, JK; Noh, WC; Park, IC; Song, JY1
Chen, A; Ding, Y; Meng, G; Su, L; Wei, J; Yan, C; Yu, D; Zhang, H1
Bol, A; Brender, JR; De Preter, G; Feron, O; Gallez, B; Grégoire, V; Jordan, BF; Joudiou, N; Kishimoto, S; Krishna, MC; Neveu, MA; Saito, K1
Blackburn, AC; Board, PG; Dahlstrom, JE; Fadia, M; Parish, CR; Sun, RC1
Martin, NK; Robey, IF1
Blackburn, AC; Board, PG; Sun, RC1

Trials

1 trial(s) available for dichloroacetic acid and Breast Neoplasms

ArticleYear
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dichloroacetic Acid; Docetaxel; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Oxygen Consumption; Taxoids; Treatment Failure

2014

Other Studies

19 other study(ies) available for dichloroacetic acid and Breast Neoplasms

ArticleYear
Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.
    BMC cancer, 2020, Jul-02, Volume: 20, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; L-Lactate Dehydrogenase; Mustard Compounds; Phenylpropionates; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyruvate Dehydrogenase Complex; Reproducibility of Results

2020
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells.
    International journal of molecular sciences, 2020, Dec-09, Volume: 21, Issue:24

    Topics: Breast Neoplasms; Cell Line; Dichloroacetic Acid; Enzyme Inhibitors; Female; Humans; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Radiation Tolerance; Reactive Oxygen Species; Tumor Hypoxia

2020
Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy.
    Biochemical and biophysical research communications, 2017, 07-22, Volume: 489, Issue:2

    Topics: Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Female; Humans; Paclitaxel; Structure-Activity Relationship; Tumor Cells, Cultured

2017
In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging.
    International journal of oncology, 2017, Volume: 51, Issue:2

    Topics: Acidosis, Lactic; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Resistance; Female; Glycolysis; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Mice

2017
Metabolic reprogramming by Dichloroacetic acid potentiates photodynamic therapy of human breast adenocarcinoma MCF-7 cells.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Dichloroacetic Acid; Drug Synergism; Energy Metabolism; Female; Humans; MCF-7 Cells; Mitochondrial Membranes; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species

2018
¹H NMR metabolomics analysis of the effect of dichloroacetate and allopurinol on breast cancers.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 93

    Topics: Allopurinol; Breast Neoplasms; Cell Line, Tumor; Dichloroacetic Acid; Enzyme Inhibitors; Female; Humans; MCF-7 Cells; Metabolomics; Proton Magnetic Resonance Spectroscopy

2014
Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells.
    Cancer letters, 2014, May-01, Volume: 346, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Respiration; Dichloroacetic Acid; Drug Synergism; Female; Glucose; HeLa Cells; Humans; MCF-7 Cells; Metformin; Mitochondria; Oxidative Stress; Pyruvate Dehydrogenase Complex

2014
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.
    Breast cancer research and treatment, 2014, Volume: 147, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Female; Humans; Lactates; MCF-7 Cells; Metformin; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species

2014
Inhibition of S6K1 enhances dichloroacetate-induced cell death.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Death; Cell Proliferation; Dichloroacetic Acid; Drug Synergism; Enzyme Inhibitors; Female; Humans; Imidazoles; MCF-7 Cells; Piperazines; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Tumor Cells, Cultured

2015
Targeting of two aspects of metabolism in breast cancer treatment.
    Cancer biology & therapy, 2014, Volume: 15, Issue:11

    Topics: Apoptosis; Arsenicals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Mitochondria; Molecular Targeted Therapy; Reactive Oxygen Species

2014
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Cell Proliferation; Dichloroacetic Acid; Drug Discovery; Female; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tumor Cells, Cultured

2016
Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation.
    Scientific reports, 2016, 06-21, Volume: 6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Dichloroacetic Acid; Female; Humans; Mice; Mice, Nude; Mitochondria; Nanoparticles; Oxidoreductases; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Xenograft Model Antitumor Assays

2016
Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cell Death; Dichloroacetic Acid; Down-Regulation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; p38 Mitogen-Activated Protein Kinases; Proteolysis; Signal Transduction; Tamoxifen

2016
TRAIL restores DCA/metformin-mediated cell death in hypoxia.
    Biochemical and biophysical research communications, 2016, 09-23, Volume: 478, Issue:3

    Topics: Breast Neoplasms; Cell Death; Cell Hypoxia; Dichloroacetic Acid; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Metformin; Receptors, Death Domain; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation

2016
Superior anti-tumor efficacy of diisopropylamine dichloroacetate compared with dichloroacetate in a subcutaneous transplantation breast tumor model.
    Oncotarget, 2016, Oct-04, Volume: 7, Issue:40

    Topics: Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Dichloroacetic Acid; Female; Humans; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Mice, Nude; Quaternary Ammonium Compounds; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2016
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Lactic Acid; Magnetic Resonance Imaging; Oxidation-Reduction; Oxygen Consumption; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Time Factors; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2016
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.
    Breast cancer research and treatment, 2010, Volume: 120, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Female; Glycolysis; Humans; In Vitro Techniques; Mammary Neoplasms, Experimental; Phenotype; Rats

2010
Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.
    BMC cancer, 2011, Jun-10, Volume: 11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Bicarbonates; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Dichloroacetic Acid; Disease Models, Animal; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lung Neoplasms; Mice; Mice, SCID; Sodium Bicarbonate; Survival Analysis; Tumor Burden; Tumor Microenvironment

2011
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.
    Molecular cancer, 2011, Nov-18, Volume: 10

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Female; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxides; Reactive Oxygen Species

2011