Page last updated: 2024-08-17

dichloroacetic acid and Brain Neoplasms

dichloroacetic acid has been researched along with Brain Neoplasms in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	14 (82.35)	24.3611
2020's	3 (17.65)	2.80

Authors

Authors	Studies
Chen, F; Chen, X; Huang, Y; She, H	1
Chang, C; Chornenkyy, Y; Hawkins, C; Joshi, S; Liu, J; Ryall, S; Shen, H; Siddaway, R; Tsoli, M; Yu, M; Ziegler, DS	1
Albayrak, G; Dere, UA; Emmez, H; Konac, E	1
D'Agostino, DP; Koutnik, AP; Poff, AM; Ward, NP	1
Kolesnik, DL; Prokhorova, IV; Pyaskovskaya, ON; Solyanik, GI	1
Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA	1
Asuthkar, S; Bhasin, A; Tsung, AJ; Velpula, KK	1
Coats, BS; Dunbar, EM; Forder, JR; Langaee, T; Lew, A; Shroads, AL; Shuster, JJ; Stacpoole, PW; Wagner, DA	1
Azadi, J; Bow, H; Brem, H; Hutt-Cabezas, M; Hwang, L; Joshi, A; Mangraviti, A; Martin, KL; Rudek, MA; Tyler, BM; Wicks, RT; Zhang, I; Zhao, M	1
Agostinelli, E; Canettieri, G; Coni, S; D'Amico, D; De Smaele, E; Di Magno, L; Di Marcotullio, L; Ferretti, E; Gulino, A; Infante, P; Macone, A; Manzi, D; Screpanti, I	1
Chen, A; Jiang, A; Li, C; Meng, G; Su, L; Wei, J; Xia, M; Xu, C; Yu, D	1
Asuthkar, S; Guda, MR; Tsung, AJ; Velpula, KK; Yuen, CA	1
Fedorchuk, AG; Gorbik, GV; Kolesnik, DL; Prokhorova, IV; Pyaskovskaya, ON; Solyanik, GI	1
Brodie, C; Brodie, Z; Cazacu, S; Finniss, S; Jiang, W; Mikkelsen, T; Poisson, L; Shackelford, DB; Xiang, C	1
Vander Heiden, MG	1
Abdulkarim, B; Dromparis, P; Fulton, D; Gammer, TL; Haromy, A; Mackey, JR; Maguire, C; McMurtry, MS; Michelakis, ED; Niven, E; Petruk, KC; Sutendra, G; Webster, L	1
Hurd, RE; Jang, T; Josan, S; Mayer, D; Merchant, M; Park, JM; Recht, LD; Spielman, DM; Yen, YF	1

Reviews

1 review(s) available for dichloroacetic acid and Brain Neoplasms

Article	Year
Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old concept. CNS oncology, 2016, Volume: 5, Issue:2 Topics: Angiogenesis Inhibitors; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Hypoxia; Cell Self Renewal; Cellular Reprogramming; Dichloroacetic Acid; Drug Resistance, Neoplasm; Glioblastoma; Glycolysis; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Neoplastic Stem Cells; Oxidative Phosphorylation; Signal Transduction; Up-Regulation	2016

Article

Year

Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old concept.

CNS oncology, 2016, Volume: 5, Issue:2

Topics: Angiogenesis Inhibitors; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Hypoxia; Cell Self Renewal; Cellular Reprogramming; Dichloroacetic Acid; Drug Resistance, Neoplasm; Glioblastoma; Glycolysis; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Neoplastic Stem Cells; Oxidative Phosphorylation; Signal Transduction; Up-Regulation

2016

Trials

1 trial(s) available for dichloroacetic acid and Brain Neoplasms

Article	Year
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors. Investigational new drugs, 2014, Volume: 32, Issue:3 Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brain Neoplasms; Breath Tests; Dichloroacetic Acid; Female; Glutathione Transferase; Haplotypes; Humans; Male; Maleates; Middle Aged; Pyruvic Acid	2014

Other Studies

15 other study(ies) available for dichloroacetic acid and Brain Neoplasms

Article	Year
Risk factors and prognostic factors for pulmonary large cell neuroendocrine carcinoma with brain metastasis. Cancer medicine, 2023, Volume: 12, Issue:4 Topics: Brain Neoplasms; Carcinoma, Neuroendocrine; Dichloroacetic Acid; Humans; Lung Neoplasms; Models, Statistical; Nomograms; Prognosis; Reproducibility of Results; Risk Factors; SEER Program	2023
Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas. Neuro-oncology, 2020, 01-11, Volume: 22, Issue:1 Topics: Aminoimidazole Carboxamide; Animals; Brain Neoplasms; Child; Dichloroacetic Acid; DNA, Mitochondrial; Energy Metabolism; Gene Dosage; Glioma; Glycolysis; Humans; Mice; Ribonucleotides; Xenograft Model Antitumor Assays	2020
Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM). Turkish neurosurgery, 2021, Volume: 31, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Dopamine Agents; Dose-Response Relationship, Drug; Glioblastoma; Humans; Hypoglycemic Agents; Memantine; Metformin; Proto-Oncogene Proteins c-bcl-2	2021
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells. PloS one, 2017, Volume: 12, Issue:6 Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Electron Transport Complex I; Glioblastoma; Membrane Potential, Mitochondrial; Metformin; Mice; Oxidative Stress; Rotenone; Superoxides	2017
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6. Experimental oncology, 2018, Volume: 40, Issue:3 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dichloroacetic Acid; Female; Glioma; Hematology; Humans; Metformin; Rats	2018
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. Medical hypotheses, 2019, Volume: 122 Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroacetic Acid; Evidence-Based Medicine; Glioblastoma; Heart; Humans; Ketones; Lactic Acid; Models, Theoretical; Neoplasms; Oxygen; Perfusion; Rats	2019
Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer research, 2013, Dec-15, Volume: 73, Issue:24 Topics: Animals; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Transformation, Neoplastic; Dichloroacetic Acid; ErbB Receptors; Female; Glioblastoma; Humans; Mice; Mice, Nude; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction	2013
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma. Neuro-oncology, 2015, Volume: 17, Issue:1 Topics: Absorbable Implants; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Dichloroacetic Acid; Drug Administration Routes; Drug Combinations; Drug Delivery Systems; Female; Glioblastoma; Glycolysis; Humans; Kaplan-Meier Estimate; Polymers; Pyruvates; Rats; Rats, Inbred F344; Temozolomide	2015
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth. Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:21 Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Dichloroacetic Acid; Glycolysis; Hedgehog Proteins; Hexokinase; Immunohistochemistry; Lactic Acid; Medulloblastoma; Mice; Mice, Nude; Oncogene Proteins; Protein Kinase Inhibitors; Pyruvate Kinase; RNA, Messenger; Signal Transduction; Trans-Activators; Transplantation, Homologous; Zinc Finger Protein GLI1	2014
Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma. Oncotarget, 2015, Jan-30, Volume: 6, Issue:3 Topics: Aerobiosis; Animals; Brain Neoplasms; Cell Line, Tumor; Dichloroacetic Acid; Glioblastoma; Glycolysis; Humans; Male; Measles virus; Mice; Mice, Inbred BALB C; Mice, Nude; Oncolytic Virotherapy; Random Allocation; Virus Replication; Xenograft Model Antitumor Assays	2015
Effectiveness of sodium dichloroacetate against glioma C6 depends on administration schedule and dosage. Experimental oncology, 2016, Volume: 38, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Administration Schedule; Female; Glioma; Mitochondria; Oxygen; Rats, Wistar	2016
Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma. Oncotarget, 2016, Aug-30, Volume: 7, Issue:35 Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Dichloroacetic Acid; Drug Repositioning; Gene Silencing; Glioblastoma; Glioma; HMGA2 Protein; Humans; Hypoglycemic Agents; Lentivirus; Mice; Mice, Nude; MicroRNAs; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neoplastic Stem Cells; Phenformin; RNA, Long Noncoding	2016
Targeting cell metabolism in cancer patients. Science translational medicine, 2010, May-12, Volume: 2, Issue:31 Topics: Brain Neoplasms; Dichloroacetic Acid; Glioblastoma; Glucose; Humans; Mitochondria; Pyruvate Dehydrogenase Complex	2010
Metabolic modulation of glioblastoma with dichloroacetate. Science translational medicine, 2010, May-12, Volume: 2, Issue:31 Topics: Adult; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dichloroacetic Acid; Female; Glioblastoma; Humans; In Vitro Techniques; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species	2010
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Neuro-oncology, 2013, Volume: 15, Issue:4 Topics: Acetyl Coenzyme A; Animals; Brain; Brain Neoplasms; Carbon Radioisotopes; Dichloroacetic Acid; Glioma; Magnetic Resonance Imaging; Male; Mitochondria; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvates; Rats; Rats, Wistar; Tumor Cells, Cultured	2013